DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and nmy-3

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_501620.2 Gene:nmy-3 / 177750 WormBaseID:WBGene00012437 Length:1464 Species:Caenorhabditis elegans


Alignment Length:1644 Identity:384/1644 - (23%)
Similarity:707/1644 - (43%) Gaps:341/1644 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 EQLTVDEDDVEKQNS--PAL-DLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPM 604
            ||...::..:||...  |:| :..||:|.|...|.|:||:.|:.||.||:|||..|...:|:||.
 Worm    62 EQGFFEKKRIEKTKCEVPSLNNYSEDLCTLTQPNAATVLNALKIRYTSNVIHTFCGLFCVVINPW 126

  Fly   605 APLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALN 669
            ..:.:||::|..:::  ...|:||||||:||.|:..:::..|:||::..|.||:||:.:.|..::
 Worm   127 RNIPIYSDEVKQLYQ--LQNDLPPHVYSVAQNAFHGILKGGRNQSILITGESGAGKTENTKKIID 189

  Fly   670 YLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLL 734
            :: |::...||.| .:.|.....:|||.||.:|..|||::|..:.:.::||:..::..|.::..|
 Worm   190 FI-LSSSVSNNTI-GDCVVTSGVLLEAMGNARTTHNSNSSRFGKFIRIEFDENSKLIGAKIECYL 252

  Fly   735 PERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAAND-- 797
            .|:.|...:...:.:|||..::|:             |........|:.||:|:.:.....||  
 Worm   253 LEKSRVVFQSDGDRNFHIFYQMLS-------------NYFDNPHKSFLKLSKKVNEYKYLRNDDS 304

  Fly   798 -------FMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFA-NPTAARK 854
                   ...|.:||..:.:..:....|:.||:|:..:   |..|.|..|.....|. :......
 Worm   305 MIDDAETAKMTDEAFTRIGLSEEEKIWIFQILSAVLWI---GDIKFGERSGLDVSFVESMQEVDN 366

  Fly   855 ASGLLGVNLEDLSSAAFGLTQPN--------APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYS 911
            .:.||.:....|..|   ||||.        ..|..|:.:.|..|            |:...||.
 Worm   367 IAELLEMKSSKLVDA---LTQPTIKVHDKLIRKNQNLAKTLSSAS------------AMAKILYE 416

  Fly   912 EALAAVVALIN--------RQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNY 964
            .....:|...|        ...|..|..||   ::|..||:    |          :......||
 Worm   417 RLFGWIVKRCNDAFSVDDTESTCRLSRFIA---VLDIAGFEIIEKN----------SFEQFCINY 468

  Fly   965 LQERLQMLFHHTTLVAPRDRYAQELVE-IEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREH 1028
            ..|:||..|:|......:..|.:|.:: .:::.|:  |..|.|.||:|.                
 Worm   469 TNEKLQQFFNHFMFAKEQSDYLEEGIKWTQVNFAN--HLQPTIDLIEKP---------------- 515

  Fly  1029 DRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDR---EHHSLLRKCAGPRQFVLHHLQGTNPVLY 1090
              .|:|..|:||.:.||.::.:.||:|.|:..:.   :.....:||:..|.|.:.|..|  .|.|
 Worm   516 --MGILSFLEEECVVPNGSEKSLLEKLCSNLSNDSSFKKSKQTQKCSTIRHFYVQHYAG--EVHY 576

  Fly  1091 AVDGWVRHSREHPGIRNAV-SLLQDSSREEINRLY----IGSL-TRGSGAMVFCGSFAGLEGTQS 1149
            .:|||:..:|::  :..:| .:|..|:...:..|:    :.:| ||              .||  
 Worm   577 NIDGWLDKNRDN--VETSVLDILSQSTHPLLKLLFPPVPVNNLKTR--------------RGT-- 623

  Fly  1150 LRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSP 1214
                           :..:::....|..:..::|||..:..||:.|.                  
 Worm   624 ---------------ITNSTVSFLYKNQLQCLLDTLNSSSAHFIRCV------------------ 655

  Fly  1215 SSAAGQVSSEEEM---VNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASN 1276
                  ||:.|::   ::.||:.:||:.:.|||..|:.|.|:|..:...||:.|:.||..:...:
 Worm   656 ------VSNYEKLPGKIDAPLVLAQLKCNGVLEGIRICREGYPSRLSHSEFIERYSLLMKNKEQS 714

  Fly  1277 KDVSVEQ--ILAVNELDVAS--YRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR 1337
            |..|.::  .|...:..|..  |.:|.:::..:.||:||||.||:..:|..||.:||..|....:
 Worm   715 KGASEKEKCTLICQDAQVRKERYAVGKTKLFCKVGVISELETKRNNYISSFIILIQANIRYLNIQ 779

  Fly  1338 KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKL 1402
            |.:.:||.:..||..||.||:.|..:..|||:|:......|:..:|.:|:::....|.|.|..::
 Worm   780 KDLIERRKKLEAVVTIQDNVRQFAELSQWPWYRIYHLTRGLIPRNRDKERIEELENEKLKLEEEI 844

  Fly  1403 EKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKN 1467
            :::|....|...||    .|||.|                 |:.|.:|::|::|||         
 Worm   845 QEMEIKNEEALKEN----LKLSML-----------------LDREKSEKVKVQKEL--------- 879

  Fly  1468 LQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDL 1532
              |..||...|.:..|                                |.||.|    |..|  :
 Worm   880 --EEVEKQGREKLLEK--------------------------------EREFRK----TMEE--M 904

  Fly  1533 EQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRK 1597
            ||...:...||.|.::.:::|::...|:.:::||.:::..|..|    ||.:|.:   |.:.|.:
 Worm   905 EQNEEIFNVLERKYNEQHKKVMKMNDVLREYERKIEQLNMEKTD----LENENQK---LRETQNR 962

  Fly  1598 FDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEK---------LAS 1653
            .|:...:|:..|.::....:....:...|..|  ..||.|...:|:...::||         :..
 Worm   963 QDSHYSNLEKEVMEKSSLIDELQNQIQKLSDE--NNEQRLTIAKLETALEDEKARFARQNNTIGD 1025

  Fly  1654 LQRELEEMTFGGGTEEEFAQL----RRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLE 1714
            :|:.:.|:      .|:.|:.    ...:|.|.:..:|:|:..:|:....:::::...:::...|
 Worm  1026 MQKLISEL------NEKIARFDNIALNERNSTRKIEREKEKLNEELTTAKEIIQKQAKKIDELKE 1084

  Fly  1715 TMRKEARRESQQRDEELEEVRGNGYKKIKALEC--QLETEHEERTLLLREK-HELERRLSSMEDR 1776
            ..||. :.|:.:.:.:||:      |:....:|  :|:..|:||...:.:| .:::|:.|.:|:.
 Worm  1085 ECRKR-KNEASRLERKLED------KEAMMADCVKELKDSHKERLKEMEQKVEDVKRKNSKLENE 1142

  Fly  1777 DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLR-NQLEDAESARSLAM 1840
            :...:...|...::...| ..|      .::...||      .||.||.. ..:....|.|::.:
 Worm  1143 NSTQKSQIETFQRESSVD-SDY------GRSSSGRL------STLGRQYSLTSIGSFSSIRTVGL 1194

  Fly  1841 KARQTAEAELTEVQAMFDESHRARNDAEERANAA-HRDRAELQAQIEENEEELGELMKKYSA--T 1902
            .:|:.:.:::|  .:|:  |.|.|:...:..::. ...|:...:|:.|.|..:.||.|:.:|  |
 Worm  1195 GSRKDSISDMT--SSMY--SLRRRDSTYDMTSSTIGLQRSPSTSQVMEKERRILELEKEKAAINT 1255

  Fly  1903 VKQLNTEQINVSEAEFKLNEMEAE---------RNNLKEQVAELQHRLDNVENLGDPSMAMMSKR 1958
            ..||...:::|.:::....|.|.|         .|.|:|...:|.....|.:||     |:..|:
 Worm  1256 DLQLVKRELDVYKSQLSAVESEKESLQTANRKQSNQLQETTRQLNSAQKNADNL-----ALRLKK 1315

  Fly  1959 LELRTKELESRLELEQATRARLEVQVNRHK-----EALEKLQNEVTQSKM-----REMQAQDVIK 2013
            ......|.:.:.| |....::.|:.:.|.:     ||.|| :.|:.||:|     ..|:....:.
 Worm  1316 ALADCDEWKKKHE-ESIVESKTEILMERKRAMDRAEACEK-ETELKQSRMATIESARMELGGELA 1378

  Fly  2014 KSQKSLRDMREEFHAVSS--REQESL-----TRRKDLEKKVEQMESEGAALKNDLRLALQRIADL 2071
            ::|..|...|:....:..  :.||||     ..:.:|..::|.:..|..|||..:|...::|..|
 Worm  1379 RTQSELDRCRQIIIQLEENLKSQESLGNSFGRHQTNLNFEIENLRDENCALKAKIRRQYKQIELL 1443

  Fly  2072 QQAMEEEGEEELSESDESL 2090
            .|  ::|..:||:..:..:
 Worm  1444 TQ--QDETNDELNHFENKV 1460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 200/810 (25%)
MYSc_Myo18 575..1305 CDD:276837 186/776 (24%)
GBP_C <1540..1750 CDD:303769 42/224 (19%)
COG1340 1565..1833 CDD:224259 54/284 (19%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
nmy-3NP_501620.2 MYSc_class_II 97..747 CDD:276951 186/776 (24%)
Smc 864..>1463 CDD:224117 146/711 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160156847
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.740

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