Protein Alignment Mhcl and myo-2

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 2022
• Identity: 464/2022 - (22%)
• Similarity: 825/2022 - (40%)
• Gaps: 535/2022 - (26%)

  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLV-HRGGFTAAIRLPTA 524
            ||||..:..:.|||                .:|         ..:.||:. ...|:...:...||
 Worm    12 LRRSREEMLQDQSR----------------AYD---------SKKNVWIPDSEDGYIEGVITKTA 51

  Fly   525 SSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNL 589
            .......       :..|.:.||.:|.|::.|.|..:..||:..|.:||:||||:.|:.|||:.|
 Worm    52 GDNVTVS-------IGQGAEKTVKKDVVQEMNPPKFEKTEDMSNLTFLNDASVLYNLKARYAAML 109

  Fly   590 IHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMG 654
            |:|.:|...:|:||...|.:|::.|..||.|.:..:||||:::::..|||::::...:||::..|
 Worm   110 IYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSDEAYRNMLQNHENQSMLITG 174

  Fly   655 RSGSGKSTSFKHALNYLALAAGAYNNFINAEK-----------------VNALCTILEAFGNTKT 702
            .||:||:.:.|..::|.|....|......|:|                 :.....:||||||.||
 Worm   175 ESGAGKTENTKKVISYFAAVGAAQQETFGAKKAATEEDKNKKKVTLEDQIVQTNPVLEAFGNAKT 239

  Fly   703 CLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKE 767
            ..|:|::|..:.:.:.|.:.|::||..::..|.|:.|..|:...|..:||..::.:.....|:|:
 Worm   240 VRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCYHIFYQVFSDYLPNLKKD 304

  Fly   768 LHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAG 832
            |.|.....:  :.||:.::.:.|......:...|.:||:.|..........:.::||:.|:|
 Worm   305 LLLNKPVKD--YWFIAQAELIIDGINDKEEHQLTDEAFDILKFTPTEKMECYRLVAAMMHMG--- 364

  Fly   833 VTKLGTGSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTG 894
              .:......|.:.|.|..   |.:|:...|::.|:...|   ||:|..             ..|
 Worm   365 --NMKFKQRPREEQAEPDGTDDAERAAKCFGIDSEEFLKA---LTRPRV-------------KVG 411

  Fly   895 HEWA----------WECLEALVIGLYSEALAAVVALINRQI----CTSSHTIASIMLIDTPGFQ- 944
            :||.          | .:.|:..||||.....:|...|:.:    .:..|.|.   ::|..||:
 Worm   412 NEWVNKGQNIEQVNW-AVGAMAKGLYSRIFNWLVKKCNQTLDQKGISRDHFIG---VLDIAGFEI 472

  Fly   945 ---NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECH 1001
               |          :...|..|::.|:||..|:|...|..::.||:|     .::..:||.: |
 Worm   473 FDFN----------SFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQA-C- 525

  Fly  1002 PGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHH 1065
                |.||:|.                  .|::.:||||.|.|.:.|.|..::|. .|.|   .|
 Worm   526 ----IELIEKP------------------LGIIAMLDEECIVPKATDLTLAQKLIDQHLG---KH 565

  Fly  1066 SLLRKCAGPR------QFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREE--INR 1122
            ....|...|:      .|.:.|..||  |.|....|:..:::  .:.:.|..:..:|:|.  |..
 Worm   566 PNFEKPKPPKGKQAEAHFAMRHYAGT--VRYNCLNWLEKNKD--PLNDTVVTVMKASKEHALIVE 626

  Fly  1123 LYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRR 1187
            ::....|:...|.      |..:||...::........|.:.:.|.|:        :.::..|..
 Worm   627 VWQDYTTQEEAAA------AAAKGTAGAKKKGKSGSFMTVSMLYRESL--------NKLMTMLHS 677

  Fly  1188 TGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLG 1252
            |..||:.|.:              .:...|:|       :::..|:.:||..:.|||..|:.|.|
 Worm   678 THPHFIRCII--------------PNEKKASG-------VIDAGLVLNQLTCNGVLEGIRICRKG 721

  Fly  1253 FPESVPLLEFVRRFGLLAGD--LASNKD------VSVEQILAVNELDVASYRIGPSQILFRSGVL 1309
            ||......:||:|:.|||.|  :....|      :.:.:::...:|:..::|:|.:::.|::|::
 Worm   722 FPNRTLHPDFVQRYALLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIV 786

  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGY---LARKKMSQRRVQEL-AVRCIQRNVKAFLAVRDWPWWR 1370
            :.||..||..|:..|..|||..|.|   :.||    |||::: |::.||||::::..:|.|.|::
 Worm   787 AHLEDLRDQSLAQLITGLQAQIRWYYQTIERK----RRVEKITALKIIQRNIRSWAELRTWVWFK 847

  Fly  1371 LLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDL----- 1430
            |..:|.||:|..:.|.|.:...|.:    |.|:.......|.|.:.|:...:|::.|.||
 Worm   848 LYGKVKPLVNSGKIEAQYEKLQETV----ATLKDTVVQEEEKKRQLQEGAERLNKETADLLAQLE 908

  Fly  1431 --------AEERSTA----HIATERLEAETAERLKLEKELGDQTNKVKNLQE------------- 1470
                    .|||.||    .:|.|...|:.:::|::|:....:.||.|.|.|
 Worm   909 ASKGSTREVEERMTAMNEQKVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDV 973

  Fly  1471 --TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLE 1533
              :..|:|.|....:..:..:.::...::|:     :.||..||..:| |..|:........:.:
 Worm   974 DLSLRKVEAEKNAKEHQIRALQDEMRQQDEN-----ISKLNKERKNQE-EQNKKLTEDLQAAEEQ 1032

  Fly  1534 QLVA--LKKHLEMKLSDAYEEVVEQ----RQVVGQWKRKAQ------------------------ 1568
            .|.|  ||..|...|.|: |:.:|:    |..:.:.||||:
 Worm  1033 NLAANKLKAKLMQSLEDS-EQTMEREKRNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENAL 1096

  Fly  1569 -KMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFT 1632
             :...|::.|.|.||::.|....|:|..::.:|..:.|.|.:..|:.|::|..|.:...|||...
 Worm  1097 RRKETELHTLGMKLEDEQAAVAKLQKGIQQDEARVKDLHDQLADEKDARQRADRSRADQQAEYDE 1161

  Fly  1633 LEQTLAD----TRLDLEF---KEEKLASLQRELEE--MTFGGGTEEEFAQLRRSKNETERRAKEQ 1688
            |.:.|.|    |...:|.   |:.:|..|:|:|||  :.||    |:...|:          |:.
 Worm  1162 LTEQLEDQARATAAQIELGKKKDAELTKLRRDLEESGLKFG----EQLTVLK----------KKG 1212

  Fly  1689 EEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEEL-----EEVRGNGYKKIKALECQ 1748
            .:.:.|::.||:.|::.|.|:|.....|::|....|...|:|.     :|....|| :::.||.:
 Worm  1213 SDAIQELSDQIEQLQKQKGRIEKEKGHMQREFDESSAALDQEAKLRADQERIAKGY-EVRLLELR 1276

  Fly  1749 LETEHEERTL----------------LLREKHELERRLSS--------MEDRDRVDRDAEEA--- 1786
            |:.:.:.|.|                |.|:..|||.::.:        ..:.|...|.|||.
 Worm  1277 LKADEQSRQLQDFVSSKGRLNSENSDLARQVEELEAKIQAANRLKLQFSNELDHAKRQAEEESRE 1341

  Fly  1787 ------LNQKLRRDLRKYKALLKD--------------AQTQLE--RLKADTPG----------K 1819
                  |::.|.|:|.:.|..::|              |..:|:  |.|.:|.|          |
 Worm  1342 RQNLSNLSKNLARELEQLKESIEDEVAGKNEASRQLSKASVELDQWRTKFETEGLIGADEFDEVK 1406

  Fly  1820 TLIRQLRNQLEDA-----------ESARSLAMKARQTAEAE---------------LTEVQAMFD 1858
            ....|..::::||           |:|||     |.||||:               |.:.|..||
 Worm  1407 KRQNQKTSEIQDALDACNAKIVALENARS-----RLTAEADANRLEAEHHAQAVSSLEKKQKAFD 1466

  Fly  1859 ---------------ESHRARNDAEERANAAHRDRAE---LQAQIE-----------------EN 1888
                           |...|:.||.:.:..||:.|.:   |..|:|                 |:
 Worm  1467 KVIDEWKKKVDDLYLELDGAQRDARQLSGEAHKLRGQHDTLADQVEGLRRENKSLSDETRDLTES 1531

  Fly  1889 EEELGELMKKYSATVKQLNTE----QINVSEAEFKLNEMEAE-----------RNNLKEQVAELQ 1938
            ..|.|......|..:::|..|    |..:.|||..|...|::           |..:::::||.:
 Worm  1532 LSEGGRATHALSKNLRRLEMEKEELQRGLDEAEAALESEESKALRCQIEVSQIRAEIEKRIAEKE 1596

  Fly  1939 HRLDN-----------------VENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVN- 1985
            ...:|                 .|......:..:.|:||....|||  :.|:.|.:|..:.|.|
 Worm  1597 EEFENHRKVHQQTIDSIQATLDSETKAKSELFRVKKKLEADINELE--IALDHANKANEDAQKNI 1659

  Fly  1986 -RHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESL--------TRRK 2041
             |:.:.:.:||..|.:.:.|..:.::.:..:::.|        ||:.:|||.|        ..|:
 Worm  1660 RRYLDQIRELQQTVDEEQKRREEFREHLLAAERKL--------AVAKQEQEELIVKLEALERARR 1716

  Fly  2042 DLEKKVE---------------------QMESEGAALKNDL--------------RLALQRIADL 2071
            .:|..|:                     |:::|.|.|.:|:              |.|....|.|
 Worm  1717 VVESSVKEHQEHNNELNSQNVALAAAKSQLDNEIALLNSDIAEAHTELSASEDRGRRAASDAAKL 1781

  Fly  2072 QQAM--EEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVV--SSTR 2132
            .:.:  |:|..::|....:.|.|  ::.||::|          ..:...::..||...:  :..|
 Worm  1782 AEDLRHEQEQSQQLERFKKQLES--AVKDLQER----------ADAAEAAVMKGGAKAIQKAEQR 1834

  Fly  2133 TVVFEKD 2139
            ...|:.|
 Worm  1835 LKAFQSD 1841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	419/1772 (24%)
		MYSc_Myo18	575..1305	CDD:276837	187/789 (24%)
myo-2	NP_510092.2	COG5022	27..1478	CDD:227355	382/1604 (24%)
		MYSc_class_II	95..782	CDD:276951	187/789 (24%)
		SMC_prok_B	1097..1936	CDD:274008	169/787 (21%)