Protein Alignment Mhcl and Myo95E

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1141
• Identity: 204/1141 - (17%)
• Similarity: 348/1141 - (30%)
• Gaps: 452/1141 - (39%)

  Fly   569 LKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSL 633
            |:.|:|.|.::.:.|||..:.|:|..|.:::.:||...:|.:|...|..:.......:|||:|.|
  Fly    13 LENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPHIYGL 77

  Fly   634 AQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL--------------------------A 672
            ...||:||.:...||.::..|.||:||:.:||..:|:|                          .
  Fly    78 TNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTSSASG 142

  Fly   673 LAAGAYN----------NFI--------------------------------------------- 682
            |...|:.          |||
  Fly   143 LVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRHMREK 207

  Fly   683 ----------NAEKVNAL------------------------CT--------------------- 692
                      ::|.::.|                        ||
  Fly   208 IVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTVYGGC 272

  Fly   693 ----------------------------------------------------------------- 692
                                                                             
  Fly   273 RQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPERERD 337

  Fly   693 ----------------------------------------------------------------I 693
                                                                            .
  Fly   338 RSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTCADVF 402

  Fly   694 LEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLA 758
            |||.||..|..|:|::|..:|..::.|..|......:...:.|:.|....:..|.:|||..:||.
  Fly   403 LEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFYQLLL 467

  Fly   759 GAAGLLQKELH----------LENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAK 813
            ||...|.|.|.          |.|.|:.:           |||    .:|..|.::.:.|.:..:
  Fly   468 GADLQLLKSLKLYRNVEKYELLRNTTAME-----------EDR----MNFHYTKRSLDVLGLSCE 517

  Fly   814 AVRGIWSILAAIYHLG---IAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQ 875
            ....|:.::|.:..||   ...:|.:  ..|...|.:|....::.:.||.:..:.|.:.   ||:
  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNI--DGTEGCQVSNVYEVQETAQLLNMEAQILINC---LTR 577

  Fly   876 PNAPNGGLSPSKSPTSDTGHEW----AWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIM 936
            .|:.|       |...|.|.|.    |......|...|||.....:|..||..: .|:....::.
  Fly   578 ANSTN-------SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL-KSTQREKNLA 634

  Fly   937 LIDTPGFQNPASCGQQVGATLADLRH--------NYLQERLQMLFHHTTLVAPRDRYAQELVEIE 993
            |:|..||:              .|.|        ||..|::...|....|.:.::.|.:|.:|..
  Fly   635 LLDFYGFE--------------ALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWS 685

  Fly   994 ----MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLER 1054
                .|..|.|      .||||...                 |:|.|::|..:  ||||...|.
  Fly   686 RIDYFDNESIC------ELIDKPSY-----------------GILSLINEPHL--NSNDALLLR- 724

  Fly  1055 LFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRN-AVSLLQDSSRE 1118
                        :.:.|||...|:   ..|:|.:.:.:       |.:..:.| ::....:.:.:
  Fly   725 ------------VQQCCAGHPNFM---TTGSNSMCFQI-------RHYASVVNYSIHRFLEKNSD 767

  Fly  1119 EINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIID 1183
            .:.: ||.:        .|..|...|  .|||....:.||..|.   |.:::...::..:..::.
  Fly   768 MLPK-YISA--------AFYQSKLSL--VQSLFPEGNPRRQVTK---KPSTLSSNIRTQLQTLLA 818

  Fly  1184 TLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARL 1248
            .::...:|:|.|  ::.|.||                   :....::.|::.|:|...::....|
  Fly   819 IVKHRRSHYVFC--IKPNEGK-------------------QPHQFDMALVQHQVRYMSLMPLVHL 862

  Fly  1249 HRLGFPESVPLLEFVRRFGLL---------AGDLASNKDVSVEQI-LAVNELDV--ASYRIGPSQ 1301
            .|.|....:..::|..|:.||         .|.       .||.| |.:..|.:  |.:.||...
  Fly   863 CRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGS-------QVEGIALIIRNLPLPSAEFTIGTKN 920

  Fly  1302 ILFRS-GVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRD 1365
            :..|| ..:.|||..|.:.:|:..:.:|...|.|.|||:..:.|..::.:...
  Fly   921 VFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSA------------ 973

  Fly  1366 WPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAK 1401
            |..||......|...........:.|.||...|:.|
  Fly   974 WRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYK 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	186/1055 (18%)
		MYSc_Myo18	575..1305	CDD:276837	178/1036 (17%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	32/98 (33%)
		Motor_domain	403..924	CDD:277568	137/652 (21%)
		Myosin_TH1	1092..1267	CDD:283635

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930