DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Cytip

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001012086.1	Gene:	Cytip / 311047	RGDID:	1307990	Length:	359	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	60/312 - (19%)
Similarity:	106/312 - (33%)	Gaps:	86/312 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPP 335
            |..|.....|..:|....:|::::.|....|:    .::...|:....|....||..:
  Rat     3 LQRLLQQQSSNGNLEYCADSAYSSYPTLTGPL----TVEDNRRIQMLADTVATLPRGR------- 56

  Fly   336 RQLVIRRQKSPRQDFGFSLRKAICLDRTESLT-----------------SPIFRPVIFAEPGAGG 383
            :||.:.|..| ..||..|.||.:.:::.::.|                 |.:...:...:..:..
  Rat    57 KQLALARSSS-LGDFSCSQRKVVTVEKQDNGTFGFEIQTYRLQNQNICSSEVCTMICKVQEDSPA 120

  Fly   384 GATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVE------VQPVAELVELSKRCMAPS 442
            ...||..||....|||........:.::::||:||..:|:|      :...|||
  Rat   121 HCAGLQVGDIFANVNGVSTEGFTHKQVVDLIRSSGNLLTIETLNGTMIHRRAEL----------- 174

  Fly   443 TATVEEIDHSITNGNCNTLRRSASKRF-KRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPER 506
                        .....||:::..|:: :.:|.|....            ..|..|.|::...|.
  Rat   175 ------------EAKLQTLKQTLKKKWVELRSLHLQEQ------------RLLHGDAANSPNLEN 215

  Fly   507 VWLVHR-------GGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDD 551
            :.|...       |...|.:..|..||....::.||        .||||.:|
  Rat   216 MNLDESSLFGNLLGPSPAFLDRPRLSSESSCKSWLS--------SLTVDSED 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	22/109 (20%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Cytip	NP_001012086.1	PDZ_signaling	76..161	CDD:238492	15/84 (18%)
Cytip	NP_001012086.1	Interaction with CYTH1. /evidence=ECO:0000250	166..188		5/44 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900