Protein Alignment Mhcl and Myh6

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_006518740.1
• Gene: Myh6 / 17888
• MGIID: 97255
• Length: 1939
• Species: Mus musculus
• Alignment Length: 707
• Identity: 124/707 - (17%)
• Similarity: 214/707 - (30%)
• Gaps: 257/707 - (36%)

  Fly    87 VDMKLASSESPNSNFYVAQCMAHNIHLLPENTNKETKLKILEFIKSEDEVDCSMNLVPLSSNRPD 151
            :::.||::|    ...:||.:...     .:::.|.|:|.|..:..:::.:|   :|.|.....|
Mouse    35 LELSLATAE----QMRLAQVIFDK-----NDSDFEAKVKQLMEVTGKNQDEC---IVALHDCNGD 87

  Fly   152 YMLTSGVRQILKNLVSAVENSKSKNTRGRKSKIQSNLTPINEKSECKIIKRKNEKTPLLLLTVPM 216
                  |.:.:..|:....::.|..|.|.|.|        |...|....|...||.
Mouse    88 ------VNKAINTLLEGSSDTTSWETVGGKKK--------NFGRESSENKENREKR--------- 129

  Fly   217 FLDPLTTSGTEIVKKASEWLTTGRNNVYNDKKFAFQKNTKSAVRSNFF--QKKGFEPLAKQKPKQ 279
                     ||  ::||.    ||.|  |::|      .:...|...|  ::.|.:.....||.:
Mouse   130 ---------TE--REASR----GRGN--NNRK------GRGGSRGREFKGEENGVDCSQGDKPSE 171

  Fly   280 SAQRAQVEVFQVEPGFDLTNLETLVTSSPICIIRGLGQAVYMDFSLF---DLQNVAGLDGEQVID 341
            ..:|.:...|....|                  ||.|:........|   |.......||.....
Mouse   172 RGKRTRGRGFGRGRG------------------RGAGRLSAQSMGTFNPADYSESMSTDGCGTKL 218

  Fly   342 VRRQRSQHSTKN----------------IKLAHTSKGSLEAAERKWNDE---ERIVEKRTLAEYA 387
            |..:.:|:.|..                .|.::..||:.:.:..:|..|   |.:.|.:.....:
Mouse   219 VVWEAAQNGTDEGPEGLAKPHSISQELPSKSSYGLKGAWKNSVEEWTAEDWTEDLSETKVFTASS 283

  Fly   388 VNYDMM----EKIGWKCVEH-------AAYKNNFE--NQAGFVQEAVDAYMKYQLPLSPTAV--- 436
            ...|..    :.|....:.|       ||..|:||  .|.||.|..|....::..|.:|...
Mouse   284 APADNHVPPGQSIDLVALLHKPAPPTQAAEVNSFETSQQQGFGQALVFTNSQHNNPTAPGTASST 348

  Fly   437 ------------------------------NGELYDR---------------------------- 443
                                          |.::.|:
Mouse   349 PASSYSPQSLSSVLGSGFGELAQSKMVNISNSQILDKLKPPGLSPFPAASSTQQNDNASPPATTA 413

  Fly   444 ------TYPLTSFATNVDLKEEQKFQPLIQE------------------LDKLPNFLKTK----- 479
                  :.|..|..:::|.|.:.:..|::.:                  |:..|:..|.:
Mouse   414 AWDLKPSAPQPSVLSHLDFKSQPEPSPVLSQLSQRQQQQNQAVSVPPPGLESFPSQTKHRESAPG 478

  Fly   480 ---GGLNEYIK------ESIGGVNEVQ-------------------MYFKQPGSRTTCHIENQAI 516
               ..:|..::      |:|...::.|                   ...:.|||.....: |...
Mouse   479 DGPSTVNRLLQLPTMAVENIVSAHQPQPKHIKLPKRRIPPASKVPVSAVEMPGSADITGL-NVQF 542

  Fly   517 GSLNLNLGPGKCIW--YAVASEHSAKFEQLLMKKNLWPYDSVLWPNEEELLNWGIPVMKFIQETD 579
            |:|.....|....:  .|.|||:|::....|..|:|           .|.||...|:...:|...
Mouse   543 GALEFGSEPSLSEFGSTASASENSSQLPISLYPKSL-----------SEPLNASFPMTSAVQNPT 596

  Fly   580 DTVYVGTGTYHWVQSIGFTGNVSWNIAESTFDQFAMAALVHDHNTEQSYDSVLPIIP 636
            .|..|.|.:.....|:..|..|:   ..|::||    :.||   |..:|.|  |..|
Mouse   597 YTTSVITSSTLTSSSVSSTSPVT---TCSSYDQ----SSVH---TRIAYQS--PASP 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948	23/120 (19%)
		COG5022	541..2019	CDD:227355	24/96 (25%)
		MYSc_Myo18	575..1305	CDD:276837	17/62 (27%)
Myh6	XP_006518740.1	Myosin_N	32..76	CDD:460670	9/49 (18%)
		MYSc_class_II	99..768	CDD:276951	109/625 (17%)
		Myosin_tail_1	848..1925	CDD:460256