DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and zip

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:1939 Identity:513/1939 - (26%)
Similarity:843/1939 - (43%) Gaps:456/1939 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   496 ADVADASQPERVWLVHRG-GFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPA 559
            |..|:.:|...||:.|.. ||.|      ||..|:..:::.:.|...|:::.:..||::|.|.|.
  Fly    71 ATQAEWTQKRLVWVPHENQGFVA------ASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPK 129

  Fly   560 LDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTE 624
            .|.|||:.||..||||||||.::.||.|.||:|.:|...:||||...|.:|:||::..::|.|..
  Fly   130 FDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRH 194

  Fly   625 DMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGA------------ 677
            ::||||:::..:|||:::..|.|||::..|.||:||:.:.|..:.:||..|.:            
  Fly   195 EVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPA 259

  Fly   678 --YNNFINAEK-------------------------VNALC-------------TILEAFGNTKT 702
              .|..:|..|                         ||:.|             .|||||||.||
  Fly   260 VLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKT 324

  Fly   703 CLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKE 767
            ..|.|::|..:.:.::||.:|.|:.|:::..|.|:.||.|:...|.:|||..:|||||....:::
  Fly   325 VKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREK 389

  Fly   768 LHLENITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHL 828
            ..|:::   .|:.|:|...    .::|    ..:|..||::...:.:.::....|:.|::|:...
  Fly   390 FILDDV---KSYAFLSNGSLPVPGVDD----YAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLF 447

  Fly   829 GIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDT 893
            |.....:......|  ...:.|.|:|.:.|||:::.|::.|   ...|....|....:|:.|.:.
  Fly   448 GSMKFRQERNNDQA--TLPDNTVAQKIAHLLGLSVTDMTRA---FLTPRIKVGRDFVTKAQTKEQ 507

  Fly   894 GHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDTPGFQ----NPASCGQQV 953
             .|:|   :||:....|......:|..|||.:..:....|| |.::|..||:    |        
  Fly   508 -VEFA---VEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN-------- 560

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAP 1013
              :...|..||..|:||.||:||..:..::.|.:|     .::..:||.      |.|.||||. 
  Fly   561 --SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQ------PTIDLIDKP- 616

  Fly  1014 QNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRK-----CAG 1073
                             .|::.|||||..:|.:.|.||:::|.|      .||:..|     ..|
  Fly   617 -----------------GGIMALLDEECWFPKATDKTFVDKLVS------AHSMHPKFMKTDFRG 658

  Fly  1074 PRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFC 1138
            ...|.:.|..|.  |.|:...|:..:.: |...|.|||||.|....:..::..:...|.......
  Fly   659 VADFAIVHYAGR--VDYSAAKWLMKNMD-PLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720

  Fly  1139 GSFAGLEGTQSL-RRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQH-- 1200
            .:..|....:.: |.||.:                 .|..:..::||||.|..:||.|.:..|  
  Fly   721 DTQFGARTRKGMFRTVSHL-----------------YKEQLAKLMDTLRNTNPNFVRCIIPNHEK 768

  Fly  1201 NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRR 1265
            .|||                       ::.||:..|||.:.|||..|:.|.|||..:|..||.:|
  Fly   769 RAGK-----------------------IDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQR 810

  Fly  1266 FGLLA------GDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRI 1324
            :.||.      |.:...|  :.|:::...|||...||:|.|:|.||:|||:.||.:||..:||.|
  Fly   811 YELLTPNVIPKGFMDGKK--ACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLI 873

  Fly  1325 IQLQAFCRGYLARKKMSQRRVQEL-AVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQL 1388
            :..||||||:|||:.. |:|:|:| |:|.||||..|:|.:|:|.||||..:|.|||.|.:.||:|
  Fly   874 VNFQAFCRGFLARRNY-QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKL 937

  Fly  1389 KTANEELLMLRAKLEKI-----------------------------------ECDRSEVKAENQK 1418
            ....:||..:|.||:.:                                   |..||.:.|..|:
  Fly   938 VQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQE 1002

  Fly  1419 LEAKLSELTVDLAEERS--------------TAHIATERLEAETAERLKLEKELGDQTNKVKNLQ 1469
            ||..:.||...:.||..              ......|:||.|.|.|.||:.|......|:|..:
  Fly  1003 LEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYE 1067

  Fly  1470 E-------TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQ 1527
            |       ..:||..|....:...|.:|:....|.|........|.|:|....|||   .||| :
  Fly  1068 EDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELE---ERLH-K 1128

  Fly  1528 HEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLE 1592
            .:...::....|:.:|.:::|..|::.|:|..|.:.:.:..|...|:....:.::|::|.....:
  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193

  Fly  1593 KKQRKFDAECQSLQDAVRQERQAK---ERYGRE-KDVLQAEKFTLEQTLADTRLDLEF---KEEK 1650
            |.||:.:::...:|:.:..|:.|:   |:..|: .:.|:|.|..|..:|..|....|.   :|::
  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQE 1258

  Fly  1651 LASLQRELEEMTFG-------------------------------------GGTEEEFAQL---- 1674
            ||:|::.|||.|..                                     |..|.|.|.|    
  Fly  1259 LATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATEL 1323

  Fly  1675 ---RRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG 1736
               ..|:.|.:||.|:.|.::.|:..::..:|:|:..|:.....:::||...:.|. ||.|....
  Fly  1324 RSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQL-EEAELKAS 1387

  Fly  1737 NGYKKIKALECQL-ETEH--EERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRD---L 1795
            ...|....:|.|| |.:.  ||.|   |:|..|..:|..:|..       :|||.::|..|   .
  Fly  1388 AAVKSASNMESQLTEAQQLLEEET---RQKLGLSSKLRQIESE-------KEALQEQLEEDDEAK 1442

  Fly  1796 RKYKALLKDAQTQLERLK------ADTPG--------------------KTLIRQ---------- 1824
            |.|:..|.:..||::.:|      ||...                    |.||.|          
  Fly  1443 RNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKK 1507

  Fly  1825 LRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERA----NAAHRDRAELQAQI 1885
            ::::||||    ::.::|::|...||.:.|..||:..     |||:|    .|..||.||.:|:.
  Fly  1508 IQSELEDA----TIELEAQRTKVLELEKKQKNFDKIL-----AEEKAISEQIAQERDTAEREARE 1563

  Fly  1886 EENE-----EELGELMKKYSATVKQLNTEQINVSE-------AEFKLNEMEAERNNLKEQVAELQ 1938
            :|.:     .||.|...|......:..|.|..:.:       |:..::|:|..:..|:.|:|||:
  Fly  1564 KETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELK 1628

  Fly  1939 HRLDNVENLGDPSMAMMSK-RLELRTKELESRLEL------EQATRAR---------LEVQVNRH 1987
            .:.:.:|:  |..:...:| |||:..:.|.|:.|.      |.|...|         ||.:::..
  Fly  1629 AQNEELED--DLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEE 1691

  Fly  1988 KE-------ALEKLQNEV----TQSKMREMQAQDVIKKSQK-------SLRDMREEFHAVSSREQ 2034
            ::       :.:||:.::    |..:|.....:|.:|.::|       :|||..|    ..:.::
  Fly  1692 RKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEE----AKAAKE 1752

  Fly  2035 ESLTRRKDLEKKVEQMESEGAALKNDLRLA--LQRIADLQQ------------------------ 2073
            |.....|:.|:||:.:|:|...|..||..:  .:|.|:.::                        
  Fly  1753 ELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRL 1817

  Fly  2074 -----AMEEEGEEELSES----DESLSSVGSISDLEDRLRPVHVKRSSQQSLNG 2118
                 .:|||.|||.|.|    |.|..:...|..|...|  .:.|.:||::.||
  Fly  1818 EARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTEL--ANEKSNSQKNENG 1869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 236/840 (28%)
MYSc_Myo18 575..1305 CDD:276837 218/809 (27%)
GBP_C <1540..1750 CDD:303769 58/261 (22%)
COG1340 1565..1833 CDD:224259 81/360 (23%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 11/42 (26%)
Myosin_head 133..854 CDD:278492 226/821 (28%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 218/809 (27%)
Myosin_tail_1 931..2011 CDD:279860 223/971 (23%)
Prefoldin 1431..1515 CDD:298833 17/83 (20%)
FAM76 <1847..1926 CDD:292665 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466217
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

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