DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and PsGEF

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster


Alignment Length:2297 Identity:434/2297 - (18%)
Similarity:716/2297 - (31%) Gaps:745/2297 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 ANGGSN----GGAVGAADPEQDRGNEEIVASVMTHIE-------SRASNGAGVSVNYSEVTHSLL 146
            ||.|.:    ..|....|.:||....|:.|:|....:       ...||.|.:::|...::.|:.
  Fly   466 ANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISID 530

  Fly   147 SGGLKNRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEG 211
            |.|.::..||..|.:|     :|.|:..:   |:.           ...|.|.....:.:...:|
  Fly   531 SMGKEDPLLPQQPQQP-----MKLSKKAL---HQR-----------DADENLFLRFLELDPPADG 576

  Fly   212 AARG----AGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANARYGALPQGNSQGSHLH 272
            .|..    |.:.||.||....:.::...|.:.   |.|.:|..|:|           ||.||   
  Fly   577 NANSTTTQAQATGSQSSASKANESNANHLNNG---TSGGRRQSTMP-----------NSGGS--- 624

  Fly   273 VLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQ 337
                      |:...........||:::.                                    
  Fly   625 ----------SVGGAVRQQQGRTPFTMTK------------------------------------ 643

  Fly   338 LVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRP-VIFAEPGAGGGATGLLPGDRLIKVNGTP 401
               |..::..:.||||:          ..|.|   | |...|.|......|:||||.:|.|:...
  Fly   644 ---RLTRTEERGFGFSI----------VWTHP---PRVEKIEAGLSADRCGILPGDYVIFVDKHN 692

  Fly   402 VGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSAS 466
            |..:|...::.:||:.|.::|:|:         .:|..|.:| |:...|....|.:.:|      
  Fly   693 VVTMPEADVLNLIRSQGSSLTLEI---------FRRSGAGAT-TITSTDLGQNNVHIST------ 741

  Fly   467 KRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRL---------- 521
                            ..|.|.|:|.:.......|:....|..:.|   |.:.|:          
  Fly   742 ----------------RLGAAVGLGSEEHTLATTATGTTTVMSLQR---TTSTRIQPLANSMSRP 787

  Fly   522 PTASSGRDEENKLSLRLLHNGEQLTVDEDDV----EKQNSPALDLVEDICELKYLNEASVLHCLR 582
            .||.||.....:.:.|.||. .|:|..::.:    :.:....|.|:.     :..|..:.||...
  Fly   788 ATACSGTTSSIEAAKRRLHL-PQVTFSKESIVPVTDNRRRFLLQLIS-----REQNFTAALHFGV 846

  Fly   583 QRYASNLIHTKAGPTLLVVNPMAPLSLY---------SEKVVSMFRGCKTEDMPPHVYSLAQTAY 638
            .|:...|     |....:::|....:|:         :|.::........:|..|.: :.|...|
  Fly   847 DRFVQPL-----GERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQEPQM-NFASRVY 905

  Fly   639 RSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTC 703
            .|                   |:|:.          ..||..:.|..| .|.|.::         
  Fly   906 LS-------------------KTTAI----------CAAYKKYCNGIK-RADCVLV--------- 931

  Fly   704 LNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAG------RRLGHEHSFHIMTRLLAGAAG 762
               |.:|          |||....|.:......|:|..      |.|.|......:.:||||...
  Fly   932 ---NKSR----------QTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAGNCH 983

  Fly   763 L-LQKELHLENITSE-------------------DSHPFISLSQKLEDR--HRAANDFMRTVQAF 805
            : .::..:...:.:|                   :..|.::| |.||.|  ......|...||..
  Fly   984 VDTEEHKNFSTVINELQAAYREITVSSGLMEPLGEGRPLLTL-QDLESRMVFTKCKPFTLAVQGR 1047

  Fly   806 ETL------NIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFAN----PTAARKASGLLG 860
            :.:      .::.::|:..|::|       .:.:......|..|..|..    |.|         
  Fly  1048 QWIFGGDLSRVEGRSVKPYWTLL-------FSDIIVFAKVSRDRVLFITEEPIPIA--------- 1096

  Fly   861 VNLED------LSSAAFGLT-QPN-----APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEA 913
             |:.|      ..:..|.|| .||     :|.|..:|..:.|...|..     .::|::...|..
  Fly  1097 -NVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGAR-----RKSLILRAPSLE 1155

  Fly   914 LAAV-VALINRQICTSSHTIASIML---IDTPGFQNPASCGQQVGATLA----------DLRHNY 964
            |.|| ..|:.|||...:..:.|..|   :|:|...|.......:|.|.|          |..|..
  Fly  1156 LKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLK 1220

  Fly   965 LQERLQML------FHHTTLVAPRDRYAQ------------ELVEIEMDLASECHPGPLISLIDK 1011
            .|::.|..      .|..|.|| .||.|.            .:.:||:.:..:|.      :::|
  Fly  1221 QQQKQQRTNNSHGHVHSATGVA-TDRTADRSHGHNHGIHGGHVEQIELLIDEKCR------ILNK 1278

  Fly  1012 --APQN---HVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKC 1071
              .|::   |:....:..|.:..::..|..:.......::.|:..:....|...:|         
  Fly  1279 TGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDER--------- 1334

  Fly  1072 AGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMV 1136
                            :.|    |.|...|             ...:|:|      |.:.:|.:.
  Fly  1335 ----------------ITY----WTRQQLE-------------KRTKELN------LAKENGGLS 1360

  Fly  1137 FCGSFAG--LEGTQ--SLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFV---- 1193
            ...:|.|  |.|.:  |:...|.|..:....||  .|::.|...|......|:|  .:..|    
  Fly  1361 ARPNFGGKRLSGVEELSMSATSDIYSTSEAEGV--TSVISQSHSTTSDSQITVR--SSPIVLDKL 1421

  Fly  1194 ----HCYLLQHNAGKHTKYTANGSPSSAAGQV--SSEEEMVNVPLLRSQLRGSQVLEAARLH--- 1249
                ||:.....:|      ..|:.....|.|  ||...::....|:.|...|......:|.   
  Fly  1422 AVCRHCHKNCQQSG------PGGARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGI 1480

  Fly  1250 ----RLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLS 1310
                .:..|::      ..|.|...|.:.|....::     ..||.        |:::..|....
  Fly  1481 AGATEMANPKN------SNRTGTGTGSVTSMSSSTI-----TGELS--------SKVVASSSRRE 1526

  Fly  1311 ELEAKRDV--LLSDRIIQLQAFCR----GYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWW 1369
            ..:.:.||  |::|.|.|.|:...    |.:.....|......:......|::       |.|  
  Fly  1527 TGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHL-------DPP-- 1582

  Fly  1370 RLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEER 1434
               |.|:.|.|.|                        |. :.|...:.|          .|...|
  Fly  1583 ---VSVSSLPNGH------------------------CS-AGVGGGSPK----------PLPPPR 1609

  Fly  1435 STAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENED 1499
            .|      |:.|:..:.....| ...|...:..:.||..      |...|...| |....|....
  Fly  1610 RT------RVVAQMCQEPPRPK-ANQQVKAIVTITETAR------IMRSSPTKG-SGSGSATGTG 1660

  Fly  1500 GVGG--GVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQ 1562
            .|||  ..|...:.|...| :||    |.|...|                               
  Fly  1661 SVGGSPAKYAACHCRCTPE-DFT----HAQLSPD------------------------------- 1689

  Fly  1563 WKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQ 1627
               |.:..|.:      |||........||:||.  |.:...:...:.|...|....|:|: :.:
  Fly  1690 ---KMEHQTCK------LLESPKQTTTTLEQKQE--DEQLSLMLIGLAQLAPAATLCGQER-IPK 1742

  Fly  1628 AEKFTLEQTLAD---------TRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETER 1683
            .|..|  .|:|.         |:......:....|        :.||||.........:|...:.
  Fly  1743 EENST--PTIAVVPPTPDSVLTKTSTHVWDNSGCS--------SNGGGTSTTSTATTTTKQPRQA 1797

  Fly  1684 RAKE------QEEELDEMAGQIQLLEQAKLRLEMTLETMRK----EARRESQQRDEELEEVRGNG 1738
            ..:.      .|..|||......:  .:.||...|:.::.|    :...|:.:.|::|:..:.||
  Fly  1798 IIENIPEDSCDESPLDEEPPYRPM--SSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFKPNG 1860

  Fly  1739 YKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALLK 1803
                          |:..              |...:.|..|.|:|.||.|              
  Fly  1861 --------------HDGN--------------SPQNEEDDEDADSERALVQ-------------- 1883

  Fly  1804 DAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAE 1868
                  ..|.|.:....::        :.|...|.|...|  |.|.:::..:.|:||....:...
  Fly  1884 ------NDLGASSSSGVIV--------NGEGLASGAWTNR--AGAYVSDKMSFFEESRAFIDKYL 1932

  Fly  1869 ERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQ 1933
            .|.||....:...|....|.:|::.|      .|....:.|::..:......|:.:         
  Fly  1933 GRWNAGDAQQQHQQGTASETDEQMDE------CTSGATSGEEVWGTPTSGGDNDDQ--------- 1982

  Fly  1934 VAELQHRLDNVENL-GDPSMAMMSKR----LELRTKELESRLELEQATRARLEVQVNR-HKEALE 1992
              :||  |.|.||. ..|:.:..|..    .||...||   |.....|.:.:...:.| ::..||
  Fly  1983 --DLQ--LINSENTHSSPTKSSTSLNDDDDTELMMDEL---LMAPPMTASTIRGLLPRFYRRRLE 2040

  Fly  1993 KLQNEVTQS-KMREMQAQDVIKKSQKSLRDMREEFHAVSSREQES------LTRRKDLEKKVEQM 2050
            .|..|.|:| :.:..|..|.|||.:.:......|..|.||.:.||      |..|..:..:.|..
  Fly  2041 PLFEEETESDEEKTQQDSDDIKKGEATTNGHYLEDSAGSSSDSESVPPAPPLVPRPVVPDREEDP 2105

  Fly  2051 ESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESL------SSVGSISDLEDRLRP---- 2105
            .:||.                |:.:..|.:|:|..|.|.|      |::|....|..||.|    
  Fly  2106 SAEGQ----------------QENLAMEDQEDLHSSVERLLPNLATSAMGPRPLLTTRLLPTTAI 2154

  Fly  2106 ------VHVKRSSQQSLN---GSIGG---GGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKL 2158
                  |.|..|.:..|:   .|:.|   .|||:.::|.|        |.|.|..||:.      
  Fly  2155 DPQPPAVLVASSCEYLLDQRPSSVPGRDLAGGSIGTTTMT--------SSRPTPLSPAK------ 2205

  Fly  2159 ALAAKAIPANKPDTKPAASTRM 2180
             .||..|..|...|....:|.|
  Fly  2206 -AAATPIGMNATMTTKTTTTTM 2226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 25/87 (29%)
MYSc 556..1317 CDD:214580 152/877 (17%)
MYSc_Myo18 575..1305 CDD:276837 148/846 (17%)
GBP_C <1540..1750 CDD:303769 38/228 (17%)
COG1340 1565..1833 CDD:224259 49/286 (17%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
PsGEFNP_996333.4 DUF4799 <102..209 CDD:292674
C2 286..>381 CDD:278593
PDZ_signaling 644..716 CDD:238492 24/84 (29%)
RhoGEF 831..1000 CDD:295373 39/231 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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