DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and nmy-1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_508504.2	Gene:	nmy-1 / 180581	WormBaseID:	WBGene00003776	Length:	1963	Species:	Caenorhabditis elegans

Alignment Length:	1942	Identity:	482/1942 - (24%)
Similarity:	851/1942 - (43%)	Gaps:	417/1942 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 ADVADASQPERVWLVHRG-GFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPA 559
            |.:|..:|.:..|:..:. ||.      ..|..|:..:::.:.|:....|:|:..|||:|.|.|.
Worm    18 ATLAAWAQRKLCWVPDQNEGFL------IGSIKRETNDEVLVELVDTSRQVTISRDDVQKANPPK 76

  Fly   560 LDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTE 624
            .|.:||:.||.|||||||||.|:.||.|:||:|.:|...:|:||...|.:|||.::..|:|.|..
Worm    77 FDKIEDMSELTYLNEASVLHNLKDRYYSSLIYTYSGLFCVVINPYKKLPIYSEDLIEEFKGKKRH 141

  Fly   625 DMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNA 689
            :||||::::|.|||||:::.|.|||::..|.||:||:.:.|..:.|||..|||..|    :.:||
Worm   142 EMPPHIFAIADTAYRSMLQEREDQSILCTGESGAGKTENTKKVIQYLAHVAGATRN----KSLNA 202

  Fly   690 LC-------------------------TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASAS 729
            ..                         .|||||||:||..|.|::|..:.:.::||.:|.|:.|:
Worm   203 AAQQNIVQKPDVRNPIGELEHQLLQANPILEAFGNSKTVKNDNSSRFGKFIRINFDMSGYISGAN 267

  Fly   730 LQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPF-----ISLSQKLE 789
            ::..|.|:.|..|:...|.||||..::|.|.:...:.|..||.:   |::.|     |:| ..::
Worm   268 IEFYLLEKSRVLRQAQDERSFHIFYQILRGCSAKEKSEYLLEGV---DNYRFLVNRGITL-PNVD 328

  Fly   790 DRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARK 854
            |    ..:|..|:.:...:......:..|..:::|:..||....|:......|..|  :....:|
Worm   329 D----VQEFHSTINSMRIMGFADDEISSIMRVVSAVLLLGNLEFTQEKKSDQAMLQ--DDRVIQK 387

  Fly   855 ASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVA 919
            ...|||:.:.:|..|   ..:|....|....:|:...:.. |:|   :||:....|......:|.
Worm   388 VCHLLGLPVIELQKA---FLRPRIKVGREFVNKAQNQEQA-EFA---VEAIAKASYERLFKWLVT 445

  Fly   920 LINRQICTSSHTIAS-IMLIDTPGFQNPASCGQQVGATLADLRH------NYLQERLQMLFHHTT 977
            .||:.:..:....|| |.::|..||:            :.|:..      ||..|:||.||::|.
Worm   446 RINKSLDRTHRQGASFIGILDIAGFE------------IFDINSFEQICINYTNEKLQQLFNNTM 498

  Fly   978 LVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLL 1037
            .:..::.|.:|     .::..:||.      |.|.||:|.                  .|:|.||
Worm   499 FILEQEEYQREGIEWDFIDFGLDLQ------PTIDLIEKP------------------MGVLALL 539

  Fly  1038 DEEAIYPNSNDDTFLERLFSHYGDREHHS----LLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRH 1098
            |||.::|.:||.:|:|:|     .:.|:.    ::........|.:.|..|.  |.|:.|.|:..
Worm   540 DEECLFPKANDKSFVEKL-----QKTHNKHPKFIVPDMRSKSHFAVVHYAGR--VDYSADQWLMK 597

  Fly  1099 SREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTA 1163
            :.: |...|.|.|:|:|:..     ::..:.:.:       .|||:...:.......:|   :..
Worm   598 NMD-PLNENVVGLMQNSTDP-----FVAGIWKDA-------EFAGICAAEMNETAFGMR---SRK 646

  Fly  1164 GVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEE 1226
            |:.|....|. |..:..::.|||.|..|||.|.:..|  .:||
Worm   647 GMFRTVSQLH-KEQLTKLMTTLRNTSPHFVRCIIPNHEKKSGK---------------------- 688

  Fly  1227 MVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDV----SVEQILAV 1287
             :|..|:..|||.:.|||..|:.|.|||..||..||..|:.:|..|:.....:    ||.:::..
Worm   689 -INSNLVLEQLRCNGVLEGIRICRQGFPNRVPFQEFRHRYEILTPDVIPKNFIDGKESVRKMITA 752

  Fly  1288 NELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRC 1352
            .::|...||||.|::.||:|||:.||.:||:.|:..|:..||.|||:|:|:..::|:.|..|:|.
Worm   753 LDIDTNLYRIGQSKVFFRTGVLAHLEEERDLKLTALIMNFQAQCRGFLSRRLYTRRQQQSSAIRI 817

  Fly  1353 IQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECD--------- 1408
            ||||..|:|.:|:|.||||..:|.|||.|.||:::::..::||...:.:|.|:|.|
Worm   818 IQRNGLAYLKLRNWQWWRLFTKVKPLLQVTRTDDEIRAKDDELRATKERLLKMEHDFRENEKKLD 882

  Fly  1409 --------------------------RSEVKAENQKLEAKLSELTVDLAEER------------- 1434
                                      |..::..||:||..::::...|:||.
Worm   883 QVIVERAVIQEQLQQESENSAELDDIRGRLQTRNQELEYIVNDMRDRLSEEEQQNEKNNDERRKQ 947

  Fly  1435 -STAHIATERLEAETAERLKLEKELGDQTN---KVKN-------LQETTEKLEMELICAKSDLNG 1488
             .|.....|:||.|...|.||   |.|:||   :::|       ||:..:||..|....:..:.|
Worm   948 METVRDLEEQLEQEEQARQKL---LLDKTNVDQRLRNLEERLVELQDAYDKLLKEKRLLEEKVEG 1009

  Fly  1489 ISE---DEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAY 1550
            ::.   |.:...:.||..   |.:.|....|||....| ..|::.:|||   .|:.|..:|.|:.
Worm  1010 LTTQLLDHEERAKHGVKA---KGRLENQLHELEQDLNR-ERQYKSELEQ---HKRKLLAELEDSK 1067

  Fly  1551 EEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQA 1615
            :.:.|:...|.:...:..|...|:.......:|::|...|::|:.|........|::.:..||.|
Worm  1068 DHLAEKMGKVEELNNQLMKRDEELQHQLTRYDEESANVTLMQKQMRDMQTTIDELREDMETERNA 1132

  Fly  1616 --KERYGREKDVLQAEKF---TLEQTLADTRLD--LEFKEEKLASLQRELEEM--TFGGGTEEEF 1671
              |....|.:.|.|.||.   .|::....|.|.  :..|:|::.:.:|.:|::  |..|..||:.
Worm  1133 RNKAEMTRREVVAQLEKVKGDVLDKVDEATMLQDLMSRKDEEVNATKRAIEQIQHTMEGKIEEQK 1197

  Fly  1672 A--------------QLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEM----------- 1711
            |              |.::.:::.|::..:.::|..:||.:|.||:.::..::.
Worm  1198 AKFSRQVEELHDQIEQHKKQRSQLEKQQNQADQERADMAQEIALLQASRADIDKKRKIHEAHLME 1262

  Fly  1712 -----------------TLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHE----- 1754
                             .||..|.|....::.|:|| |....|..:::...|.|::..:|
Worm  1263 IQANLAESDEHKRTLIDQLERSRDELDHLNRVREEE-EHAFANMQRRLATAEGQIQELNEQIQEE 1326

  Fly  1755 ----------------ERTLLLREKHE-------LERRL-SSMEDRDRVDRDAEEALNQKLR--- 1792
                            |:..||.||.|       ||:.: ::.:......|.|||::||:|.
Worm  1327 TRLKIANINRARQLEDEKNALLDEKEEAEGLRAHLEKEIHAARQGAGEARRKAEESVNQQLEELR 1391

  Fly  1793 ----RDL---------------------RKYKALLKDAQTQLERLKA---DTPGKTLIRQLRNQL 1829
                ||:                     :|.:..|:|:..:||.::|   |:..:.  ::..:|:
Worm  1392 KKNLRDVEHLQKQLEESEVAKERILQSKKKIQQELEDSSMELENVRASHRDSEKRQ--KKFESQM 1454

  Fly  1830 EDAESARSLAMKARQTAEAEL----TEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEE--- 1887
            .:...|...|:..|.....||    |.|.::.:|....:...||    :.|.|..||.::::
Worm  1455 AEERVAVQKALLDRDAMSQELRDRETRVLSLLNEVDIMKEHLEE----SDRVRRSLQQELQDSIS 1515

  Fly  1888 NEEELG----ELMKKYSATVKQLNTEQINVSEAEFKLN--------------------------- 1921
            |:::.|    ||.|...:...:||..::.:.|.|..|.
Worm  1516 NKDDFGKNVHELEKAKRSLEAELNDMRVQMEELEDNLQIAEDARLRLEVTNQALKSESDRAISNK 1580

  Fly  1922 --EMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQV 1984
              |.|.:|..|.:|:.:|::.|:| |..|........|::|.:..|||.:||:....:.....|:
Worm  1581 DVEAEEKRRGLLKQIRDLENELEN-EKRGKSGAVSHRKKIENQIGELEQQLEVANRLKEEYNKQL 1644

  Fly  1985 NRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLE---KK 2046
            .::::.:::.|.|..:::..:.....:::::.:..|.:..|...:....:..:..||.||   .:
Worm  1645 KKNQQIIKEYQIECEEARQAKEDIAALLREADRKFRAVEAEREQLREANEGLMQARKQLELENDE 1709

  Fly  2047 VEQMESEGAALKNDLRLALQ-RIADLQQAMEEEGEE-ELSESDESLSSVGSISDLEDRLRPVHVK 2109
            :|::.::|..:.::.:..|: :||.|::.:|||... ||:...:..:.|        :|..:...
Worm  1710 LEELRAKGGGISSEEKRRLEAKIAQLEEELEEEQSNCELAIDKQRKAQV--------QLEQITTD 1766

  Fly  2110 RSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVT---SPSSPHIHKLALAAK 2163
            .|.:::||........|:..|.|       |...:||..   :.|.......||.||
Worm  1767 LSMERTLNQKTEAEKQSLERSNR-------DYKAKITELESGAQSRARAQMAALEAK 1816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	230/812 (28%)
		MYSc_Myo18	575..1305	CDD:276837	212/781 (27%)
		GBP_C	<1540..1750	CDD:303769	53/260 (20%)
		COG1340	1565..1833	CDD:224259	74/378 (20%)
		coiled coil	1723..1734	CDD:293879	4/10 (40%)
nmy-1	NP_508504.2	Myosin_N	27..65	CDD:280832	8/43 (19%)
		Myosin_head	80..770	CDD:278492	220/793 (28%)
		MYSc_class_II	92..770	CDD:276951	212/781 (27%)
		Myosin_tail_1	847..1919	CDD:279860	205/1003 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810