DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh7

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_058936.1	Gene:	Myh7 / 29557	RGDID:	62030	Length:	1935	Species:	Rattus norvegicus

Alignment Length:	2088	Identity:	479/2088 - (22%)
Similarity:	803/2088 - (38%)	Gaps:	632/2088 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADV---ADASQPERVWLVHRGGFTAAIRLP 522
            ||:|..:|.:.|:|                ..||:.||   .|..:..:..:|.|.|...
  Rat    16 LRKSEKERLEAQTR----------------PFDLKKDVFVPDDKEEFVKAKIVSREGGKV----- 59

  Fly   523 TASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYAS 587
            ||.:             .||:.:||.||.|.:||.|..|.:||:..|.:|:|.:||:.|::||||
  Rat    60 TAET-------------ENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAS 111

  Fly   588 NLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIF 652
            .:|:|.:|...:.|||...|.:|:.:||:.:||.|..:.|||::|::..||:.::..|.:||::.
  Rat   112 WMIYTYSGLFCVTVNPYKWLPVYNAQVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILI 176

  Fly   653 MGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTI----------LEAFGNTKTCLNSN 707
            .|.||:||:.:.|..:.|.|:.| |..:....::.....|:          ||||||.||..|.|
  Rat   177 TGESGAGKTVNTKRVIQYFAVIA-AIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDN 240

  Fly   708 ATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLEN 772
            ::|..:.:.:.|..||::|||.::..|.|:.|...:|..|..:||..::|:.....|...|.:.|
  Rat   241 SSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITN 305

  Fly   773 ITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGV 833
              :...:.|.|..:    .::|    :.:.|.|..||:.|....:....|:.:..||.|.|
  Rat   306 --NPYDYAFFSQGETTVASIDD----SEEHMATDSAFDVLGFTPEEKNSIYKLTGAIMHFG---- 360

  Fly   834 TKLGTGSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGH 895
             .:......|.:.|.|..   |.|::.|:|:|..||..   ||..|....|    ::..|.....
  Rat   361 -NMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLK---GLCHPRVKVG----NEYVTKGQNV 417

  Fly   896 EWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGAT 956
            :.....:.||...:|.:....:|..||..:.|.......|.::|..||:    |          :
  Rat   418 QQVAYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN----------S 472

  Fly   957 LADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNH 1016
            ...|..|:..|:||..|:|...|..::.|.:|     .::..|||.: |     |.||:|.
  Rat   473 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQA-C-----IDLIEKP---- 527

  Fly  1017 VVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FV 1078
                          .|::.:|:||.::|.:.|.||..:|: :|.|...:....|...|.::  |.
  Rat   528 --------------MGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFS 578

  Fly  1079 LHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAG 1143
            |.|..||  |.|.:.||::.::: |.....|.|.|.||.:.::.|:..  ..|:.|.|..|....
  Rat   579 LIHYAGT--VDYNILGWLQKNKD-PLNETVVGLYQKSSLKLLSNLFAN--YAGADAPVDKGKGKA 638

  Fly  1144 LEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKY 1208
            .:|: |.:.||::.|.                 .::.::..||.|..|||.|.:     ...||
  Rat   639 KKGS-SFQTVSALHRE-----------------NLNKLMTNLRSTHPHFVRCII-----PNETK- 679

  Fly  1209 TANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL---- 1269
                ||.           :::.||:..|||.:.|||..|:.|.|||..:...:|.:|:.:|
  Rat   680 ----SPG-----------VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAA 729

  Fly  1270 --AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCR 1332
              .|....::. ..|::|...::|...|:.|.:::.|::|:|..||..||..||..|.::||..|
  Rat   730 IPEGQFIDSRK-GAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSR 793

  Fly  1333 GYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEE 1394
            |.|:|   ||:.:||...|   .||.|::||:.|::|||.:|..::.|||....||:::....||
  Rat   794 GVLSRMEFKKLLERRDSLL---IIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMANMKEE 855

  Fly  1395 LLMLRAKLEKIECDRSE------------------VKAENQ-----------------KLEAKLS 1424
            ...::..|||.|..|.|                  |:||..                 :||||:.
  Rat   856 FGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920

  Fly  1425 ELTVDLA-EERSTAHIATE--RLEAETAE-----------RLKLEKELGDQTNKVKNLQE----- 1470
            |:|..|. ||...|.:..:  :||.|.:|           ..|:|||.....||||||.|
  Rat   921 EMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985

  Fly  1471 -------TTE-----------------------------------------------KLEMELIC 1481
                   |.|                                               |:.|:|..
  Rat   986 DEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLDQDKKVRMDLER 1050

  Fly  1482 AKSDLNG-----------ISEDED-------------------AENEDGVGGGVYK--------- 1507
            ||..|.|           :..|:.                   .|:|..:|..:.|
  Rat  1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115

  Fly  1508 ------LKYERVA--------------------------------------RELEFTKRR----- 1523
                  |:.||.|                                      ||.||.|.|
  Rat  1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180

  Fly  1524 -----------LHTQH------------------------------------------------- 1528
                       |..:|
  Rat  1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1245

  Fly  1529 ------------EH------------DL------------------------------------E 1533
                        ||            ||                                    :
  Rat  1246 EKMCRTLEDQMNEHRSKAEETQRSVNDLTRQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQ 1310

  Fly  1534 QLVALKKHLEMK--------------------LSDAYEEVVE-----QRQV------VGQWKRKA 1567
            ||..||:.||.:                    |.:.|||..|     ||.:      |.||:.|.
  Rat  1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375

  Fly  1568 Q-------------------------------------------KMTNEMNDLRMLLEEQNARNN 1589
            :                                           ::.||:.||.:.:|..||...
  Rat  1376 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440

  Fly  1590 LLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLE-FKEEKLAS 1653
            .|:||||.||......:....:.:...|...:|...|..|.|.|:....::...|| ||.|. .:
  Rat  1441 ALDKKQRNFDKILVEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN-KN 1504

  Fly  1654 LQRELEEMTFG-GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMR 1717
            ||.|:.::|.. |.|.:...:|.:.:.:.|....|.:..|:|....::..|...||.::....::
  Rat  1505 LQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569

  Fly  1718 KEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDRVDR 1781
            .|..|:..::|||:|:.:.|..:.:.:|:..|:.|...|...||.|.::|..|:.|| .....:|
  Rat  1570 AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANR 1634

  Fly  1782 DAEEALNQKLRRDLRKYKALLKDAQTQLE---RLKADTPGKTLIRQLRNQLEDAESARSLAMKAR 1843
            .|.||     ::.::..::||||.|.||:   |...|......|.:.||.|
  Rat  1635 MAAEA-----QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL-------------- 1680

  Fly  1844 QTAEAELTEVQAMFDESHRARNDAE-------ERANAAH--------------RDRAELQAQIEE 1887
              .:|||.|::|:.:::.|:|..||       ||....|              .|.::||.::||
  Rat  1681 --LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEE 1743

  Fly  1888 NEEELGELMKKYSATVKQLNTEQINVSEAEFKLNE-----MEAERNNLKEQVAELQHRLDNVENL 1947
            ..:|.....:|    .|:..|:...::| |.|..:     :|..:||:::.:.:||||||..|.:
  Rat  1744 AVQECRNAEEK----AKKAITDAAMMAE-ELKKEQDTSAHLERMKNNMEQTIKDLQHRLDEAEQI 1803

  Fly  1948 GDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVI 2012
            .........::||.|.:|||:.||.||...|.....:.:.:..:::|..:..:.:...::.||::
  Rat  1804 ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1868

  Fly  2013 KKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEE 2077
            .|.|..::..:.:......:...:|::.:.::.::::.|...       .:|..::..|:....:
  Rat  1869 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA-------DIAESQVNKLRAKSRD 1926

  Fly  2078 EGEEELSE 2085
            .|.:.|:|
  Rat  1927 IGAKGLNE 1934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	210/795 (26%)
		MYSc_Myo18	575..1305	CDD:276837	197/764 (26%)
		GBP_C	<1540..1750	CDD:303769	60/285 (21%)
		COG1340	1565..1833	CDD:224259	75/316 (24%)
		coiled coil	1723..1734	CDD:293879	4/10 (40%)
Myh7	NP_058936.1	Myosin_N	35..72	CDD:280832	11/54 (20%)
		Myosin_head	87..766	CDD:278492	202/776 (26%)
		MYSc_class_II	99..766	CDD:276951	197/764 (26%)
		Actin-binding	655..677		7/26 (27%)
		Actin-binding	757..771		3/13 (23%)
		Myosin_tail_1	846..1923	CDD:279860	212/1110 (19%)
		MM_CoA_mutase	<1132..1293	CDD:294532	12/160 (8%)
		BAR	1232..1424	CDD:299863	21/191 (11%)
		TMPIT	1740..>1830	CDD:285135	27/94 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1915..1935		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810