|
Fly 1 MFNFMKKSAGDEDKERRKREKKLRKEAKGTSGGPGMGGVTGVTGSMSTDELLRLDE--VRR---S 60
|||.||| |:||:..::|||.:||.| ..||..||..|:| :|| :
Rat 1 MFNLMKK---DKDKDGGRKEKKEKKEKK---------------ERMSAAELRSLEEMSMRRGFFN 47
Fly 61 LKIRGRRKEKEKLPSGITADYSADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHIE 125
|....:|:.|.:|
Rat 48 LNRSSKRESKTRL---------------------------------------------------- 60
Fly 126 SRASNGAGVSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGG 190
|::: |||.| :..||..::|::..:
Rat 61 --------------EISN-------------PIPIK-----VASGSDLHLTDIDSD--------- 84
Fly 191 AGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPAN 255
...|||..:|. |.::.:|.:.|: ||: |..|...|...
Rat 85 -----------------------SNRGSIILDSG-HLSTASSSDDLK--GEE--GSFRGSVLQRA 121
Fly 256 ARYGALPQGNSQGSHLHVLTSPSPSADSLTDT-TNSSFATPPFSLSPVGESQGIDRWARVHAFED 319
|::|:|.:.|||........|.....:|.::| |.|..:..| ||..|.:.::.....|:...
Rat 122 AKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAP---SPQVEVRTLEGQLMQHSGLG 183
Fly 320 VELPLP------------PVQ-----LVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLT 367
:..|.| |.. ||..|||....:..|:.|..|||||||:...|||...
Rat 184 IPRPGPRSRVPELVTKRFPADLRLPALVPPPPPALRELELQRRPTGDFGFSLRRTTMLDRAPE-- 246
Fly 368 SPIFRPVI-FAEPGAGGG--ATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVA 429
...:|.|: |||||||.. |.||:|||||:::||..|....|:.|:||||.||::|.::|||:.
Rat 247 GQAYRRVVHFAEPGAGTKDLALGLVPGDRLVEINGQNVENKSRDEIVEMIRQSGDSVRLKVQPIP 311
Fly 430 ELVELSKRCMAPSTATVEE---ID-------HSITNGNCNTLRRSASKRFKRQSRHENG-----N 479
||.|||:..:........| :| ||....:|.|...||.. .:|. .
Rat 312 ELSELSRSWLRTGEGHRREPTDLDPVAASPAHSQVGCSCPTQEPSAFS-------SDNPPPPPYT 369
Fly 480 GGGEEGGAKGVGHDLEADVADAS---QPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHN 541
..|....|.......|..:|... :.|:||||||.||:.|.:|.:..... .|.|:.::|.|:
Rat 370 WAGVCARASCWSAKTEEQIAAEEAWYETEKVWLVHRDGFSLASQLKSEELSL-PEGKVRVKLDHD 433
Fly 542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
|..|.||||||||.|:|:.|.:||:..|.||||:||||.|||||.::|:||.|||:|||::|...
Rat 434 GAILDVDEDDVEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLSPRGA 498
Fly 607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
.::|||||:.||:||:.|||.||:|::||||||:::.:|:|||::.:|.|||||:||.:|.:.||
Rat 499 PAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIVLLGSSGSGKTTSSQHLVQYL 563
Fly 672 ALAAGAYNNFI-NAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLP 735
|..||...|.: :.||..||.|:||||||:.|.:|.:|||.:|:|||||||.||:||||:|.:|.
Rat 564 ATIAGTSGNKVFSVEKWQALATLLEAFGNSPTIMNGSATRFSQILSLDFDQAGQVASASVQTMLL 628
Fly 736 ERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMR 800
|:.|..||...|.:|::...|||.....|:.||||.::...:....:.|| |.|::.|||..|.:
Rat 629 EKLRVARRPASEATFNVFYYLLACGDSTLRTELHLNHLAENNVFGIVPLS-KPEEKQRAAQQFSK 692
Fly 801 TVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTK------LGTGSTARTQFANPTAARKASGLL 859
...|.:.|.|..:..:..|.|||:|||||.||.|| .......|.|||....|:||:.||
Rat 693 LQTAMKVLAISPEEQKACWLILASIYHLGAAGATKEPLEEQAEAAEGGRKQFARHEWAQKAAYLL 757
Fly 860 GVNLEDLSSAAF-----GLTQPNAPNGGLSPSKSPTSD-TGHEW-AWECLEALVIGLYSEALAAV 917
|.:||:||||.| |.|...:.:....|.:|...: ||.:. |.||||.:..|||||....:
Rat 758 GCSLEELSSAIFKHQLKGGTLQRSTSFRQGPEESGLGEGTGTKLSALECLEGMASGLYSELFTLL 822
Fly 918 VALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPR 982
::|:||.:.:|.|::.|:|::||||||||...|...||:..:|.|||.|:|||.|||..|.:...
Rat 823 ISLVNRALKSSQHSLCSMMIVDTPGFQNPEWGGSARGASFEELCHNYAQDRLQKLFHERTFLQEL 887
Fly 983 DRYAQELVEIEMDLASECHP--GPLISLIDKAPQNHVVRS-SQRDLREHDRRGMLWLLDEEAIYP 1044
:||.::.:|:..| :..| ...::.:|:|....:||| :..| :.||:||||:|||:.|
Rat 888 ERYKEDNIELAFD---DLEPVTDDSVAAVDQASHQSLVRSLAHAD----EARGLLWLLEEEALVP 945
Fly 1045 NSNDDTFLERLFSHY----GDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGI 1105
.:.:||.|:||||:| ||::..|.|.:.:.||.|:|.|..|||.|.|.|.||:.:::::|..
Rat 946 GATEDTLLDRLFSYYGPQEGDKKGQSPLLRSSKPRHFLLGHSHGTNWVEYNVTGWLNYTKQNPAT 1010
Fly 1106 RNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQ--SLRRVSSIRRSFTT--AGVK 1166
:||..|||||.::.|:.|::| |...|.|..||.|||||.. :|||.:|:|::||| |.||
Rat 1011 QNAPRLLQDSQKKIISNLFLG---RAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVK 1072
Fly 1167 RNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSP----SSAAGQVSSEEEM 1227
:.|:.:|:|..||.:|||::|:..|||||:| ..|.|.| |:::.:|||..|:
Rat 1073 KKSLCIQIKLQVDALIDTIKRSKMHFVHCFL----------PVAEGWPGEPRSASSRRVSSSSEL 1127
Fly 1228 --------------VNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLAS--- 1275
::|.|||:|||||::|:|.|::|.|:|:.:...||.|||.:||..|..
Rat 1128 DLPPGDPCEAGLLQLDVSLLRAQLRGSRLLDAIRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHG 1192
Fly 1276 ------NKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGY 1334
::..:||::|...:|:.:|..:|.|::.||:|.|:.||.:||...|..:...||.||||
Rat 1193 RNYIMVDEKRAVEELLESLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEETSRHLTLFQAACRGY 1257
Fly 1335 LARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR 1399
|||:...:|::|:||:||:|:|:|....|:|||||:|...|.||:.|..:|||::..:||:..||
Rat 1258 LARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIQVQLSEEQIRNKDEEIQQLR 1322
Fly 1400 AKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNK 1464
.||||:|.:|:|::..:.:||.::||||.:|.:||:|...|::.|:|||||||:.|||:.:...:
Rat 1323 NKLEKVEKERNELRLNSDRLETRISELTSELTDERNTGESASQLLDAETAERLRTEKEMKELQTQ 1387
Fly 1465 VKNLQETTEKLEMELICAK----SDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLH 1525
...|::..|.::||::.|: :::||..:|:|| ||.::|||||..||::|||:||.
Rat 1388 YDALKKQMEAMDMEVMEARLIRAAEINGEVDDDDA-------GGEWRLKYERAVREVDFTKKRLQ 1445
Fly 1526 TQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNL 1590
.:.|..:|.....::.||.:|.|...:..|.::.:.|.|:|.|::|.|:.|.::.||.|..||:.
Rat 1446 QELEDKMEVEQQNRRQLERRLGDLQADSDESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHE 1510
Fly 1591 LEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQ 1655
||||||:||:|.....:..::|:..:|:..||||:|.||.|:|:|.:.:..||:....:|:.||:
Rat 1511 LEKKQRRFDSELSQAHEETQREKLQREKLQREKDMLLAEAFSLKQQMEEKDLDIAGFTQKVVSLE 1575
Fly 1656 RELEEMTFGGGTEE-EFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKE 1719
.||::::.....:| ..|::::...:.|.:.|:|||||||.||.||:||||||||||.:|.||:.
Rat 1576 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGSIQMLEQAKLRLEMEMERMRQT 1640
Fly 1720 ARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAE 1784
..:|.:.||||:||.|.:..||::.:|.|||.|:|::...||||.|||.:||::.|:.. .||.|
Rat 1641 HSKEMESRDEEVEEARQSCQKKLRQMEVQLEEEYEDKQKALREKRELESKLSTLSDQVN-QRDFE 1704
Fly 1785 EALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAE 1849
. .::||:||::.||||.|||..|:.||.:.|.|..|.||:||||::|...:.|:|||:..|.|
Rat 1705 S--EKRLRKDLKRTKALLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE 1767
Fly 1850 LTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVS 1914
:.::....|:..:|:...||:.:...|::.|:|.::||::|::.|||||:.|.|.|.:.:...::
Rat 1768 MEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMN 1832
Fly 1915 EAEFKLNEMEAERNNLKEQVAELQHRLDNVE-NLGDPSMAMMSKRLELRTKELESRLELEQATRA 1978
:.:.:|.|...|:..|:|::..||.:::.:| ::.|.|:. .|.|.:.:|||:|||.|:....
Rat 1833 DLQAQLEESNKEKQELQEKLQALQSQVEFLEQSMVDKSLV---SRQEAKIRELETRLEFEKTQVK 1894
Fly 1979 RLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDL 2043
|||...:|.||.:|||..|..|....|.:.::..|:.|:.|||.:||...::.:|.|:..::.:|
Rat 1895 RLESMASRLKENMEKLTEERDQRAAAENREKEQNKRLQRQLRDTKEEMSELARKEAEASRKKHEL 1959
Fly 2044 EKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGSI------------ 2096
|..:|.:|:...:|:.||:||.:||.|||.|:|:| .||||:...:.|:
Rat 1960 EMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDE-----MESDENEDLINSLQDMVTKYQKRKN 2019
Fly 2097 ---------SDLEDRL------------------------------------------RPVHVKR 2110
|:||||: ||..|..
Rat 2020 KLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAPSDDGSLKSSRTALNSLPKEGKGPEERPSSVLS 2084
Fly 2111 S----SQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPD 2171
| .:.:|..||||.|.. .|..|.:.|: .|||..| ...|:..|..:||
Rat 2085 SLSYRKRLTLKDSIGGTGDQ--DSLLTTLSER--------ATSPERP-----PRKARVGPREEPD 2134
Fly 2172 2171
Rat 2135 2134
| 
