DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Lnx2

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	118/626 - (18%)
Similarity:	197/626 - (31%)	Gaps:	219/626 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 HIESRASNGAGVSVNY----SEVTHSLLSGGLKNRFLPPIPPKPPKR---GILKGSRSNMTNVHE 180
            |:::|....:...|:.    :...|:.:.|...:..:.|..|.||:.   |.:.|.|::
  Rat   133 HLKNRCLGASHRRVDLERRKTSQAHTQIEGETGSTVIDPPGPSPPETDCLGTVPGERNS------ 191

  Fly   181 EISFAGSAGGAGGTPEMLLRNT----FQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDG- 240
                         ||..|...|    ..|.:..|.||  |.|:....|......|::|..|::.
  Rat   192 -------------TPAPLPVWTEDPGLDNPAFEESAA--ADSVQQPLSLPEGEITTIEIHRTNPY 241

  Fly   241 -----EQTGGQ---------QRAMTLPANARYGALPQGN----------SQGSHLH---VLTSPS 278
                 ...||.         |......|.||.|.|..|:          |..||.:   ||:.|.
  Rat   242 IQLGISIVGGNETPLINIVIQEVYRDGAIARDGRLLAGDQILQVNNCDISNVSHNYARAVLSQPC 306

  Fly   279 PSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQ 343
             |...||......|.                  :|.:...|...|...|        .|:::.::
  Rat   307 -STLHLTVLRERRFG------------------SRANNHADGSAPRDEV--------FQVLLHKR 344

  Fly   344 KSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGA-------GGGAT---GLLPGDRLIKVN 398
            .|..| .|..|     :.||:             |||.       ||.|.   .|...||::.:|
  Rat   345 DSAEQ-LGIKL-----VRRTD-------------EPGVFILDLLEGGLAAQDGRLSSNDRVLAIN 390

  Fly   399 GTPVGELPREIIIEMIRNSGEAVTVEV------QPVAELVELSKRCMAPSTATVEEIDHSITNGN 457
            |..:.:...|:...:|:.|||.|.:.:      ||    ...|:...|.|:...:...||..:.:
  Rat   391 GHDLKQGTPELAAHIIQASGERVNLTIARPGKPQP----SNGSREAGAHSSNHAQPPSHSRPSSH 451

  Fly   458 CNTLRRSASKRFK----RQSRHEN-----GNGGGEEGGAKGV------GHDLEA----------- 496
             ..|.|..:.:.|    ::..||:     ..|.|.:.|...:      .|...|
  Rat   452 -KDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVL 515

  Fly   497 ------DVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQ 555
                  |:.:.|..|.|.::.....:.|:.|          ..|.:::.....|.|.::.....:
  Rat   516 LNINGIDLTNLSHSEAVAMLKASAASPAVIL----------KALEVQIAEEAAQATEEQPGAFSE 570

  Fly   556 N------SPALDLVEDICELKYLNEASVLH-C----LRQRYASN------------------LIH 591
            |      ||:.        :.:|...|.|| |    ||:.|..:                  .|.
  Rat   571 NEYDASWSPSW--------VMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHSNQPFFIK 627

  Fly   592 T-------------KAGPTLLVVNPMAPLSLYSEKVVSMFR 619
            |             |.|..::.||.::.:.:....:|.|.:
  Rat   628 TIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/102 (23%)
		MYSc	556..1317	CDD:214580	19/106 (18%)
		MYSc_Myo18	575..1305	CDD:276837	15/81 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	21/86 (24%)
		PDZ	335..421	CDD:214570	25/112 (22%)
		PDZ_signaling	462..538	CDD:238492	12/75 (16%)
		PDZ_signaling	595..679	CDD:238492	11/74 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900