Protein Alignment Mhcl and myp2

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_593816.1
• Gene: myp2 / 2543576
• PomBaseID: SPAC4A8.05c
• Length: 2104
• Species: Schizosaccharomyces pombe
• Alignment Length: 1886
• Identity: 419/1886 - (22%)
• Similarity: 750/1886 - (39%)
• Gaps: 427/1886 - (22%)

  Fly   498 VADASQPERVWLVHRGGFTAAIRLPTASSG-------RDEENKLSLRLLHNGEQLTVDEDDVEKQ 555
            |.|||..||.|          |.:|.:...       .|...|..::|..:|.:..||..|.||.
pombe    29 VKDASFDERTW----------IWIPDSKESFVKAWIVEDLGEKYRVKLERDGSERIVDGFDAEKV 83

  Fly   556 NSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRG 620
            |.|..|:|:|:..|..|||.||::.|.|||..:||:|.:|..|:.|||...|.:|.:.||..::.
pombe    84 NPPKFDMVDDMAALTCLNEPSVVNNLTQRYEKDLIYTYSGLFLVAVNPYCHLPIYGDDVVRKYQS 148

  Fly   621 CKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFIN-- 683
            .:.::..||::..|..|||||:|.|.:||::..|.||:||:.:.|..:.||.....|..:...
pombe   149 KQFKETKPHIFGTADAAYRSLLERRINQSILVTGESGAGKTETTKKVIQYLTSVTDASTSDSQQL 213

  Fly   684 AEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEH 748
            .:|:.....:||||||.:|..|:|::|..:.:.::|...|.|..|:|...|.|:.|......:|.
pombe   214 EKKILETNPVLEAFGNAQTVRNNNSSRFGKFIRIEFSNNGSIVGANLDWYLLEKSRVIHPSSNER 278

  Fly   749 SFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAK 813
            ::|:..:||.||.|.|.:.|.|:...  |.:.::....|..:......:|.:......||..|..
pombe   279 NYHVFYQLLRGADGSLLESLFLDRYV--DHYSYLKNGLKHINGVDDGKEFQKLCFGLRTLGFDNN 341

  Fly   814 AVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNA 878
            .:..::.|:|:|.|:|...|....:|   :.:|.:.|...:...||.:.::...:||.
pombe   342 EIHSLFLIIASILHIGNIEVASDRSG---QARFPSLTQIDQLCHLLEIPVDGFVNAAL------- 396

  Fly   879 PNGGLSPSKSPTSDTGHEW---------AWECLEALVIGLYSEALAAVVALINRQICTS-SHTIA 933
                     .|.|..|.||         ....|::|..|||....|.:|..:|:.:..| |....
pombe   397 ---------HPKSKAGREWIVTARTREQVVHTLQSLAKGLYERNFAHLVKRLNQTMYYSQSEHDG 452

  Fly   934 SIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIE- 993
            .|.::|..||:    |          :...|..|:..|:||..|:|...|..::.|.||.:|.:
pombe   453 FIGVLDIAGFEIFTFN----------SFEQLCINFTNEKLQQFFNHYMFVLEQEEYTQERIEWDF 507

  Fly   994 MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSH 1058
            :|..::..  |.|..|:|:                :..|:...|||:.:.|.:.|.||.|:|
pombe   508 IDYGNDLQ--PTIDAIEKS----------------EPIGIFSCLDEDCVMPMATDATFTEKL--- 551

  Fly  1059 YGDREHHSLLR--------KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDS 1115
                  |.|.:        |......|||.|..|  .|.|....|:..::: |......:|:..|
pombe   552 ------HLLFKGKSDIYRPKKFSSEGFVLKHYAG--DVEYDTKDWLEKNKD-PLNACLAALMFKS 607

  Fly  1116 SREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDG 1180
            :...::.|:....:..||.       ..:|.....|.||...|.      :.:|:|.|
pombe   608 TNSHVSSLFDDYSSNASGR-------DNIEKKGIFRTVSQRHRR------QLSSLMHQ------- 652

  Fly  1181 IIDTLRRTGTHFVHCYL-----LQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGS 1240
                |..|..|||.|.:     ..||..|                          .|:..|||.:
pombe   653 ----LEATQPHFVRCIIPNNLKQPHNLDK--------------------------SLVLHQLRCN 687

  Fly  1241 QVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASN-KDVSVEQILAVNELDVAS--YRIGPSQI 1302
            .|||..|:.:.|||..:...||..|:|:|:..|... .:.....|..:|||.:.|  ||:|.:::
pombe   688 GVLEGIRIAQTGFPNKLFYTEFRARYGILSQSLKRGYVEAKKATITIINELKLPSTVYRLGETKV 752

  Fly  1303 LFRSGVLSELEAKRDVLLSDRII--QLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRD 1365
            .|::.||..||.:|:.||  |:|  ...|..||:|.|:::.:...::.|...:|.|::....::.
pombe   753 FFKASVLGSLEDRRNALL--RVIFNSFSARIRGFLTRRRLYRFNHRQDAAILLQHNLRQLKLLKP 815

  Fly  1366 WPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDL 1430
            .|||.|.:.:.|||...:|:|.|:..:..:..|:.:||..:    ||..|....:.::.:||.||
pombe   816 HPWWNLFLHLKPLLGTTQTDEYLRRKDALINNLQNQLESTK----EVANELTITKERVLQLTNDL 876

  Fly  1431 AEERSTAH----------------------------IATERLEAETAERLKLEKELGDQTNKVKN 1467
            .||::.||                            ||.|:.|...||:..:|::|.::..::..
pombe   877 QEEQALAHEKDILVERANSRVEVVHERLSSLENQVTIADEKYEFLYAEKQSIEEDLANKQTEISY 941

  Fly  1468 LQETTEKLEMELICAKSDLNGISED-------------------------EDAENEDGVGGGVYK 1507
            |.:.:..||.:|...|.|...||..                         |.|.||..:......
pombe   942 LSDLSSTLEKKLSSIKKDEQTISSKYKELEKDYLNIMADYQHSSQHLSNLEKAINEKNLNIRELN 1006

  Fly  1508 LKYERVARELEFTKRRLHTQ-----------------HEHDLEQLVALKKHLEMKLSDAYEEVVE 1555
            .|..|:..||...:|...|:                 :|..|..||:.....|.:|:....|:|.
pombe  1007 EKLMRLDDELLLKQRSYDTKVQELREENASLKDQCRTYESQLASLVSKYSETESELNKKEAELVI 1071

  Fly  1556 QRQVVGQWKRKAQK------MTNEMNDLR------------------MLLEEQNARNNLLEKKQR 1596
            .::.:.:::.:..|      .|:.:||::                  .:|::.....:|..|:..
pombe  1072 FQKEITEYRDQLHKAFQNPEKTHNINDVKSGPLNSDENIYSTSSTTLSILKDVQELKSLHTKEAN 1136

  Fly  1597 KFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRE 1657
            :.....:.:.:.:.|....:|:..|:.    |:::|.|:.::.           :|.::.||..:
pombe  1137 QLSERIKEISEMLEQSIATEEKLRRKNSELCDIIEALKYQIQD-----------QETEIISLNAD 1190

  Fly  1658 LEEMTFGGGTEE----EFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRK 1718
            ..::....|..|    :|...:..|:..|.:..:...:|.:...::.||:|......:|..|:..
pombe  1191 NLDLKDTNGVLEKNASDFIDFQGIKSRYEHKISDLLNQLQKERCKVGLLKQKTENRSVTQHTLDG 1255

  Fly  1719 EARR---ESQQRDEELEEVRGNG-------------YKKIKALECQLETE--------------- 1752
            .:..   |.:...:.|:.:.||.             .|.:.||:..:|.|
pombe  1256 NSPHPSFEEKHSGDPLKRIDGNNDDRKIDNKLLKTISKSLDALQLTVEEELSNLYSLSKDLSFTD 1320

  Fly  1753 ---HEERTLLLREK-----HELERRL-SSMEDRDRVD-------------------RDAEEALNQ 1789
               |...::...||     .||:.|| :|..||...|                   .||:..|..
pombe  1321 ISGHIPNSIRKLEKGLSTLSELKERLNASNSDRPSPDIFKDTQAIMNSRKLLSNPNSDAQSGLIS 1385

  Fly  1790 KLRRDL------RKYKALLKDAQTQLERLKADTPGKTLIRQ------LRNQLEDAESARSLAMKA 1842
            .|::.|      .::..|...:.:::..|.:..||....|.      :||..:::.......:..
pombe  1386 SLQKKLYNPESNMEFTGLKPLSPSKISNLPSSQPGSPSKRSGKMEALIRNFDQNSSIPDPFIVNQ 1450

  Fly  1843 RQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAE----LQAQIEENEEELGELMKKYSATV 1903
            |.:.      :|..|::.:....:|.:.....::|.::    :|:.::||||            :
pombe  1451 RNSV------LQTEFEKINLKLKEATKSGILDNKDLSKFSELIQSLLKENEE------------L 1497

  Fly  1904 KQLNTEQINVSEAEFKLNEMEAE-----RNNLK---EQVAELQHRLDNVENLGDPSMAMMSKRLE 1960
            |.|.|..:...:.......:..:     ||.:|   |:....:..:..:.:..:..:....|.|.
pombe  1498 KNLTTSNLGSDDKMLDFAPLLEDVPNNTRNQIKGFVEKAISSKRAIAKLYSASEEKLFSTEKALR 1562

  Fly  1961 LRTKELESRLE-----------LEQATRARLEV-----QVNRH--KEALEKLQNEVTQSKMREMQ 2007
            ..|||.:..|.           |:..|.::|.:     .:..:  :|..|.||.||...|::|:.
pombe  1563 EITKERDRLLHGLQGPSVPTSPLKAPTASQLIIPNFDGSITNYSGEEETEWLQEEVNIMKIKELT 1627

  Fly  2008 AQDVIKKSQKSL---RDMREEFHAVSS-----REQESLT-RRKDLEKKVEQMESEGAALKNDLRL 2063
            :  .:.|.::.|   :.:.|  ||.||     |.:..|| |.:::|:.....::..|.|:|:|..
pombe  1628 S--TVNKYREQLAMVQSLNE--HAESSLSKAERSKNYLTGRLQEVEELARGFQTTNADLQNELAD 1688

  Fly  2064 ALQRIADLQQAMEEEG----------EEELSESDESLSSVGSISDLEDRLRPVHVK-RSSQQSLN 2117
            |:.:..:.:....|:.          |:.:.:.||  ..|..:.|||:|.:...:. :..|:.||
pombe  1689 AVVKQKEYEVLYVEKSNDYNTLLLQKEKLMKQIDE--FHVIRVQDLEEREKKDQLLFQRYQKELN 1751

  Fly  2118 G 2118
            |
pombe  1752 G 1752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	207/793 (26%)
		MYSc_Myo18	575..1305	CDD:276837	193/762 (25%)
		GBP_C	<1540..1750	CDD:303769	38/257 (15%)
		COG1340	1565..1833	CDD:224259	59/370 (16%)
		coiled coil	1723..1734	CDD:293879	2/10 (20%)
myp2	NP_593816.1	COG5022	17..1607	CDD:227355	381/1733 (22%)
		Myosin_N	38..76	CDD:280832	7/47 (15%)
		MYSc_class_II	103..755	CDD:276951	193/762 (25%)
		Tup_N	1684..1759	CDD:285748	16/71 (23%)
		RILP-like	<1997..2072	CDD:304877

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45615
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000