Protein Alignment Mhcl and didum

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Alignment Length: 1801
• Identity: 408/1801 - (22%)
• Similarity: 712/1801 - (39%)
• Gaps: 386/1801 - (21%)

  Fly   502 SQPERVWLVHR----------------GGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDED 550
            :|..::|:.|.                .||   :::.| .||:.:|.||.           .|..
  Fly     9 AQGAKIWVPHADLVWESATLEESYRKGAGF---LKICT-DSGKLKEVKLK-----------ADGS 58

  Fly   551 DVEKQNSPALDLV--EDICELKYLNEASVLHCLRQRYAS-NLIHTKAGPTLLVVNPMAPLSLYSE 612
            |:....:||: ||  .|:..|.||:|..|||.||.|:.. .:|:|..|..|:.:||.|.:.||..
  Fly    59 DLPPLRNPAI-LVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGP 122

  Fly   613 KVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGA 677
            .::..:||....|:.||:::||:.||..|.....:.|:|..|.||:||:.|.|:|:.|.|...|:
  Fly   123 SIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS 187

  Fly   678 YNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDF-DQTGQ--IASASLQVLLPERQR 739
            .:......||.|...|:|||||.||..|.|::|..:...|.| :|.|.  :..|::...|.|:.|
  Fly   188 ESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSR 252

  Fly   740 AGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLE-DRHRAANDFMRTVQ 803
            ...:...|.::||..:|.  ||.....||.|::   :|...|:::....| :|...|..|..|||
  Fly   253 VVYQAQGERNYHIFYQLC--AARSKYPELVLDH---QDKFQFLNMGGAPEIERVSDAEQFNETVQ 312

  Fly   804 AFETLNIDAKAVRGIWSILAAIYHLGIAGVT-KLGTGSTARTQ-----FANPTAARKASGLLGVN 862
            |...|....:.:..|..|||.|.|||...|: |...||.....     |.|....:..:.||.|:
  Fly   313 AMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVS 377

  Fly   863 LEDL---------SSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVV 918
            .:||         .|....:..||:                .|.|....:||...:|::....:|
  Fly   378 ADDLRRWLLMRKIESVNEYVLIPNS----------------IEAAQAARDALAKHIYAKLFQYIV 426

  Fly   919 ALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRD 983
            .::|:.:...|...:.|.::|..||:.     .:|. :......||..|:||..|:.......::
  Fly   427 GVLNKSLNNGSKQCSFIGVLDIYGFET-----FEVN-SFEQFCINYANEKLQQQFNQHVFKLEQE 485

  Fly   984 RYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSND 1048
            .|.:|.:...|           |...|..|...::.|         |.|:|.|||||...|..:|
  Fly   486 EYLKEGITWTM-----------IDFYDNQPCIDLIES---------RLGVLDLLDEECRMPKGSD 530

  Fly  1049 DTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQ 1113
            :::..:|........|....|  .|...|.:.|...|  |.|.|:|::..:|:... :....:|.
  Fly   531 ESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDT--VEYDVNGFLEKNRDTVS-KELTQVLS 590

  Fly  1114 DSSR---------EEINRLYIGSLTRGS-GAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRN 1168
            :|:.         |||:.|.:.|....: |..|...:....:|..:.|||...::...|.|
  Fly   591 ESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVG---- 651

  Fly  1169 SIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLL 1233
               .|.:.::..:|.||..|..|:|.|  ::.|..|                |:.:.|...:
  Fly   652 ---SQFQESLASLISTLHATTPHYVRC--IKPNDDK----------------VAFKWETAKI--- 692

  Fly  1234 RSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKD---VSVEQILAVNELDVASY 1295
            ..|||...|||..|:...|||......:|..|:.||......:|:   :|...|:.....|...|
  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKY 757

  Fly  1296 RIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAF 1360
            |.|.:||.||:|.::.||..|..|....|..:|:..|.::.|::.  .|:|:: :..||::.:.:
  Fly   758 RFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQF--LRIQKV-INGIQKHARGY 819

  Fly  1361 LA-------------------VRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIE 1406
            ||                   .|.|...|..:|:...::..:|..:...|..:...:|.....::
  Fly   820 LARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQ 884

  Fly  1407 CDR----SEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKN 1467
            ..|    :..:...||....:  :....|..|..|....:|::||......:|.:.....||:.:
  Fly   885 IQRFVRGALARRAYQKRRRNI--IICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIIS 947

  Fly  1468 LQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYE-RVARELEFTKRRLHTQHEHD 1531
            :|:..::|..:....|...:.||              |.|:|.| :...|.||...:...|   |
  Fly   948 MQQRIDELNRDNSNLKHKTSEIS--------------VLKMKLELKKTLEAEFKNVKAACQ---D 995

  Fly  1532 LEQLV-ALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEE-----QNARNNL 1590
            .::|: ||.|.||.:..:..:.:.|......:|..:.|....|..:||..::|     :||..|.
  Fly   996 KDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQ 1060

  Fly  1591 LEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQ 1655
            ..::.|.. ||..:     |:..:|.:|..::|:|::.|.|.|::
  Fly  1061 RNQEDRML-AEIDN-----RELNEAYQRAIKDKEVIENENFMLKE-------------------- 1099

  Fly  1656 RELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEA 1720
             ||..:|.|..:    ...|::.|     |..|.|  |::.     ...||..|::
  Fly  1100 -ELSRLTAGSFS----LHARKASN-----ASSQNE--DDVG-----YASAKNTLDI--------- 1138

  Fly  1721 RRESQQRDEELEEVRGNGYKKIKALECQLET---EHEERTLLLREKH-ELERRLSSMEDRDRVDR 1781
                 .|..:|.. :...|....:|..:|.:   |.:::..:|:|:: :|..|....||..||..
  Fly  1139 -----NRPPDLLS-KNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSE 1197

  Fly  1782 DAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTA 1846
              .|..|:|||.:..:.:..:|.. .::..|.|.  ...|..::|.:.|:....:::.::..|:
  Fly  1198 --LEVENEKLRSEYDQLRTSIKHG-VEINELNAQ--HAALQEEVRRRREECIQLKAVLLQQSQS- 1256

  Fly  1847 EAELTEVQAMFDESHRAR-NDAEERANAAHRDR-------AELQAQIEENEEELGELMKKYSATV 1903
                  ::::..||.:.| ||..|...|.|..:       :||:|..||:..:|.|:.::    :
  Fly  1257 ------MRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQE----I 1311

  Fly  1904 KQLNTEQINVSEA------EFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELR 1962
            ::||.|:..:.:.      ||:.:.::..|.|.:....|||..:        ....::.:.|:|.
  Fly  1312 ERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAV--------AQFLLVQEELKLA 1368

  Fly  1963 TK----------ELESRLELE------QATRARLEVQVNRHK----------------EALEKLQ 1995
            ..          :||.::|.|      ..|.|.:...|.:.|                :.|::|.
  Fly  1369 NAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLL 1433

  Fly  1996 NEVT----------------------------QSKMREMQAQDVIKKSQKSLRDMREEFHAVSSR 2032
            :.:|                            ...:||:.::.||:     ::.|....|.:.:|
  Fly  1434 SALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQ-----IKKMHRTPHPIENR 1493

  Fly  2033 E---QESLT------RRKDLE-------KKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEE 2081
            .   ..|:|      :..|::       :|..|.:.:...|....|:.|..|.:|.||:..:.:.
  Fly  1494 VIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQG 1558

  Fly  2082 ELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIG---GGG 2124
            .|   |..:......:|...|.|..|..||...|:..|..   |||
  Fly  1559 LL---DPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGG 1601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	369/1620 (23%)
		MYSc_Myo18	575..1305	CDD:276837	200/762 (26%)
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	200/762 (26%)
		IQ	900..922	CDD:197470	4/23 (17%)
		SMC_prok_B	<942..1365	CDD:274008	107/521 (21%)
		Myo5_CBD	1424..1792	CDD:271254	35/186 (19%)