DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and MYO16

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001185879.1	Gene:	MYO16 / 23026	HGNCID:	29822	Length:	1880	Species:	Homo sapiens

Alignment Length:	1367	Identity:	284/1367 - (20%)
Similarity:	512/1367 - (37%)	Gaps:	367/1367 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 GELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITN-GNCN------- 459
            |.:|.:..:|...:|...:|...:...:|..|.:..:....:.:.::.|.::: ||.|
Human   181 GNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGV 245

  Fly   460 -TLRRSASKRFKRQSRHENGNGG-------------------GEEGGAK------------GVGH 492
             .|..:.:..:|........:||                   |:....|            ....
Human   246 TLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNE 310

  Fly   493 DLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEE--------------NKLSLRLLHNGE 543
            :..:|:|.:...|.:.|.....:...::.|.::|...:|              :|||..:|...:
Human   311 EKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAK 375

  Fly   544 QLTVDEDDV------------EKQNS--------------------PALDLVEDICELKYLNEAS 576
            |.::.|.|:            :.|:|                    ||.:  :|:..|..||:.|
Human   376 QDSLLEKDIMFKDATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPN--DDLATLSELNDGS 438

  Fly   577 VLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMF---RGCKTEDMPPHVYSLAQTAY 638
            :|:.:::|:.:|.|:|..|..||:|||...|.:||..|..::   .|.....:|||::|..:.|:
Human   439 LLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAF 503

  Fly   639 RSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTC 703
            ..|...:|.|..|..|..|||||.:.|..:.:|...|||....:::...:.:| ||||||:.||.
Human   504 HQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVC-ILEAFGHAKTT 567

  Fly   704 LNSNATRMTQLLSLDF-DQTGQIASASLQVLLPERQR-AGRRLGHEHSFHIMTRLLAGAAGLLQK 766
            ||..::...:...|.| ::..|:..|.:...|.|:.| ..:.|| :.:|.|...|:.|.:...:.
Human   568 LNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLG-QSNFLIFYLLMDGLSAEEKY 631

  Fly   767 ELHLENITSEDSHPFISLSQKLED----RHRAANDFMRTV--QAFETLNIDAKAVRGIWSILAAI 825
            .|||.|:.   :|.:  |:|.::|    ..|:.|.....|  :|...:...:..|..::.|||||
Human   632 GLHLNNLC---AHRY--LNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAI 691

  Fly   826 YHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPT 890
            .|||....|.|..|::|..  ::.....:.:|:|.|:.::|:||.                   |
Human   692 LHLGDIRFTALNEGNSAFV--SDLQLLEQVAGMLQVSTDELASAL-------------------T 735

  Fly   891 SDTGH------------EWAWECLEALVIGLYSEALAAVVALINRQICTSSH------TIASIML 937
            :|..:            :.|....:.|...|||...:.:|..:|.  |..|.      ....|.:
Human   736 TDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNS--CLHSQDEQKSMQTLDIGI 798

  Fly   938 IDTPGFQN-PASCGQQVGATLADLR-HNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASEC 1000
            :|..||:. ..:..:|:...:.:.: |:|:.|   :||.|..:         |.|:..:.:.:..
Human   799 LDIFGFEEFQKNEFEQLCVNMTNEKMHHYINE---VLFLHEQV---------ECVQEGVTMETAY 851

  Fly  1001 HPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTF---LERLFSHYGDR 1062
            .||         .||.|:     |.......|.|.|||||:....|.:..|   |:.|.......
Human   852 SPG---------NQNGVL-----DFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTN 902

  Fly  1063 EHHSLLRKCAG-------PRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEI 1120
            ..:|.::...|       ...|.:.|..|.  |:|.|.|.:..:::... :|.:.:::.|....|
Human   903 AVYSPMKDGNGNVALKDHGTAFTIMHYAGR--VMYDVVGAIEKNKDSLS-QNLLFVMKTSENVVI 964

  Fly  1121 NRLY------IGSLTRGSGAMVFCGSFAGL------------EGTQSLRRVSSIRRSFTTAGVKR 1167
            |.|:      .|||.....:..|.|..:.|            |....|.....:::..|:..::|
Human   965 NHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR 1029

  Fly  1168 ------NSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEE 1226
                  .:|..|::.::..||..|::...||:||  ::.|..|......|...|
Human  1030 LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHC--IRPNNSKLPDTFDNFYVS----------- 1081

  Fly  1227 MVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGD-LASNKDVSVEQ--ILAVN 1288
                    :||:...|||..::.|.|:|..:...:|:.|:..||.. |...|:.|..:  .|.:.
Human  1082 --------AQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQ 1138

  Fly  1289 ELDVASYRIGPSQILFR---SGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQR---RVQE 1347
            :..:..:::|..::..:   :..|::|    .:.|..:||..|...||:|||:.:.||   |.||
Human  1139 QCKLQGWQMGVRKVFLKYWHADQLNDL----CLQLQRKIITCQKVIRGFLARQHLLQRISIRQQE 1199

  Fly  1348 LAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQ-LKTANEELLMLRAKLEKIECDRSE 1411
            :.      ::.:||                    ..||:. |||.:..::.          :.|:
Human  1200 VT------SINSFL--------------------QNTEDMGLKTYDALVIQ----------NASD 1228

  Fly  1412 VKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLE 1476
            :..||.:|.::::            |....|:||                   |:|:||...|..
Human  1229 IARENDRLRSEMN------------APYHKEKLE-------------------VRNMQEEGSKRT 1262

  Fly  1477 ME------------LICAKSD---------------LNGISEDEDAEN-------------EDGV 1501
            .:            .:||..|               |:.:...:|:.:             .|
Human  1263 DDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRD-- 1325

  Fly  1502 GGGVYKLKYERV------ARELEFTKRRLHTQHEHDLEQLVAL-----KKHLEMKLSDAYEEVVE 1555
            ........||.|      |||...........|..|...:..:     |:....|||.:|||:..
Human  1326 PNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISG 1390

  Fly  1556 QR 1557
            .|
Human  1391 SR 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	5/22 (23%)
		MYSc	556..1317	CDD:214580	196/851 (23%)
		MYSc_Myo18	575..1305	CDD:276837	187/797 (23%)
		GBP_C	<1540..1750	CDD:303769	7/18 (39%)
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
MYO16	NP_001185879.1	ANKYR	81..332	CDD:223738	21/150 (14%)
		ANK repeat	86..112	CDD:293786
		ANK	89..190	CDD:238125	2/8 (25%)
		ANK repeat	114..145	CDD:293786
		ANK	142..297	CDD:238125	17/115 (15%)
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786	5/28 (18%)
		ANK repeat	243..274	CDD:293786	4/30 (13%)
		ANK repeat	276..307	CDD:293786	2/30 (7%)
		ANK repeat	309..335	CDD:293786	4/25 (16%)
		MYSc	426..1165	CDD:214580	192/818 (23%)
		MYSc_Myo16	437..1155	CDD:276844	187/797 (23%)
		NYAP_N	1253..1590	CDD:292079	26/142 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810