DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Myh11

DIOPT Version :10

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001389724.1 Gene:Myh11 / 17880 MGIID:102643 Length:1979 Species:Mus musculus


Alignment Length:407 Identity:70/407 - (17%)
Similarity:135/407 - (33%) Gaps:120/407 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 KNLVSAVENSKSKNTRGRKSKIQ---SNLTPINEKSECKIIKRKNEKTPLLLLTVPMFLDPLTTS 224
            :::::....:|:.....|:..:.   :::|..|..|..:::|.|..:..:.|.  |...||.:.:
Mouse    52 ESIINEYNRTKALKDETRRKMVNILAADMTEKNGGSPPRLVKEKYARGIVALF--PYLSDPYSKN 114

  Fly   225 GTEIVKKASE------W-LTTGRNNVYNDKKFAFQKNTKSAVRSN-------------------- 262
            |.|.......      | :.|.:.|:..:::.:|:.....|.|.:                    
Mouse   115 GFEHYYDGESGTGYLAWRIKTIQRNLAKERRGSFEGQVSYAERGSGGPTVARHSKFTSEIVLSED 179

  Fly   263 -------FFQKKGFEPLAKQKPKQSAQRAQVEVFQVEPGFDLTN---LETLVTSSPICI------ 311
                   |......|...|:|.|.:              ||...   |:.:.:|..:.|      
Mouse   180 ECKEAIAFMNHSADEDAIKKKMKLT--------------FDYRRKMVLDPMQSSDLLTIFPRFKD 230

  Fly   312 IRGLGQAVYMDFSLFDLQNVAGLDGEQVIDVRRQRSQHSTKNIKLAHTSKGSLEAAERKWNDEE- 375
            |:||   :..||.|...:.|:|...|:.....:::.....|.:......:..|.|||...:|.| 
Mouse   231 IKGL---IEQDFVLMFGEGVSGKLLEKWTTAFKKKVIQQCKRLPATSDLQELLLAAESLRDDTED 292

  Fly   376 --RIVEKRTLAEYAVNYDMME----------KIGWKCVEH--AAYK---NNFENQAGFVQEAVDA 423
              .||....||...:...::.          |:.....|:  ..:|   .|.|.|...:..:...
Mouse   293 DVHIVWDSDLASVLLLLHLIPPSAQGRKRPGKVSASQAENHLVVFKKSGTNIEEQLQDISASAQP 357

  Fly   424 YM------------------KYQLPLSPTAVNG---ELYDRTYPL-TSFAT-------------- 452
            |:                  ::.:|...|:..|   ||:...|.. ||:.|              
Mouse   358 YLLAVGPQKDSIHQFFIILDQHAIPCKSTSSLGAFDELFKAHYVFGTSYNTMLHNMYTFIQTTVY 422

  Fly   453 NVDLKEEQKFQPLIQEL 469
            |:|: .:.|..|.:.|:
Mouse   423 NIDV-GKVKESPRVAEV 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_canonical 337..426 CDD:483948 19/124 (15%)
COG5022 541..2019 CDD:227355
MYSc_Myo18 575..1305 CDD:276837
Myh11NP_001389724.1 Myosin_N 32..76 CDD:460670 2/23 (9%)
MYSc_class_II 99..778 CDD:276951 63/360 (18%)
Actin-binding. /evidence=ECO:0000250 668..690
Actin-binding. /evidence=ECO:0000250 769..783
Myosin_tail_1 855..1935 CDD:460256
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1804
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1874..1979
C-terminal 1942..1979
Blue background indicates that the domain is not in the aligned region.

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