Protein Alignment Mhcl and Myh7b

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001101264.2
• Gene: Myh7b / 311570
• RGDID: 1307994
• Length: 1941
• Species: Rattus norvegicus
• Alignment Length: 1818
• Identity: 460/1818 - (25%)
• Similarity: 779/1818 - (42%)
• Gaps: 352/1818 - (19%)

  Fly   505 ERVWLV-HRGGFTAAIRLPTASSGR-DEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDIC 567
            :|||:. .:..:..|.....|:.|| ..|.|       :.:.|||.|.:::..|.|..||:||:.
  Rat    33 KRVWVPDEQDAYVEAEVKTEATGGRVTVETK-------DQKVLTVRETEMQPMNPPRFDLLEDMA 90

  Fly   568 ELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYS 632
            .:.:||||:|||.||||||..:|:|.:|...:.:||...|.:|:..||:.::|.:..:.|||:|:
  Rat    91 MMTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTATVVAAYKGKRRSEAPPHIYA 155

  Fly   633 LAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCT----- 692
            :|..||..::..|.:||::..|.||:||:.:.|..:.|.|:.|...:.  ..:|...|.|
  Rat   156 VADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDG--PGKKAQFLATKTGGT 218

  Fly   693 ----------ILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHE 747
                      .:|||||.||..|.|::|..:.:.:.|..||::|||.:...|.|:.|...:|..|
  Rat   219 LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDSYLLEKSRVIFQLPGE 283

  Fly   748 HSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDA 812
            ..:|:..::|:|....|| ::.|.::...|.| |.|......|......:.:.|..|.:.|....
  Rat   284 RGYHVYYQILSGKKPELQ-DMLLLSMNPYDYH-FCSQGVTTVDNMNDGEELIATDHAMDILGFSV 346

  Fly   813 KAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPN 877
            ......:.|:.|:.|.|.....:......|...  ...:|.||:.|:||:..||..   ||..|.
  Rat   347 DEKCACYKIVGALLHFGNMKFKQKQREEQAEAD--GTESADKAAYLMGVSSGDLLK---GLLHPR 406

  Fly   878 APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPG 942
            ...|    ::..|.....|.....:.||....|......:|:.||:.:.|.......|.::|..|
  Rat   407 VRVG----NEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAG 467

  Fly   943 FQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLAS 998
            |:    |          :...|..|:..|:||..|:....|..::.|.:|     .::..:||.
  Rat   468 FEIFEFN----------SFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQ- 521

  Fly   999 ECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDRE 1063
                 |.|.||:|.                  .|:|.:|:||.::|.::|.:|..:|:.::..:.
  Rat   522 -----PCIDLIEKP------------------LGILSILEEECMFPKASDASFRAKLYDNHSGKS 563

  Fly  1064 HHSLLRKCAGPRQFVLH----HLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRL- 1123
            .:....:....|::..|    |..|..|  |::.||:..::: |.....|.:.|.|.    |||
  Rat   564 PNFQQPRPDKKRKYQAHFEVVHYAGVVP--YSIVGWLEKNKD-PLNETVVPIFQKSQ----NRLL 621

  Fly  1124 ------YIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGII 1182
                  |.||          |.:.....|.:..|:.::   ||.|.....       |..::.::
  Rat   622 ATLYENYAGS----------CSTEPPKSGVKEKRKKAA---SFQTVSQLH-------KENLNKLM 666

  Fly  1183 DTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAAR 1247
            ..||.|..|||.|.:...|              ...|.:.|.       |:..|||.:.|||..|
  Rat   667 TNLRATQPHFVRCIVPNEN--------------KTPGVMDSF-------LVLHQLRCNGVLEGIR 710

  Fly  1248 LHRLGFPESVPLLEFVRRFGLL-----AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSG 1307
            :.|.|||..:...:|.:|:.:|     ..|...:...:.|::|...::|...|:.|.:::.|::|
  Rat   711 ICRQGFPNRLLYADFRQRYRILNPSAIPDDTFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFKAG 775

  Fly  1308 VLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLL 1372
            :|..||..||..|:..:..|||..||.|.|.:..:......|:..||.|::||.||::|.|.:|.
  Rat   776 LLGILEELRDQRLAKVLTLLQARSRGRLMRLEYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKLF 840

  Fly  1373 VRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVK------------------------ 1413
            .::.|||...:.||:|.....||..||..|...|..|.|::
  Rat   841 FKMKPLLRSAQAEEELAALRAELRGLRGALATAEAKRQELEETQVSVTQEKNDLALQLQAEQDNL 905

  Fly  1414 --AENQ---------KLEAKLSELTVDLA-EERSTAHIATER--LEAETAE-----------RLK 1453
              ||.:         :||||:.||...|. ||...|.:|..|  ||.|..|           ..|
  Rat   906 ADAEERCHLLIKSKVQLEAKVKELNERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAK 970

  Fly  1454 LEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISE-------DEDAENEDGVGG-GVYKLKY 1510
            .|||.....||||||.|....|:..::....:...:.|       |..|| ||.|.. ...|::.
  Rat   971 AEKEKQATENKVKNLTEEMAALDESVVRLTKEKKALQEAHQQALGDLQAE-EDRVSALAKAKIRL 1034

  Fly  1511 ERVARELEFT-----KRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKM 1570
            |:...:||.:     |.|:.|:.         .|:.||..|....|.|.:..|...|.:.|.:|.
  Rat  1035 EQQVEDLECSLEQEKKLRMDTER---------AKRKLEGDLKLTQETVTDTTQDKQQLEEKLKKK 1090

  Fly  1571 TNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQ 1635
            .:|::.|.:.:|::......|:||.::..|..:.|::.:..||.|:.|..:::.....|...|.:
  Rat  1091 DSELSQLSLRVEDEQLLGAQLQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1155

  Fly  1636 TL-------ADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELD 1693
            .|       |..|.....:|.:|..|:|||||...  ..|...|.|||.:.::.....||.:.|.
  Rat  1156 RLEEAGGASAGQREGCRKREAELGRLRRELEETVL--RHEATVAALRRKQADSAAELSEQVDSLQ 1218

  Fly  1694 EMAGQIQLLEQAKLRLEM-----TLETM-RKEARRESQQR--DEELEEVRGNGYKKIKALECQ-- 1748
            .:..::: .|:::||:|:     ::||: |.:|..|...|  :::|.|.      |||..|.|
  Rat  1219 RIRQKLE-KEKSELRMEVDDLGASVETLARGKASAEKLCRTYEDQLSEA------KIKVEELQRQ 1276

  Fly  1749 ----------LETEHEERTLLLREKHELERRLS--------SMED-RDRVDRD--AEEALN---Q 1789
                      |:||:.|...||.||..:..:||        |:|: |.:::.:  |:.||.   |
  Rat  1277 LTDASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLEELRRQLEEESKAKGALAHAVQ 1341

  Fly  1790 KLRRD---LRKYKALLKDAQTQLERL--KADTPGKTLIRQLRNQLE-DA--------ESARSLAM 1840
            .||.|   ||:......:||.:|:||  ||:..    :.|.|::.| ||        |:.:.||:
  Rat  1342 ALRHDCDLLREQHEEESEAQAELQRLLSKANAE----VAQWRSKYEADAIQRTEELEEAKKKLAL 1402

  Fly  1841 K---ARQTAEAELTEVQAMFDESHRARNDAE------ERANAA----HRDRAELQAQIEENEEEL 1892
            :   |.:..||...:..::.....|.:.::|      |||.:|    .:.:..|:..:||...:.
  Rat  1403 RLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQE 1467

  Fly  1893 GELMKKYSATVKQ---LNTEQINV----SEAEFKLNEMEAERNNLKEQVAELQHRLD----NVEN 1946
            .|:.::..|..::   |.||...:    .||...|..::.|..||:|::::|..::.    :::.
  Rat  1468 EEMQRELEAAQREARGLGTELFRLRHSHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQE 1532

  Fly  1947 LGDPSMAMMSKRLELRT--KELESRLELEQATRARLEVQVNR----------------------H 1987
            |.....|:..::.||:.  :|.|..||||:....|:::::::                      |
  Rat  1533 LEKAKKALEGEKSELQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNH 1597

  Fly  1988 KEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF-HAV-SSREQESLTRRKDLEKKVEQ- 2049
            :.|:|.||..:........:|..:.||.:..|.|:..:. ||. .:.|.::.||....:.|.||
  Rat  1598 QRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQA 1662

  Fly  2050 -----------MESEGAALKNDLRLALQRIADLQQAMEEE------GEEELSESDESLSSVGS 2095
                       :..:|.||:....|....:.:|:.|:|:.      .|:||.|:.|.|:.:.|
  Rat  1663 GRDEEQRLAAELREQGQALERRAALLASELEELRAALEQGERSRRLAEQELLEATERLNLLHS 1725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	427/1682 (25%)
		MYSc_Myo18	575..1305	CDD:276837	189/769 (25%)
Myh7b	NP_001101264.2	Myosin_N	30..74	CDD:460670	13/47 (28%)
		myosin head (motor domain)	86..773		194/781 (25%)
		MYSc_Myh7b	98..773	CDD:276953	189/769 (25%)
		Myosin_tail_1	853..1930	CDD:460256	220/896 (25%)
		myosin tail	1075..1933		159/664 (24%)