DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myhc4

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001018321.1 Gene:myhc4 / 334274 ZFINID:ZDB-GENE-030131-6206 Length:1935 Species:Danio rerio


Alignment Length:2013 Identity:477/2013 - (23%)
Similarity:817/2013 - (40%) Gaps:516/2013 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   533 KLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPT 597
            |:::..|...|:..|.||||...|.|..|.:||:..:.:|||.|||:.|::|||:.:|:|.:|..
Zfish    59 KVTVITLDTKEERVVKEDDVHPMNPPKYDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLF 123

  Fly   598 LLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKST 662
            ...|||...|.:|..:||:.:||.|..:.|||::|::..||:.::..|.:||::..|.||:||:.
Zfish   124 CATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTV 188

  Fly   663 SFKHALNYLALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            :.|..:.|.|..|            |.....:. :::.|...:|||:||.||..|.|::|..:.:
Zfish   189 NTKRVIQYFATVAVQGGDKKKEQAPGKMQGSLE-DQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252

  Fly   716 SLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP 780
            .:.|..||::|||.::..|.|:.|...:|..|..:||..:::...    :.||....:.:.:.:.
Zfish   253 RIHFGTTGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNH----KPELIEMTLITTNPYD 313

  Fly   781 FISLSQ------KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            |...||      .::|:    .:.|.|..|.:.|....:...||:....|:.|.|     .:...
Zfish   314 FPMCSQGQITVASIDDK----EELMATDSAIDILGFTGEEKMGIYKFTGAVLHHG-----NMKFK 369

  Fly   840 STARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWEC 901
            ...|.:.|.|..   |.|.|.|||:|..:|..|   |..|....|....:|..|...    .:..
Zfish   370 QKQREEQAEPDGTEEADKISYLLGLNSAELLKA---LCYPRVKVGNEFVTKGQTVPQ----VYNS 427

  Fly   902 LEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRH 962
            :.||...:|.:....:|..||:.:.|.......|.::|..||:    |          ::..|..
Zfish   428 VSALSKSIYEKMFLWMVIRINQMLDTKQQRNFFIGVLDIAGFEIFDFN----------SMEQLCI 482

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQ-----ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            |:..|:||..|:|...|..::.|.:     |.::..||||: |     |.||:|.          
Zfish   483 NFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAA-C-----IELIEKP---------- 531

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAG---PR--------Q 1076
                    .|:..:|:||.::|.:.|.:|..:|:..:        |.||..   ||        .
Zfish   532 --------MGIFSILEEECMFPKATDVSFKNKLYDQH--------LGKCNAFQKPRPQKGKAEAH 580

  Fly  1077 FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSF 1141
            |.|.|..||  |.|.|:||:..::: |...:.|.|.|.||.:.:..||...:....|     |..
Zfish   581 FSLVHYAGT--VDYNVNGWLDKNKD-PLNESVVQLYQKSSVKLLATLYPPVVEETGG-----GKK 637

  Fly  1142 AGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHT 1206
            .|.:...|::.|||                 |.:..:..::..||.|..|||.|.:         
Zfish   638 GGKKKGGSMQTVSS-----------------QFRENLGKLMTNLRSTHPHFVRCLI--------- 676

  Fly  1207 KYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-- 1269
                   |:.     |....::...|:..|||.:.|||..|:.|.|||..:...:|.:|:.:|  
Zfish   677 -------PNE-----SKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNA 729

  Fly  1270 ----AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAF 1330
                .|....||..| |::|...:::...||.|.:::.|::|:|..||..||..|:..:...||.
Zfish   730 SVIPEGQFIDNKKAS-EKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLATLVTMTQAL 793

  Fly  1331 CRGYLARK---KMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTAN 1392
            ||.||.|:   ||.:||.   ::..||.|:::|:.|:.|||.::..::.|||....||::|.|..
Zfish   794 CRAYLMRREFVKMMERRE---SIYTIQYNIRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMK 855

  Fly  1393 EELLMLRAKLEKIECDRSEV--------------------KAENQ---------------KLEAK 1422
            |:.:..:..|.|.|..:.|:                    :|||.               :||||
Zfish   856 EDFVKCKEDLVKAEAKKKELEEKMVALLQEKNDLQLAVASEAENLSDAEERCEGLIKSKIQLEAK 920

  Fly  1423 LSELTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDL 1486
            |.|.|..|.:|        |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:
Zfish   921 LKETTERLEDE--------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 977

  Fly  1487 NGISEDEDAENEDGVGGGVYKLKYERVARE-------------------LEFTKRRLHTQ---HE 1529
            ..::|:..:::|     .:.||..|:.|.:                   |..:|.:|..|   .|
Zfish   978 KNLTEEMASQDE-----SIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLE 1037

  Fly  1530 HDLEQ-------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNAR 1587
            ..|||       |...|:.||..|..|.|.:::......|.:.|.:|...|...|...:|::.:.
Zfish  1038 GSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKIKKKDFETAQLLSKIEDEQSL 1102

  Fly  1588 NNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEF-- 1646
            ...|:||.::..|..:.|::.:..||.|:.:..:::..|..|...:.:.|.:    |...:|.  
Zfish  1103 GAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNK 1167

  Fly  1647 -KEEKLASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDE 1694
             :|.:...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:
Zfish  1168 KREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDD 1232

  Fly  1695 MAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG-----------NG---------- 1738
            ::..::.:.:||..||....|:..:......:.||.|.::..           ||          
Zfish  1233 LSSNMEAVAKAKANLEKMCRTVEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKE 1297

  Fly  1739 -------------YKKIKALECQLETEHEERTL-------------LLRE--------KHELERR 1769
                         .::|:.|:.|:|.|.:.:..             ||||        |.||:|.
Zfish  1298 ALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRG 1362

  Fly  1770 LSSME----------DRDRVDRDAE-------------------EALNQK---LRRDLRKYKALL 1802
            :|...          :.|.:.|..|                   ||:|.|   |.:..::.:..:
Zfish  1363 MSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEV 1427

  Fly  1803 KDAQTQLERLKADTPGKTLIRQLRN-----------------QLEDAE-SARSLA---------- 1839
            :|....:||  |:.....|.::.||                 :||.|: .||||:          
Zfish  1428 EDLMIDVER--ANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSY 1490

  Fly  1840 ----------MKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEEL-- 1892
                      .:..:..:.|::::.....|:.::.::.|:.......::||:|..:||.|..|  
Zfish  1491 EETLDQLETLKRENKNLQQEISDLTEQIGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTLEH 1555

  Fly  1893 ----------------GELMKKYS---ATVKQLNTEQINVSEA---------------------- 1916
                            ||:.:|.:   ..::|:......|:||                      
Zfish  1556 EESKILRVQLELNQVKGEIDRKLAEKDEEIEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKKKM 1620

  Fly  1917 EFKLNEMEAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTK 1964
            |..|||||.:.::...|.||.|.:|.||:        :|.|         ..:||:.:|..|...
Zfish  1621 EGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQS 1685

  Fly  1965 ELES-RLELEQATRARLEVQ--------------------VNRHKEA---LEKLQNEVTQSKMRE 2005
            |:|. |..|||..|.|...:                    :|..|:.   |.::|.||..:....
Zfish  1686 EIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLESDLVQIQGEVEDTVQEA 1750

  Fly  2006 MQAQDVIKKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---K 2058
            ..|::..||:......|.||.    .:||::   |.| :|:||..|:.:     |:|..|:   |
Zfish  1751 RNAEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEITVKDLQHRLDEAENLAMKGGK 1811

  Fly  2059 NDLRLALQRIADLQQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRLRPV 2106
            ..|:....|:.:|:..:|.|..                :||: :::|...::..:.||.|:|: :
Zfish  1812 KQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNINRLQDLVDKLQ-L 1875

  Fly  2107 HVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANK 2169
            .||...:||....  ....|.:|..|.|..|.::...|..:   |...::|  |.||:..|.|
Zfish  1876 KVKAYKRQSEEAE--EQANSHLSKLRKVQHELEEAEERADI---SESQVNK--LRAKSRDAGK 1931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 211/807 (26%)
MYSc_Myo18 575..1305 CDD:276837 198/776 (26%)
GBP_C <1540..1750 CDD:303769 52/266 (20%)
COG1340 1565..1833 CDD:224259 74/394 (19%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
myhc4NP_001018321.1 Myosin_N 36..74 CDD:280832 3/14 (21%)
Myosin_head 89..768 CDD:278492 203/788 (26%)
MYSc_class_II 101..768 CDD:276951 198/776 (26%)
Myosin_tail_1 848..1925 CDD:279860 228/1103 (21%)
SPEC 881..1043 CDD:295325 39/174 (22%)
RILP-like <1002..1096 CDD:304877 20/93 (22%)
MIT_CorA-like <1297..>1409 CDD:294313 18/111 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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