DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Mpdz

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	1672	Identity:	296/1672 - (17%)
Similarity:	517/1672 - (30%)	Gaps:	605/1672 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ILKGSRSNMTNVHEEISFAGSAGGAGGTP-----EMLLRNTFQNE-----SLYEGAARGAG--SI 219
            :|..|..|:    |.||..|:.....|.|     :.|:::..|..     .|.:....|.|  .:
  Rat    94 LLSPSNGNL----EAISGPGAPPAMDGKPACEELDQLIKSMAQGRHVEIFELLKPPCGGLGFSVV 154

  Fly   220 GSNSSQHGTSFTSVESLRS------DG----------------EQTGGQQRAMTLPANAR----- 257
            |..|...|.....|:.::.      ||                :||...|:|:::...|:
  Rat   155 GLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTIQL 219

  Fly   258 ---YGALPQGNSQGSHLHVLTSP----SPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVH 315
               .|:||.          ::||    ||||.|    |.|:.:.|             ..|..|.
  Rat   220 VIARGSLPH----------ISSPRISRSPSAAS----TVSAHSNP-------------THWQHVE 257

  Fly   316 AFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSL--RKAICLDRTESLTSPIFRPVIFAE 378
            ..|.|                        :.....||.:  .||         |..|.:.::
  Rat   258 TIELV------------------------NDGSGLGFGIIGGKA---------TGVIVKTIL--- 286

  Fly   379 PGAGGGATG-LLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAV-------TVEVQPVAELVELS 435
            ||......| |..||.::|:..|.:..:..|.:.:::|..|..|       .||..|....:.::
  Rat   287 PGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPAPSSLGIT 351

  Fly   436 KRCMAPSTATVE-EIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGG------------EEGG- 486
               ::.||:|.| .:|.|       |.:...|:.|..:.. :|..|.|            |..|
  Rat   352 ---LSSSTSTSEMRVDAS-------TQKNEESETFDVELT-KNVQGLGITIAGYIGDKKLEPSGI 405

  Fly   487 -----AKGVGHDLEADVADASQPERVWLVHRGGFT------------AAIRLPTASSGRDEENKL 534
                 .|....:|:..:....|...|...:..|||            ..:||.....|..:|.::
  Rat   406 FVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMRKGASQEAEI 470

  Fly   535 SLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLL 599
            :.|           ||..:..:.||.:..:|...|......|:|....:.|.  |:.|:...|..
  Rat   471 TSR-----------EDTAKDVDLPAENYEKDEESLSLKRSTSILPIEEEGYP--LLSTELEETED 522

  Fly   600 VVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQT-----AYRSLVETRRDQSLIFMGRSG-S 658
            |....|.|:.:..     ..|...|.:..||...::.     :..:.|.....:|::..|..| |
  Rat   523 VQQEAALLTKWQR-----IMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHS 582

  Fly   659 GKSTSFKHAL--NYLALAAGAYNNFINAEK-----VNALC-------TILEAFGNTK-------- 701
            ||..|....|  |.:.|....:.:.:|..|     |..:|       |.|....:..
  Rat   583 GKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPTALSEVDSLDIHDLELTE 647

  Fly   702 -------TCLNSNATRMTQLLSLDFDQTGQ-------IASASLQVLLPERQRAGRRLGHEHSFHI 752
                   ..:.|:.|....|...|.||..:       :..|.:|.:  |.::..|.||    |.|
  Rat   648 KPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGIQAI--ELEKGSRGLG----FSI 706

  Fly   753 MT---------------------------RLLAGAAGLLQKELHLENITSEDSHPF--------- 781
            :.                           ||..|...:...:::|||.|.|::...
  Rat   707 LDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMV 771

  Fly   782 -ISLSQKL----EDRHRAAND--FMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
             |.:::.|    |:.:.:|.:  |:.:....:.:.:..|          |::...:|.:......
  Rat   772 RIGVAKPLPLSPEEGYVSAKEDTFLCSPHTCKEMGLSDK----------ALFRADLALIDTPDAE 826

  Fly   840 STARTQFANPTA-------ARKASGLLGVNLEDLSSAAFGLTQ-PNAPNGGLSPSKSPTSDTGHE 896
            |.|.::|.:..:       :.:||.|   :|.| .:.:.|:.. |:.|:   ||.|..|:.:.
  Rat   827 SVAESRFESQFSPDNDSVYSTQASVL---SLHD-GACSDGMNYGPSLPS---SPPKDVTNSSD-- 882

  Fly   897 WAWECLEALVIG-------LYSEALAAVVALINRQ-----------ICTSSHTIASIMLIDTP-- 941
                    ||:|       ||::      .|:.||           ..||..|::..    ||
  Rat   883 --------LVLGLHLSLEELYTQ------NLLQRQHAGSPPTDMSPAATSGFTVSDY----TPAN 929

  Fly   942 GFQNPASCGQQVGAT-------------------------------LADLRHNYLQERLQMLFHH 975
            ..:....|...|..|                               ::|.....||...|..|..
  Rat   930 AVEQKYECANTVAWTPSQLPSGLSTTELAPALPAVAPKYLTEQSSLVSDAESVTLQSMSQEAFER 994

  Fly   976 TTLVAPRDRYAQELVEIEMD-----LASECHPGP------------LISLIDKAPQNHVVRSSQR 1023
            |..:|.........|....|     :.|..|.|.            ::|:.:::..:.....::.
  Rat   995 TVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNAQARA 1059

  Fly  1024 DLREH--------------DRRGMLWLLDEEAIYPNSNDDTF-------------LERLFSHYGD 1061
            .||.|              |.|...:::   ...|..:.:.|             |: :||.|..
  Rat  1060 MLRRHSLIGPDIKFSAAPADDRAPFYVI---TYVPAEHLEEFRVSFGQQAGGIMALD-IFSSYTG 1120

  Fly  1062 REHHSLLRKCAGPRQFVLHHLQGTNPVLY--AVDGWVRHSR----EHPGIRNAVSLLQDSSREEI 1120
            |:...|..:..|         :|....|.  |...|.:..|    ..|.....:|::  ..|...
  Rat  1121 RDIPELPEREEG---------EGEESELQNAAYSSWSQPRRVELWREPSKSLGISIV--GGRGMG 1174

  Fly  1121 NRLYIGSLTRGSGAMVFC-----GSFAGLEGT------------QSLR------RVSSIRRSFTT 1162
            :||..|.:.||    :|.     .|.||..||            ..||      .|.:||::.:
  Rat  1175 SRLSNGEVMRG----IFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGS- 1234

  Fly  1163 AGVKRNSIMLQVKFTVDGIIDTLRRTG----THFVH--CYLLQHNA-GKHTKYTANGSPSSAAGQ 1220
                      .|.|.|..|::..|::.    .|.::  |.....|. .:..:.|::.:||.:..:
  Rat  1235 ----------PVVFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSDKAPSQSESE 1289

  Fly  1221 VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLE--------------FVRRFGLLAG 1271
             |.:..:.:||.....:......:.|:      |.:..:.|              ...|:|.|.|
  Rat  1290 -SEKATLCSVPSSSPSVFSEMSSDYAQ------PSATTVAEDEDKEDEFGYSWKNIQERYGTLTG 1347

  Fly  1272 ----------------DLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLL 1320
                            .||.|||.:...:..|.        |.|:....|.|.|.         :
  Rat  1348 QLHMIELEKGHSGLGLSLAGNKDRTRMSVFIVG--------IDPTGAAGRDGRLQ---------I 1395

  Fly  1321 SDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLN----- 1380
            :|.::::    .|.:...:..|.  ....::|....||.           :.:|....:|
  Rat  1396 ADELLEI----NGQILYGRSHQN--ASSIIKCAPSKVKI-----------IFIRNADAVNQMAVC 1443

  Fly  1381 VHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKL--SELTVDLAEERSTAHIATER 1443
            .....:.|.:.:|                   ..:|:::|..:  |...|||:...:..|
  Rat  1444 PGSAADPLPSTSE-------------------SPQNKEVEPSITTSASAVDLSSLTNVYH----- 1484

  Fly  1444 LEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGIS 1490
                    |:|.|:.|.              |.: .||.:..|||::
  Rat  1485 --------LELPKDQGG--------------LGI-AICEEDTLNGVT 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	20/96 (21%)
		MYSc	556..1317	CDD:214580	178/1014 (18%)
		MYSc_Myo18	575..1305	CDD:276837	171/983 (17%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492	14/81 (17%)
		PDZ_signaling	256..335	CDD:238492	21/114 (18%)
		PDZ	374..463	CDD:214570	15/89 (17%)
		PDZ_signaling	552..621	CDD:238492	14/68 (21%)
		PDZ_signaling	693..776	CDD:238492	15/88 (17%)
		PDZ_signaling	993..1063	CDD:238492	9/69 (13%)
		PDZ_signaling	1150..1241	CDD:238492	22/107 (21%)
		PDZ	1348..1433	CDD:214570	17/118 (14%)
		PDZ_signaling	1482..1561	CDD:238492	11/55 (20%)
		MPDZ_u10	1563..1624	CDD:293272
		PDZ	1625..1709	CDD:214570
		PDZ_signaling	1721..1801	CDD:238492
		PDZ_signaling	1858..1943	CDD:238492
		PDZ_signaling	1984..2067	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900