Protein Alignment Mhcl and zip

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1939
• Identity: 513/1939 - (26%)
• Similarity: 843/1939 - (43%)
• Gaps: 456/1939 - (23%)

  Fly   496 ADVADASQPERVWLVHRG-GFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPA 559
            |..|:.:|...||:.|.. ||.|      ||..|:..:::.:.|...|:::.:..||::|.|.|.
  Fly    71 ATQAEWTQKRLVWVPHENQGFVA------ASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPK 129

  Fly   560 LDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTE 624
            .|.|||:.||..||||||||.::.||.|.||:|.:|...:||||...|.:|:||::..::|.|..
  Fly   130 FDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRH 194

  Fly   625 DMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGA------------ 677
            ::||||:::..:|||:::..|.|||::..|.||:||:.:.|..:.:||..|.:
  Fly   195 EVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPA 259

  Fly   678 --YNNFINAEK-------------------------VNALC-------------TILEAFGNTKT 702
              .|..:|..|                         ||:.|             .|||||||.||
  Fly   260 VLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKT 324

  Fly   703 CLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKE 767
            ..|.|::|..:.:.::||.:|.|:.|:::..|.|:.||.|:...|.:|||..:|||||....:::
  Fly   325 VKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREK 389

  Fly   768 LHLENITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHL 828
            ..|:::   .|:.|:|...    .::|    ..:|..||::...:.:.::....|:.|::|:...
  Fly   390 FILDDV---KSYAFLSNGSLPVPGVDD----YAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLF 447

  Fly   829 GIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDT 893
            |.....:......|  ...:.|.|:|.:.|||:::.|::.|   ...|....|....:|:.|.:.
  Fly   448 GSMKFRQERNNDQA--TLPDNTVAQKIAHLLGLSVTDMTRA---FLTPRIKVGRDFVTKAQTKEQ 507

  Fly   894 GHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDTPGFQ----NPASCGQQV 953
             .|:|   :||:....|......:|..|||.:..:....|| |.::|..||:    |
  Fly   508 -VEFA---VEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN-------- 560

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAP 1013
              :...|..||..|:||.||:||..:..::.|.:|     .::..:||.      |.|.||||.
  Fly   561 --SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQ------PTIDLIDKP- 616

  Fly  1014 QNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRK-----CAG 1073
                             .|::.|||||..:|.:.|.||:::|.|      .||:..|     ..|
  Fly   617 -----------------GGIMALLDEECWFPKATDKTFVDKLVS------AHSMHPKFMKTDFRG 658

  Fly  1074 PRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFC 1138
            ...|.:.|..|.  |.|:...|:..:.: |...|.|||||.|....:..::..:...|.......
  Fly   659 VADFAIVHYAGR--VDYSAAKWLMKNMD-PLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720

  Fly  1139 GSFAGLEGTQSL-RRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQH-- 1200
            .:..|....:.: |.||.:                 .|..:..::||||.|..:||.|.:..|
  Fly   721 DTQFGARTRKGMFRTVSHL-----------------YKEQLAKLMDTLRNTNPNFVRCIIPNHEK 768

  Fly  1201 NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRR 1265
            .|||                       ::.||:..|||.:.|||..|:.|.|||..:|..||.:|
  Fly   769 RAGK-----------------------IDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQR 810

  Fly  1266 FGLLA------GDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRI 1324
            :.||.      |.:...|  :.|:::...|||...||:|.|:|.||:|||:.||.:||..:||.|
  Fly   811 YELLTPNVIPKGFMDGKK--ACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLI 873

  Fly  1325 IQLQAFCRGYLARKKMSQRRVQEL-AVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQL 1388
            :..||||||:|||:.. |:|:|:| |:|.||||..|:|.:|:|.||||..:|.|||.|.:.||:|
  Fly   874 VNFQAFCRGFLARRNY-QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKL 937

  Fly  1389 KTANEELLMLRAKLEKI-----------------------------------ECDRSEVKAENQK 1418
            ....:||..:|.||:.:                                   |..||.:.|..|:
  Fly   938 VQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQE 1002

  Fly  1419 LEAKLSELTVDLAEERS--------------TAHIATERLEAETAERLKLEKELGDQTNKVKNLQ 1469
            ||..:.||...:.||..              ......|:||.|.|.|.||:.|......|:|..:
  Fly  1003 LEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYE 1067

  Fly  1470 E-------TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQ 1527
            |       ..:||..|....:...|.:|:....|.|........|.|:|....|||   .||| :
  Fly  1068 EDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELE---ERLH-K 1128

  Fly  1528 HEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLE 1592
            .:...::....|:.:|.:::|..|::.|:|..|.:.:.:..|...|:....:.::|::|.....:
  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193

  Fly  1593 KKQRKFDAECQSLQDAVRQERQAK---ERYGRE-KDVLQAEKFTLEQTLADTRLDLEF---KEEK 1650
            |.||:.:::...:|:.:..|:.|:   |:..|: .:.|:|.|..|..:|..|....|.   :|::
  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQE 1258

  Fly  1651 LASLQRELEEMTFG-------------------------------------GGTEEEFAQL---- 1674
            ||:|::.|||.|..                                     |..|.|.|.|
  Fly  1259 LATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATEL 1323

  Fly  1675 ---RRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG 1736
               ..|:.|.:||.|:.|.::.|:..::..:|:|:..|:.....:::||...:.|. ||.|....
  Fly  1324 RSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQL-EEAELKAS 1387

  Fly  1737 NGYKKIKALECQL-ETEH--EERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRD---L 1795
            ...|....:|.|| |.:.  ||.|   |:|..|..:|..:|..       :|||.::|..|   .
  Fly  1388 AAVKSASNMESQLTEAQQLLEEET---RQKLGLSSKLRQIESE-------KEALQEQLEEDDEAK 1442

  Fly  1796 RKYKALLKDAQTQLERLK------ADTPG--------------------KTLIRQ---------- 1824
            |.|:..|.:..||::.:|      ||...                    |.||.|
  Fly  1443 RNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKK 1507

  Fly  1825 LRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERA----NAAHRDRAELQAQI 1885
            ::::||||    ::.::|::|...||.:.|..||:..     |||:|    .|..||.||.:|:.
  Fly  1508 IQSELEDA----TIELEAQRTKVLELEKKQKNFDKIL-----AEEKAISEQIAQERDTAEREARE 1563

  Fly  1886 EENE-----EELGELMKKYSATVKQLNTEQINVSE-------AEFKLNEMEAERNNLKEQVAELQ 1938
            :|.:     .||.|...|......:..|.|..:.:       |:..::|:|..:..|:.|:|||:
  Fly  1564 KETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELK 1628

  Fly  1939 HRLDNVENLGDPSMAMMSK-RLELRTKELESRLEL------EQATRAR---------LEVQVNRH 1987
            .:.:.:|:  |..:...:| |||:..:.|.|:.|.      |.|...|         ||.:::..
  Fly  1629 AQNEELED--DLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEE 1691

  Fly  1988 KE-------ALEKLQNEV----TQSKMREMQAQDVIKKSQK-------SLRDMREEFHAVSSREQ 2034
            ::       :.:||:.::    |..:|.....:|.:|.::|       :|||..|    ..:.::
  Fly  1692 RKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEE----AKAAKE 1752

  Fly  2035 ESLTRRKDLEKKVEQMESEGAALKNDLRLA--LQRIADLQQ------------------------ 2073
            |.....|:.|:||:.:|:|...|..||..:  .:|.|:.::
  Fly  1753 ELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRL 1817

  Fly  2074 -----AMEEEGEEELSES----DESLSSVGSISDLEDRLRPVHVKRSSQQSLNG 2118
                 .:|||.|||.|.|    |.|..:...|..|...|  .:.|.:||::.||
  Fly  1818 EARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTEL--ANEKSNSQKNENG 1869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	466/1757 (27%)
		MYSc_Myo18	575..1305	CDD:276837	218/809 (27%)
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	12/48 (25%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	218/809 (27%)
		Myosin_tail_1	931..2011	CDD:460256	223/971 (23%)