Protein Alignment Mhcl and Myh1

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_109604.1
• Gene: Myh1 / 17879
• MGIID: 1339711
• Length: 1942
• Species: Mus musculus
• Alignment Length: 596
• Identity: 118/596 - (19%)
• Similarity: 199/596 - (33%)
• Gaps: 189/596 - (31%)

  Fly    51 KTLTLPDSPSRKRKAPNDESSTFKIPKTEDPANNVEVDMKLASSESPNSNFY--VAQCMAH---- 109
            |:..:..||:.||::|:.:..          |||.          |.|..|.  |.|.:..
Mouse   902 KSSVIKHSPTVKRESPSPQGR----------ANNT----------SENQQFLKEVVQSVLEGQGV 946

  Fly   110 ------NIHLLPENTNKETKLKILEFIKS--EDEVDCSMNLV-PLSSNRPDYMLTSGVRQILKNL 165
                  .:..|.|  |::.::.:|..:..  :.|.|....:: .:..||..|   .|:..|||..
Mouse   947 GWLNMKKVRRLLE--NEQLRVFVLSKLNRAVQSEEDAQQEVIRDVEINRKVY---KGMLDILKCT 1006

  Fly   166 VSAVENSKSKNTRGRKSKIQSNLTPINEKSECK-IIKRKNEKTPLL------------------- 210
            ||::|:|.:....|..:.:.|.|.......:.| ..|||...|..|
Mouse  1007 VSSLEHSYTNAGLGGMASVFSLLEIARTHYQTKDPEKRKRSPTEGLSSPGSKESPSGRMESARAA 1071

  Fly   211 -LLTVPMFLDPLTTSGTEIVKKASEWLTTGRNNVYNDKKFAFQKNTKSAVRSNFFQK---KGFEP 271
             :|.||....|..:||     |:|....|   ...|::.|.......|..:.|..||   |....
Mouse  1072 GVLLVPRIQLPPPSSG-----KSSRQFDT---RSLNEENFIASIELWSKHQDNRKQKALEKEQSG 1128

  Fly   272 LAKQKPKQSAQRAQVE---------------VFQVEPGFDLTNLETLVTSSPICIIRGL------ 315
            |.|:|......:.:||               ...|..|...::.::|.:|.|..:.|..
Mouse  1129 LNKRKSGADGVKQRVEGGDTEEKKSQISADSGLSVTSGSQKSDTDSLASSEPPALTRSTSQDSEA 1193

  Fly   316 --------GQAVYMDFSLFDLQNVAGLDGEQVIDVRRQRSQHSTKNIKLAHTSKGSLEAAERKWN 372
                    |:.:..|   .||.:.|| ||     :..:..||       .:.|:|:|..:|.:.|
Mouse  1194 STVVSNSSGETLGAD---SDLSSTAG-DG-----LTGRHGQH-------LNLSRGTLSDSEIETN 1242

  Fly   373 DEERIVEKRTLAEYAVNYDMMEKIG-------------------------------WKCVEHAAY 406
            .....|..:|   :.:...:.|.:|                               |..:|.||.
Mouse  1243 PATSSVFGKT---HKLKPGVKEPVGVNKAAPAPPVEDVSMRIYLCEGLLGRDKSSVWDQLEDAAM 1304

  Fly   407 --------KNNFENQAGFVQEA-VDAYMKYQLPLSPTAVNGELYDRTYPLTSF-ATNVDLKEEQK 461
                    ::...:|..|.::| :||.|..:..:.......|:.||...|... ...::..|::.
Mouse  1305 ETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRL 1369

  Fly   462 FQPLIQELDKLPNFLKTKGGLNEYIKE--------SIG-----GVNEV----------QMYFKQP 503
            ...|:..:  :...|..|.|.|:..|:        .||     .:|||          ::..:..
Mouse  1370 LATLLHNM--IAYMLMMKVGKNDIRKKVRRLMGKSHIGLTHSQEINEVLDRLAHLSGRELSIRPS 1432

  Fly   504 GSRTTCHIENQ 514
            |||   ||:.|
Mouse  1433 GSR---HIKKQ 1440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948	20/128 (16%)
		COG5022	541..2019	CDD:227355
		MYSc_Myo18	575..1305	CDD:276837
Myh1	NP_109604.1	Myosin_N	33..77	CDD:460670
		MYSc_Myh1_mammals	100..773	CDD:276875
		Actin-binding. /evidence=ECO:0000250	662..684
		Actin-binding. /evidence=ECO:0000250	764..778
		Myosin_tail_1	853..1930	CDD:460256	118/596 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1175		2/18 (11%)