DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Pard3b

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001178737.1	Gene:	Pard3b / 301455	RGDID:	1584992	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	142/719 - (19%)
Similarity:	240/719 - (33%)	Gaps:	242/719 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1554 VEQRQVVGQWKRKAQKM---TNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQA 1615
            |..|.|.|:.:.:...|   |.:...:.:::..|...   ...::.|.:.:|.:|
  Rat   436 VNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQEGS---FLPRELKGEPDCYAL---------- 487

  Fly  1616 KERYGREKDVLQAEKFTLEQTLADT---RLDLEFKEEKLASLQREL----EEMTFGGGTEEEFAQ 1673
                    .:..:|:.|||..|.|:   .|.:..|..|......:|    :.:..||...:: .:
  Rat   488 --------SLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKD-GR 543

  Fly  1674 LRRSKN------------------ETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMR--- 1717
            ||.:..                  ||.||:...|   ..:.|.|||:  ...|||..||.:.
  Rat   544 LRMNDQLIAVNGETLLGKSNHEAMETLRRSMSME---GNIRGMIQLV--ILRRLERPLEEISECG 603

  Fly  1718 ----------KEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKH-------- 1764
                      :||...|::.|..|            ...|...:..::|..||....
  Rat   604 ALSRPCFENCQEALSASRRNDSSL------------LYPCGTYSPQDKRKDLLLPSDGWAENEVP 656

  Fly  1765 -------ELERRLSSMEDRDRVDRDA-----------------EEALNQKLRRDLRKYKALLKD- 1804
                   .||..|.......|||...                 .|::|.|..:.:    .|:.|
  Rat   657 PSPPPHPSLEWGLEDFSHSSRVDSTGYFPDQHVNFRIVTPVGQPESINLKASKSM----DLVPDE 717

  Fly  1805 --AQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDA 1867
              .|:..:| ::|:|||.....|  .|:.:.|..||     |||.||:.:....|
  Rat   718 SKVQSLADR-RSDSPGKDFGPTL--GLKKSSSLESL-----QTAVAEVRKNDLPF---------- 764

  Fly  1868 EERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKE 1932
                   ||.|..:......||.....:.|.|.                    ...|||.:.|.:
  Rat   765 -------HRPRPHMVRGRGCNESFRAAIDKSYD--------------------GPEEAEADGLSD 802

  Fly  1933 QVAELQHRLDNVENL--GDPSMAMMSKRLE--LRTKELESRLELEQATRARLEVQVNRHKEALEK 1993
            :.:...|...|.|:.  |:|.:..:..:.:  .:|||.|     ::..:.:::|     ||..:|
  Rat   803 KSSHSGHTALNCESAPQGNPELDDVENKAKNVKKTKEKE-----KKKGKGKMKV-----KEKKQK 857

  Fly  1994 LQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDL--EKKVEQMESEGAA 2056
            .::|.|:.||:.       |.....||..:::...|...||:. |::...  |:::|:|:.|
  Rat   858 EEHEDTERKMKR-------KGFGAMLRFGKKKDDKVGKTEQKG-TQKSGHPGEEELERMKEE--- 911

  Fly  2057 LKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGSISDL-EDRLRP--------------V 2106
                    .:||....|.:.|:....|  .|.:..:.|.:.|: :|.:.|              .
  Rat   912 --------RERIGAKHQELREKQARGL--VDYATVATGPVHDIDDDEMDPNYARVNHFREPCTSA 966

  Fly  2107 HVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPD 2171
            :|.||......|::|              :.:|..        |.||. |...|.||   .|||.
  Rat   967 NVFRSPSPPRAGTLG--------------YPRDGR--------PLSPD-HLEGLYAK---VNKPY 1005

  Fly  2172 TKPA 2175
            ..||
  Rat  1006 HPPA 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	44/236 (19%)
		COG1340	1565..1833	CDD:224259	62/343 (18%)
		coiled coil	1723..1734	CDD:293879	3/10 (30%)
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873
		PDZ_signaling	201..288	CDD:238492
		PDZ	380..469	CDD:214570	6/32 (19%)
		PDZ_signaling	501..589	CDD:238492	19/93 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900