DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Whrn

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_038965801.1	Gene:	Whrn / 313255	RGDID:	631330	Length:	969	Species:	Rattus norvegicus

Alignment Length:	1235	Identity:	231/1235 - (18%)
Similarity:	381/1235 - (30%)	Gaps:	453/1235 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LNADANG--------GSNGGAVGAADPEQDRGNEEIVASV------------------MTHIESR 127
            :||..:|        ||.|.|..||......|...:.|:|                  .||
  Rat     1 MNAQLDGLSVSSSSTGSLGSAAAAAGGGGGAGLRLLSANVRQLHQALTALLSEPEREQFTH---- 61

  Fly   128 ASNGAGVSVNYSEVTHS---LLSGGLKNRFLPPIPPKPPKRGIL-------KGSRSNMTNVHEEI 182
            ..|......|..::..:   ||...:|.|.||.:....|:...|       :|.....|..:.:.
  Rat    62 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQP 126

  Fly   183 SFAGSAGGAGGTPEML-LRNTFQNE----SLYEGAARGAG------SIGSNSSQHG--------- 227
            ::|...|...|...:: ||....:|    |:..|:..|.|      ..||.:.:.|
  Rat   127 AWAAPDGAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILR 191

  Fly   228 ---------TSFTSVESLRSDGEQTGGQQRAMTLPANARYGALPQGNSQGSHL--HVLTSPSPSA 281
                     |...:|::|:      |.::..:::     |.|   |...|.::  |:.|...|..
  Rat   192 VNDKSLARVTHAEAVKALK------GSKKLVLSV-----YSA---GRIPGGYVTNHIYTWVDPQG 242

  Fly   282 DSLTDTTNSSFATPPFSLSPVGES---QGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQ 343
            .|         .:||.|| |.|.:   ...||.:.:|..:..:  ...|.|| |...|.|.:..:
  Rat   243 RS---------TSPPSSL-PHGSTLRQHEDDRRSALHLLQSGD--EKKVNLV-LGDGRSLGLTIR 294

  Fly   344 KSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELPRE 408
            .......|..                    :...:||:...::||..||::::|||.....:..:
  Rat   295 GGAEYGLGIY--------------------ITGVDPGSEAESSGLKVGDQILEVNGRSFLSILHD 339

  Fly   409 IIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEE--------IDHSITNGNCNTLRRSA 465
            ..::::::|...: :.|:.|..|..        :..||::        |..||||
  Rat   340 EAVKLLKSSRHLI-LTVKDVGRLPH--------ARTTVDQTKWIASSRIGESITN---------- 385

  Fly   466 SKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDE 530
            |..|......|..|..|...|..|               .:|.|...|..|.|:        .|:
  Rat   386 SAGFPGDLTEEGTNKPGFYKGPAG---------------SQVTLSSLGNQTRAL--------LDD 427

  Fly   531 ENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAG 595
            :.:   .||...|:.|:                     :.||::          |....|..:|.
  Rat   428 QAR---HLLTEQERATM---------------------MYYLDQ----------YRGGTISVEAL 458

  Fly   596 PTLL--VVNPMAPLSLYSEKVVSMFRG-CKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSG 657
            ...|  ::|..|..||.||     .|| ...:|:         ..:..||..|..:|:......|
  Rat   459 VMALFELLNTHAKFSLLSE-----VRGIISPQDL---------DRFDHLVLRREIESMKARQPPG 509

  Fly   658 SGKSTSFKHALNY--LALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL----- 715
            .|...::. .::|  ...:.|::                    .|.|.::|...|:..|:
  Rat   510 PGVGDTYS-MVSYSDTGSSTGSH--------------------GTSTTVSSARERLLWLIDLMEN 553

  Fly   716 SLDFDQTGQIASASLQVL---------LPERQRAGRR---------LGHEHSFHIMTRLLAGAAG 762
            :||.:.||:....|...|         .|.....|.:         .||:       |||    |
  Rat   554 TLDLEGTGETTQGSTNALPDVSVDDVRSPSEDLPGIKPPPPPPPLAQGHD-------RLL----G 607

  Fly   763 LLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYH 827
            ..:|.:.      |||.|                             :.:.|..||  :.:|..:
  Rat   608 QTRKPVR------EDSAP-----------------------------LSSAAHSGI--VFSAPRN 635

  Fly   828 L------GIAGVTKLGTGST---------ARTQFANPTAARKASGLLGVNLEDLSSAAFG----- 872
            .      |||.....|..|.         |....|||::.:.    |..:|..::....|
  Rat   636 RSPPPPPGIAPTPTPGPSSARDSPSSPIYASISHANPSSRKP----LDTHLALVNQHPIGPFPRV 696

  Fly   873 -----LTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAA----VVALINR----- 923
                 |..|.|...|......|.|.:.|               ::|:.|    |:..::|
  Rat   697 QSPPHLKSPPAEAPGAGAGLPPPSPSEH---------------ADAVGANQHFVLVEVHRPDSEP 746

  Fly   924 ------------------QICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQ 970
                              |:..|..|::....:|. |....::.|:  |...|:.::...:|..|
  Rat   747 DVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDA-GETEASTSGR--GRQTANTKNKNGKELPQ 808

  Fly   971 -------------MLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
                         :|...:||:..|...|...:.||.. |:...|.|.|..|.       :...:
  Rat   809 TERTTEGANKPPGLLEPTSTLIRVRKSAATLGIAIEGG-ANTRQPLPRIVTIQ-------ICLPR 865

  Fly  1023 RDLREHDRRGM----------LWLLD--EEAIYPNSNDDTFL----ERLFSHYGDREHHSLLRKC 1071
            ||....||.|.          ||..|  ..|.||.   |..|    :|     |...|:     |
  Rat   866 RDTEPRDRHGQAPLHAPTLPGLWTRDWQHPARYPR---DPCLCLPVQR-----GGSAHN-----C 917

  Fly  1072 AGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMV 1136
            .   |..:.|      |:..|:|.....:||   |.|..::.::.:.: .|.||..|......|:
  Rat   918 G---QLKVGH------VILEVNGQTLRGKEH---REAARVIAEAFKTK-ERDYIDFLVTEFNVML 969

Fly 1137 1136
Rat 970 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	11/86 (13%)
		MYSc	556..1317	CDD:214580	127/690 (18%)
		MYSc_Myo18	575..1305	CDD:276837	125/671 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Whrn	XP_038965801.1	HN_L-whirlin_R1_like	38..113	CDD:259822	14/78 (18%)
		PDZ_signaling	139..216	CDD:238492	14/82 (17%)
		PDZ_signaling	276..356	CDD:238492	17/101 (17%)
		HN_L-whirlin_R2_like	418..498	CDD:259823	25/135 (19%)
		PDZ_signaling	<908..949	CDD:238492	13/62 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900