DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and ck

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:1612 Identity:338/1612 - (20%)
Similarity:611/1612 - (37%) Gaps:351/1612 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   525 SSGRDEENKLSLRLLH-NGEQLTVDEDD-----------VEKQNSPALDLVEDICELKYLNEASV 577
            :|||:.:..:..|::. .|.::.|.:||           ::..::.::..|||:..|..|:||.:
  Fly    15 ASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGI 79

  Fly   578 LHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLV 642
            |..|..||..|||:|..|..|:.|||...|.:|:...:.:::..|..::|||::::...||..:.
  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMK 144

  Fly   643 ETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSN 707
            ..|:||.::..|.||:||:.|.|..|.|||..:|.: ::|..:.:.| ..|||||||.||..|.|
  Fly   145 RYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH-SWIEQQILEA-NPILEAFGNAKTIRNDN 207

  Fly   708 ATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLEN 772
            ::|..:.:.:.|...|.|..|.::..|.|:.|...:...|.::|:...:|||.:...:..|.| .
  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDL-G 271

  Fly   773 ITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLG 837
            :.::..:.....|...|.|..|| :|.....|.:.|....:.:..|..:|||:.|.|........
  Fly   272 MAADYKYLTGGNSITCEGRDDAA-EFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATV 335

  Fly   838 TGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECL 902
            ..:...|:........:.:||||:.::.|..|   ||:...    .:..::..|....:.:.:..
  Fly   336 VDNLDATEIPEHINVERVAGLLGLPIQPLIDA---LTRRTL----FAHGETVVSTLSRDQSVDVR 393

  Fly   903 EALVIGLYSEALAAVVALINRQIC----TSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHN 963
            :|.|.|:|......:|..||..|.    ||.:.|.   ::|..||:|   ..|.   :......|
  Fly   394 DAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIG---VLDIFGFEN---FDQN---SFEQFCIN 449

  Fly   964 YLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREH 1028
            |..|.||..|........::.|..|.:..:       |    |..:|......::...|.::   
  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQ-------H----IEFVDNQDALDLIAIKQLNI--- 500

  Fly  1029 DRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVD 1093
                 :.|:||||.:|...|.|.|.:|...:|..::: |..|......|.|:|..|.  |.|...
  Fly   501 -----MALIDEEARFPKGTDQTMLAKLHKTHGSHKNY-LKPKSDINTSFGLNHFAGV--VFYDTR 557

  Fly  1094 GWVRHSRE--HPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSI 1156
            |::..:|:  .|.:.:.||   .|:.:.:.:::...:..|:               ::.:|..::
  Fly   558 GFLDKNRDTFSPDLLHLVS---QSTNKFLRQIFAQDIEMGA---------------ETRKRTPTL 604

  Fly  1157 RRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQV 1221
            ...|      |.|:        |.::.||......|:.|  ::.|..|                 
  Fly   605 STQF------RKSL--------DALMKTLSSCQPFFIRC--IKPNELK----------------- 636

  Fly  1222 SSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDL--ASNKD--VSVE 1282
              :..|.:..|...|||.|.::|..|:.|.|:|......|||.|:..|...:  |...|  .:..
  Fly   637 --KPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATS 699

  Fly  1283 QILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQE 1347
            :|.|| .|..:.|::|.:::..:......||.:||.:|:.:|:.||...||::.|::..:.|...
  Fly   700 RICAV-VLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAA 763

  Fly  1348 LAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEV 1412
            :.|   ||            :|:          .:...::.:......:.|:|.:      ||.|
  Fly   764 ITV---QR------------FWK----------GYAQRKRYRNMRVGYMRLQALI------RSRV 797

  Fly  1413 KAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEM 1477
                  |..:...|         ..||.  .|:|. |....:.:|.|.:...|..:|....::..
  Fly   798 ------LSHRFRHL---------RGHIV--GLQAH-ARGYLVRREYGHKMWAVIKIQSHVRRMIA 844

  Fly  1478 ELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTK----RRLHTQHEHDLEQLVAL 1538
            .....|                      .:|::::.|..|:..|    ..||..::|..|   ..
  Fly   845 MRRYRK----------------------LRLEHKQFAEVLQLRKLEEQELLHRGNKHARE---IA 884

  Fly  1539 KKHLEMKLSDAYEEVVEQRQVVGQW--KRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAE 1601
            ::|...:|.:     :|:|::..|.  :|:.:...|.:||.....||......|:|   ..||..
  Fly   885 EQHYRDRLHE-----LERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVE---AMFDFL 941

  Fly  1602 CQSLQDAVRQERQAKERYGRE----KDVLQAEKFTLEQTLADTRL-----DL-EFKEEKLASLQR 1656
            ..|..||      .....|||    .|:..|:....:..:|...:     || |||.:|.|:.. 
  Fly   942 PDSSSDA------PTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATY- 999

  Fly  1657 ELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEAR 1721
                  |.|....::|     |...:........:.|::|.|...:...:...:|.........|
  Fly  1000 ------FQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDR 1053

  Fly  1722 RESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEA 1786
            .::.....::....|..:                    :|.|...|.:|..:        |.:..
  Fly  1054 MDTTSVMSKVTATLGRNF--------------------IRSKEFQEAQLMGL--------DPDAF 1090

  Fly  1787 LNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELT 1851
            |.||.|....|..:|....:.:|        |:.:.|:|::....|:|.:|. :::|.|:..|  
  Fly  1091 LKQKPRSIRHKLVSLTLKRKNKL--------GEDVRRRLQDDEYTADSYQSW-LQSRPTSNLE-- 1144

  Fly  1852 EVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEA 1916
              :..|...|...             ||||:.:|             |....|||....:..|.|
  Fly  1145 --KLHFIIGHGIL-------------RAELRDEI-------------YCQICKQLTNNPLKSSHA 1181

  Fly  1917 E-----------FKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRL 1970
            .           |..:|...  |.|:..:.|           |.|..|...:....||       
  Fly  1182 RGWILLSLCVGCFAPSEKFV--NYLRAFIRE-----------GPPGYAPYCEERLKRT------- 1226

  Fly  1971 ELEQATRAR----LEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF-HAVS 2030
             ....||.:    ||:|..:.|:.:      :......:...:.::..|..:.|::..:. ..:|
  Fly  1227 -FNNGTRNQPPSWLELQATKSKKPI------MLPITFMDGNTKTLLADSATTARELCNQLSDKIS 1284

  Fly  2031 SREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEE 2082
            .::|...:....|..||..:.|.|..:       :..|:..:|..:|:|.:|
  Fly  1285 LKDQFGFSLYIALFDKVSSLGSGGDHV-------MDAISQCEQYAKEQGAQE 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 186/770 (24%)
MYSc_Myo18 575..1305 CDD:276837 178/739 (24%)
GBP_C <1540..1750 CDD:303769 41/221 (19%)
COG1340 1565..1833 CDD:224259 51/277 (18%)
coiled coil 1723..1734 CDD:293879 0/10 (0%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 186/764 (24%)
MYSc_Myo7 77..721 CDD:276832 178/739 (24%)
MyTH4 <1138..1245 CDD:214535 31/157 (20%)
B41 1251..1467 CDD:214604 14/86 (16%)
FERM_B-lobe 1355..1439 CDD:271216
FERM_C1_MyoVII 1461..1559 CDD:270019
SH3 1560..1624 CDD:302595
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466248
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.