DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh14

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_038967907.1	Gene:	Myh14 / 308572	RGDID:	1306821	Length:	2041	Species:	Rattus norvegicus

Alignment Length:	2009	Identity:	518/2009 - (25%)
Similarity:	839/2009 - (41%)	Gaps:	514/2009 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 DVADASQPERVWLVHR--------GGFTAAIRLPTASSGRDE-ENKLSLRLLHNGEQLTVDEDDV 552
            :|.....|:..|...|        .||.||       :.||| |.:..:.|..:|.:|.:..|.:
  Rat    35 NVGGPGGPQVEWTARRMVWVPSELHGFEAA-------ALRDEGEEEAEVELAESGRRLRLPRDQI 92

  Fly   553 EKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSM 617
            ::.|.|.....||:.||..||||||||.||:||.|.||:|.:|...:|:||...|.:|:|.:|.|
  Rat    93 QRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEM 157

  Fly   618 FRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAA------- 675
            :||.|..::|||:|::.:.||||:::.|.|||::..|.||:||:.:.|..:.|||..|
  Rat   158 YRGKKRHEVPPHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRK 222

  Fly   676 -----GAYNNFINAEKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQV 732
                 .:.:.....|....|.   .|||||||.||..|.|::|..:.:.::||..|.|..|:::.
  Rat   223 EPGVPASVSTMSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDIAGYIVGANIET 287

  Fly   733 LLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSH-------PFISLSQKLED 790
            .|.|:.||.|:...|.||||..:||.||...|:.:|.||..    ||       |..|..|:.|
  Rat   288 YLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPY----SHYRFLTNGPSSSPGQERE- 347

  Fly   791 RHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKA 855
                  .|..|:::...|.:..:.:..:...::|:...|...:.|  ..:|.:....:.|||:|.
  Rat   348 ------LFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKK--ERNTDQATMPDNTAAQKL 404

  Fly   856 SGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVAL 920
            ..|||:.:.|.|.|   |..|....|.....|:.|.    |.|...||||....|......:|..
  Rat   405 CRLLGLGVTDFSRA---LLTPRIKVGRDYVQKAQTK----EQADFALEALAKATYERLFRWLVLR 462

  Fly   921 INRQICTSSHTIASIM-LIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVA 980
            :||.:..|....||.: ::|..||:    |          :...|..||..|:||.||:||..|.
  Rat   463 LNRALDRSPRQGASFLGILDIAGFEIFQLN----------SFEQLCINYTNEKLQQLFNHTMFVL 517

  Fly   981 PRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEE 1040
            .::.|.:|     .::..:||.      |.|.||:: |.|              ..|:|.|||||
  Rat   518 EQEEYQREGIPWTFLDFGLDLQ------PCIDLIER-PAN--------------PPGLLALLDEE 561

  Fly  1041 AIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGI 1105
            ..:|.:.|.:|:|::....|........|.......|.:.|..|  .|.|..:.|:..:.: |..
  Rat   562 CWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAG--KVDYKANEWLMKNMD-PLN 623

  Fly  1106 RNAVSLLQDSS---REEINRLYIGSLTRGSGAMVFCGSF-------AG----------------- 1143
            .|..:||..|:   ..||.:...|.|.:    ..|.|||       ||
  Rat   624 DNVAALLHQSTDRLTAEIWKDEQGGLQQ----FTFLGSFPSPSPGPAGGLSSGASPPGLGSLCAP 684

  Fly  1144 -LEGTQSLRRVSSI----------RRSFTTAGVKRNSIMLQV-KFTVDGIIDTLRRTGTHFVHCY 1196
             :||...|.:|||:          |..|.|.|        |: |.::..::.||..|...||.|.
  Rat   685 TVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVG--------QLYKESLSRLMATLSNTNPSFVRCI 741

  Fly  1197 LLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPL 1259
            :..|  .|||                       :...|:..|||.:.|||..|:.|.|||..:..
  Rat   742 VPNHEKRAGK-----------------------LEPRLVLDQLRCNGVLEGIRICRQGFPNRILF 783

  Fly  1260 LEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVL 1319
            .||.:|:.:|..:     ....|. :.|:::...|||...||:|.|:|.||:|||::||.:||:.
  Rat   784 QEFRQRYEILTPNAIPKGFMDGKQ-ACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLK 847

  Fly  1320 LSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRT 1384
            ::|.|:..||..||||||:...:|:.|:.|:|.:|||..|:|.:|:|.||||.::|.|||.|.|.
  Rat   848 VTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTRQ 912

  Fly  1385 EEQLKTANEELLM--------------LRAKLEKIECDRSEVKAENQKLEAKL----SELTVDLA 1431
            :|.|:...:||..              |:.::.::|.:|:.: ||..:.||:|    .|....||
  Rat   913 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARL-AEQLRAEAELCSEAEETRARLA 976

  Fly  1432 EERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAE 1496
            ..:....:....|||...|..:..::|  |:.| |.||:..::||..|              :||
  Rat   977 ARKQELELVVTELEARVGEEEECSRQL--QSEK-KRLQQHIQELETHL--------------EAE 1024

  Fly  1497 NEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDL----EQLVALKKH---LEMKLSDAYEEVV 1554
            .     |...||:.|:|..|.:..|      .|.||    :|...|.|.   ||.:|::...:..
  Rat  1025 E-----GARQKLQLEKVTTEAKMKK------FEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAA 1078

  Fly  1555 EQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKE-- 1617
            |:.:.|....:...|....:.|:...|:::......|||.:|:.|.|...||:.:.:::|..|
  Rat  1079 EEEEKVKSLNKLRVKYEATIADMEDRLKKEEKGRQELEKLKRRLDGESSELQEQMMEQKQRAEEL 1143

  Fly  1618 --RYGREKDVLQAEKFTLEQT-----------------LADTRLDLEFKE--------------E 1649
              :.||:::.||:.....|:.                 ||:.:.|||.:.              |
  Rat  1144 LIQLGRKEEELQSALVRAEEEGGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGE 1208

  Fly  1650 KLASLQRELEEMTFGGGTEEEFAQLRRSKNETE----RRAKEQEEELDEMAGQ----------IQ 1700
            :|.:|:.|||:.......::|.    |||.|.|    ::..|:|....|:|.|          ::
  Rat  1209 ELEALRGELEDTLDSTNAQQEL----RSKREQEVTELKKTLEEEARTHEVAMQELRQRHSQALVE 1269

  Fly  1701 L---LEQA--------KLRLEM------------TLETMRKEARRESQQRDEELEEVRG------ 1736
            |   ||||        |.||.:            :|:|.|:|..::.::.:.:|:||:|
  Rat  1270 LTEQLEQARRGKSVWEKTRLSLEAEVSELKTELSSLQTSRQEGEQKRRRLESQLQEVQGRSSDSE 1334

  Fly  1737 ----NGYKKIKALECQLE------TEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKL 1791
                ...:|::..:.:||      :|.|.:.:      .|.:.|||.|.:   ..|.:|.|.::.
  Rat  1335 RARAEAAEKLQRAQVELESVSTALSEAESKAI------RLSKELSSAESQ---LHDTQELLQEET 1390

  Fly  1792 RRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTE---- 1852
            |..|    ||    .:::..|:|:..|      ||.|:|:...||..|.:..||.:|:|:|
  Rat  1391 RAKL----AL----GSRVRALEAEAAG------LREQMEEEVVARERAGRELQTTQAQLSEWRRR 1441

  Fly  1853 -------VQAMFDESHRARNDAE----------ERANAAHRDRAELQAQIEENEEELGELMKKYS 1900
                   ::|..:...||..:||          |......|.|..||.::::...:||: .|:..
  Rat  1442 QEEEAAVLEAGEEARRRAAREAETLAQRLAEKTEAVERLERARRRLQQELDDATVDLGQ-QKQLL 1505

  Fly  1901 ATV--KQLNTEQINVS---------------EAEFKLNEM-----------------EAERNN-- 1929
            :|:  ||...:|:...               |||.:..|.                 |.||.|
  Rat  1506 STLEKKQRKFDQLLAEEKAAVLRAVEDRERVEAEGREREARALSLTRALEEEQEAREELERQNRA 1570

  Fly  1930 ----------LKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTK--ELESRLELEQATRARLEV 1982
                      .|:.|.:..|.|:....:.:.:.:      :|||:  |||..|...:..:.||||
  Rat  1571 LRAELEALLSSKDDVGKNVHELERARRVAEQAAS------DLRTQVTELEDELTAAEDAKLRLEV 1629

  Fly  1983 ----------------------------------QVNRHKE---------ALEKLQNEVTQSKMR 2004
                                              :|.|.:|         |.:||:.|:.:.|.:
  Rat  1630 TVQALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEERKQRALAMAARKKLELELEELKAQ 1694

  Fly  2005 -------EMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLR 2062
                   :.:|...:||.|..::::..|.....|..:|..|..::.||:::.:|:|...|:.:|.
  Rat  1695 TSAAGQGKEEAVKQLKKMQAQMKELWREVEETRSSREEMFTLSRESEKRLKGLEAEVLRLQEELA 1759

  Fly  2063 LALQRIADLQQAMEEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSV 2127
            .:.:.....||..:|..||..|      .::...:.||::           :.|.|.:|
  Rat  1760 ASDRARRQAQQDRDEMAEEVAS------GNLSKAATLEEK-----------RQLEGRLG------ 1801

  Fly  2128 VSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKA----IPANKPDTKPAASTRMEL 2182
              .....:.|:.:||..:      ..|..||.|..:.    :.|.:..:..|.|.|.:|
  Rat  1802 --QLEEELEEEQNNSELL------KDHYRKLVLQVETLTTELSAERSFSAKAESGRQQL 1852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	248/838 (30%)
		MYSc_Myo18	575..1305	CDD:276837	232/807 (29%)
		GBP_C	<1540..1750	CDD:303769	63/294 (21%)
		COG1340	1565..1833	CDD:224259	80/355 (23%)
		coiled coil	1723..1734	CDD:293879	1/10 (10%)
Myh14	XP_038967907.1	Motor_domain	115..833	CDD:419868	232/807 (29%)
Myh14	XP_038967907.1	Myosin_tail_1	910..1990	CDD:396244	222/1037 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810