DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh3

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_036736.1	Gene:	Myh3 / 24583	RGDID:	3138	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	1966	Identity:	480/1966 - (24%)
Similarity:	826/1966 - (42%)	Gaps:	518/1966 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            ::.|:::....| ..|.|..:||...|.|..|.:||:..|.:|||.:||:.|:.||.|.:|:|.:
  Rat    56 QDGKVTVETEDN-RTLVVKPEDVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|:.:||..:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
  Rat   120 GLFCVTVNPYKWLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLALAAGA---------------YNNFINAEKVNALCTILEAFGNTKTCLNSNAT 709
            |:.:.|..:.|.|..|..               .:..|:|.      .:||||||.||..|.|::
  Rat   185 KTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISAN------PLLEAFGNAKTVRNDNSS 243

  Fly   710 RMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENIT 774
            |..:.:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::|:.....|.:.|.:  .|
  Rat   244 RFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLI--TT 306

  Fly   775 SEDSHPFIS----LSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTK 835
            :...:||||    |...::||    .:.:.|..|.:.|....:...|::.:..|:.|.|     .
  Rat   307 NPYDYPFISQGEILVASIDDR----EELLATDSAIDILGFTPEEKSGLYKLTGAVMHYG-----N 362

  Fly   836 LGTGSTARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEW 897
            :......|.:.|.|   ..|.|.:.|:|:|..||..|   |..|....|....:|..|.|..|
  Rat   363 MKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKA---LCFPRVKVGNEYVTKGQTVDQVH-- 422

  Fly   898 AWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLA 958
              ..:.||...:|.:....:|..||:|:.|.......|.::|..||:    |          :|.
  Rat   423 --HAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYN----------SLE 475

  Fly   959 DLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVV 1018
            .|..|:..|:||..|:|...|..::.|.:|     .::..||||: |     |.||:|.
  Rat   476 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP------ 528

  Fly  1019 RSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLH 1080
                        .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.
  Rat   529 ------------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGKAEAHFSLI 581

  Fly  1081 HLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLE 1145
            |..||  |.|:|.||:..::: |.....|.|.|.||...:..||              .:||..:
  Rat   582 HYAGT--VDYSVSGWLEKNKD-PLNETVVGLYQKSSNRLLAHLY--------------ATFATTD 629

  Fly  1146 GTQSLRRVSSIR-RSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYT 1209
            .....::|:..: .||.|       :....:..::.::..||.|..|||.|.:
  Rat   630 ADGGKKKVAKKKGSSFQT-------VSALFRENLNKLMSNLRTTHPHFVRCII------------ 675

  Fly  1210 ANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL----- 1269
            .|.:.:..|.:.|         |:..|||.:.|||..|:.|.|||..:...:|.:|:.:|
  Rat   676 PNETKTPGAMEHS---------LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAI 731

  Fly  1270 -AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRG 1333
             .|....:|. :.|::||..::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||
  Rat   732 PEGQFIDSKK-ACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRG 795

  Fly  1334 YLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEEL 1395
            :|.|   :||.|||.   ::.|||.|::||:.|:.|||.:|..::.|||....||:::.|..||.
  Rat   796 FLMRVEFQKMMQRRE---SIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEF 857

  Fly  1396 LMLRAKLEKIECDRSE------------------VKAENQ-----------------KLEAKLSE 1425
            ...:.:|.|.|..|.|                  |:||::                 :||||:.|
  Rat   858 QKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKE 922

  Fly  1426 LTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGI 1489
            :| :.||:.       |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..:
  Rat   923 VT-ERAEDE-------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 979

  Fly  1490 SEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVA----------LKKHLEM 1544
            :|:     ..|:...:.||..|         |:.|...|:..|:.|.|          ||..||.
  Rat   980 TEE-----LAGLDETIAKLTRE---------KKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQ 1030

  Fly  1545 KLSDAYEEVVEQRQVVGQWKRKAQKMTNEM-----------NDLRML-----------------L 1581
            ::.|....:.:::::....:|..:|:..::           ||.:.|                 :
  Rat  1031 QVDDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKV 1095

  Fly  1582 EEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKER-------YGREKDVLQAEKFTLEQTLAD 1639
            |::...:..|:||.::..|..:.|::.:..||..:.:       |.||.:.| :|:......:..
  Rat  1096 EDEQTLSLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEEL-SERLEEAGGVTS 1159

  Fly  1640 TRLDLEFKEE-KLASLQRELEEMTF----------------GGGTEEEFAQLRRSKNETERRAKE 1687
            |:::|..|.| :...|:|:|||.|.                .....|:...|:|.|.:.|:...|
  Rat  1160 TQIELNKKREAEFLKLRRDLEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSE 1224

  Fly  1688 QEEELDEMAGQIQLLEQAKLRLE---MTLETMRKEARRESQQRDEELEEVRGNGYK--------- 1740
            .:.|:|:::..::.:.::|..||   .|||....|||.::::....|.|:.....:
  Rat  1225 FKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQKSRLQTEAGELS 1289

  Fly  1741 ----------------------KIKALECQLETEHEERTL-------------LLRE-------- 1762
                                  :|:.|:.|||.|::.:..             ||||
  Rat  1290 RQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354

  Fly  1763 KHELERRLSSME----------DRDRVDR----------------DAEE---------------- 1785
            |.||:|.||...          :.|.:.|                |:||
  Rat  1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419

  Fly  1786 ----------------------ALNQKLR---RDLRKYKALLKDAQTQLE-RLKADTPGKTLIRQ 1824
                                  ||::|.|   :.|.::|...:::|.:|| .||......|.:.:
  Rat  1420 QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFK 1484

  Fly  1825 LRNQLED--------------------------AESARSL--AMKARQTAEAELTEVQAMFDESH 1861
            |:|..|:                          ||:.:|:  ..|:|:..|.|..::|...:|:.
  Rat  1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAE 1549

  Fly  1862 RARNDAEERANAAHRD----RAELQAQIEENEEELGELMKKYSATVK----QLNTEQINVSEA-- 1916
            .|....|.:......:    ::|:..:|.|.:||:.:|.:.|..||:    .|:.|..:.:||
  Rat  1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIR 1614

  Fly  1917 -----EFKLNEMEAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRL 1959
                 |..|||:|.:.::...|.||....|.:|:        :|.|         ..:|::.:|.
  Rat  1615 LKKKMEGDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 1679

  Fly  1960 ELRTKELES-RLELEQATRAR----------------LEVQVNRHKEALEKLQNEVT--QSKMRE 2005
            .|...|:|. |..|||..|||                |..|........:||:.::|  ||::.:
  Rat  1680 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVED 1744

  Fly  2006 --MQAQDVIKKSQKSLRD---MREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAA 2056
              ..|::..:|::|::.|   |.||.    .:||::   |.| :|:||:.|:.:     |:|..|
  Rat  1745 ASRDARNAEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1805

  Fly  2057 L---KNDLRLALQRIADLQQAMEEEGEE------------------ELS-ESDESLSSVGSISDL 2099
            |   |..::....||.:|:  .|.|||:                  ||: :|:|...:|..:.||
  Rat  1806 LKGGKKQIQKLETRIRELE--FELEGEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDL 1868

  Fly  2100 EDRLRPVHVKRSSQQS 2115
            .|:|: |.||...:|:
  Rat  1869 VDKLQ-VKVKSYKRQA 1883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	215/801 (27%)
		MYSc_Myo18	575..1305	CDD:276837	201/770 (26%)
		GBP_C	<1540..1750	CDD:303769	53/295 (18%)
		COG1340	1565..1833	CDD:224259	83/468 (18%)
		coiled coil	1723..1734	CDD:293879	1/10 (10%)
Myh3	NP_036736.1	Myosin_N	36..73	CDD:280832	3/17 (18%)
		Myosin_head	88..767	CDD:278492	207/782 (26%)
		MYSc_Myh3	100..767	CDD:276878	201/770 (26%)
		Actin-binding	656..678		7/33 (21%)
		Actin-binding	758..772		3/13 (23%)
		GrpE	843..>962	CDD:295646	31/126 (25%)
		Myosin_tail_1	847..1924	CDD:279860	228/1067 (21%)
		RILP-like	962..1095	CDD:304877	24/146 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1289		4/28 (14%)
		MIT_CorA-like	<1296..>1408	CDD:294313	21/111 (19%)
		COG6	1373..>1506	CDD:303003	20/132 (15%)
		TMPIT	1739..>1828	CDD:285135	26/94 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810