DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myo-3

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_506065.2 Gene:myo-3 / 179676 WormBaseID:WBGene00003515 Length:1969 Species:Caenorhabditis elegans


Alignment Length:1869 Identity:456/1869 - (24%)
Similarity:802/1869 - (42%) Gaps:448/1869 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   477 NGNGGGEEG--GAKGVGHDLEADVADASQP----ERVWLVH-RGGFTAAIRLPTASSGRDEENKL 534
            :||....|.  |...:|...||..|.|::|    :..|:.. ..||.||   ...|:..::...:
 Worm     2 SGNPDAFENDPGFPFLGISREARAATAARPFDSKKNCWIPDPEDGFVAA---EIQSTTGEQVTVV 63

  Fly   535 SLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLL 599
            :::    |.|:||.:|..::.|.|..|..||:..|.:|||||||..|:.||...:|:|.:|...:
 Worm    64 TVK----GNQITVKKDQCQEMNPPKFDKTEDMANLTFLNEASVLGNLKDRYKDLMIYTYSGLFCV 124

  Fly   600 VVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSF 664
            |:||...|.:|||.|:..|.|.:..:||||:::::..|||::|:.:.:||::..|.||:||:.:.
 Worm   125 VINPYKRLPIYSESVIKHFMGKRRNEMPPHLFAVSDEAYRNMVQDKENQSMLITGESGAGKTENT 189

  Fly   665 KHALNYLALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSL 717
            |..::|.|:..            |.....:. |::.....:||||||.||..|:|::|..:.:..
 Worm   190 KKVISYFAIVGATQAASGKEAKDGKKGGTLE-EQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRT 253

  Fly   718 DFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLEN-ITSEDSHPF 781
            .|..:|::|...::..|.|:.|..|:...|..:||..::::|....|:.:|.|.| ||   .:.|
 Worm   254 HFSGSGKLAGGDIEHYLLEKSRVVRQAPGERCYHIFYQIMSGNDPSLRGKLKLSNDIT---YYHF 315

  Fly   782 ISLS----QKLEDRHRAANDFMR-TVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGST 841
            .|.:    :.::|:..     || |.:||:.:..:......::...|.|.|:|     ::.....
 Worm   316 CSQAELTIEGMDDKEE-----MRLTQEAFDIMGFEDNETMDLYRSTAGIMHMG-----EMKFKQR 370

  Fly   842 ARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWA----- 898
            .|.:.|.|..   |..|:.:||:..|:...|   ||:|..             ..|.||.     
 Worm   371 PREEQAEPDGEEDALNAAAMLGIQAEEFLKA---LTKPRV-------------RVGTEWVNKGQN 419

  Fly   899 -----WECLEALVIGLYSEALAAVVALINRQI----CTSSHTIASIMLIDTPGFQNPASCGQQVG 954
                 | .:..|...:|:.....::...|:.:    ....|.|.   ::|..||:          
 Worm   420 LEQVNW-AVSGLAKAIYARMFKWIITRCNKTLDAKEIERKHFIG---VLDIAGFE---------- 470

  Fly   955 ATLADLRH------NYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISL 1008
              :.||..      |::.||||..|:|...|..::.|.:|     .::..:||.: |     |.|
 Worm   471 --IFDLNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKREGIAWTFIDFGLDLQA-C-----IEL 527

  Fly  1009 IDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCA 1072
            |:|.                  .|::.:||||.|.|.:.|.|:.::|. .|.|   .|...:|..
 Worm   528 IEKP------------------LGIISILDEECIVPKATDMTYAQKLLDQHLG---KHPNFQKPK 571

  Fly  1073 GPR------QFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRG 1131
            .|:      .|.:.|..||  |.|....::..::: |....||:||:.|:.   |.|.:..    
 Worm   572 PPKGKQGDAHFAIVHYAGT--VRYNATNFLEKNKD-PLNDTAVALLKHSTD---NSLMLDI---- 626

  Fly  1132 SGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRN------SIMLQVKFTVDGIIDTLRRTGT 1190
                        .:..|:....:...::..|||.||.      ::.:..:.:::.:::.|.:|..
 Worm   627 ------------WQDYQTQEEAAEAAKAGQTAGGKRGKSSSFATVSMIYRESLNNLMNMLYQTHP 679

  Fly  1191 HFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPE 1255
            ||:.|.:              .:...|:|.:.|       .|:.:||..:.|||..|:.|.|||.
 Worm   680 HFIRCII--------------PNEKKASGVIDS-------ALVLNQLTCNGVLEGIRICRKGFPN 723

  Fly  1256 SVPLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDV------ASYRIGPSQILFRSGVLSELEA 1314
            .:...:|..|:.:||.|.|...|.....:..::::.|      ..:::|.::|.|::|||::||.
 Worm   724 RMLYPDFKHRYAILAADAAKESDPKKASVGILDKISVDGNLTDEEFKVGETKIFFKAGVLAKLED 788

  Fly  1315 KRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLL 1379
            .||.:||..:...|:..|.|||:.::.:|..|:..:..:||||:|:..:|.|.|::|..:|.|:|
 Worm   789 LRDEILSRIVTMFQSRIRSYLAKAEVRRRYEQQTGLLVVQRNVRAWCTLRTWEWFKLFGKVKPML 853

  Fly  1380 NVHRTEEQLKTANEELLMLRAKLEKIE--CDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATE 1442
            ...:.:|.:..       |..|::|:|  ..|.|: |.:| ||::::    ||.||::...::  
 Worm   854 KAGKEQEAMGE-------LAVKIQKLEEAVQRGEI-ARSQ-LESQVA----DLVEEKNALFLS-- 903

  Fly  1443 RLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYK 1507
             ||.|.|       .|.|...:.:.|.:....||.:|    ||:.|..||....|||      ..
 Worm   904 -LETEKA-------NLADAEERNEKLNQLKATLESKL----SDITGQLEDMQERNED------LA 950

  Fly  1508 LKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLS------DAYEEVVEQRQVVGQWKRK 1566
            .:.::..:||..||:     |..|||  ::|:|..:.|.|      ...:|:..|.:.|.:..::
 Worm   951 RQKKKTDQELSDTKK-----HVQDLE--LSLRKAEQEKQSRDHNIRSLQDEMANQDEAVAKLNKE 1008

  Fly  1567 AQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK-------- 1623
            .:........|...|:.:..:.|.|||.:.|.:.:...|::.:.:|::::....:.|        
 Worm  1009 KKHQEESNRKLNEDLQSEEDKVNHLEKIRNKLEQQMDELEENIDREKRSRGDIEKAKRKVEGDLK 1073

  Fly  1624 ------DVLQAEKFTLEQTLADTRLDLEFKEEKL-------ASLQRELEEMTF-GGGTEEEFAQL 1674
                  |.:..:|..:|.||.....||.....||       |.|||.::|:|. ....|||....
 Worm  1074 VAQENIDEITKQKHDVETTLKRKEEDLHHTNAKLAENNSIIAKLQRLIKELTARNAELEEELEAE 1138

  Fly  1675 RRSKNETERRAKEQEEELDEM-----------AGQIQL-----LEQAKLR--------------- 1708
            |.|:.:::|...|.|.||:|:           |.|::.     .|.||||               
 Worm  1139 RNSRQKSDRSRSEAERELEELTERLEQQGGATAAQLEANKKREAEIAKLRREKEEDSLNHETAIS 1203

  Fly  1709 ----------LEMT--LETMRK-----EARRESQQRD-EELE-----EVRGNG--YKKIKALECQ 1748
                      .|:|  |||::|     ||.:...||| ||.:     |||...  .|.:|.:|.|
 Worm  1204 SLRKRHGDSVAELTEQLETLQKLKAKSEAEKSKLQRDLEESQHATDSEVRSRQDLEKALKTIEVQ 1268

  Fly  1749 ---LETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLE 1810
               |:|:.:|::..|::...|:.||:: |:.| ::|..||..||  ...|.:.|:.|   |:||:
 Worm  1269 YSELQTKADEQSRQLQDFAALKNRLNN-ENSD-LNRSLEEMDNQ--LNSLHRLKSTL---QSQLD 1326

  Fly  1811 RLKADTPGKTLIRQ---------------LRNQL-EDAESARSL--------------------- 1838
            ..:.:...::..||               ||..| |:|||...|                     
 Worm  1327 ETRRNYDEESRERQALAATAKNLEHENTILREHLDEEAESKADLTRQISKLNAEIQQWKARFDSE 1391

  Fly  1839 ----------AMKARQTAEAELTEVQ---------------AMFDESHRARNDAEERANAA---H 1875
                      |.||.|....|||:..               .:..:...|::|.|:.|...   .
 Worm  1392 GLNKLEEIEAAKKALQLKVQELTDTNEGLFAKIASQEKVRFKLMQDLDDAQSDVEKAAAQVAFYE 1456

  Fly  1876 RDRAELQAQIEENEEELGELMKKYSATV---KQLNTEQINVSEAEFKLNE----MEAERNNLKEQ 1933
            :.|.:.::.|.|.:::..:|..:..|..   :||:|:......|..:|.|    ...|..:|.::
 Worm  1457 KHRRQFESIIAEWKKKTDDLSSELDAAQRDNRQLSTDLFKAKTANDELAEYLDSTRRENKSLAQE 1521

  Fly  1934 VAELQHRLDNVENLGDPSMAMMSK---RLELRTKEL-------ESRLELEQATRARLEVQVNRHK 1988
            |.:|..:|..    |..|:|.:.|   :||:..:||       |:.||.|:|...|.:::|::.:
 Worm  1522 VKDLTDQLGE----GGRSVAELQKIVRKLEVEKEELQKALDEAEAALEAEEAKVLRAQIEVSQIR 1582

  Fly  1989 EALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESE 2053
            ..:||...|      :|.:.::..:..|::|..|:....|.:.:::|:|..:|.||..:      
 Worm  1583 SEIEKRIQE------KEEEFENTRRNHQRALESMQATLEAETKQKEEALRIKKKLESDI------ 1635

  Fly  2054 GAALKNDLRLAL----QRIADLQ----------QAMEEEGEEELSESDE 2088
                 |||.:||    :..||.|          |.::.:.|||..:.||
 Worm  1636 -----NDLEIALDHANRAYADAQKTIKKYMETVQELQFQIEEEQRQKDE 1679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 202/825 (24%)
MYSc_Myo18 575..1305 CDD:276837 187/794 (24%)
GBP_C <1540..1750 CDD:303769 69/296 (23%)
COG1340 1565..1833 CDD:224259 89/364 (24%)
coiled coil 1723..1734 CDD:293879 5/16 (31%)
myo-3NP_506065.2 Myosin_N 36..73 CDD:280832 9/43 (21%)
Myosin_head 88..779 CDD:278492 193/806 (24%)
MYSc_class_II 100..779 CDD:276951 187/794 (24%)
Myosin_tail_1 857..1937 CDD:279860 210/891 (24%)
DUF4795 932..1090 CDD:292662 36/174 (21%)
SPEC 1186..1391 CDD:295325 53/211 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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