DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Tamalin

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_620249.1	Gene:	Tamalin / 192254	RGDID:	70554	Length:	394	Species:	Rattus norvegicus

Alignment Length:	196	Identity:	42/196 - (21%)
Similarity:	70/196 - (35%)	Gaps:	38/196 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 QQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDR 310
            ||:.....|....|..|...:      ...:|:||.             ||.:.:|.| :.|.:.
  Rat    10 QQKEEATAAPDLAGRAPDSEA------ARAAPTPSG-------------PPAAAAPPG-APGDEL 54

  Fly   311 WARVHAFEDVEL---------PLPP--------VQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAI 358
            :|.:..:...||         .||.        ....:.|..::.|:..:|...|.|||.: :..
  Rat    55 YAALEDYHPAELYRALAVSGGTLPRRKGSGFRWKNFTQSPEQQRKVLTLEKGDNQTFGFEI-QTY 118

  Fly   359 CLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTV 423
            .|...|.....:...|......:.....||.|||.:..|||..|..:....|:::|:.||..:.:
  Rat   119 GLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRL 183

  Fly   424 E 424
            |
  Rat   184 E 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/86 (27%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Tamalin	NP_620249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		12/60 (20%)
		PDZ_signaling	99..184	CDD:238492	22/85 (26%)
		Interaction with PSCD3. /evidence=ECO:0000250	180..257		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..318
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900