DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and d

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1337	Identity:	282/1337 - (21%)
Similarity:	461/1337 - (34%)	Gaps:	366/1337 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 SVESLRSDGEQTGGQQR-------AMTLPANARYGALP-QGNSQGSHLHVLTSPSPSADSLTDTT 288
            ::....|..|....|||       .:||......|..| ||.|||:....: :|:|:|....:..
  Fly   210 NITDASSSNEAVHLQQRLKSLSTELVTLRNRLHVGHGPGQGQSQGNGAQPV-APAPNAGPKANNF 273

  Fly   289 NSSFATPPFSLSPVG----------ESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQ 343
            :.:.::|..:||..|          .:.|....::.|:|
  Fly   274 DLNASSPNLNLSSSGAGLSASAVQQHTNGHHTTSKNHSF-------------------------- 312

  Fly   344 KSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGE-LPR 407
                                 |.|.|       |..|:|||  |...|..::....|.:.. ||.
  Fly   313 ---------------------SHTLP-------ANSGSGGG--GGAGGGAVVSARNTSIPHPLPH 347

  Fly   408 EI-----IIEMIRNSGEAVTVEVQP----VAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRR 463
            ::     :......||...:....|    :..::..:....||       ::::..|.|...:|.
  Fly   348 QLAEKPGLSHQQSGSGHGQSTGTLPHMSGMGSILGQNSHSHAP-------VNNNSNNSNTLPMRT 405

  Fly   464 SASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGR 528
            |       .|.|...|||       ||||.|..  |.:.|                 ||.....:
  Fly   406 S-------NSGHLGINGG-------GVGHHLSH--AHSQQ-----------------LPFIPQSK 437

  Fly   529 DEENKLSLRLLHNGEQLTVDEDDVEKQ----NSPALDLVEDICELK-YLNEASVLHCLRQRYASN 588
            ......|::.|..|...:..:..:::|    ||...|: :|:..|. .|.|.:|:..|:.|:...
  Fly   438 HTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDM-QDLIHLSGPLTEHAVMRTLQARFNER 501

  Fly   589 LIHTKAGPTLLVVNPMA----PLSLYSEKVVSMFRGCKTEDMP--PHVYSLAQTAYRSLVETRRD 647
            ...|..||.||.:||..    ||:|.|           |..||  |.:..:.|.|.|...||...
  Fly   502 RYFTNVGPILLSINPYLDVGNPLTLTS-----------TRAMPLAPQLQKIVQEAVRQQSETGYP 555

  Fly   648 QSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMT 712
            |::|..|.||:||:.:....|..|...||........:.:.|..|:|.:.|:.||..||.::|:.
  Fly   556 QAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIG 620

  Fly   713 QLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSED 777
            |.:.:.... |.:....:.....::.|..|.|..|.::||..:||||.:...:::|||      |
  Fly   621 QFIEVQVTD-GALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL------D 678

  Fly   778 SHPFISLSQKLEDRHRAANDFMRTVQAFET-LNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGST 841
            .:...:|.....|..:...:.....||::| |.|.......:..:|||:.   :.|..:...|..
  Fly   679 GYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVL---LLGNVQFIDGGG 740

  Fly   842 ARTQFANPTAARKASGLLGVNLEDLSSAAF-GL-TQPNAPNGGLSPSKSPTSDTGHEWAWECLEA 904
            ........|.....:.||||.    .:|.| || |:.:...|.|  .||...|.......:||..
  Fly   741 LEVDVKGETELNSVASLLGVP----PAALFRGLTTRTHNVRGQL--VKSVCGDGDANMTRDCLAK 799

  Fly   905 LVIGLYSEALAAVVALIN--RQICTSSHTIAS--------------------------------- 934
               .||...:|.:|...|  :::.::..|::|
  Fly   800 ---ALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAAL 861

  Fly   935 ------------IMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQ 987
                        |.::|..||:.|:.     .|.|..|..|...|.:|. |::|.:.       :
  Fly   862 NNAVRHATSDGFIGILDMFGFEEPSP-----HAHLEHLCINLCAETMQH-FYNTHIF-------K 913

  Fly   988 ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFL 1052
            ..||...|....|...  :..:|..|...::.|.        |.|:|.:||.|... ....::::
  Fly   914 SSVESCRDEGIVCDTE--VDYVDNVPCIDLISSL--------RTGLLSMLDAECSV-RGTAESYV 967

  Fly  1053 ERLFSHYGDREHHSLLR-------KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVS 1110
            .:|     ..:|.|..|       :...||.|::.|..|.  |.|....::..:|:
  Fly   968 TKL-----KVQHRSSTRLETKPTAEPHDPRMFLIRHFAGR--VEYDTTDFLDTNRD--------- 1016

  Fly  1111 LLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTT-----AGVKRNSI 1170
            ::.|   :.:...|..:...|....:|......|...|...|..|.|.|.|:     .|.:..|.
  Fly  1017 VVPD---DLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVST 1078

  Fly  1171 MLQVKFT-VDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLR 1234
            :.|...| :|.::.||.....|||.|            ..:||:.::        .......::|
  Fly  1079 LTQDFHTRLDNLLRTLVHARPHFVRC------------IRSNGTEAA--------RSFDRATVVR 1123

  Fly  1235 SQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGD--LASNKDVSVEQILAVNELDVASYRI 1297
             |:|..||||...|...|||..:...:|..|:.:||..  |..::|.::|....     :..|.:
  Fly  1124 -QIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQL-----ILKYAM 1182

  Fly  1298 GPSQILFRSGVLSELEAKRDVLLSDRIIQ----------------LQAFCRGYLARKKMSQRRVQ 1346
            ....:|..|..|:....||.|.||:.|.|                :||..||:..||||.....:
  Fly  1183 EQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKKMGNGGAK 1247

  Fly  1347 ELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSE 1411
            ...:..:|:                    .||.| ::|.......|
  Fly  1248 RSKIPGLQQ--------------------APLPN-NKTTPNSAAQN------------------- 1272

  Fly  1412 VKAENQKLEAKLSELTVDLAEERSTAHIATERLEAET 1448
             ||.:..:.|        ||...:.|.|:..||.|:|
  Fly  1273 -KAASSTMAA--------LAAVAAAAPISVPRLSAKT 1300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	15/92 (16%)
		MYSc	556..1317	CDD:214580	187/832 (22%)
		MYSc_Myo18	575..1305	CDD:276837	177/800 (22%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
d	NP_001188730.1	MYSc	476..1217	CDD:214580	190/839 (23%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	182/816 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930