DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Myo10A

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster


Alignment Length:2017 Identity:405/2017 - (20%)
Similarity:706/2017 - (35%) Gaps:589/2017 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNP--MAPLSLYSEKVVSMFRGCKTED 625
            |||:..|..|:|||:|..||.||...||:|.||..|:.|||  |.| ..|..:|...:.|.....
  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFP-DAYGLEVAKQYAGRPLGS 220

  Fly   626 MPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLA--LAAGAYNNFINAEKVN 688
            :|||::::...|:.:|..   .|.::..|.|||||:.|.|..:.|||  :..|...:.:..|::.
  Fly   221 LPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282

  Fly   689 ALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIM 753
            ....:||||||.:|..|.|::|..:.|.:.| ::|.|..|.:...|.|:.|...:...|.::|:.
  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346

  Fly   754 TRLLAGAA-------GLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNID 811
            ..||.|.:       |||:.:            .:..|:|...|......|:.....|.:.|.:.
  Fly   347 YELLGGLSETERSKYGLLEAD------------KYFYLNQGATDCASGRVDWESLQGAMQVLGVS 399

  Fly   812 AKAVRGIWSILAAIYHLGIA---------GVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867
            .....||..:|||:.|||..         |...:..||.|..::        |:.||.::.:.|.
  Fly   400 EGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW--------AAHLLHISADGLH 456

  Fly   868 SAAFGLTQPNAPNGGLSPSKSPTSDT--GHEWAWECLEALVIGLYSEALAAVVALINRQICT-SS 929
            .|....|         :.:::....|  |.:.|.:..:|....||:.....:|:.||..:.. .:
  Fly   457 RALTSRT---------TEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT 512

  Fly   930 HTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEM 994
            |....|.::|..||::.|.      .:...|..||..|.||:.|:.......:..||:|.:| ..
  Fly   513 HDAHRISILDIFGFEDLAE------NSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLE-WT 570

  Fly   995 DLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHY 1059
            .||.:.:. |:|.|:.|.|.                 |:..|||:|:.:|.:.|.:|||:  .||
  Fly   571 PLAWDDNL-PVIHLLAKKPV-----------------GICHLLDDESNFPRATDLSFLEK--CHY 615

  Fly  1060 GDREHHSLLRKCAGPR----QFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEI 1120
                :|:|....|.||    :|.:.|..|  .|.|.|||::..:|:  .:|..|..|..|||..:
  Fly   616 ----NHALSELYARPRIGAQEFGVTHYAG--QVWYCVDGFLDKNRD--ALRGDVLELLASSRLPL 672

  Fly  1121 NRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTL 1185
                :|.||:...|....|        ::|.:.|:.|  |.|...:..::..:...::..::.::
  Fly   673 ----VGELTKQLRAQRDAG--------KTLPKGSNGR--FVTMKPRTPTVAARFADSLQQLLQSM 723

  Fly  1186 RRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHR 1250
            .|....||.|  ::.|..||..                   .:::|.:..|||...:|:..::.:
  Fly   724 GRCHPWFVRC--IKPNQEKHAL-------------------RMDMPCVLQQLRYLGMLDTIQIRQ 767

  Fly  1251 LGFPESVPLLEFVRRF-GLLAGDLASNKDV-----SVEQILAVNELDVASYRIGPSQILFRSGVL 1309
            .|:|..:....||.|: .||...||.....     ::.:.:....::...|::|.:::..|..:.
  Fly   768 RGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALH 832

  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVK-----------AFLAV 1363
            ..||:.|...|....:.:|...||.|.|:::::|:.....::...|..:           |..|.
  Fly   833 RALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ 897

  Fly  1364 RDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR----AKLEKIECDRSEVKAENQKLEAKLS 1424
            |.|...:...||..|.:.||..::.:.|.:.....|    |.||:.:....::.||...:.:||.
  Fly   898 RLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQ 962

  Fly  1425 ELTVDLAEERSTAHIATERLEAETAERLKLEKELGD---------QTNKVKNLQETTEKLEMELI 1480
            ..:....:......:.|  :....:..::|.::||.         ..|.:: ||...|.:...|:
  Fly   963 GWSPPHGDRHLVKVLGT--VPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLR-LQPRREPITAPLL 1024

  Fly  1481 CAKSDLNGISEDEDAE-------------NEDGVGGGVYKLKYERVARELEFTKRRLHTQ----- 1527
                 ....|.|:|.:             |:..:.|...||..:.:..: ..:.|.|..:     
  Fly  1025 -----TRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK-ALSSRGLRDEILVQL 1083

  Fly  1528 --HEHDLE----------QLV-----------ALKKHLEMKLSDAYEEVVEQ---RQVVGQ---- 1562
              ..|.|.          ||:           |..|:|...:.|...|.:..   ||::.|    
  Fly  1084 CNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGG 1148

  Fly  1563 -----------------------WKR--------------------------------------- 1565
                                   |.|                                       
  Fly  1149 TSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV 1213

  Fly  1566 ----------KAQKMTNE--MNDLRMLLEEQN-------ARNNLLEKKQRKFDAECQSLQDAVRQ 1611
                      ..|::|:.  ::.:..|:.|:.       .|::|| :...||..  .:|.|||::
  Fly  1214 ASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLL-RSGAKFAR--TTLPDAVKR 1275

  Fly  1612 ---------ERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELE-EMTFGGG 1666
                     ....||...||:                 |...|......|..:|..| |.:.|.|
  Fly  1276 PAVPPPAPPTSSGKEDVPRER-----------------RSSRELLSRSSALNERYFEREPSPGPG 1323

  Fly  1667 TEEEFAQLRRSKNETERRAKEQEEELDE-MAGQIQLL-----EQAKLRLEMTLETMRKEARRESQ 1725
                       :..:..:||.:.:.||: :||.|..:     .|..|. .:.|...|...|..|.
  Fly  1324 -----------QGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLH-TLGLSESRLNDRYHSA 1376

  Fly  1726 QRDEELEEVRGNGYKKIK-ALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQ 1789
            :|...:.:..|..|:|.: |........|...:....:|.|...|.|:|.|....     .:|..
  Fly  1377 ERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA-----PSLAS 1436

  Fly  1790 KLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQ 1854
            .:||  .:..:...|....|:.|.:..        |...|::...|||||...|..:..:..|.:
  Fly  1437 HVRR--VRVPSQASDVDQFLDDLFSPV--------LDGSLDELSDARSLAASIRGGSYEQENEAE 1491

  Fly  1855 AMFDESHRARND----------AEERAN-------------AAHRDRAELQAQIEENEEELGELM 1896
            :..|:.....||          .|:..:             |:..:..:.:::||:.::.:.||.
  Fly  1492 SEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELF 1556

  Fly  1897 KKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVA-ELQHRLDNVENLGDPSMAMMSKRLE 1960
                        |.|.|:|...||..        ||.:| .::.......|..||   ::.:.::
  Fly  1557 ------------EPIPVAEGLDKLTS--------KEHLAVSIRGGGSTDSNGADP---LLHQLMQ 1598

  Fly  1961 LRTKELES--RLELEQATRARLEVQVNRHKEALEKL--QNEVTQS-------------------- 2001
            | ..|.||  .|..:|..||.|:..:.::.:..::|  ||:..|:                    
  Fly  1599 L-PGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPA 1662

  Fly  2002 ------------------KMREMQAQDVIKKS--------------------------------- 2015
                              :|:..::..|:.:|                                 
  Fly  1663 PPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGR 1727

  Fly  2016 QKSLR---------------DMREEFHAVSSREQESLT----RRKDLEKKVEQMES--------- 2052
            .|::|               ...|:|.|...|:.:..|    :...:......|||         
  Fly  1728 AKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASA 1792

  Fly  2053 ------------------EGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSV------ 2093
                              .|..:::.:||..............:.:.|..:..:.:.||      
  Fly  1793 TAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLA 1857

  Fly  2094 -------------GSI------SDLEDRLRPV---HVKRSS---------------------QQS 2115
                         ||:      |::..||..|   |..||:                     ||.
  Fly  1858 KKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQ 1922

  Fly  2116 LNG---SIGGGG---GSVVSSTRTV--VFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPDT 2172
            |.|   |:.||.   |.||.|..||  ..|:.:.........||......|...|.::||..|..
  Fly  1923 LGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPI 1987

  Fly  2173 KP 2174
            :|
  Fly  1988 RP 1989

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 197/786 (25%)
MYSc_Myo18 575..1305 CDD:276837 188/762 (25%)
GBP_C <1540..1750 CDD:303769 52/314 (17%)
COG1340 1565..1833 CDD:224259 59/342 (17%)
coiled coil 1723..1734 CDD:293879 2/10 (20%)
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 195/782 (25%)
MYSc_Myo15 169..828 CDD:276838 188/762 (25%)
MyTH4 1014..1171 CDD:295320 23/162 (14%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466245
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.