Protein Alignment Mhcl and unc-54

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_493596.1
• Gene: unc-54 / 259839
• WormBaseID: WBGene00006789
• Length: 1963
• Species: Caenorhabditis elegans
• Alignment Length: 2094
• Identity: 484/2094 - (23%)
• Similarity: 824/2094 - (39%)
• Gaps: 652/2094 - (31%)

  Fly   495 EADVADASQP----ERVWL--VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVE 553
            |..:.|.|:|    :.||:  ...|.....|   ||:.| |:...::.|    |.::|:.::.|:
 Worm    17 EQVLEDQSKPYDSKKNVWIPDPEEGYLAGEI---TATKG-DQVTIVTAR----GNEVTLKKELVQ 73

  Fly   554 KQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMF 618
            :.|.|..:..||:..|.:||:|||||.||.|||:.||:|.:|...:|:||...|.:|::....||
 Worm    74 EMNPPKFEKTEDMSNLSFLNDASVLHNLRSRYAAMLIYTYSGLFCVVINPYKRLPIYTDSCARMF 138

  Fly   619 RGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFIN 683
            .|.:..:||||:::::..|||::::...:||::..|.||:||:.:.|..:.|.| |.||......
 Worm   139 MGKRKTEMPPHLFAVSDEAYRNMLQDHENQSMLITGESGAGKTENTKKVICYFA-AVGASQQEGG 202

  Fly   684 AE------------KVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPE 736
            ||            ::.....:||||||.||..|:|::|..:.:.:.|::.|::||..::..|.|
 Worm   203 AEVDPNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGRLASCDIEHYLLE 267

  Fly   737 RQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRT 801
            :.|..|:...|..:||..::.:.....|:|||.|: :..:| :.|::.::.:.|......:|..|
 Worm   268 KSRVIRQAPGERCYHIFYQIYSDFRPELKKELLLD-LPIKD-YWFVAQAELIIDGIDDVEEFQLT 330

  Fly   802 VQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTA---ARKASGLLGVNL 863
            .:||:.||..|...:..:.:::|..|:|     .:......|.:.|.|..   |.|||.:.|:..
 Worm   331 DEAFDILNFSAVEKQDCYRLMSAHMHMG-----NMKFKQRPREEQAEPDGTDEAEKASNMYGIGC 390

  Fly   864 EDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVAL-------- 920
            |:...|   ||:|....|....||....:..: ||   :.|:..||||.....:|..
 Worm   391 EEFLKA---LTKPRVKVGTEWVSKGQNCEQVN-WA---VGAMAKGLYSRVFNWLVKKCNLTLDQK 448

  Fly   921 -INRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDR 984
             |:|........||...:.|...|:              .|..|::.|:||..|:|...|..::.
 Worm   449 GIDRDYFIGVLDIAGFEIFDFNSFE--------------QLWINFVNEKLQQFFNHHMFVLEQEE 499

  Fly   985 YAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYP 1044
            ||:|     .::..:||.: |     |.||:|.                  .|::.:||||.|.|
 Worm   500 YAREGIQWVFIDFGLDLQA-C-----IELIEKP------------------LGIISMLDEECIVP 540

  Fly  1045 NSNDDTFLERLF-SHYGDREHHSLLRKCAGPR------QFVLHHLQGTNPVLYAVDGWVRHS--- 1099
            .:.|.|...:|. .|.|   .|....|...|:      .|.:.|..||  |.|....|:..:
 Worm   541 KATDLTLASKLVDQHLG---KHPNFEKPKPPKGKQGEAHFAMRHYAGT--VRYNCLNWLEKNKDP 600

  Fly  1100 ---------REHPGIRNAVSLLQD-SSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVS 1154
                     ::..|....|.:.|| :::||.    ......|.|.    |...|..|
 Worm   601 LNDTVVSAMKQSKGNDLLVEIWQDYTTQEEA----AAKAKEGGGG----GKKKGKSG-------- 649

  Fly  1155 SIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAG 1219
                ||.|       :.:..:.:::.::..|.:|..||:.|.:                |:.
 Worm   650 ----SFMT-------VSMLYRESLNNLMTMLNKTHPHFIRCII----------------PNE--- 684

  Fly  1220 QVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKD---VSV 1281
              ..:..|::..|:.:||..:.|||..|:.|.|||......:||:|:.:||...|.:.|   ...
 Worm   685 --KKQSGMIDAALVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYAILAAKEAKSDDDKKKCA 747

  Fly  1282 EQILA--VNE--LDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQ 1342
            |.|::  ||:  |....:|||.:::.|::|||:.||..||..|:..:...|:..|.:|..|...:
 Worm   748 EAIMSKLVNDGSLSEEMFRIGLTKVFFKAGVLAHLEDIRDEKLATILTGFQSQIRWHLGLKDRKR 812

  Fly  1343 RRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR---AKLEK 1404
            |..|...:..:||||:::..:|.|.|::|..:|.|:|...:..|:|:..|:::..|.   ||.||
 Worm   813 RMEQRAGLLIVQRNVRSWCTLRTWEWFKLYGKVKPMLKAGKEAEELEKINDKVKALEDSLAKEEK 877

  Fly  1405 I--ECDRSEVK---------------------AENQ--KLEA-------KLSELTVDLAE-ERST 1436
            :  |.:.|..|                     ||.:  ||||       :||||...||: |..|
 Worm   878 LRKELEESSAKLVEEKTSLFTNLESTKTQLSDAEERLAKLEAQQKDASKQLSELNDQLADNEDRT 942

  Fly  1437 AHI--ATERLEAET--------------------------------------------------- 1448
            |.:  |.:::|||.
 Worm   943 ADVQRAKKKIEAEVEALKKQIQDLEMSLRKAESEKQSKDHQIRSLQDEMQQQDEAIAKLNKEKKH 1007

  Fly  1449 --------AERLKLEKELGDQTNKVK--------NLQETTE--------------KLEMELICA- 1482
                    .|.|:.|::.|:..||||        :|:::.|              |:|.||..|
 Worm  1008 QEEINRKLMEDLQSEEDKGNHQNKVKAKLEQTLDDLEDSLEREKRARADLDKQKRKVEGELKIAQ 1072

  Fly  1483 --------------------KSDLNGIS---EDEDA-----------------------ENE--- 1498
                                :|:|:.:|   |||.|                       |||
 Worm  1073 ENIDESGRQRHDLENNLKKKESELHSVSSRLEDEQALVSKLQRQIKDGQSRISELEEELENERQS 1137

  Fly  1499 ----------------------DGVGGGVY----------------------------------- 1506
                                  |..||...
 Worm  1138 RSKADRAKSDLQRELEELGEKLDEQGGATAAQVEVNKKREAELAKLRRDLEEANMNHENQLGGLR 1202

  Fly  1507 ------------------------------------------------KLKYERVARELE----- 1518
                                                            ||..|::|::.|
 Worm  1203 KKHTDAVAELTDQLDQLNKAKAKVEKDKAQAVRDAEDLAAQLDQETSGKLNNEKLAKQFELQLTE 1267

  Fly  1519 --------------FT--KRRLHTQH----------EHDLEQLVALKKHLEMKLSDA-------- 1549
                          ||  |.|||:::          |..:.||..||..|..:|.:|
 Worm  1268 LQSKADEQSRQLQDFTSLKGRLHSENGDLVRQLEDAESQVNQLTRLKSQLTSQLEEARRTADEEA 1332

  Fly  1550 ------------YEEVVEQ----------------RQV------VGQWK---------------- 1564
                        |:...||                ||:      :.|||
 Worm  1333 RERQTVAAQAKNYQHEAEQLQESLEEEIEGKNEILRQLSKANADIQQWKARFEGEGLLKADELED 1397

  Fly  1565 ---RKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQ--------ERQAK-- 1616
               |:|||    :|:|:..|:..|::|..|||.:.:...:....|..|.:        |::.|
 Worm  1398 AKRRQAQK----INELQEALDAANSKNASLEKTKSRLVGDLDDAQVDVERANGVASALEKKQKGF 1458

  Fly  1617 ----ERYGREKDVLQAEKFTLEQTLADTRLDLEFK----EEKLA-----------SLQRELEEMT 1662
                :.:.::.|.|.||....::.|.:|..|| ||    :|:||           ||.:|::::|
 Worm  1459 DKIIDEWRKKTDDLAAELDGAQRDLRNTSTDL-FKAKNAQEELAEVVEGLRRENKSLSQEIKDLT 1522

  Fly  1663 ----FGGGTEEEFAQ-LRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARR 1722
                .||.:..|..: :||.:.|.|    |.:..|||....::..|...||.::.:..:|.|..:
 Worm  1523 DQLGEGGRSVHEMQKIIRRLEIEKE----ELQHALDEAEAALEAEESKVLRAQVEVSQIRSEIEK 1583

  Fly  1723 ESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEAL 1787
            ..|:::||.|..|.|..:.:::::..||||.:.:..|||.|.:||..::.:|    :..|.....
 Worm  1584 RIQEKEEEFENTRKNHARALESMQASLETEAKGKAELLRIKKKLEGDINELE----IALDHANKA 1644

  Fly  1788 NQKLRRDLRKYKALLKDAQTQLE---RLKADTPGK--------TLIRQLRNQLEDAESARSLAMK 1841
            |...:::|::|:..:::.|.|:|   |..|||..:        ||   |:::.|:...|...|.:
 Worm  1645 NADAQKNLKRYQEQVRELQLQVEEEQRNGADTREQFFNAEKRATL---LQSEKEELLVANEAAER 1706

  Fly  1842 ARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQL 1906
            ||:.||.|..:.:   |::    |:|..:.::....:.:|:.:|:....:|.|.:.:|.|..::
 Worm  1707 ARKQAEYEAADAR---DQA----NEANAQVSSLTSAKRKLEGEIQAIHADLDETLNEYKAAEER- 1763

  Fly  1907 NTEQINVSEAEFKLNEMEAE----------RNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLEL 1961
              .:..:::|.....|:..|          |..|::|:.|:|.|||..|.........:..:||.
 Worm  1764 --SKKAIADATRLAEELRQEQEHSQHVDRLRKGLEQQLKEIQVRLDEAEAAALKGGKKVIAKLEQ 1826

  Fly  1962 RTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF 2026
            |.:||||.|:.||.........:.|....:.:||.:|.:.|....:.||:|.|.|:.|:
 Worm  1827 RVRELESELDGEQRRFQDANKNLGRADRRVRELQFQVDEDKKNFERLQDLIDKLQQKLK------ 1885

  Fly  2027 HAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLS 2091
                       |::|.:|      |:|..|     .|.||:...|...: |:.||...:::.|||
 Worm  1886 -----------TQKKQVE------EAEELA-----NLNLQKYKQLTHQL-EDAEERADQAENSLS 1927

  Fly  2092 SVGSISDLEDRLRP 2105
            .:.|.|.....:.|
 Worm  1928 KMRSKSRASASVAP 1941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	451/1954 (23%)
		MYSc_Myo18	575..1305	CDD:276837	201/785 (26%)
unc-54	NP_493596.1	Myosin_N	28..72	CDD:460670	11/51 (22%)
		MYSc_class_II	95..775	CDD:276951	201/785 (26%)
		Myosin_tail_1	853..1932	CDD:460256	231/1133 (20%)