DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and myh9a

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001091647.2	Gene:	myh9a / 333938	ZFINID:	ZDB-GENE-030131-5870	Length:	1961	Species:	Danio rerio

Alignment Length:	1887	Identity:	500/1887 - (26%)
Similarity:	832/1887 - (44%)	Gaps:	393/1887 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562
            ||.:..:.||: ..:.||.|      .|...:..::..:.|..:|:::.|::||::|.|.|....
Zfish    22 ADWATKKLVWVPSEKLGFEA------GSIKEETGDECLVELADSGKKIKVNKDDIQKMNPPKFSK 80

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |||:.||..||||||||.||:||.|.||:|.:|...:|:||...|.:|:|::|.|::|.|..:||
Zfish    81 VEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRHEMP 145

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALC- 691
            ||:|::..|||||:::.|.|||::..|.||:||:.:.|..:.|||..|.::....:...: ||.
Zfish   146 PHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSFKTKKDQSSI-ALSH 209

  Fly   692 -----------TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLG 745
                       .|||||||.||..|.|::|..:.:.::||..|.|..|:::..|.|:.||.|:..
Zfish   210 GELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAK 274

  Fly   746 HEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNI 810
            .|.:|||...||.||...|:.||.||:.   :.:.|:|.........:....|..|:.||..:.|
Zfish   275 DERAFHIFYYLLTGAGDKLRSELCLEDY---NKYRFLSNGNVTIPGQQDRELFAETIDAFRIMGI 336

  Fly   811 DAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQ 875
            ......|:..:::|:..||.....|  ..::.:....:.|||:|.|.|||:|:.|.:.|   :..
Zfish   337 PEDEQTGLLKVVSAVLQLGNMSFKK--ERNSDQASMPDDTAAQKVSHLLGMNVTDFTRA---ILS 396

  Fly   876 PNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLID 939
            |....|.....|:.|.:.. |:|   :|||....|......:|..||:.:..:....|| |.::|
Zfish   397 PRIKVGRDFVQKAQTQEQA-EFA---VEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILD 457

  Fly   940 TPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMD 995
            ..||:    |          :...|..||..|:||.||:||..:..::.|.:|     .::..:|
Zfish   458 IAGFEIFELN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLD 512

  Fly   996 LASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYG 1060
            |.      |.|.||:|               .:...|:|.|||||..:|.:.|.:|:|::....|
Zfish   513 LQ------PCIELIEK---------------PNGPPGILALLDEECWFPKATDKSFVEKVVQELG 556

  Fly  1061 DREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYI 1125
            :.......:|......|.:.|..|  .|.|..:.|:..:.: |...|..:||..|..:     ::
Zfish   557 NNPKFQKPKKLKDDADFCIIHYAG--KVDYKANEWLMKNMD-PLNDNVATLLNQSVDK-----FV 613

  Fly  1126 GSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRS-FTTAG-VKRNSIMLQVKFTVDGIIDTLRRT 1188
            ..|.:....:|.....||:  .:||......|:. |.|.| :.:..:|        .::.|||.|
Zfish   614 SELWKDVDRIVGLDKVAGM--GESLHGAVKTRKGMFRTVGQLYKEQLM--------NLMTTLRNT 668

  Fly  1189 GTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGF 1253
            ..:||.|.:..|              ...||:::..       |:..|||.:.|||..|:.|.||
Zfish   669 NPNFVRCIIPNH--------------EKKAGKLAHH-------LVLDQLRCNGVLEGIRICRQGF 712

  Fly  1254 PESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELE 1313
            |..:...||.:|:.:|..:     ....|...|..:.|: |||...||||.|::.||:|||:.||
Zfish   713 PNRIVFQEFRQRYEILTPNAIPKGFMDGKQACVLMVKAL-ELDSNLYRIGQSKVFFRAGVLAHLE 776

  Fly  1314 AKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPL 1378
            .:||:.::|.||..||:||||:||:..::|:.|..|:|.||||..|:|.:|:|.||||..:|.||
Zfish   777 EERDMKITDVIINFQAWCRGYVARRAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRLFTKVKPL 841

  Fly  1379 LNVHRTEEQLKTANEELLMLRAK-------LEKIECDRSEVKAENQKLEAKL------------- 1423
            |.|.|.||::....|||:.::.:       |::.|..:.::.||...|:.:|
Zfish   842 LQVTRQEEEMVAKEEELVKMKERQQQAEDQLKESEAKQKQLNAEKLALQEQLQAETELCQEAEEM 906

  Fly  1424 -SELTVDLAEERSTAHIATERLEAE-------TAERLKLEKELGDQTNKVKNLQETTEKLEMELI 1480
             |.||..:.|.....|....|||.|       .:|:.|:::.:||...::...:...:||::|.:
Zfish   907 RSRLTARMQEMEEVLHELESRLEEEEERVAQFQSEKKKMQQNIGDLEQQLDEEEAARQKLQLEKV 971

  Fly  1481 CAKSDLNGISED----EDAENEDGVGGGVYKLKYERVARELEFTK------------RRLHTQHE 1529
            ...:.|..|.||    ||...:      :.|.|.:...|..|||.            ::|.|:||
Zfish   972 TMDAKLKKIEEDLMVIEDQNAK------LSKEKKQMEERISEFTTNLAEEEEKSKSLQKLKTKHE 1030

  Fly  1530 ---HDLE-----------QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRML 1580
               .|||           :|...::.||...::.::::.|.:..:.:.:.:..|...|:......
Zfish  1031 TMITDLEDRLRKEEKMRQELEKNRRKLEGDSTELHDQIAELQAQIAELRAQLAKKEEELQAALAR 1095

  Fly  1581 LEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKFTLEQTLADTR 1641
            :||:.|..|..:|..|:.:|:...||:.:..|:.|:.:..:::    :.|:|.|..||.||..|.
Zfish  1096 IEEEAALKNAAQKSIREMEAQISELQEDLELEKAARNKAEKQRRDLGEELEALKTELEDTLDSTA 1160

  Fly  1642 LDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQ---------EEELDEMAG 1697
            ...|.:.::                 |.|..||:::. |.|.||.||         .:..:|:..
Zfish  1161 AQQELRAKR-----------------ETEVTQLKKTL-EDEARAHEQMLSEVRQKHNQAFEELNE 1207

  Fly  1698 QIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLRE 1762
            |::..:::|..::...:.:..| |.|.|...:.|.:.:.:...:.|..|.||:....:.|...|:
Zfish  1208 QLEQSKRSKASVDKAKQALESE-RNELQIELKSLSQSKNDSENRRKKAESQLQELQVKHTESERQ 1271

  Fly  1763 KHELERRLSSMEDRDRVDRDAE-----------EALNQKLRRDLRKYKALLKDAQTQLERLKADT 1816
            ||||..::|.|:        ||           |:.:.|..:|....::.|||||..||.   :|
Zfish  1272 KHELLDKVSKMQ--------AELESLQGTVTKVESKSIKAAKDCSAVESQLKDAQALLEE---ET 1325

  Fly  1817 PGK----TLIRQLRNQ-------LEDAESARSLAMKARQTAEAELTE-----------VQAMFDE 1859
            ..|    |.:|||.::       ||:.|.::....|...||:|:|.|           :::|.|.
Zfish  1326 RQKLAISTRLRQLEDEQNNLKEMLEEEEESKKNVEKQLHTAQAQLAEMKKKIEQEAQSLESMEDG 1390

  Fly  1860 SHRARNDAE------ERANAAH--------RDRAEL------QAQIEENEEELGELMKKYS---A 1901
            ..:.:.:.|      |..||::        |.:.||      |..:.:..:||....||:.   |
Zfish  1391 KKKLQREVESVLQQLEERNASYDKLDKTKTRLQRELDDVLVDQGHLRQTVQELERKQKKFDQMLA 1455

  Fly  1902 TVKQLNT---EQINVSEAEFK-------------------LNEMEAERNNLKEQVAELQHRLD-- 1942
            ..|.::|   |:.:.:|||.:                   .||:|.....||.::.:|....|
Zfish  1456 EEKSISTKYAEERDRAEAEAREKETKSLTLARELEAMTDLKNELERVNKQLKTEMEDLVSSKDDA 1520

  Fly  1943 --NVENLGDPSMAMMSKRLELRT--KELESRLELEQATRARLEVQV------------NRHKEAL 1991
              :|..|......|..:..|::|  :|||..|:|.:..:.||||.:            :|.::..
Zfish  1521 GKSVHELERAKRGMEQQLEEMKTQLEELEDELQLTEDAKLRLEVNMQALKAQFERDLQSRDEQGE 1585

  Fly  1992 EKLQNEVTQSKMREMQAQD--------------------------------------VIKKSQKS 2018
            ||.:..|.|.:..||:.:|                                      .:||.|..
Zfish  1586 EKRKQLVKQVREMEMELEDERKQRAQAVSVRKKLELDLSELAAQIDLANKARDEALKQLKKLQAQ 1650

  Fly  2019 LRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEEL 2083
            :::...||..:.....|||.:.|:.|:|::.||:|...|..||..|.:....:||..:|..:|..
Zfish  1651 MKEQMREFEDLRLSRDESLNQAKENERKIKSMEAEIMQLHEDLAAADRAKRQIQQERDELQDEIN 1715

  Fly  2084 SE-------SDESLSSVGSISDLEDRLRPVHV-------------------------KRSSQQSL 2116
            |:       |||.......|:.||:.|...|:                         :||:.|.|
Zfish  1716 SQNAKNSLSSDERRRLEARIAQLEEELEEEHLSVELVNDRLKKASLQAEQVTVELTAERSNSQRL 1780

  Fly  2117 NG 2118
            .|
Zfish  1781 EG 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	236/789 (30%)
		MYSc_Myo18	575..1305	CDD:276837	219/758 (29%)
		GBP_C	<1540..1750	CDD:303769	46/222 (21%)
		COG1340	1565..1833	CDD:224259	72/302 (24%)
		coiled coil	1723..1734	CDD:293879	3/10 (30%)
myh9a	NP_001091647.2	Myosin_N	28..66	CDD:280832	8/43 (19%)
		Myosin_head	81..768	CDD:278492	227/770 (29%)
		MYSc_Myh18	93..768	CDD:276895	219/758 (29%)
		Myosin_tail_1	845..1925	CDD:279860	216/974 (22%)
		crotonase-like	1067..>1101	CDD:304874	5/33 (15%)
		DUF2570	1777..1878	CDD:305162	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810