DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and CG5921

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	156/903 - (17%)
Similarity:	273/903 - (30%)	Gaps:	354/903 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 QGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVK 331
            |||     |:.|.|:|.:|.||.::                 ..|..:.|...:.:    ::||:
  Fly    30 QGS-----TTSSASSDVMTLTTTAA-----------------SSWCAIPASSRLRV----LRLVR 68

  Fly   332 LPPPRQLVIRRQKSPRQ--DFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRL 394
             |..|:|::   ..|.:  .:||::|..     .|..|. .|  |...|.|......||..||::
  Fly    69 -PHQRRLLV---GGPERGSTYGFTVRGG-----REHGTG-FF--VSHVEHGGEAHLKGLRIGDQI 121

  Fly   395 IKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNCN 459
            :::||..:.:...:..|:::... :.||::|
  Fly   122 LRINGFRLDDAVHKEFIQLVAGQ-DRVTLKV---------------------------------- 151

  Fly   460 TLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTA 524
                                        :|||   ...|.|..:....|.|        ::||:.
  Fly   152 ----------------------------RGVG---MLPVRDLPEERLSWSV--------VKLPSV 177

  Fly   525 SSGRDEENKLSLRLLHNGEQLTVDED-DVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASN 588
            |....|.:       ..||:.....| .|....:|...|...||:.........:...:.|..:.
  Fly   178 SGTPSESS-------FKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAR 235

  Fly   589 LIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFM 653
            ....:.|..:|.||.:....:...:.|::.:.....||              :|.|
  Fly   236 EAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDM--------------VVRT--------- 277

  Fly   654 GRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLD 718
                                |||.                 :.|....:..||:|:.:|.
  Fly   278 --------------------AAGC-----------------DLFPGESSGYNSSASSVTG----- 300

  Fly   719 FDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFIS 783
             ||:...|.|..:.|...|:.:|                ||..|.        .::|.......:
  Fly   301 -DQSPCWADAKSKRLTAVREESG----------------AGGGGC--------GLSSAPGAGSPN 340

  Fly   784 LSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQ--F 846
            .||.:|...:.....::..:...::|.         :.:|:.....::|....|:|::.|:|  .
  Fly   341 WSQGVEVHKQMNKTIIKLTENGTSINN---------TYIASTGGSSVSGSGSTGSGTSGRSQQSQ 396

  Fly   847 ANPT-AARKASGLLGVNLEDLSSA--AFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIG 908
            :||: .:|.::.:...:|..::||  ..||:..:|.:.|.:.|....|.:|             |
  Fly   397 SNPSNPSRNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGSAGSSGSGSRSG-------------G 448

  Fly   909 LYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLF 973
            :.:.|.|.                      ..|.....|:....||::|:......|::|
  Fly   449 VIAPAPAP----------------------PPPAMNEGANASGSVGSSLSSAITEELKKR----- 486

  Fly   974 HHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLD 1038
                    :::..|                          |.|    .||..|:.||.|
  Fly   487 --------KEKQQQ--------------------------QQH----QQRHNRDRDRDG------ 507

  Fly  1039 EEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHP 1103
                  |.|.|   .:|..|.|:..|.|.:                         |.|.| |:..
  Fly   508 ------NGNVD---RQLTGHNGNGGHRSSV-------------------------GQVSH-RQRA 537

  Fly  1104 GIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGS--FAGLEGTQSLRRVSSIRRS 1159
            .:....:.||.|.|       |.:||.|.||....||  .||..|.|....:...:|:
  Fly   538 NVAGVAATLQGSER-------ISNLTGGGGAGGAGGSNGAAGAGGDQHTALMDEFKRA 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	19/88 (22%)
		MYSc	556..1317	CDD:214580	104/611 (17%)
		MYSc_Myo18	575..1305	CDD:276837	100/592 (17%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	19/140 (14%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	13/92 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900