Protein Alignment Mhcl and myhc4

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001018321.1
• Gene: myhc4 / 334274
• ZFINID: ZDB-GENE-030131-6206
• Length: 1935
• Species: Danio rerio
• Alignment Length: 2013
• Identity: 477/2013 - (23%)
• Similarity: 817/2013 - (40%)
• Gaps: 516/2013 - (25%)

  Fly   533 KLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPT 597
            |:::..|...|:..|.||||...|.|..|.:||:..:.:|||.|||:.|::|||:.:|:|.:|..
Zfish    59 KVTVITLDTKEERVVKEDDVHPMNPPKYDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLF 123

  Fly   598 LLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKST 662
            ...|||...|.:|..:||:.:||.|..:.|||::|::..||:.::..|.:||::..|.||:||:.
Zfish   124 CATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTV 188

  Fly   663 SFKHALNYLALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            :.|..:.|.|..|            |.....:. :::.|...:|||:||.||..|.|::|..:.:
Zfish   189 NTKRVIQYFATVAVQGGDKKKEQAPGKMQGSLE-DQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252

  Fly   716 SLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP 780
            .:.|..||::|||.::..|.|:.|...:|..|..:||..:::...    :.||....:.:.:.:.
Zfish   253 RIHFGTTGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNH----KPELIEMTLITTNPYD 313

  Fly   781 FISLSQ------KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            |...||      .::|:    .:.|.|..|.:.|....:...||:....|:.|.|     .:...
Zfish   314 FPMCSQGQITVASIDDK----EELMATDSAIDILGFTGEEKMGIYKFTGAVLHHG-----NMKFK 369

  Fly   840 STARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWEC 901
            ...|.:.|.|..   |.|.|.|||:|..:|..|   |..|....|....:|..|...    .:..
Zfish   370 QKQREEQAEPDGTEEADKISYLLGLNSAELLKA---LCYPRVKVGNEFVTKGQTVPQ----VYNS 427

  Fly   902 LEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRH 962
            :.||...:|.:....:|..||:.:.|.......|.::|..||:    |          ::..|..
Zfish   428 VSALSKSIYEKMFLWMVIRINQMLDTKQQRNFFIGVLDIAGFEIFDFN----------SMEQLCI 482

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQ-----ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            |:..|:||..|:|...|..::.|.:     |.::..||||: |     |.||:|.
Zfish   483 NFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAA-C-----IELIEKP---------- 531

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAG---PR--------Q 1076
                    .|:..:|:||.::|.:.|.:|..:|:..:        |.||..   ||        .
Zfish   532 --------MGIFSILEEECMFPKATDVSFKNKLYDQH--------LGKCNAFQKPRPQKGKAEAH 580

  Fly  1077 FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSF 1141
            |.|.|..||  |.|.|:||:..::: |...:.|.|.|.||.:.:..||...:....|     |..
Zfish   581 FSLVHYAGT--VDYNVNGWLDKNKD-PLNESVVQLYQKSSVKLLATLYPPVVEETGG-----GKK 637

  Fly  1142 AGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHT 1206
            .|.:...|::.|||                 |.:..:..::..||.|..|||.|.:
Zfish   638 GGKKKGGSMQTVSS-----------------QFRENLGKLMTNLRSTHPHFVRCLI--------- 676

  Fly  1207 KYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-- 1269
                   |:.     |....::...|:..|||.:.|||..|:.|.|||..:...:|.:|:.:|
Zfish   677 -------PNE-----SKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNA 729

  Fly  1270 ----AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAF 1330
                .|....||..| |::|...:::...||.|.:::.|::|:|..||..||..|:..:...||.
Zfish   730 SVIPEGQFIDNKKAS-EKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLATLVTMTQAL 793

  Fly  1331 CRGYLARK---KMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTAN 1392
            ||.||.|:   ||.:||.   ::..||.|:::|:.|:.|||.::..::.|||....||::|.|..
Zfish   794 CRAYLMRREFVKMMERRE---SIYTIQYNIRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMK 855

  Fly  1393 EELLMLRAKLEKIECDRSEV--------------------KAENQ---------------KLEAK 1422
            |:.:..:..|.|.|..:.|:                    :|||.               :||||
Zfish   856 EDFVKCKEDLVKAEAKKKELEEKMVALLQEKNDLQLAVASEAENLSDAEERCEGLIKSKIQLEAK 920

  Fly  1423 LSELTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDL 1486
            |.|.|..|.:|        |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:
Zfish   921 LKETTERLEDE--------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 977

  Fly  1487 NGISEDEDAENEDGVGGGVYKLKYERVARE-------------------LEFTKRRLHTQ---HE 1529
            ..::|:..:::|     .:.||..|:.|.:                   |..:|.:|..|   .|
Zfish   978 KNLTEEMASQDE-----SIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLE 1037

  Fly  1530 HDLEQ-------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNAR 1587
            ..|||       |...|:.||..|..|.|.:::......|.:.|.:|...|...|...:|::.:.
Zfish  1038 GSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKIKKKDFETAQLLSKIEDEQSL 1102

  Fly  1588 NNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEF-- 1646
            ...|:||.::..|..:.|::.:..||.|:.:..:::..|..|...:.:.|.:    |...:|.
Zfish  1103 GAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNK 1167

  Fly  1647 -KEEKLASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDE 1694
             :|.:...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:
Zfish  1168 KREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDD 1232

  Fly  1695 MAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG-----------NG---------- 1738
            ::..::.:.:||..||....|:..:......:.||.|.::..           ||
Zfish  1233 LSSNMEAVAKAKANLEKMCRTVEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKE 1297

  Fly  1739 -------------YKKIKALECQLETEHEERTL-------------LLRE--------KHELERR 1769
                         .::|:.|:.|:|.|.:.:..             ||||        |.||:|.
Zfish  1298 ALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRG 1362

  Fly  1770 LSSME----------DRDRVDRDAE-------------------EALNQK---LRRDLRKYKALL 1802
            :|...          :.|.:.|..|                   ||:|.|   |.:..::.:..:
Zfish  1363 MSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEV 1427

  Fly  1803 KDAQTQLERLKADTPGKTLIRQLRN-----------------QLEDAE-SARSLA---------- 1839
            :|....:||  |:.....|.::.||                 :||.|: .||||:
Zfish  1428 EDLMIDVER--ANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSY 1490

  Fly  1840 ----------MKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEEL-- 1892
                      .:..:..:.|::::.....|:.::.::.|:.......::||:|..:||.|..|
Zfish  1491 EETLDQLETLKRENKNLQQEISDLTEQIGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTLEH 1555

  Fly  1893 ----------------GELMKKYS---ATVKQLNTEQINVSEA---------------------- 1916
                            ||:.:|.:   ..::|:......|:||
Zfish  1556 EESKILRVQLELNQVKGEIDRKLAEKDEEIEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKKKM 1620

  Fly  1917 EFKLNEMEAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTK 1964
            |..|||||.:.::...|.||.|.:|.||:        :|.|         ..:||:.:|..|...
Zfish  1621 EGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQS 1685

  Fly  1965 ELES-RLELEQATRARLEVQ--------------------VNRHKEA---LEKLQNEVTQSKMRE 2005
            |:|. |..|||..|.|...:                    :|..|:.   |.::|.||..:....
Zfish  1686 EIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLESDLVQIQGEVEDTVQEA 1750

  Fly  2006 MQAQDVIKKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---K 2058
            ..|::..||:......|.||.    .:||::   |.| :|:||..|:.:     |:|..|:   |
Zfish  1751 RNAEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEITVKDLQHRLDEAENLAMKGGK 1811

  Fly  2059 NDLRLALQRIADLQQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRLRPV 2106
            ..|:....|:.:|:..:|.|..                :||: :::|...::..:.||.|:|: :
Zfish  1812 KQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNINRLQDLVDKLQ-L 1875

  Fly  2107 HVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANK 2169
            .||...:||....  ....|.:|..|.|..|.::...|..:   |...::|  |.||:..|.|
Zfish  1876 KVKAYKRQSEEAE--EQANSHLSKLRKVQHELEEAEERADI---SESQVNK--LRAKSRDAGK 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	431/1824 (24%)
		MYSc_Myo18	575..1305	CDD:276837	198/776 (26%)
myhc4	NP_001018321.1	Myosin_N	33..78	CDD:460670	6/18 (33%)
		MYSc_class_II	101..768	CDD:276951	198/776 (26%)
		Myosin_tail_1	848..1925	CDD:460256	228/1103 (21%)