DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh9

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_037326.2	Gene:	Myh9 / 25745	RGDID:	3140	Length:	1960	Species:	Rattus norvegicus

Alignment Length:	2057	Identity:	521/2057 - (25%)
Similarity:	864/2057 - (42%)	Gaps:	560/2057 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 ADASQPERVWLVH-RGGFTAAIRLPTASSGRDEENKLSL-RLLHNGEQLTVDEDDVEKQNSPALD 561
            ||.:..:.||:.. :.||..|       |.::|..:.:: .|:.||:::.|::||::|.|.|...
  Rat    24 ADWAAKKLVWVPSTKNGFEPA-------SLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFS 81

  Fly   562 LVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDM 626
            .|||:.||..||||||||.|::||.|.||:|.:|...:|:||...|.:|||::|.|::|.|..:|
  Rat    82 KVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEM 146

  Fly   627 PPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNN----------F 681
            |||:|::..|||||:::.|.|||::..|.||:||:.:.|..:.|||..|.::.:          .
  Rat   147 PPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQL 211

  Fly   682 INAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGH 746
            :.|.      .|||||||.||..|.|::|..:.:.::||..|.|..|:::..|.|:.||.|:...
  Rat   212 LQAN------PILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKE 270

  Fly   747 EHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNID 811
            |.:|||...||:||...|:.:|.||   ..:.:.|:|.........:..:.|..|::|...:.|.
  Rat   271 ERTFHIFYYLLSGAGEHLKTDLLLE---PYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIP 332

  Fly   812 AKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQP 876
            .....|:..:::.:..||  .:......:|.:....:.|||:|.|.|||:|:.|.:.   |:..|
  Rat   333 EDEQMGLLRVISGVLQLG--NIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTR---GILTP 392

  Fly   877 NAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDT 940
            ....|.....|:.|.    |.|...:|||....|......:|..||:.:..:....|| |.::|.
  Rat   393 RIKVGRDYVQKAQTK----EQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDI 453

  Fly   941 PGFQNPASCGQQVGATLADLRH------NYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEM 994
            .||:            :.||..      ||..|:||.||:||..:..::.|.:|     .::..:
  Rat   454 AGFE------------IFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGL 506

  Fly   995 DLASECHPGPLISLIDK--APQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFS 1057
            ||.      |.|.||:|  .|.                 |:|.|||||..:|.:.|.:|:|::..
  Rat   507 DLQ------PCIDLIEKPAGPP-----------------GILALLDEECWFPKATDKSFVEKVVQ 548

  Fly  1058 HYGDREHHSLLRKCAGPRQ------FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSS 1116
            ..|.   |...:|   |:|      |.:.|..|  .|.|..|.|:..:.: |...|..:||..||
  Rat   549 EQGT---HPKFQK---PKQLKDKADFCIIHYAG--KVDYKADEWLMKNMD-PLNDNIATLLHQSS 604

  Fly  1117 REEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQV-KFTVDG 1180
            .:     ::..|.:....::.....||:..|.......:.:..|.|.|        |: |..:..
  Rat   605 DK-----FVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVG--------QLYKEQLAK 656

  Fly  1181 IIDTLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVL 1243
            ::.|||.|..:||.|.:..|  .|||                       ::..|:..|||.:.||
  Rat   657 LMATLRNTNPNFVRCIIPNHEKKAGK-----------------------LDPHLVLDQLRCNGVL 698

  Fly  1244 EAARLHRLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQIL 1303
            |..|:.|.|||..|...||.:|:.:|..:     ....|...|..|.|: |||...||||.|::.
  Rat   699 EGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKAL-ELDSNLYRIGQSKVF 762

  Fly  1304 FRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPW 1368
            ||:|||:.||.:||:.::|.||..||.||||||||..::|:.|..|::.:|||..|:|.:|:|.|
  Rat   763 FRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLRLRNWQW 827

  Fly  1369 WRLLVRVTPLLNVHRTEEQLKTANEELLMLRAK-------LEKIECDRSEVKAENQKLEAKL--- 1423
            |||..:|.||||..|.|::|.....||..:|.|       |.::|..:|::.||..:|:.:|
  Rat   828 WRLFTKVKPLLNSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAE 892

  Fly  1424 SELTVDLAEE---RSTA---------HIATERLEAE-------TAERLKLEKELGDQTNKVKNLQ 1469
            :||..: |||   |.||         |....|:|.|       .||:.|:::.:.:...:::..:
  Rat   893 TELCAE-AEELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEE 956

  Fly  1470 ETTEKLEMELICAKSDLNGISED------------------ED----------AENEDGVGGGVY 1506
            ...:||::|.:..::.|..:.||                  ||          .|.|........
  Rat   957 SARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKL 1021

  Fly  1507 KLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMT 1571
            |.|:|.:..:||...||    .|...::|...::.||...:|..:::.|.:..:.:.|.:..|..
  Rat  1022 KNKHEAMITDLEERLRR----EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082

  Fly  1572 NEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKFT 1632
            .|:......:||:.|:.|:..||.|:.:.:...||:.:..||..:.:..::|    :.|:|.|..
  Rat  1083 EELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERACRNKAEKQKRDLGEELEALKTE 1147

  Fly  1633 LEQTLADTRLDLEF---KEEKLASLQRELEE-------------MTFGGGTE---EEFAQLRRSK 1678
            ||.||..|....|.   :|::::.|::.||:             .......|   |:..|.:|.|
  Rat  1148 LEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK 1212

  Fly  1679 NETERRAKEQEEELDEMAGQIQLLEQ-------------------------------------AK 1706
            ...|:..:..|.|..|:|.:::.|.|                                     :|
  Rat  1213 ATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVSK 1277

  Fly  1707 LRLEM------------------------------TLETMRKEARRE-------SQQRD------ 1728
            |::|:                              |.|.:::|.|::       .|..|
  Rat  1278 LQVELDSVTGLLNQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQMEDEKNSFR 1342

  Fly  1729 ---EELEEVRGNGYKKIKALECQ--------------LETEHEERTLLLREKHELERRLSS---- 1772
               ||.||.:.|..|:|..|..|              |||..|.:..|.::...|.:||..
  Rat  1343 EQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRRLQKDLEGLSQRLEEKVAA 1407

  Fly  1773 -----------------------------------------------------MEDRDRVDRDA- 1783
                                                                 .|:|||.:.:|
  Rat  1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472

  Fly  1784 -------------EEALNQK------------------------------LRRDLRKYKALLKDA 1805
                         |||:.||                              |.:..|..:..:::.
  Rat  1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537

  Fly  1806 QTQLERL-------------------------KADTPG---------KTLIRQLRN---QLEDAE 1833
            :||||.|                         :.|..|         |.|:||:|.   :|||..
  Rat  1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602

  Fly  1834 SARSLAMKARQTAEAELTEVQAMFDESHRARNDAEE---RANAAHRD-----------RAELQAQ 1884
            ..||:||.||:..|.:|.:::|..|.:::.|.:|.:   :..|..:|           |.|:.||
  Rat  1603 KQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667

  Fly  1885 IEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGD 1949
            .:|||::|    |...|.:.||..|   ::.||....:.:.||:.|.:::|         .:.|.
  Rat  1668 AKENEKKL----KSMEAEMIQLQEE---LAAAERAKRQAQQERDELADEIA---------NSSGK 1716

  Fly  1950 PSMAMMSK-RLELRTKELESRLELEQAT---------RARLEV-QVN-----------RHKEALE 1992
            .::|:..| |||.|..:||..||.||..         :|.|:: |:|           :::.|.:
  Rat  1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ 1781

  Fly  1993 KL--QNEVTQSKMREMQA-------------QDVIKKSQKSLRDMREEFHAVSSREQESLTRRKD 2042
            :|  ||:..::|::||::             :..|.:.::.|.:..:|..|.|.:.:.:..:.||
  Rat  1782 QLERQNKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQAASKQVRRAEKKLKD 1846

  Fly  2043 LEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEE-------------ELSESDESLSSVG 2094
            :..:||.........|:....|..|:..|::.:||..||             ||.::.|:..::.
  Rat  1847 VLLQVEDERRNAEQFKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911

  Fly  2095 -SISDLEDRLR----PVHVKR---------SSQQSLNGSIGG 2122
             .:|.|:::||    |..|.|         .|.:.::|...|
  Rat  1912 REVSSLKNKLRRGDMPFVVTRRIVRKGTGDCSDEEVDGKADG 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	239/798 (30%)
		MYSc_Myo18	575..1305	CDD:276837	222/767 (29%)
		GBP_C	<1540..1750	CDD:303769	62/329 (19%)
		COG1340	1565..1833	CDD:224259	92/525 (18%)
		coiled coil	1723..1734	CDD:293879	5/26 (19%)
Myh9	NP_037326.2	Myosin_N	29..68	CDD:397036	10/45 (22%)
		Motor_domain	95..764	CDD:419868	222/767 (29%)
		Myosin_tail_1	842..1921	CDD:396244	224/1099 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810