DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and inaD

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	652	Identity:	123/652 - (18%)
Similarity:	223/652 - (34%)	Gaps:	215/652 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1623 KDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAK- 1686
            |||    :.:.||.:.|...:.:||        .|||..||....|::.....||....:.:.|
  Fly    89 KDV----RNSTEQAVIDLIKEADFK--------IELEIQTFDKSDEQQAKSDPRSNGYMQAKNKF 141

  Fly  1687 EQEEELDEMA--------GQIQLLEQAKLRLEMTLE--------TMRKEARRESQQRDEELEEVR 1735
            .||:..:..|        ||.|....|.:..:.:::        :||::....:.:.||:..::.
  Fly   142 NQEQTTNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMT 206

  Fly  1736 GN-----GYK--KIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRR 1793
            |.     ||:  :..|..|:|..:.::|                       |::.|:.....:.:
  Fly   207 GRIRTEAGYEIDRASAGNCKLNKQEKDR-----------------------DKEQEDEFGYTMAK 248

  Fly  1794 DLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFD 1858
            ..::|. ::||                 :|::..| .||.....||:
  Fly   249 INKRYN-MMKD-----------------LRRIEVQ-RDASKPLGLAL------------------ 276

  Fly  1859 ESHRARNDAEERANAAHRDRAELQ---AQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKL 1920
                          |.|:||.::.   |.::.| ..||.:..|....:.::|.   ||.:....|
  Fly   277 --------------AGHKDRQKMACFVAGVDPN-GALGSVDIKPGDEIVEVNG---NVLKNRCHL 323

  Fly  1921 NEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKR------------LELRTKELESRLELE 1973
            |.....:|            :|     ||..:.:.|:|            .:..|...|::...:
  Fly   324 NASAVFKN------------VD-----GDKLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFD 371

  Fly  1974 QATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLT 2038
            |..:|| .|||  .||..  |...|...|..|:.:...|.       |:||     .|..:.:..
  Fly   372 QFPKAR-TVQV--RKEGF--LGIMVIYGKHAEVGSGIFIS-------DLRE-----GSNAELAGV 419

  Fly  2039 RRKDLEKKVEQ---MES------------EGAALKNDLRLALQRIADLQQAMEEEGEEELSESDE 2088
            :..|:...|.|   :||            ||......|.|..:.....::|.||:.:||..:.:|
  Fly   420 KVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEE 484

  Fly  2089 SLSSVGSISDLEDRLRP---VHVKRSSQQSLNGSIGGGG-----------------GSVVSSTRT 2133
            ......:.     .::|   :.::...::...|.|..||                 |.|.:..|.
  Fly   485 KPQEPATA-----EIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGCVITHVYPEGQVAADKRL 544

  Fly  2134 VVFEK--DDNSPRITVTSPSSPHIHKL-------ALAAKAIPANKPDTKPAASTRMELTVPAGQH 2189
            .:|:.  |.|...|.|.|.::..:|:|       |:......|:.|:.:   ...::|...||:.
  Fly   545 KIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPPELE---KFNVDLMKKAGKE 606

  Fly  2190 NG 2191
            .|
  Fly   607 LG 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	33/150 (22%)
		COG1340	1565..1833	CDD:224259	43/233 (18%)
		coiled coil	1723..1734	CDD:293879	2/10 (20%)
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	11/37 (30%)
		PDZ_signaling	259..340	CDD:238492	24/134 (18%)
		PDZ_signaling	377..457	CDD:238492	22/96 (23%)
		PDZ_signaling	500..584	CDD:238492	16/83 (19%)
		PDZ_signaling	597..672	CDD:238492	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900