Protein Alignment Mhcl and myo-5

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_505094.1
• Gene: myo-5 / 179190
• WormBaseID: WBGene00019064
• Length: 1974
• Species: Caenorhabditis elegans
• Alignment Length: 1920
• Identity: 454/1920 - (23%)
• Similarity: 807/1920 - (42%)
• Gaps: 441/1920 - (22%)

  Fly   494 LEADVADASQPERVWLVH-RGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNS 557
            |.|........:.||:.. ..||.||       ..:..:....:.:...|.:.|:.:||.::.|.
 Worm    20 LAATTKKFDSKKNVWVADPEEGFIAA-------EIKSSKGDTVVVVTSKGVEKTIKKDDAQQMNP 77

  Fly   558 PALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCK 622
            |..:..||:..|.:||:|||||.|||||.|.:|:|.:|...:|:||...|.:|||.|..|:.|.:
 Worm    78 PKYEKTEDMANLTFLNDASVLHNLRQRYYSMMIYTYSGLFCVVINPYKRLPIYSESVCQMYLGKR 142

  Fly   623 TEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLAL-AAGAYNNFINAEK 686
            ..:||||:::::..|||::...|.:||::..|.||:||:.:.|..::|.|: .|...:|...::|
 Worm   143 RNEMPPHLFAVSDEAYRNMTNDRENQSMLITGESGAGKTENTKKVISYFAMVGASQQSNKKKSKK 207

  Fly   687 VNALCT----------ILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAG 741
            ..|..:          :||||||.||..|:|::|..:.:.:.|:..|::|.|.::..|.|:.|..
 Worm   208 DKAQVSLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNTGGKVAGADIEHYLLEKSRVI 272

  Fly   742 RRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFE 806
            ::...|.|:||..::.:.|...|:::|.|.....|  :.|:|.::...|......:.:.|.:||:
 Worm   273 KQAPGERSYHIFYQIYSDAVKGLREKLFLTRPIKE--YTFVSQAEVTIDGVDDKEEMLITDEAFD 335

  Fly   807 TLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAF 871
            .:...|.....:::|.|.|.|:|     :|......|.:.|.....::  |.|...|..:.|..|
 Worm   336 IMKFTATEKSELFAITAGIMHMG-----ELKFKQRPREEQAELEEGKE--GELACKLYCVESEKF 393

  Fly   872 GLTQPNAPNGGLSPSKSPTSDTGHEWA----------WECLEALVIGLYSEALAAVVALINRQIC 926
                       ::....|....|.||.          | .:.||...|::...:.::...|:.:
 Worm   394 -----------INALLKPRVKVGTEWVNKGQNLDQVNW-AVGALAKALFARMFSWLIRRCNKTL- 445

  Fly   927 TSSHTIAS---IMLIDTPGFQNPASCGQQVGATLADLRH------NYLQERLQMLFHHTTLVAPR 982
             .:..::.   |.::|..||:            :.||..      |::.|:||..|:|...|..:
 Worm   446 -DAQDLSRDFFIGVLDIAGFE------------IFDLNSFEQLWINFVNEKLQQFFNHHMFVLEQ 497

  Fly   983 DRYAQ-----ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAI 1042
            :.|.:     |.::..:||.: |     |.||:|.                  .|::.:||||.|
 Worm   498 EEYKREGIQWEFIDFGLDLQA-C-----IELIEKP------------------LGIVSMLDEECI 538

  Fly  1043 YPNSNDDTFLERL-FSHYGDREHHSLLRKCAGPR------QFVLHHLQGTNPVLYAVDGWVRHSR 1100
            .|.::|.|...:| ..|.|   .|...:|...|:      ...:.|..||  |.|.|.||:..::
 Worm   539 VPKASDLTLASKLNDQHLG---KHPNFQKPRPPKGKQAEAHLAIVHYAGT--VRYNVKGWLEKNK 598

  Fly  1101 EHPGIRNAVSLLQDSSREEINR-LYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAG 1164
            : |....||::|:.:...::.. |:....|:...|.      |..:|.:::.:......||.|
 Worm   599 D-PLNDTAVTVLKANKGNQLMADLWADYATQEDVAA------AAKDGKKAVGKKKGKSASFMT-- 654

  Fly  1165 VKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPS--SAAGQVSSEEEM 1227
                 :.:..:.:::.::..|.:|..||:.|.:                |:  ..||       |
 Worm   655 -----VSMMYRESLNKLMHMLHQTHPHFIRCII----------------PNELKKAG-------M 691

  Fly  1228 VNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLA-SNKDV--SVEQILAV-- 1287
            ::..|:.:||..:.|||..|:.|.|||..:|.|:|.:|:.:||.|.| :.||.  :.|:|.|.
 Worm   692 IDANLVLNQLTCNGVLEGIRICRKGFPNRMPFLDFKQRYAVLAADAAKAGKDPKDAGEKISAALI 756

  Fly  1288 --NELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAV 1350
              ..|....::.|.:::.|::|||:.||..||..|...:.:.|..||.|||:.:..::..|::.:
 Worm   757 KDGSLKQEEFQCGLTKVFFKAGVLAHLEELRDEALGKIMAKFQCACRHYLAQCEYKRKLDQKVGL 821

  Fly  1351 RCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAE 1415
            ..:|||::|:..:|.|.|::|..||.||:...:..|:.:...::..:|..:..:.|..|.:::||
 Worm   822 IVLQRNIRAWCTLRSWSWFKLFGRVKPLIKGSKKNEEFEALEKKFKVLEEEKTQEERKRKDMEAE 886

  Fly  1416 NQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKV-----KNLQETTEKL 1475
            |.:|||:...|.:.|.:||.::....||.....|::..|||::.:..:::     ||...|.:|.
 Worm   887 NARLEAEKQALLIQLEQERDSSAEGEERSAKLLAQKADLEKQMANMNDQLCDEEEKNAALTKQKK 951

  Fly  1476 EMELICAKSDLNGISED-EDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHD-LEQLVAL 1538
            ::|     .|..|:.:. .|.|..      :.|.:.|:.|::.:....:...|.:.: :.:|...
 Worm   952 KIE-----QDNEGLKKTVSDLETT------IKKQESEKQAKDHQIRSLQDEIQSQDEVISKLNKE 1005

  Fly  1539 KKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAE-- 1601
            |||.|.......|::..:...|....:...|:.:.:::|...||.:.......||::||.:.|
 Worm  1006 KKHQEEVNRKLLEDIQAEEDKVNHLNKTKAKLESTLDELEDTLEREKRGRQDCEKQRRKVEGELK 1070

  Fly  1602 -CQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFG- 1664
             .|.|.:.:.:.:..:|:..::||:          .|:..:..||.::..:|.|||:::|:...
 Worm  1071 IAQELIEELNRHKHEQEQVIKKKDI----------ELSSIQSRLEDEQSLVAKLQRQIKELLARI 1125

  Fly  1665 GGTEEEFAQLRRSKNETERRAKEQEEELDEM------AG-----QIQL-----LEQAKLRLEM-- 1711
            ...|||....|.|:::.|:...|.:.||:|:      ||     ||:|     .|.||||.::
 Worm  1126 QELEEELDAERNSRSKAEKARNEMQMELEELGDRLDEAGGATQAQIELNKKREAELAKLRQDLED 1190

  Fly  1712 ----------------------------TLETMRKEARRESQQRDEELEEV----------RGNG 1738
                                        |::.||.:..||...:..|::|:          |.|.
 Worm  1191 AAINSETSMAALRKKHNDAVAELSDQLDTIQKMRGKLEREKNDKQREVDELQQSADVEAKQRQNC 1255

  Fly  1739 YKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALL- 1802
            .:..|.||.||    .:.||...|:..|.:.|:.  .:::|..:     ||.|.|.|...:|.|
 Worm  1256 ERMAKQLEAQL----TDMTLKSDEQARLIQELTM--GKNKVHNE-----NQDLNRQLEDAEAQLC 1309

  Fly  1803 ------KDAQTQLERLKADTPGKTLIR---------------QLRNQLEDAESARSLAMKARQTA 1846
                  :...:|||.||.....:|..|               |.|..||:.:.|::...:....|
 Worm  1310 ALNRIKQQQHSQLEELKRTLDQETRERQSLHSQVSNYQLECEQFRESLEEEQDAKTDVQRQLSKA 1374

  Fly  1847 EAELTEVQAMFDES--HRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTE 1909
            .:|:.:.:|.|:..  .||....|.|....|:.: |:|.|:|...:::|.|.|........|...
 Worm  1375 NSEIQQWRAKFEGEGVSRAEELEETRRKLTHKVQ-EMQEQLENANQKIGTLEKNKQRLAHDLEDA 1438

  Fly  1910 QIN--------------------------------VSEAEFKLNEMEAE-------RNNL----- 1930
            |::                                |:|.|....|..|.       ||.|
 Worm  1439 QVDADRANSIASSLEKKQKGFDKVLDEWRRKCEALVAEVEQSQRETRAAATETFRLRNQLEESGE 1503

  Fly  1931 ------KEQVAELQHRLDNVENLGDPSMAM-----MSKRLELRTKEL-------ESRLELEQATR 1977
                  :|..|..|...|..:.||:...::     |.:|||:..:||       |..||.|:|..
 Worm  1504 QTEAVKRENKALAQELKDIADQLGEGGKSVHDLQKMRRRLEIEKEELQQALDEAECALEAEEAKV 1568

  Fly  1978 ARLEVQVNR----------------------HKEALEKLQ------------------------N 1996
            .|.:::|::                      |...:|.:|                        |
 Worm  1569 MRAQIEVSQIRSEIEKRLQEKEEEFENTRKNHSRTIESMQVSLETESRGRAELLKTKKKLEGDVN 1633

  Fly  1997 EV--------------------TQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRK 2041
            |:                    .|..:||:|.|  :::.|:||.:.|:..:....|.|.....::
 Worm  1634 ELEIALDHSNKLNVDGQKSMKKLQDTIRELQYQ--VEEEQRSLSESRDHANLAERRSQVLQQEKE 1696

  Fly  2042 DL-------EKKVEQMESEGAALK---------NDLRLALQR--IADLQQAMEEEGEEELSE--- 2085
            ||       |:...|.|.|.|.:|         |.|.||.:|  ..|| |.::.|.||.:|:
 Worm  1697 DLAIIYEQSERTRRQAELELAEVKDSVNELSNSNSLLLATKRKVEGDL-QLLQSEIEEAMSDAKT 1760

  Fly  2086 SDE-SLSSVGSISDLEDRLRPVHVKRSSQQSLNGS 2119
            ||| :..::...|.|.|.||.   ::....:||.|
 Worm  1761 SDEKAKKAIMDASKLADELRS---EQEHASNLNQS 1792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	410/1748 (23%)
		MYSc_Myo18	575..1305	CDD:276837	194/781 (25%)
myo-5	NP_505094.1	Myosin_N	28..71	CDD:460670	8/49 (16%)
		MYSc_class_II	95..776	CDD:276951	194/781 (25%)
		Myosin_tail_1	853..1933	CDD:460256	213/979 (22%)