DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and CG31638

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_723186.2	Gene:	CG31638 / 33910	FlyBaseID:	FBgn0051638	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	160/754 - (21%)
Similarity:	284/754 - (37%)	Gaps:	194/754 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1483 KSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKL- 1546
            ::::.|:          ||.|.....:|    .|.|:..|  .:|.:.:|.:..|....:|..:
  Fly    21 RNEVGGV----------GVIGTTMSARY----GETEWEAR--ESQRQRELHEARARAAQMEKTMK 69

  Fly  1547 --SDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQ-DA 1608
              ||.          ...|:.|..|:.||.|..|.            |.||       .||: |.
  Fly    70 WWSDC----------TANWREKWSKVRNERNKARE------------ESKQ-------LSLKLDG 105

  Fly  1609 VRQERQAKERYGREKDVLQAEKFTLEQTL----------------ADTRLDLE-----------F 1646
            |.:|..:.:   |||:.|:.:...|::.:                |||..|.|           .
  Fly   106 VMKEAHSLK---REKNDLELQITQLKKEMEKVHTLMMKHAGQFHRADTSEDAEANGRDANCSPDI 167

  Fly  1647 KEEKLASLQRE---------------LEEMTFGGGTEEEFAQLRRSKNETERRAKEQ--EEELDE 1694
            ..:.|.::..|               :||....|...:...:|..:....|:|..:|  :::.||
  Fly   168 SSDGLKNINSEDGLVTKLPNDVKDLDIEEFAMKGAMPKHLTELDEAAAAEEKRLIQQLSKDDFDE 232

  Fly  1695 --MAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERT 1757
              :..:|.:|:   |||:...:|::.|       |||:||.     :|.|:.|..:::.....:.
  Fly   233 DYLLQKISMLQ---LRLDEAQKTLQAE-------RDEKLEL-----HKSIEKLTLEIQDVRGRQE 282

  Fly  1758 LLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKAL---LKDAQTQLERLKADTP-- 1817
            .:...|.|..|.|.:::::.|.:.   ..:|..|:.::...:.|   |.:.:|:||.|:|:..
  Fly   283 EMRSAKQEAVRELLTLQEQHRAEM---RIVNNSLQEEIAARENLERRLTELRTELEHLQAENASE 344

  Fly  1818 -GKTLIRQLRNQLEDAESARSLAM-KARQTAEAELTEVQAMFDESHR--ARNDAEERANAAHRDR 1878
             ||      |.:||    :..||| :..:...|||.:.|...|...|  ..||.|.||
  Fly   345 WGK------RERLE----SEKLAMERDNKKLRAELRDYQERSDRKCRPMQANDVELRA------- 392

  Fly  1879 AELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDN 1943
              ||.::.|..:|:.|:...::...|.|......:..|..:..:.|||...|:::|.||:..|..
  Fly   393 --LQQELSERNKEISEVKMSHAKLKKLLAETNTELGHAVRRAEQYEAEVKRLRQRVEELKRELAG 455

  Fly  1944 VENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQS------- 2001
            .|:..|.::..: :||:....||..:.|       .|:||:       :.|||....|
  Fly   456 AEDELDSAVNQV-RRLQRSNDELVGQTE-------GLQVQI-------QHLQNRRAPSPQLRGMG 505

  Fly  2002 --KMREMQAQDVIKKSQKSLRDMREEF------------------HAVSSREQESLTRRKDLEKK 2046
              ::|...|.::......::.|:|:.|                  |..:|.::.|.|.|..|:::
  Fly   506 GVQLRNKIAVELPNDCLPNINDLRQIFDDSQAGLRSSHNGSDAAMHHAASVKRSSHTERTLLQQQ 570

  Fly  2047 VEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSES-DESLSSVGSISDLEDRLRPVHVKR 2110
            .....:..||       |....|....|.....||.:.|| ..:|....:....::.....|...
  Fly   571 QSSAAASAAA-------AAAAAAAFFDAKPTHLEENIFESKSRNLEFERAKQKFDNPHGQHHHHH 628

  Fly  2111 SSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTS 2149
            ..|:|.||..|..|.|...:...:..:...|....:|:|
  Fly   629 QRQRSGNGRYGSAGSSASRANLALPLKGTTNGGSSSVSS 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	54/259 (21%)
		COG1340	1565..1833	CDD:224259	69/320 (22%)
		coiled coil	1723..1734	CDD:293879	5/10 (50%)
CG31638	NP_723186.2	DUF4201	284..457	CDD:290581	49/194 (25%)
		Ax_dynein_light	<300..369	CDD:287215	19/81 (23%)
		RILP-like	<312..448	CDD:304877	40/154 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930