Protein Alignment Mhcl and Myh2

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001034634.2
• Gene: Myh2 / 17882
• MGIID: 1339710
• Length: 1942
• Species: Mus musculus
• Alignment Length: 1993
• Identity: 469/1993 - (23%)
• Similarity: 839/1993 - (42%)
• Gaps: 494/1993 - (24%)

  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..|||.||.:...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
Mouse    67 GATLTVKEDQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
Mouse   132 LPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAA------------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQ 724
            |..|            |.....:..:.::| ..:||||||.||..|.|::|..:.:.:.|..||:
Mouse   197 ATIAVTGDKKKEEATSGKMQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 260

  Fly   725 IASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ--- 786
            :|||.::..|.|:.|...:|..|.|:||..::.:.....|.:.|.:  .|:...:||:|..:
Mouse   261 LASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLI--TTNPYDYPFVSQGEISV 323

  Fly   787 -KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANP- 849
             .::|:    .:.|.|..|.:.|.........|:.:..|:.|.|     .:......|.:.|.|
Mouse   324 ASIDDQ----EELMATDSAIDILGFTNDEKVSIYKLTGAVMHYG-----NMKFKQKQREEQAEPD 379

  Fly   850 --TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSE 912
              ..|.||:.|.|:|..||..|   |..|....|....:|..|.    |.....:.||...:|.:
Mouse   380 GTEVADKAAYLQGLNSADLLKA---LCYPRVKVGNEYVTKGQTV----EQVTNAVGALAKAMYEK 437

  Fly   913 ALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLF 973
            ....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:||..|
Mouse   438 MFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEKLQQFF 492

  Fly   974 HHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGM 1033
            :|...|..::.|.:|     .::..||||: |     |.||:|.                  .|:
Mouse   493 NHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP------------------MGI 533

  Fly  1034 LWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLYAVDGW 1095
            ..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||  |.|.:.||
Mouse   534 FSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGT--VDYNITGW 596

  Fly  1096 VRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSF 1160
            :..::: |.....|.|.|.||.:.:..|:.|:.|..:.|     |..|.....:.::.||.:
Mouse   597 LDKNKD-PLNETVVGLYQKSSVKTLAYLFSGAQTAEAEA-----SSGGAAKKGAKKKGSSFQ--- 652

  Fly  1161 TTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEE 1225
            |.:.:.|.::        :.::..||.|..|||.|.:                |:......:.|.
Mouse   653 TVSALFRENL--------NKLMTNLRSTHPHFVRCII----------------PNETKTPGAMEH 693

  Fly  1226 EMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDVSVEQI 1284
            |:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..| |::
Mouse   694 ELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYIDSKKAS-EKL 752

  Fly  1285 LAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMSQRRVQ 1346
            |...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|||   :||.:||.
Mouse   753 LGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFLARVEYQKMVERRE- 816

  Fly  1347 ELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSE 1411
              ::.|||.|::||:.|:.|||.:|..::.|||....||:::.|..||....:..|.|.|..|.|
Mouse   817 --SIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDDLAKSEAKRKE 879

  Fly  1412 ------------------VKAENQ-----------------KLEAKLSELTVDLAEERSTAHIAT 1441
                              |:||.:                 :||||:.|:| :.||:.
Mouse   880 LEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVT-ERAEDE------- 936

  Fly  1442 ERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGV 1505
            |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|:     ..|:...:
Mouse   937 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-----MAGLDETI 996

  Fly  1506 YKLKYERVA---------RELE--------FTKRRLHTQHEHD-----LEQ-------LVALKKH 1541
            .||..|:.|         .:|:        .||.::..:.:.|     |||       |...|:.
Mouse   997 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1061

  Fly  1542 LEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQ 1606
            ||..|..|.|.:::......|...:.:|...||::|:..:|::.|....|:||.::..|..:.|:
Mouse  1062 LEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELE 1126

  Fly  1607 DAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKLASLQ---RELEEMTFG 1664
            :.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.|..|   |:|||.|..
Mouse  1127 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1191

  Fly  1665 ----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTL 1713
                            ....|:...|:|.|.:.|:...|.:.|:|::|..::.:.:||..||...
Mouse  1192 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1256

  Fly  1714 ETMRKE-----ARRESQQR-----------------------DE-----------------ELEE 1733
            .|:..:     ::.|.|||                       ||                 ::||
Mouse  1257 RTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1321

  Fly  1734 VRGNGYKKIKAL------------ECQL---------------------------------ETEH 1753
            ::....:::||.            :|.|                                 ||:.
Mouse  1322 LKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTKYETDA 1386

  Fly  1754 EERTLLLRE-KHELERRLSSMED---------------RDRVDRDAEE-------------ALNQ 1789
            .:||..|.| |.:|.:||.:.|:               :.|:..:.|:             ||::
Mouse  1387 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1451

  Fly  1790 KLRR-------------------------------DLRKYKALLKDAQTQLERLKADTPGKTLIR 1823
            |.|.                               :|.|.|...:::..|||.||.:  .|.|.:
Mouse  1452 KQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRE--NKNLQQ 1514

  Fly  1824 QLRNQLED-AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRD----RAEL 1881
            ::.:..|. ||..:.:  ..|.::..|.|..|:||..:|:..:....|.:......:    ::|:
Mouse  1515 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEI 1579

  Fly  1882 QAQIEENEEELGELMKKYSATVKQLNT----------EQINV-SEAEFKLNEMEAERNNLKEQVA 1935
            ..:|.|.:||:.:|.:.:...|:.:.:          :.|.: .:.|..|||||.:.|:.....|
Mouse  1580 DRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAA 1644

  Fly  1936 E--------------LQHRLDNV----ENLGDPSMAMMSKRLELRTKELES-RLELEQATRAR-- 1979
            |              .|..||:.    |:|.: .:||:.:|..|...|:|. |..|||..|:|
Mouse  1645 EALRNYRNTQGILKDTQLHLDDALRGQEDLKE-QLAMVERRANLLQAEIEELRATLEQTERSRKI 1708

  Fly  1980 --------------LEVQVNRHKEALEKLQNEVT--QSKMREM--QAQDVIKKSQKSLRD---MR 2023
                          |..|........:||:.:::  |.:|.::  :|::..:|::|::.|   |.
Mouse  1709 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMA 1773

  Fly  2024 EEFHAVSSREQESLTRRKDLEKKVEQM---------ESEGAAL---KNDLRLALQRIADLQQAME 2076
            ||.    .:||::....:.::|.:||.         |:|..||   |..::....|:.:|:..:|
Mouse  1774 EEL----KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1834

  Fly  2077 EEGE----------------EELS-ESDESLSSVGSISDLEDRL--RPVHVKRSSQQSLNGSIGG 2122
            .|.:                :||: :::|...::..:.||.|:|  :....||.::::...|
Mouse  1835 SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS--- 1896

  Fly  2123 GGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAI 2165
              .:.:|..|.:..|.::...|..:   :...::||.:.::.:
Mouse  1897 --NTNLSKFRKIQHELEEAEERADI---AESQVNKLRVKSREV 1934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	435/1811 (24%)
		MYSc_Myo18	575..1305	CDD:276837	199/766 (26%)
Myh2	NP_001034634.2	Myosin_N	33..77	CDD:460670	6/9 (67%)
		Motor_domain	100..773	CDD:473979	199/766 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	662..684		8/45 (18%)
		Myosin_tail_1	853..1930	CDD:460256	221/1104 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1130..1175		7/44 (16%)