Protein Alignment Mhcl and MYH15

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_011510861.1
• Gene: MYH15 / 22989
• HGNCID: 31073
• Length: 1946
• Species: Homo sapiens
• Alignment Length: 1909
• Identity: 469/1909 - (24%)
• Similarity: 793/1909 - (41%)
• Gaps: 480/1909 - (25%)

  Fly   541 NGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMA 605
            :||.|::.||.:::.|.|..:::||:..|.:||||||||.|::||...:|:|.:|...:.:||..
Human    83 DGESLSIKEDKIQQMNPPEFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYK 147

  Fly   606 PLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNY 670
            .|.:|.::|::.::|.:..:.|||::::|..|::.::..|.:||::|.|.||:||:.:.||.:.|
Human   148 WLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQY 212

  Fly   671 LALAAGAYNNFINAEKVNAL-------CTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASA 728
            .|..|....   :.:|..||       .||||||||.||..|.|::|..:.:.:.|...|.::|.
Human   213 FATIAAMIE---SRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSV 274

  Fly   729 SLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELH---LENITSEDSHPFISLS----Q 786
            .:.:.|.|:.|...:...|.::||..::|:|     |||||   |.:....|.| |.|..    :
Human   275 DIDIYLLEKSRVIFQQAGERNYHIFYQILSG-----QKELHDLLLVSANPSDFH-FCSCGAVTVE 333

  Fly   787 KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTA 851
            .|:|    |.:.:.|.||.:.|........|.:.:..||.|.   |..|...........|:.|.
Human   334 SLDD----AEELLATEQAMDILGFLPDEKYGCYKLTGAIMHF---GNMKFKQKPREEQLEADGTE 391

  Fly   852 -ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALA 915
             |.||:.|:|:|..:|...   |..|....|....::..|.    |.....:.||...:|.....
Human   392 NADKAAFLMGINSSELVKC---LIHPRIKVGNEYVTRGQTI----EQVTCAVGALSKSMYERMFK 449

  Fly   916 AVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHT 976
            .:||.|||.:.........|.::|..||:    |          :|..|..|:..|:||..|:..
Human   450 WLVARINRALDAKLSRQFFIGILDITGFEILEYN----------SLEQLCINFTNEKLQQFFNWH 504

  Fly   977 TLVAPRDRYAQELVE-----IEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWL 1036
            ..|..::.|.:|.:|     ..:||.: |     |.||:|.                  .|:|.:
Human   505 MFVLEQEEYKKESIEWVSIGFGLDLQA-C-----IDLIEKP------------------MGILSI 545

  Fly  1037 LDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQFVLH----HLQGTNPVLYAVDGWV 1096
            |:||.::|.:.|.||..:|| :|:|...|  |.:.....::|..|    |..|..|  |.:.||:
Human   546 LEEECMFPKATDLTFKTKLFDNHFGKSVH--LQKPKPDKKKFEAHFELVHYAGVVP--YNISGWL 606

  Fly  1097 RHSREHPGIRN--AVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRS 1159
            ..:::   :.|  .|::.|.||...:..|:...::..| |:.|        |.:..::.:|.:
Human   607 EKNKD---LLNETVVAVFQKSSNRLLASLFENYMSTDS-AIPF--------GEKKRKKGASFQ-- 657

  Fly  1160 FTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSE 1224
             |.|.:.:.::        :.::..|:.|..|||.|  :..|..|
Human   658 -TVASLHKENL--------NKLMTNLKSTAPHFVRC--INPNVNK-------------------- 691

  Fly  1225 EEMVNVP------LLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-------AGDLASN 1276
                 :|      |:..|||.:.|||..|:.|.|||..:...:|.:|:.:|       :..::|.
Human   692 -----IPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSR 751

  Fly  1277 KDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMS 1341
            |  :.|::|...|:|...||.|.:::.|::|.|.:|||.||..||......||..:|.|.|.|..
Human   752 K--AAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQ 814

  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIE 1406
            :...:..|:..||.|::||:||::|||.||..::.||:......|::....||...|:..|||.|
Human   815 KILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSE 879

  Fly  1407 CDRSEVKAENQKLEAKLSELTVDL-AEERSTAHI--------------------ATERLEAE--- 1447
            ..|.|:||:...|..:.::|.:.| ||:.:.|::                    .:||:|.|
Human   880 FQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEI 944

  Fly  1448 ----TAERLKLE-------KELGD--------------QTNKVKNL------------------- 1468
                ||...|||       ||:.|              ..:|||||
Human   945 NSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAK 1009

  Fly  1469 ------QETTEKLEME-------------LICAKSDLNGISEDE-----DAENEDGVGGGVYKLK 1509
                  |:|.:.|.||             |.....:|.|..|.|     :.|.|.....|..||.
Human  1010 VVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN 1074

  Fly  1510 YERV---------------ARELEFTKRRLHTQHEHDL-EQLVALKKHLEMKLSDAYEEVVEQRQ 1558
            .|.:               .:|||.::.....::|..| .||....|.|:.::.|..|::..:|.
Human  1075 RESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERT 1139

  Fly  1559 VVGQWKRKAQKMTNEMNDLRMLLEEQN----ARNNLLEKKQRKFDAECQSLQDA----------- 1608
            ...:.:|:...:|.::.||...|||..    |:..:.:|::.||....:.:::|
Human  1140 TRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASL 1204

  Fly  1609 --------------VRQERQAKERYGREKDVLQAE--------------KFTLEQ--TLADTRL- 1642
                          |...:|.|::..::|..||.|              |...|:  ||.:.||
Human  1205 KKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLH 1269

  Fly  1643 --------------DLEFKEEKLAS----LQRELEEMTFGGGTEEEFAQLRRSKN---------- 1679
                          ||..::.||.|    ..|.|||      .|....||.|.|:
Human  1270 EATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEE------KEALINQLSREKSNFTRQIEDLR 1328

  Fly  1680 -ETERRAKEQ----------EEELDEMAGQIQLLEQAKLRLEMTLETMRKE-----ARRESQ--Q 1726
             :.|:..|.|          :.:.|.:..|.:..::.|..|..||..:..|     .:.|:.  |
Human  1329 GQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQ 1393

  Fly  1727 RDEELEEVRGNGYKKIKALECQLETE-----HEERTLLLREKHELERRL-SSMEDRDRVDRDAEE 1785
            |.|:||:.     ||..|:..|...|     :.....|.|.:|:|:..| .::.|..:| |.|..
Human  1394 RTEDLEDA-----KKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKV-RSAAA 1452

  Fly  1786 ALNQKLRRDLRKYKAL------------LKDA--------QTQLERLKADTPGKTLIRQ------ 1824
            .|:||   .|:..|||            |.||        .|:|.:|| :|..::::.|
Human  1453 RLDQK---QLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLK-NTYEESIVGQETLRRE 1513

  Fly  1825 ----------LRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRA--RNDAE------ERA 1871
                      |.||:.:.....:...|.::..|.|.||||...:|:..|  ||:::      |..
Human  1514 NKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELL 1578

  Fly  1872 NAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNT-------EQINVSEAEFK----LNEMEA 1925
            .|    :|||:.::.|.:||:....:|...|:..|.:       .:|.|:..:.|    |||||.
Human  1579 EA----KAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMEL 1639

  Fly  1926 ERN--------------NLKEQVAELQHRLDNVENLGD---PSMAMMSKRLELRTKELESRLELE 1973
            :.:              .|:.|:.:||.:||:...|..   ..:|:..:|..|...|||....|:
Human  1640 QLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQ 1704

  Fly  1974 QATRARLEVQVNRHKEALEKL-----QNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSRE 2033
            :.|.....:......||.|::     ||....|:.::::|.  :.:.||...::.:|......:.
Human  1705 EQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEAD--VARMQKEAEEVVQECQNAEEKA 1767

  Fly  2034 QESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGS--- 2095
            :::.....:|.:::::.:...|.|:.......|.|.|||:.:.|.         |.::.:||
Human  1768 KKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEA---------EQMALMGSRKQ 1823

  Fly  2096 ISDLEDRLRPV------HVKRSSQ 2113
            |..||.|:|.:      .::||::
Human  1824 IQKLESRVRELEGELEGEIRRSAE 1847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	449/1804 (25%)
		MYSc_Myo18	575..1305	CDD:276837	200/773 (26%)
MYH15	XP_011510861.1	COG5022	53..1460	CDD:227355	379/1504 (25%)
		MYSc_Myh15_mammals	117..778	CDD:276892	200/773 (26%)
		SMC_prok_B	1093..1932	CDD:274008	174/786 (22%)