Protein Alignment Mhcl and Myh15

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_038944797.1
• Gene: Myh15 / 303965
• RGDID: 1565858
• Length: 1987
• Species: Rattus norvegicus
• Alignment Length: 1999
• Identity: 477/1999 - (23%)
• Similarity: 813/1999 - (40%)
• Gaps: 512/1999 - (25%)

  Fly   541 NGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMA 605
            :||.|.:.||::::.|...|:::||:..|.|:||.||||.||:||...:|:|.:|...:.:||..
  Rat    63 DGESLRIREDEIQQMNPAELEMIEDLSMLLYINEGSVLHTLRKRYDHWMIYTYSGLFCVAINPYK 127

  Fly   606 PLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNY 670
            .|.:|.::|::.::..:..:.|||::::|..|::.::....:||::|.|.|||||:.:.|..:.|
  Rat   128 WLPVYQKEVMAAYKRKRRSEAPPHIFAVANHAFQDMLRNGENQSILFTGESGSGKTVNTKMIIQY 192

  Fly   671 LALAAGA------YNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASAS 729
            .|..|..      ..|.  .:::..:..|||||||.||..|.|::|..:.:.:.|...|.::.|.
  Rat   193 FATMAATSEPKKKLGNL--EDQIVQMNPILEAFGNAKTLRNDNSSRFGKFIRMYFGVRGTLSFAD 255

  Fly   730 LQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPF---ISLSQKLEDR 791
            :|:...|:.|...:...|.::||..::|:|...|  :::.|.:....|.|..   :...:.|:|
  Rat   256 IQIYFLEKSRVVYQQPGERNYHIFYQILSGKQEL--QDMLLVSTNPSDFHICSCGVVAVENLDD- 317

  Fly   792 HRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQF-ANPTA---- 851
               |..|:.|.:|.:.|........|.:.::.||.|.|             ..:| .||..
  Rat   318 ---AKGFLATEKAIDVLGFLPDEKFGCYKLVGAIMHFG-------------NLKFRQNPREEQLE 366

  Fly   852 ------ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLY 910
                  |.||:.|:|:|..:|..   ||..|....|    ::..|.....:.....:.||...:|
  Rat   367 ADGTENADKAALLMGINASELLK---GLIYPRIKVG----NEYVTRSQNIQQVTYAVGALSKSIY 424

  Fly   911 SEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQM 971
            ......:||.:|:.:.....:...|.::|..||:    |          :|..|..|:..|:||.
  Rat   425 ERMFKWLVARMNQVLDAKVTSHFFIGILDITGFEILDYN----------SLEQLCINFTNEKLQQ 479

  Fly   972 LFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRR 1031
            .|:....|..::...:|     .::..:||.: |     |.||:|.                  .
  Rat   480 FFNQQLFVLEQEECRKEGLDWMSIDYGLDLQA-C-----IDLIEKP------------------M 520

  Fly  1032 GMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQ-----FVLHHLQGTNPVLYA 1091
            |:|.:|:||.:.|.:.|:||..:||:|:..:.  :..:|...|.:     |.|.|..|..|  |.
  Rat   521 GILSILEEECMLPKATDNTFKTKLFAHHFGKS--AYFQKPTAPEKNFEVHFELAHYAGVVP--YD 581

  Fly  1092 VDGWVRHSREHPGIRN--AVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVS 1154
            :.||:..::|   :.|  .|:|||.||.:.:..|:..:...|||.:      ..:|..:..||.:
  Rat   582 ISGWIGKNKE---LLNETVVALLQKSSNKVLASLFTNNTIAGSGEL------DSIEFGEKPRRKA 637

  Fly  1155 SIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAG 1219
            :..:..|:..          |.:::.::..|:.|..|||.|              .|.:.:...|
  Rat   638 TSFQLITSLH----------KESINKLMADLKSTAPHFVRC--------------INPNENKIPG 678

  Fly  1220 QVSSEEEMVNVPL-LRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLAS-NKDVSV- 1281
                    |..|. :..|||.:.|||..|:....||..:...:|.:|:.:|...:.| :|.|::
  Rat   679 --------VMDPFWVLQQLRCNGVLEGTRVCCKAFPIRMLYDDFKQRYCILNPRIFSKSKFVNIR 735

  Fly  1282 ---EQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQR 1343
               |::||:.|:|.:.|:.|.:::.|::.:|..||.:||..:|......||..||.|.|....:.
  Rat   736 KATEEVLALLEIDQSQYQCGVTKVFFKARILDRLEERRDEKISKVFTLFQARARGKLMRITFQKI 800

  Fly  1344 RVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECD 1408
            ..:..|:..||.|::||:||:.|||..|..:|.||.......|::....||...|:..||..|..
  Rat   801 LEERDALALIQENIRAFIAVKTWPWMGLFFKVKPLAKSVGAGEEIAGLKEECAQLQKSLETSESQ 865

  Fly  1409 RSEVK------------------AENQ-----------------KLEAKLSELTVDLAEERSTAH 1438
            |.|:|                  ||.:                 :||||:.||:..:.||.....
  Rat   866 REELKTKQVSLVQERNDLLLQLQAEQETLANSEELCESLIKSKIELEAKIKELSRRVEEEEEINS 930

  Fly  1439 IATER---LEAETAERLKLEKELGD--------------QTNKVKNL------------------ 1468
            ..|.|   ||.|.:|   |:||:.|              ..:||:||
  Rat   931 ELTARGRKLEDECSE---LKKEIYDLEAILAKSEKAKCAAEHKVRNLTEEVHSLHEDVSKLTRAM 992

  Fly  1469 -------QETTEKL--EMELICAKSDLN-GISEDEDA---------------ENEDGVGGGVYKL 1508
                   |:|.|.|  |.|.:...|.:| .:|:..||               |.|.....|..||
  Rat   993 QAAQEAQQQTQEHLHIEEEKLSNVSKVNQKLSQQVDALEGDLERERKARMKCEREKHKLEGELKL 1057

  Fly  1509 KYE-------------RVARELEFTKRRLHTQHEHD---LEQLVALKKHLEMKLSDAYEEVVEQR 1557
            ..|             ...|:.||...:::::.|::   :.||....|.|:.::.:..||:..:|
  Rat  1058 NQEGAENLESSRQQLIEQLRKKEFEMGQMNSKVENEKNLVSQLQKTVKELQTQILNLKEELESER 1122

  Fly  1558 QVVGQWKRKAQKMTNEMNDLRMLLEE--------------QNAR----NNLLEKKQRKFDAECQS 1604
            .:..:.:|:...:..::.||...|||              |.||    .:.:|:..|.|:|...|
  Rat  1123 TIRAKVERERGDLAQDLEDLNERLEEAGGTSLAQMEITRQQEARFQKLRHDMEETTRHFEATSVS 1187

  Fly  1605 L-----QDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD--TRLD----LEFKEEKLASL-QRE 1657
            |     ::....|.|. |...:.:.||..||..|:..:.|  ||:|    .:...|||..| :|.
  Rat  1188 LKRRHAENVAELEGQV-EHLQQVRQVLDQEKSDLQLQVDDLLTRVDQMARAKANAEKLCGLYERR 1251

  Fly  1658 LEEMTFGGGTE-EEFAQLRRSKNETERRAKEQEE------ELDEMAGQIQLLEQAKLRLEMTLET 1715
            |.|    ..|: :|..||  :|:.|.:|.|.|.|      .|:|....|..|.:.|..|.:.:|.
  Rat  1252 LNE----ANTKLDEATQL--AKDLTSQRTKLQNESGEFFKRLEEKEALISQLSREKSNLILQVEE 1310

  Fly  1716 MRKEARRESQ------------------------------------------------------- 1725
            :|.:...||:
  Rat  1311 LRVQLEEESKSQSALAHALQSTKHDYDLLREQYEEEQEVKSELHRALSKGNKETVQWRTKYEHDA 1375

  Fly  1726 -QRDEELEEVRGNGYKKIKALECQ-----LETEHEERTLLLREKHELERRL-SSMEDRDRVDRDA 1783
             ||.|:|||.     ||..|:..|     :|..:.:...|.|.:|.|:..| .::.|..:. |..
  Rat  1376 MQRTEDLEEA-----KKKLAIRLQEAAEAMEVSNAKNASLERARHRLQLELGDALSDLGKA-RSV 1434

  Fly  1784 EEALNQKLR---RDLRKYKALLKDAQTQLERLKADTPG-------------------KTLIRQ-- 1824
            ..||.||.:   :.|..:|...::||..|:..:.:...                   :||.||
  Rat  1435 AAALGQKQQHSDKALASWKQKQEEAQELLQASQKEARALSSEVLMLRQACEESNEAQETLKRQNQ 1499

  Fly  1825 --------LRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRD---- 1877
                    |.||:.:.....:...||::..|.|.||:||..:|:..|....|.:......|
  Rat  1500 DLQERICCLTNQVREGIKNLTEVEKAKKLIEQEKTEIQARLEEAEGALERNESKILRFQLDLSEA 1564

  Fly  1878 RAELQAQIEENEEELGELMKKYSATV----KQLNTEQINVSEA-------EFKLNEME-----AE 1926
            :|||..::.|.|:|.|.|.:|:...:    ..|::|..:..||       |..|.|||     |.
  Rat  1565 KAELGRKLSEKEDEAGRLREKHQQALGSLQSSLDSEASSRIEATKMRKKIEGDLKEMEIQLCTAN 1629

  Fly  1927 R---------NNLKEQVAELQHRLDNV----ENLGDPSMAMMSKRLELRTKELESRLEL-EQATR 1977
            |         ..|:.|:.:||..||:.    ::|.| .:|:..:|..|...|||....| ||..|
  Rat  1630 RQVSQTTRALGQLQSQMKDLQQHLDDSIYQNKDLKD-QVALAEQRNILLQSELEELRSLQEQTER 1693

  Fly  1978 ARLEVQVNRHKEALE--------------------KLQNEVTQSKMR--EM-----QAQDVIKKS 2015
            .|...:    ||.||                    ||:.:|.|::..  ||     :|::..||:
  Rat  1694 GRKLAE----KELLEATERISLFHTQNASLLSQKKKLEADVAQAQKEAGEMLQACQKAEEKAKKT 1754

  Fly  2016 QKSLRDMREEFHAVSSREQES-----LTRR------KDLEKK---------------VEQMESEG 2054
            .....:|.||.    .:||::     .||:      |||:|:               ::::||..
  Rat  1755 AAEAANMWEEL----KKEQDTNAHLERTRKNMEQTIKDLQKRLDEAEQTAVVGSKKQIQKLESRV 1815

  Fly  2055 AALKNDLRLALQRIADLQQAME--EEGEEELS-ESDESLSSVGSISDLEDRLRPVHVKRSSQQSL 2116
            ..|:.:|...::|.|:.|:...  |.|.:||: :::|...::..:..|.|:|:   :|..|.:..
  Rat  1816 RDLEGELESEVRRSAEAQREARRLERGIKELTYQAEEDKKNLSRMQALSDKLQ---LKVQSYKQQ 1877

  Fly  2117 NGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAI 2165
            ..::.......:|..:....|.::...|   ...:...::||...||.:
  Rat  1878 VEAVEAQANQYLSKYKKQQHELNEAKER---AEAAESQVNKLRARAKEL 1923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	442/1822 (24%)
		MYSc_Myo18	575..1305	CDD:276837	187/771 (24%)
Myh15	XP_038944797.1	Myosin_N	29..74	CDD:460670	5/10 (50%)
		Motor_domain	98..762	CDD:473979	187/770 (24%)
		Myosin_tail_1	843..1919	CDD:460256	247/1106 (22%)