DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Myh2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus


Alignment Length:1993 Identity:469/1993 - (23%)
Similarity:839/1993 - (42%) Gaps:494/1993 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..|||.||.:...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
Mouse    67 GATLTVKEDQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
Mouse   132 LPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQ 724
            |..|            |.....:..:.::| ..:||||||.||..|.|::|..:.:.:.|..||:
Mouse   197 ATIAVTGDKKKEEATSGKMQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 260

  Fly   725 IASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ--- 786
            :|||.::..|.|:.|...:|..|.|:||..::.:.....|.:.|.:  .|:...:||:|..:   
Mouse   261 LASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLI--TTNPYDYPFVSQGEISV 323

  Fly   787 -KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANP- 849
             .::|:    .:.|.|..|.:.|.........|:.:..|:.|.|     .:......|.:.|.| 
Mouse   324 ASIDDQ----EELMATDSAIDILGFTNDEKVSIYKLTGAVMHYG-----NMKFKQKQREEQAEPD 379

  Fly   850 --TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSE 912
              ..|.||:.|.|:|..||..|   |..|....|....:|..|.    |.....:.||...:|.:
Mouse   380 GTEVADKAAYLQGLNSADLLKA---LCYPRVKVGNEYVTKGQTV----EQVTNAVGALAKAMYEK 437

  Fly   913 ALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLF 973
            ....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:||..|
Mouse   438 MFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEKLQQFF 492

  Fly   974 HHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGM 1033
            :|...|..::.|.:|     .::..||||: |     |.||:|.                  .|:
Mouse   493 NHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP------------------MGI 533

  Fly  1034 LWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLYAVDGW 1095
            ..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||  |.|.:.||
Mouse   534 FSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGT--VDYNITGW 596

  Fly  1096 VRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSF 1160
            :..::: |.....|.|.|.||.:.:..|:.|:.|..:.|     |..|.....:.::.||.:   
Mouse   597 LDKNKD-PLNETVVGLYQKSSVKTLAYLFSGAQTAEAEA-----SSGGAAKKGAKKKGSSFQ--- 652

  Fly  1161 TTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEE 1225
            |.:.:.|.::        :.::..||.|..|||.|.:                |:......:.|.
Mouse   653 TVSALFRENL--------NKLMTNLRSTHPHFVRCII----------------PNETKTPGAMEH 693

  Fly  1226 EMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDVSVEQI 1284
            |:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..| |::
Mouse   694 ELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYIDSKKAS-EKL 752

  Fly  1285 LAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMSQRRVQ 1346
            |...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|||   :||.:||. 
Mouse   753 LGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFLARVEYQKMVERRE- 816

  Fly  1347 ELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSE 1411
              ::.|||.|::||:.|:.|||.:|..::.|||....||:::.|..||....:..|.|.|..|.|
Mouse   817 --SIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDDLAKSEAKRKE 879

  Fly  1412 ------------------VKAENQ-----------------KLEAKLSELTVDLAEERSTAHIAT 1441
                              |:||.:                 :||||:.|:| :.||:.       
Mouse   880 LEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVT-ERAEDE------- 936

  Fly  1442 ERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGV 1505
            |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|:     ..|:...:
Mouse   937 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-----MAGLDETI 996

  Fly  1506 YKLKYERVA---------RELE--------FTKRRLHTQHEHD-----LEQ-------LVALKKH 1541
            .||..|:.|         .:|:        .||.::..:.:.|     |||       |...|:.
Mouse   997 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1061

  Fly  1542 LEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQ 1606
            ||..|..|.|.:::......|...:.:|...||::|:..:|::.|....|:||.::..|..:.|:
Mouse  1062 LEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELE 1126

  Fly  1607 DAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKLASLQ---RELEEMTFG 1664
            :.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.|..|   |:|||.|..
Mouse  1127 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1191

  Fly  1665 ----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTL 1713
                            ....|:...|:|.|.:.|:...|.:.|:|::|..::.:.:||..||...
Mouse  1192 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1256

  Fly  1714 ETMRKE-----ARRESQQR-----------------------DE-----------------ELEE 1733
            .|:..:     ::.|.|||                       ||                 ::||
Mouse  1257 RTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1321

  Fly  1734 VRGNGYKKIKAL------------ECQL---------------------------------ETEH 1753
            ::....:::||.            :|.|                                 ||:.
Mouse  1322 LKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTKYETDA 1386

  Fly  1754 EERTLLLRE-KHELERRLSSMED---------------RDRVDRDAEE-------------ALNQ 1789
            .:||..|.| |.:|.:||.:.|:               :.|:..:.|:             ||::
Mouse  1387 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1451

  Fly  1790 KLRR-------------------------------DLRKYKALLKDAQTQLERLKADTPGKTLIR 1823
            |.|.                               :|.|.|...:::..|||.||.:  .|.|.:
Mouse  1452 KQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRE--NKNLQQ 1514

  Fly  1824 QLRNQLED-AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRD----RAEL 1881
            ::.:..|. ||..:.:  ..|.::..|.|..|:||..:|:..:....|.:......:    ::|:
Mouse  1515 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEI 1579

  Fly  1882 QAQIEENEEELGELMKKYSATVKQLNT----------EQINV-SEAEFKLNEMEAERNNLKEQVA 1935
            ..:|.|.:||:.:|.:.:...|:.:.:          :.|.: .:.|..|||||.:.|:.....|
Mouse  1580 DRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAA 1644

  Fly  1936 E--------------LQHRLDNV----ENLGDPSMAMMSKRLELRTKELES-RLELEQATRAR-- 1979
            |              .|..||:.    |:|.: .:||:.:|..|...|:|. |..|||..|:|  
Mouse  1645 EALRNYRNTQGILKDTQLHLDDALRGQEDLKE-QLAMVERRANLLQAEIEELRATLEQTERSRKI 1708

  Fly  1980 --------------LEVQVNRHKEALEKLQNEVT--QSKMREM--QAQDVIKKSQKSLRD---MR 2023
                          |..|........:||:.:::  |.:|.::  :|::..:|::|::.|   |.
Mouse  1709 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMA 1773

  Fly  2024 EEFHAVSSREQESLTRRKDLEKKVEQM---------ESEGAAL---KNDLRLALQRIADLQQAME 2076
            ||.    .:||::....:.::|.:||.         |:|..||   |..::....|:.:|:..:|
Mouse  1774 EEL----KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1834

  Fly  2077 EEGE----------------EELS-ESDESLSSVGSISDLEDRL--RPVHVKRSSQQSLNGSIGG 2122
            .|.:                :||: :::|...::..:.||.|:|  :....||.::::...|   
Mouse  1835 SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS--- 1896

  Fly  2123 GGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAI 2165
              .:.:|..|.:..|.::...|..:   :...::||.:.::.:
Mouse  1897 --NTNLSKFRKIQHELEEAEERADI---AESQVNKLRVKSREV 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 211/797 (26%)
MYSc_Myo18 575..1305 CDD:276837 199/766 (26%)
GBP_C <1540..1750 CDD:303769 57/322 (18%)
COG1340 1565..1833 CDD:224259 79/441 (18%)
coiled coil 1723..1734 CDD:293879 7/50 (14%)
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832 3/5 (60%)
Myosin_head 88..773 CDD:278492 203/778 (26%)
Motor_domain 100..773 CDD:277568 199/766 (26%)
Myosin_tail_1 853..1930 CDD:279860 221/1104 (20%)
RILP-like 968..1101 CDD:304877 28/137 (20%)
MIT_CorA-like <1302..>1414 CDD:294313 17/111 (15%)
DUF342 <1673..1770 CDD:302792 23/97 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.