DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Myh4

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_062198.1 Gene:Myh4 / 360543 RGDID:3139 Length:1939 Species:Rattus norvegicus


Alignment Length:2049 Identity:465/2049 - (22%)
Similarity:791/2049 - (38%) Gaps:652/2049 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..:||.||.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
  Rat    67 GATVTVKEDQVFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
  Rat   132 LPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQ 724
            |..|            |.....:..:.::| ..:||||||.||..|.|::|..:.:.:.|..||:
  Rat   197 ATIAVTGDKKKEEAPSGKMQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 260

  Fly   725 IASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ--- 786
            :|||.::..|.|:.|...:|..|.|:||..::::..    :.||....:.:.:.:.|..:||   
  Rat   261 LASADIETYLLEKSRVTFQLKAERSYHIFYQVMSNK----KPELIEMLLITTNPYDFAYVSQGEI 321

  Fly   787 ---KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFAN 848
               .::|:    .:.|.|..|.:.|...|.....|:.:..|:.|.|     .:......|.:.|.
  Rat   322 TVPSIDDQ----EELMATDTAVDILGFTADEKVAIYKLTGAVMHYG-----NMKFKQKQREEQAE 377

  Fly   849 P---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLY 910
            |   ..|.||:.|..:|..||..|   |..|....|....:|..|.    :..:..:.||...:|
  Rat   378 PDGTEVADKAAYLTSLNSADLLKA---LCYPRVKVGNEYVTKGQTV----QQVYNSVGALAKAMY 435

  Fly   911 SEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQM 971
            .:....:|..||:|:.|.......|.::|..||:    |          ||..|..|:..|:||.
  Rat   436 EKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------TLEQLCINFTNEKLQQ 490

  Fly   972 LFHHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRR 1031
            .|:|...|..::.|.:|.:|.|     ||||: |     |.||:|.                  .
  Rat   491 FFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAA-C-----IELIEKP------------------M 531

  Fly  1032 GMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLYAVD 1093
            |:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||  |.|.:.
  Rat   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGT--VDYNII 594

  Fly  1094 GWVRHSREHPGIRNAVSLLQDSSREEINRLYIG---SLTRGSGAMVFCGSFAGLEGTQSLRRVSS 1155
            ||:..::: |.....|.|.|.|..:.:..|:.|   :...|.|     |...|.:...|.:.||:
  Rat   595 GWLDKNKD-PLNETVVGLYQKSGLKTLAFLFSGGQAAEAEGGG-----GKKGGKKKGSSFQTVSA 653

  Fly  1156 IRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQ 1220
            :.|.                 .::.::..|:.|..|||.|.:                |:.....
  Rat   654 LFRE-----------------NLNKLMTNLKSTHPHFVRCLI----------------PNETKTP 685

  Fly  1221 VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDV 1279
            .:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..
  Rat   686 GAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKA 745

  Fly  1280 SVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMS 1341
            | |::|...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||||.|   :||.
  Rat   746 S-EKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAVCRGYLMRVEFRKMM 809

  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKT-------ANEELLMLR 1399
            :||.   ::.|||.||:||:.|:.|||.:|..::.|||....||:::.|       |.|:|....
  Rat   810 ERRE---SIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMATMKEDFEKAKEDLAKSE 871

  Fly  1400 AKLEKIE------------------------------CDR------------------------- 1409
            ||.:::|                              ||:                         
  Rat   872 AKRKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKIQLEAKIKELTERAEDEEEI 936

  Fly  1410 -SEVKAENQKLEAKLSELTVDL------------------------------------------- 1430
             :|:.|:.:|||.:.|||..|:                                           
  Rat   937 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIVKLTKEKK 1001

  Fly  1431 --------------AEE------------------------------------------------ 1433
                          |||                                                
  Rat  1002 ALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1066

  Fly  1434 -RSTAHIAT------------------------------------------------ERLEAETA 1449
             .||..|..                                                |.:|||.|
  Rat  1067 QESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131

  Fly  1450 ERLKLEK---------------------------------------------------------- 1456
            .|.|.||                                                          
  Rat  1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1196

  Fly  1457 ---------ELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVG---GGVYKL- 1508
                     |||:|   :.|||...:|||.|    ||:|. :..|:.|.|.:.|.   |.:.|: 
  Rat  1197 RKKHADSVAELGEQ---IDNLQRVKQKLEKE----KSELK-MEIDDLASNMETVSKAKGNLEKMC 1253

  Fly  1509 ---------------KYERVARELEFTKRRLHTQ--------HEHD-------------LEQLVA 1537
                           :.:|:..||...|.||||:        .|.|             .:|:..
  Rat  1254 RTLEDQLSEVKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEE 1318

  Fly  1538 LKKHLEMK--------------------LSDAYEEVVE-----QRQV------VGQWKRK----- 1566
            ||:.||.:                    |.:.|||..|     ||.:      |.||:.|     
  Rat  1319 LKRQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDA 1383

  Fly  1567 --------------------------------------AQKMTNEMNDLRMLLEEQNARNNLLEK 1593
                                                  .|::.||:.||.:.:|..||....|:|
  Rat  1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACAALDK 1448

  Fly  1594 KQRKFD---AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQ 1655
            |||.||   ||.:...:..:.|.:|.::..|.   |..|.|.::....::...||..:.:..:||
  Rat  1449 KQRNFDKVLAEWKQKYEETQAELEASQKESRS---LSTELFKVKNAYEESLDQLETLKRENKNLQ 1510

  Fly  1656 RELEEMT---FGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMR 1717
            :|:.::|   ..||  :...:|.:.|.:.::...|.:..|:|....::..|...||:::.|..::
  Rat  1511 QEISDLTEQIAEGG--KHIHELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQLELNQVK 1573

  Fly  1718 KEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDRVDR 1781
            .|..|:..::|||:::::.|..:.:::::..|:.|...|...||.|.::|..|:.|| ..:..:|
  Rat  1574 SEIDRKIAEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR 1638

  Fly  1782 DAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTA 1846
            .|.||:     |:||..:.:|||.|..|:            ..||.| :|.:...::..:.....
  Rat  1639 QAAEAI-----RNLRNTQGMLKDTQLHLD------------DALRGQ-DDLKEQLAMVERRANLM 1685

  Fly  1847 EAELTEVQAMFDESHRARN-------DAEERANAAH--------------RDRAELQAQIEENEE 1890
            :||:.|::|..:::.|:|.       ||.||....|              .|.:::|.::|:..:
  Rat  1686 QAEIEELRASLEQTERSRRVAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQ 1750

  Fly  1891 ELGELMKKYSATVKQLNTEQINVSEAEFKLNE-----MEAERNNLKEQVAELQHRLDNVENLGDP 1950
            |.....:|    .|:..|:...::| |.|..:     :|..:.|:::.|.:||||||..|.|...
  Rat  1751 EARNAEEK----AKKAITDAAMMAE-ELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALK 1810

  Fly  1951 SMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKS 2015
            ......::||.|.:|||:.:|.||.........:.:|:..:::|..:..:.:...::.||::.|.
  Rat  1811 GGKKQIQKLEARVRELENEVENEQKRNIEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKL 1875

  Fly  2016 QKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGE 2080
            |                     |:.|..:::.|:.|.:.       .:.|.:...:|..:||  .
  Rat  1876 Q---------------------TKVKAYKRQAEEAEEQS-------NVNLAKFRKIQHELEE--A 1910

  Fly  2081 EELSESDESLSSVGSISDLEDRLRPVHVKRSSQQ 2114
            ||.::..||     .::.|..:.|.||.|..|::
  Rat  1911 EERADIAES-----QVNKLRVKSREVHTKVISEE 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 210/802 (26%)
MYSc_Myo18 575..1305 CDD:276837 198/771 (26%)
GBP_C <1540..1750 CDD:303769 59/289 (20%)
COG1340 1565..1833 CDD:224259 73/317 (23%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
Myh4NP_062198.1 Myosin_N 36..73 CDD:280832 2/5 (40%)
Myosin_head 88..770 CDD:278492 202/783 (26%)
MYSc_Myh4 100..770 CDD:276879 198/771 (26%)
Actin-binding. /evidence=ECO:0000250 659..681 7/37 (19%)
Actin-binding. /evidence=ECO:0000250 761..775 3/13 (23%)
Myosin_tail_1 850..1927 CDD:279860 212/1147 (18%)
RILP-like <994..1098 CDD:304877 6/103 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1147 7/18 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1172 0/18 (0%)
MIT_CorA-like <1299..>1411 CDD:294313 17/111 (15%)
COG6 1376..>1511 CDD:303003 27/137 (20%)
DUF342 <1506..1582 CDD:302792 17/77 (22%)
DUF342 <1670..1767 CDD:302792 19/100 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.