DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myo-2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_510092.2 Gene:myo-2 / 181404 WormBaseID:WBGene00003514 Length:1947 Species:Caenorhabditis elegans


Alignment Length:2022 Identity:464/2022 - (22%)
Similarity:825/2022 - (40%) Gaps:535/2022 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLV-HRGGFTAAIRLPTA 524
            ||||..:..:.|||                .:|         ..:.||:. ...|:...:...||
 Worm    12 LRRSREEMLQDQSR----------------AYD---------SKKNVWIPDSEDGYIEGVITKTA 51

  Fly   525 SSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNL 589
            .......       :..|.:.||.:|.|::.|.|..:..||:..|.:||:||||:.|:.|||:.|
 Worm    52 GDNVTVS-------IGQGAEKTVKKDVVQEMNPPKFEKTEDMSNLTFLNDASVLYNLKARYAAML 109

  Fly   590 IHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMG 654
            |:|.:|...:|:||...|.:|::.|..||.|.:..:||||:::::..|||::::...:||::..|
 Worm   110 IYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSDEAYRNMLQNHENQSMLITG 174

  Fly   655 RSGSGKSTSFKHALNYLALAAGAYNNFINAEK-----------------VNALCTILEAFGNTKT 702
            .||:||:.:.|..::|.|....|......|:|                 :.....:||||||.||
 Worm   175 ESGAGKTENTKKVISYFAAVGAAQQETFGAKKAATEEDKNKKKVTLEDQIVQTNPVLEAFGNAKT 239

  Fly   703 CLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKE 767
            ..|:|::|..:.:.:.|.:.|::||..::..|.|:.|..|:...|..:||..::.:.....|:|:
 Worm   240 VRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCYHIFYQVFSDYLPNLKKD 304

  Fly   768 LHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAG 832
            |.|.....:  :.||:.::.:.|......:...|.:||:.|..........:.::||:.|:|   
 Worm   305 LLLNKPVKD--YWFIAQAELIIDGINDKEEHQLTDEAFDILKFTPTEKMECYRLVAAMMHMG--- 364

  Fly   833 VTKLGTGSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTG 894
              .:......|.:.|.|..   |.:|:...|::.|:...|   ||:|..             ..|
 Worm   365 --NMKFKQRPREEQAEPDGTDDAERAAKCFGIDSEEFLKA---LTRPRV-------------KVG 411

  Fly   895 HEWA----------WECLEALVIGLYSEALAAVVALINRQI----CTSSHTIASIMLIDTPGFQ- 944
            :||.          | .:.|:..||||.....:|...|:.:    .:..|.|.   ::|..||: 
 Worm   412 NEWVNKGQNIEQVNW-AVGAMAKGLYSRIFNWLVKKCNQTLDQKGISRDHFIG---VLDIAGFEI 472

  Fly   945 ---NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECH 1001
               |          :...|..|::.|:||..|:|...|..::.||:|     .::..:||.: | 
 Worm   473 FDFN----------SFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQA-C- 525

  Fly  1002 PGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHH 1065
                |.||:|.                  .|::.:||||.|.|.:.|.|..::|. .|.|   .|
 Worm   526 ----IELIEKP------------------LGIIAMLDEECIVPKATDLTLAQKLIDQHLG---KH 565

  Fly  1066 SLLRKCAGPR------QFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREE--INR 1122
            ....|...|:      .|.:.|..||  |.|....|:..:::  .:.:.|..:..:|:|.  |..
 Worm   566 PNFEKPKPPKGKQAEAHFAMRHYAGT--VRYNCLNWLEKNKD--PLNDTVVTVMKASKEHALIVE 626

  Fly  1123 LYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRR 1187
            ::....|:...|.      |..:||...::........|.:.:.|.|:        :.::..|..
 Worm   627 VWQDYTTQEEAAA------AAAKGTAGAKKKGKSGSFMTVSMLYRESL--------NKLMTMLHS 677

  Fly  1188 TGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLG 1252
            |..||:.|.:              .:...|:|       :::..|:.:||..:.|||..|:.|.|
 Worm   678 THPHFIRCII--------------PNEKKASG-------VIDAGLVLNQLTCNGVLEGIRICRKG 721

  Fly  1253 FPESVPLLEFVRRFGLLAGD--LASNKD------VSVEQILAVNELDVASYRIGPSQILFRSGVL 1309
            ||......:||:|:.|||.|  :....|      :.:.:::...:|:..::|:|.:::.|::|::
 Worm   722 FPNRTLHPDFVQRYALLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIV 786

  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGY---LARKKMSQRRVQEL-AVRCIQRNVKAFLAVRDWPWWR 1370
            :.||..||..|:..|..|||..|.|   :.||    |||::: |::.||||::::..:|.|.|::
 Worm   787 AHLEDLRDQSLAQLITGLQAQIRWYYQTIERK----RRVEKITALKIIQRNIRSWAELRTWVWFK 847

  Fly  1371 LLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDL----- 1430
            |..:|.||:|..:.|.|.:...|.:    |.|:.......|.|.:.|:...:|::.|.||     
 Worm   848 LYGKVKPLVNSGKIEAQYEKLQETV----ATLKDTVVQEEEKKRQLQEGAERLNKETADLLAQLE 908

  Fly  1431 --------AEERSTA----HIATERLEAETAERLKLEKELGDQTNKVKNLQE------------- 1470
                    .|||.||    .:|.|...|:.:::|::|:....:.||.|.|.|             
 Worm   909 ASKGSTREVEERMTAMNEQKVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDV 973

  Fly  1471 --TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLE 1533
              :..|:|.|....:..:..:.::...::|:     :.||..||..:| |..|:........:.:
 Worm   974 DLSLRKVEAEKNAKEHQIRALQDEMRQQDEN-----ISKLNKERKNQE-EQNKKLTEDLQAAEEQ 1032

  Fly  1534 QLVA--LKKHLEMKLSDAYEEVVEQ----RQVVGQWKRKAQ------------------------ 1568
            .|.|  ||..|...|.|: |:.:|:    |..:.:.||||:                        
 Worm  1033 NLAANKLKAKLMQSLEDS-EQTMEREKRNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENAL 1096

  Fly  1569 -KMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFT 1632
             :...|::.|.|.||::.|....|:|..::.:|..:.|.|.:..|:.|::|..|.:...|||...
 Worm  1097 RRKETELHTLGMKLEDEQAAVAKLQKGIQQDEARVKDLHDQLADEKDARQRADRSRADQQAEYDE 1161

  Fly  1633 LEQTLAD----TRLDLEF---KEEKLASLQRELEE--MTFGGGTEEEFAQLRRSKNETERRAKEQ 1688
            |.:.|.|    |...:|.   |:.:|..|:|:|||  :.||    |:...|:          |:.
 Worm  1162 LTEQLEDQARATAAQIELGKKKDAELTKLRRDLEESGLKFG----EQLTVLK----------KKG 1212

  Fly  1689 EEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEEL-----EEVRGNGYKKIKALECQ 1748
            .:.:.|::.||:.|::.|.|:|.....|::|....|...|:|.     :|....|| :::.||.:
 Worm  1213 SDAIQELSDQIEQLQKQKGRIEKEKGHMQREFDESSAALDQEAKLRADQERIAKGY-EVRLLELR 1276

  Fly  1749 LETEHEERTL----------------LLREKHELERRLSS--------MEDRDRVDRDAEEA--- 1786
            |:.:.:.|.|                |.|:..|||.::.:        ..:.|...|.|||.   
 Worm  1277 LKADEQSRQLQDFVSSKGRLNSENSDLARQVEELEAKIQAANRLKLQFSNELDHAKRQAEEESRE 1341

  Fly  1787 ------LNQKLRRDLRKYKALLKD--------------AQTQLE--RLKADTPG----------K 1819
                  |::.|.|:|.:.|..::|              |..:|:  |.|.:|.|          |
 Worm  1342 RQNLSNLSKNLARELEQLKESIEDEVAGKNEASRQLSKASVELDQWRTKFETEGLIGADEFDEVK 1406

  Fly  1820 TLIRQLRNQLEDA-----------ESARSLAMKARQTAEAE---------------LTEVQAMFD 1858
            ....|..::::||           |:|||     |.||||:               |.:.|..||
 Worm  1407 KRQNQKTSEIQDALDACNAKIVALENARS-----RLTAEADANRLEAEHHAQAVSSLEKKQKAFD 1466

  Fly  1859 ---------------ESHRARNDAEERANAAHRDRAE---LQAQIE-----------------EN 1888
                           |...|:.||.:.:..||:.|.:   |..|:|                 |:
 Worm  1467 KVIDEWKKKVDDLYLELDGAQRDARQLSGEAHKLRGQHDTLADQVEGLRRENKSLSDETRDLTES 1531

  Fly  1889 EEELGELMKKYSATVKQLNTE----QINVSEAEFKLNEMEAE-----------RNNLKEQVAELQ 1938
            ..|.|......|..:::|..|    |..:.|||..|...|::           |..:::::||.:
 Worm  1532 LSEGGRATHALSKNLRRLEMEKEELQRGLDEAEAALESEESKALRCQIEVSQIRAEIEKRIAEKE 1596

  Fly  1939 HRLDN-----------------VENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVN- 1985
            ...:|                 .|......:..:.|:||....|||  :.|:.|.:|..:.|.| 
 Worm  1597 EEFENHRKVHQQTIDSIQATLDSETKAKSELFRVKKKLEADINELE--IALDHANKANEDAQKNI 1659

  Fly  1986 -RHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESL--------TRRK 2041
             |:.:.:.:||..|.:.:.|..:.::.:..:::.|        ||:.:|||.|        ..|:
 Worm  1660 RRYLDQIRELQQTVDEEQKRREEFREHLLAAERKL--------AVAKQEQEELIVKLEALERARR 1716

  Fly  2042 DLEKKVE---------------------QMESEGAALKNDL--------------RLALQRIADL 2071
            .:|..|:                     |:::|.|.|.:|:              |.|....|.|
 Worm  1717 VVESSVKEHQEHNNELNSQNVALAAAKSQLDNEIALLNSDIAEAHTELSASEDRGRRAASDAAKL 1781

  Fly  2072 QQAM--EEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVV--SSTR 2132
            .:.:  |:|..::|....:.|.|  ::.||::|          ..:...::..||...:  :..|
 Worm  1782 AEDLRHEQEQSQQLERFKKQLES--AVKDLQER----------ADAAEAAVMKGGAKAIQKAEQR 1834

  Fly  2133 TVVFEKD 2139
            ...|:.|
 Worm  1835 LKAFQSD 1841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 198/820 (24%)
MYSc_Myo18 575..1305 CDD:276837 187/789 (24%)
GBP_C <1540..1750 CDD:303769 62/252 (25%)
COG1340 1565..1833 CDD:224259 84/376 (22%)
coiled coil 1723..1734 CDD:293879 3/15 (20%)
myo-2NP_510092.2 Myosin_N 31..68 CDD:280832 7/43 (16%)
Myosin_head 83..782 CDD:278492 192/801 (24%)
MYSc_class_II 95..782 CDD:276951 187/789 (24%)
Myosin_tail_1 876..1939 CDD:279860 216/1015 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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