DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001128630.1	Gene:	Myh1 / 287408	RGDID:	735061	Length:	1942	Species:	Rattus norvegicus

Alignment Length:	1802	Identity:	453/1802 - (25%)
Similarity:	791/1802 - (43%)	Gaps:	370/1802 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..:||.:|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
  Rat    67 GATVTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
  Rat   132 LPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQ 724
            |..|            |.....:..:.::| ..:||||||.||..|.|::|..:.:.:.|..||:
  Rat   197 ATIAVTGEKKKEEAPSGKMQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 260

  Fly   725 IASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ--- 786
            :|||.::..|.|:.|...:|..|.|:||..::::.....|.:.|.:  .|:...:.|:|..:
  Rat   261 LASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLI--TTNPYDYAFVSQGEITV 323

  Fly   787 -KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANP- 849
             .::|:    .:.|.|..|.:.|...:.....|:.:..|:.|.|     .:......|.:.|.|
  Rat   324 PSIDDQ----EELMATDSAIDILGFTSDERVSIYKLTGAVMHYG-----NMKFKQKQREEQAEPD 379

  Fly   850 --TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSE 912
              ..|.||:.|..:|..||..|   |..|....|....:|..|.    :..:..:.||...:|.:
  Rat   380 GTEVADKAAYLQNLNSADLLKA---LCYPRVKVGNEYVTKGQTV----QQVYNAVGALAKAVYEK 437

  Fly   913 ALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLF 973
            ....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:||..|
  Rat   438 MFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEKLQQFF 492

  Fly   974 HHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGM 1033
            :|...|..::.|.:|.:|.|     ||||: |     |.||:|.                  .|:
  Rat   493 NHHMFVLEQEEYKKEGIEWEFIDFGMDLAA-C-----IELIEKP------------------MGI 533

  Fly  1034 LWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAG--PRQFVLHHLQGTNPVLYAVDGW 1095
            ..:|:||.::|.:.|.:|..:|: .|.|...:....:...|  ...|.|.|..||  |.|.:.||
  Rat   534 FSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLVHYAGT--VDYNIAGW 596

  Fly  1096 VRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQ----SLRRVSSI 1156
            :..::: |.....|.|.|.||.:.:..|:.|:   .:.|....|...|.:|.:    |.:.||::
  Rat   597 LDKNKD-PLNETVVGLYQKSSMKTLAYLFSGA---AAAAEAESGGGGGKKGAKKKGSSFQTVSAL 657

  Fly  1157 RRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQV 1221
            .|.                 .::.::..||.|..|||.|.:                |:......
  Rat   658 FRE-----------------NLNKLMTNLRSTHPHFVRCII----------------PNETKTPG 689

  Fly  1222 SSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDVS 1280
            :.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..|
  Rat   690 AMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKAS 749

  Fly  1281 VEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMSQ 1342
             |::|...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||||||   :||.:
  Rat   750 -EKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGYLARVEYQKMVE 813

  Fly  1343 RRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIEC 1407
            ||.   ::.|||.||:||:.|:.|||.:|..::.|||....||:::....||....:..|.|.|.
  Rat   814 RRE---SIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKENLAKAEA 875

  Fly  1408 DRSEVK--------------------------AENQ---------KLEAKLSELTVDLAEERSTA 1437
            .|.|::                          ||.:         :||||:.|:| :.||:.
  Rat   876 KRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVT-ERAEDE--- 936

  Fly  1438 HIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGV 1501
                |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|:     ..|:
  Rat   937 ----EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-----MAGL 992

  Fly  1502 GGGVYKLKYERVA---------RELE--------FTKRRLHTQHEHD-----LEQ-------LVA 1537
            ...:.||..|:.|         .:|:        .||.::..:.:.|     |||       |..
  Rat   993 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLER 1057

  Fly  1538 LKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAEC 1602
            .|:.||..|..|.|..::......|...|.:|...||::|:..:|::.|....|:||.::..|..
  Rat  1058 AKRKLEGDLKLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARI 1122

  Fly  1603 QSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKLASLQ---RELEE 1660
            :.|::.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.|..|   |:|||
  Rat  1123 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1187

  Fly  1661 MTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRL 1709
            .|..                ....|:...|:|.|.:.|:...|.:.|:|::|..::::.::|..|
  Rat  1188 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNL 1252

  Fly  1710 EMTLETMRKE-----ARRESQQR-DEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELER 1768
            |....|:..:     .:.|.||| ..||...||           :|:||..|.:..|.||..|..
  Rat  1253 EKMCRTLEDQVSELKTKEEEQQRLINELTAQRG-----------RLQTESGEYSRQLDEKDSLVS 1306

  Fly  1769 RLSS-----MEDRDRVDRDAEEALN---------QKLRRD---LRKYKALLKDAQTQLERLKADT 1816
            :||.     .:..:.:.|..||.:.         |..|.|   ||:.....::|:.:|:|  |.:
  Rat  1307 QLSRGKQAFTQQIEELKRQLEEEVKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR--AMS 1369

  Fly  1817 PGKTLIRQLRNQLE-DA--------ESARSLAMK---ARQTAEAELTEVQAMFDESHRARNDAE- 1868
            ...:.:.|.|.:.| ||        |:.:.||.:   |.:..||...:..::.....|.:|:.|
  Rat  1370 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVED 1434

  Fly  1869 -----ERANAA---------HRDR--AELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEA- 1916
                 ||.|||         :.|:  ||.:.:.||...|| |..:|.|   :.|:||...:..|
  Rat  1435 LMIDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAEL-EASQKES---RSLSTELFKIKNAY 1495

  Fly  1917 EFKLNEMEA----------ERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLE 1971
            |..|:::|.          |.::|.||:||...|:..:|.:        .|::|....||::.||
  Rat  1496 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI--------KKQIEQEKSELQAALE 1552

  Fly  1972 LEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQ-KSLRDMREEFHAVSSREQE 2035
            ..:|:....|.::.|.:..|.::::|:.:....:.:..|.:|::. :.:..|:....|......:
  Rat  1553 EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRND 1617

  Fly  2036 SLTRRKDLEKKVEQMESE--------GAALKN-----------------------DLR--LAL-Q 2066
            ::..:|.:|..:.:||.:        ..||:|                       ||:  ||: :
  Rat  1618 AIRIKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVE 1682

  Fly  2067 RIADLQQAMEEEGEEELSESDESLS-SVGSISDLEDRLRPVHVKRSS 2112
            |.|:|.||..||....|.:::.|.. :...:.|..:|::.:|.:.:|
  Rat  1683 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	210/801 (26%)
		MYSc_Myo18	575..1305	CDD:276837	198/770 (26%)
		GBP_C	<1540..1750	CDD:303769	53/238 (22%)
		COG1340	1565..1833	CDD:224259	74/322 (23%)
		coiled coil	1723..1734	CDD:293879	6/11 (55%)
Myh1	NP_001128630.1	Myosin_N	35..73	CDD:397036	2/5 (40%)
		MYSc_Myh1_mammals	100..773	CDD:276875	198/770 (26%)
		Myosin_tail_1	853..1930	CDD:396244	205/915 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900