DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Dlg5

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	150/780 - (19%)
Similarity:	282/780 - (36%)	Gaps:	198/780 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1440 ATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISED-EDAENEDGVGG 1503
            :|...|.|::|.:..:..|...:|.    ..:|....|      |:.||.|:. .......|:.|
  Fly    13 STSSQEEESSEYVGYDNTLRPPSNS----SGSTTAANM------SNNNGPSKGVSSGVGVSGISG 67

  Fly  1504 G------VYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQ 1562
            |      :.:.:|:....||. |.|..|...:...::|             |.|..:.|...|..
  Fly    68 GNGANYDILQAQYKSALLELN-TLRHQHANTKRRCDEL-------------ATELTLYQEHYVAD 118

  Fly  1563 WKRKAQKMTNEMNDLRMLLEEQNARNNLLEK-----------------KQRKFDAECQSLQDAVR 1610
            ..:....:.......|:|||.||.::...:.                 |.:..|..|......::
  Fly   119 RNKFTDMVEESARFKRLLLETQNQQSQQAQNGNSQVPPVGSGNPYYFGKTQGCDGSCSEKLAELK 183

  Fly  1611 QERQ--AKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQ 1673
            :||.  |.||...:|..::.||            |..:..|:               |.|.:  :
  Fly   184 KERNMVAVEREKYKKSYIELEK------------DRNYYRER---------------GDENQ--K 219

  Fly  1674 LRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNG 1738
            |:...::..:......|||:::..:...:.|...::...|....||..|  .::||:|...
  Fly   220 LKVLLSQESKNVLSLTEELNQLLSEKDNVLQEHQKMSDDLVLANKEIER--LKKDEQLARA---- 278

  Fly  1739 YKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALLK 1803
              :||.|  ||....      |:::..|:.|.||........::.|.:      ::|.|.:..|:
  Fly   279 --EIKVL--QLANAD------LKKRDLLKSRDSSWSKEFPSGKELENS------KELEKLRKSLE 327

  Fly  1804 DAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAE 1868
            .|.:::||...|.             |:|:..|..|:..|:....|...|:.:.|:....|:.|.
  Fly   328 KALSEVERSSQDA-------------EEAKRVRDWAISQREKIVQERDSVKTLCDKMRHERDKAI 379

  Fly  1869 ERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQ 1933
            ..:..|.||..:::.|.:|.::::..|.::.....:|......:.|...|:.:..|.| :.|:.:
  Fly   380 SDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGE-DLLEVE 443

  Fly  1934 VAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEV 1998
            ::..:|..|    ||                     :.|:.:.:.:|...|.....|..||:...
  Fly   444 LSGYEHTSD----LG---------------------IILDDSNKRKLVCGVTSSSPACGKLKIND 483

  Fly  1999 TQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGA------AL 2057
            ...|:..:..|.:.|      |.:.:|..|.:.|....::|.:..::....::.:..      .|
  Fly   484 VICKVNNLDCQSLSK------RMVLDEIRACAPRSLLLVSRTRHSKRHAYSVQLKTRDRDCPHGL 542

  Fly  2058 KNDLRLALQRIADLQQAMEEE----GEEELSESDESLSSVGSISD-------------------- 2098
            :.|:.:.:.:|.....|..|.    |:..||.:::|:.||.||.:
  Fly   543 QLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKY 607

  Fly  2099 LEDRLRPVHVKRSSQ-QSLN-----GSIGGGGGSVVSST------------RTVVFEK----DDN 2141
            ::|:|.|.....|:| .|::     .|.||||||..||.            |.:.|.|    :||
  Fly   608 VQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDN 672

Fly 2142 2141
Fly 673 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	41/228 (18%)
		COG1340	1565..1833	CDD:224259	52/286 (18%)
		coiled coil	1723..1734	CDD:293879	3/10 (30%)
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	42/218 (19%)
		CENP-F_leu_zip	229..360	CDD:287450	34/165 (21%)
		DUF1090	<326..408	CDD:284007	21/94 (22%)
		PDZ_signaling	439..516	CDD:238492	18/107 (17%)
		PDZ_signaling	533..592	CDD:238492	13/58 (22%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900