DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Grip2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_006506166.1 Gene:Grip2 / 243547 MGIID:2681173 Length:1049 Species:Mus musculus


Alignment Length:1162 Identity:226/1162 - (19%)
Similarity:347/1162 - (29%) Gaps:404/1162 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 TFQNESLY-EGAARGAGSIGS------NSSQHGTSFTSVESLRSDGEQTG----------GQQRA 249
            |.:::..| :|....||:.|:      :..:.....|.||.::.:|...|          |:.|.
Mouse    23 TARDDGPYSKGGKDTAGADGALVCRRQSIPEEFRGITMVELIKREGSTLGLTISGGTDKDGKPRV 87

  Fly   250 MTLPANARYGALPQGN---SQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRW 311
                :|.|.|.|...:   :.|.::.     |.:...||...:....|   .|..|||       
Mouse    88 ----SNLRPGGLAARSDLLNVGDYIR-----SVNGIHLTRLRHDEIIT---LLKNVGE------- 133

  Fly   312 ARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPR--------------QDFGFSLRKAICLDR 362
               ....:||..|||      |.|       :.:||              ..|||.||.....|.
Mouse   134 ---RVVLEVEYELPP------PAP-------ENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDL 182

  Fly   363 TESLTSPIFRPVI--FAEPGAGGGATGLLP-GDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVE 424
            .:|      ||::  :..||......|.|. ||||:.::|.|:........|..::........:
Mouse   183 HKS------RPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALFQ 241

  Fly   425 VQ-------PVAE-----LVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHEN 477
            |:       .||.     :||::|   .|.:|    :..|:|.|:..........|.|..|    
Mouse   242 VEYDVATPDTVANASGPLVVEIAK---TPGSA----LGISLTTGSHRNKPAITIDRIKPAS---- 295

  Fly   478 GNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIR-------LPTASSGRDEENKLS 535
               ..:..||...|..:.|  .|.:..|...||......|::.       ||:..|.|..:...:
Mouse   296 ---VVDRSGALHAGDHILA--IDGTSTEHCSLVEATKLLASVTEKVRLEILPSPQSRRPLKPPEA 355

  Fly   536 LRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLV 600
            :| :...|||...:......:||...                 ||....:|:      .||....
Mouse   356 VR-IQRSEQLHRWDPSAPSCHSPRPS-----------------HCRAPTWAA------GGPDQSR 396

  Fly   601 VNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFK 665
            .....|.|  |..:...|.......:|....|...||.|.....:..:|.:.:..|..|......
Mouse   397 SVSSTPFS--SPTMNPAFPCANASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIV 459

  Fly   666 HALNY-------------LALAAGAYN----------NFINAEKVNALCTILEAFGNTKTCLNSN 707
            |....             |.|..|.:.          .||..:.....|.:|:. |:....:|..
Mouse   460 HTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVRFIEPDSPAERCGLLQV-GDRVLAINGI 523

  Fly   708 AT------RMTQL-----------LSLDFDQTGQI--ASASLQVLLPERQ---------RAGRRL 744
            ||      ...||           |.::||....:  :|.:..|.||:|:         .|.|:.
Mouse   524 ATEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKR 588

  Fly   745 GHEHSFHIMTRLLAGA----AGLLQ---KELHLENI-----TSEDSHPFISLSQKL--------- 788
            |..   .|::.:..|:    .|.|:   |.|.::||     ..||:...:...:.|         
Mouse   589 GEP---LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEDAVQILRQCEDLVKLKIRKDE 650

  Fly   789 --EDRHRAANDFMRTV-----------------QAFETLNIDAKAVRGIWS----------ILA- 823
              .|...::.....||                 :.|:.:.|.....||:..          ||| 
Mouse   651 DNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAI 715

  Fly   824 ------------AIYHLGIAGVT----------------KLGTGSTARTQFANPTAARKASGLLG 860
                        ||:.|.:||.|                :.|:.|.|.....:|..|.| .|||.
Mouse   716 NSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPPEALK-GGLLA 779

  Fly   861 VN-----------LEDLSSAA----FGLTQPNAPNGGLSPSKSPTSDTGHEWA------------ 898
            ..           :|...|:|    ||.|      |..:|..:..|.|..||.            
Mouse   780 TRFSPAVPSVDSAVESWGSSATDGGFGGT------GSYTPQVAVRSVTPQEWRPSRLKSSPPPLE 838

  Fly   899 --------------------------------------W----ECLEALVIGLYSEALAAVVALI 921
                                                  |    |.||.|.....||.|..:.|.|
Mouse   839 PRRTSYTPGPSDESFPEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASI 903

  Fly   922 NRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYA 986
                  .:.|:.|:.:...|| ..|....::|..:..||:...|...|:|  |..||  .:|   
Mouse   904 ------MTGTVHSVAVDGRPG-SRPWRRSREVRTSPEDLQELLLPTPLEM--HRVTL--HKD--- 954

  Fly   987 QELVEIEMDLASECHPGPLISLIDKAPQNHVVR----SSQRDLREHDRRGMLWLLDEEAIYPNSN 1047
                .:..|.......|    |::|....|.||    :....|:..||     ||....:.....
Mouse   955 ----PVRNDFGFSVSDG----LLEKGVYVHTVRIDGPAQLGGLQPFDR-----LLQVNHVRTRDF 1006

  Fly  1048 DDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPG 1104
            |......|.:..||                :|..:...||        :..||..||
Mouse  1007 DCCLAVPLLAEAGD----------------ILELVVSRNP--------LAQSRRTPG 1039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 22/103 (21%)
MYSc 556..1317 CDD:214580 140/752 (19%)
MYSc_Myo18 575..1305 CDD:276837 138/733 (19%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
Grip2XP_006506166.1 PDZ_signaling 58..140 CDD:238492 20/103 (19%)
PDZ_signaling 160..243 CDD:238492 20/88 (23%)
PDZ_signaling 258..341 CDD:238492 20/98 (20%)
PDZ_signaling 463..551 CDD:238492 14/88 (16%)
PDZ_signaling 564..647 CDD:238492 18/85 (21%)
PDZ_signaling 664..744 CDD:238492 15/79 (19%)
PDZ_signaling 947..1026 CDD:238492 21/112 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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