DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh6

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_006518740.1	Gene:	Myh6 / 17888	MGIID:	97255	Length:	1939	Species:	Mus musculus

Alignment Length:	2024	Identity:	458/2024 - (22%)
Similarity:	777/2024 - (38%)	Gaps:	635/2024 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 NGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMA 605
            ||:.:|:.||.|.:||.|..|.:||:..|.:|:|.:||:.|::|||:.:|:|.:|...:.|||..
Mouse    65 NGKTVTIKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYK 129

  Fly   606 PLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNY 670
            .|.:|:.:||:.:||.|..:.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|
Mouse   130 WLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQY 194

  Fly   671 LALAAGAYNNFINAEKVNA-----------LCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQ 724
            .|..| |..:....|..||           ....||||||.||..|.|::|..:.:.:.|..||:
Mouse   195 FASIA-AIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258

  Fly   725 IASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ--- 786
            :|||.::..|.|:.|...:|..|.::||..::|:.....|...|.:.|  :...:.|:|..:
Mouse   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTN--NPYDYAFVSQGEVSV 321

  Fly   787 -KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPT 850
             .::|    :.:.:.|..||:.|:..|:...|::.:..||.|.|     .:......|.:.|.|.
Mouse   322 ASIDD----SEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYG-----NMKFKQKQREEQAEPD 377

  Fly   851 A---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSE 912
            .   |.|::.|:|:|..||..   ||..|....|    ::..|.....:..:..:.||...:|.:
Mouse   378 GTEDADKSAYLMGLNSADLLK---GLCHPRVKVG----NEYVTKGQSVQQVYYSIGALAKSVYEK 435

  Fly   913 ALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLF 973
            ....:|..||..:.|.......|.::|..||:    |          :...|..|:..|:||..|
Mouse   436 MFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN----------SFEQLCINFTNEKLQQFF 490

  Fly   974 HHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGM 1033
            :|...|..::.|.:|.:|.|     |||.: |     |.||:|.                  .|:
Mouse   491 NHHMFVLEQEEYKKEGIEWEFIDFGMDLQA-C-----IDLIEKP------------------MGI 531

  Fly  1034 LWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLYAVDGW 1095
            :.:|:||.::|.::|.||..:|: :|.|...:....|...|.::  |.|.|..||  |.|.:.||
Mouse   532 MSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGT--VDYNIMGW 594

  Fly  1096 VRHSREHPGIRNAVSLLQDSSREEINRLY-------IGSLTRGSGAMVFCGSFAGLEGTQSLRRV 1153
            :..::: |.....|.|.|.||.:.:..|:       .|...:|.|         |.:...|.:.|
Mouse   595 LEKNKD-PLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKG---------GKKKGSSFQTV 649

  Fly  1154 SSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAA 1218
            |::.|.                 .::.::..|:.|..|||.|.:              .:...|.
Mouse   650 SALHRE-----------------NLNKLMTNLKTTHPHFVRCII--------------PNERKAP 683

  Fly  1219 GQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNK 1277
            |       :::.||:..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....::
Mouse   684 G-------VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSR 741

  Fly  1278 DVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KK 1339
            . ..|::|...::|...|:.|.:::.|::|:|..||..||..||..|.::||..||.|.|   ||
Mouse   742 K-GAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKK 805

  Fly  1340 MSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEK 1404
            :.:||.   |:..||.|::||:.|::|||.:|..::.|||....||:::....||...::..|||
Mouse   806 IVERRD---ALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEK 867

  Fly  1405 IE-------------------------------------CDR----------------------- 1409
            .|                                     ||:
Mouse   868 SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEE 932

  Fly  1410 ---SEVKAENQKLEAKLSELTVD------------------------------------------ 1429
               :|:.|:.:|||.:.|||..|
Mouse   933 EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 997

  Fly  1430 ----------------------------------------------------------------- 1429

Mouse   998 KKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1062

  Fly  1430 -----------------------------------------------LAEERSTAHIATERLEAE 1447
                                                           |.|.::......|.||||
Mouse  1063 LTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAE 1127

  Fly  1448 TAERLKLEK-------------------------------------------------------- 1456
            ...|.|:||
Mouse  1128 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192

  Fly  1457 -----------ELGDQTNKVKNLQETTEKLEME-----------------LICAKSDLNGISED- 1492
                       |||:|   :.|||...:|||.|                 :|.||::|..:|..
Mouse  1193 ALRKKHADSVAELGEQ---IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254

  Fly  1493 EDAENEDGVGGGVYKLKYERVAREL-EFTKRRLHTQHEHD-----------------------LE 1533
            ||..||       |::|.|...|.| :||.:|...|.|:.                       .:
Mouse  1255 EDQANE-------YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312

  Fly  1534 QLVALKKHLEMK--------------------LSDAYEEVVE-----QRQV------VGQWKRKA 1567
            |:..||:.||.:                    |.:.|||.:|     ||.:      |.||:.|.
Mouse  1313 QMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKY 1377

  Fly  1568 Q-------------------------------------------KMTNEMNDLRMLLEEQNARNN 1589
            :                                           ::.||:.||.:.:|..||...
Mouse  1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1442

  Fly  1590 LLEKKQRKFD---AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLE-FKEEK 1650
            .|:||||.||   ||.:...:..:.|.::.::..|.   |..|.|.|:....::...|| ||.|.
Mouse  1443 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS---LSTELFKLKNAYEESLEHLETFKREN 1504

  Fly  1651 LASLQRELEEMT----FGGGTEEEFAQLRR----SKNETERRAKEQEEELDEMAGQIQLLEQAKL 1707
             .:||.|:.::|    .||....|..::|:    .|.|.:...:|.|..|:...|:|       |
Mouse  1505 -KNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKI-------L 1561

  Fly  1708 RLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSS 1772
            |.::....::.|..|:..::|||:|:.:.|..:.:.:|:..|:.|...|...||.|.::|..|:.
Mouse  1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNE 1626

  Fly  1773 ME-DRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLE---RLKADTPGKTLIRQLRNQLEDAE 1833
            || ...:.:|.|.||     ::.|:..:|.|||.|.||:   ....|......|.:.||.|
Mouse  1627 MEIQLSQANRIASEA-----QKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNL---- 1682

  Fly  1834 SARSLAMKARQTAEAELTEVQAMFDESHRARNDAE-------ERANAAHRDRAELQAQIEENEEE 1891
                        .:|||.|::|:.:::.|:|..||       ||....|.....|..|.::.|.:
Mouse  1683 ------------LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESD 1735

  Fly  1892 LGELMKKYSATVKQL-NTEQ---INVSEAEFKLNEMEAE----------RNNLKEQVAELQHRLD 1942
            |.:|..:....|::. |.|:   ..:::|.....|::.|          :.|:::.:.:||||||
Mouse  1736 LTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1800

  Fly  1943 NVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQ 2007
            ..|.:.........::||.|.:|||:.||.||...|.....:.:.:..:::|..:..:.|...|:
Mouse  1801 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMR 1865

  Fly  2008 AQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALK---NDLRLALQRIA 2069
            .||::.|.|..::..:.:......:...:|::.:.::.::::.|......:   |.||...:.|.
Mouse  1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1930

  Fly  2070 DLQQAMEEE 2078
            ..|:..:||
Mouse  1931 AKQKMHDEE 1939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	209/803 (26%)
		MYSc_Myo18	575..1305	CDD:276837	196/772 (25%)
		GBP_C	<1540..1750	CDD:303769	65/295 (22%)
		COG1340	1565..1833	CDD:224259	80/326 (25%)
		coiled coil	1723..1734	CDD:293879	4/10 (40%)
Myh6	XP_006518740.1	Myosin_N	34..72	CDD:367160	3/6 (50%)
		MYSc_class_II	99..768	CDD:276951	196/772 (25%)
		Myosin_tail_1	848..1925	CDD:366712	208/1118 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810