DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myo-6

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001022590.1 Gene:myo-6 / 176764 WormBaseID:WBGene00009730 Length:1235 Species:Caenorhabditis elegans


Alignment Length:1535 Identity:369/1535 - (24%)
Similarity:646/1535 - (42%) Gaps:395/1535 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   468 RFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEEN 532
            ::.||::.|    ..:|..|:...:...|.|.||::         |..|||:.:       .|.:
 Worm    13 KYLRQAQDE----ALKEQAARRFDNKTHAWVPDAAE---------GFVTAAVAV-------QEGD 57

  Fly   533 KLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPT 597
            .|:. .:.:|....:...:|::.|....:..||:..|.:||||||||.|||||.|.:|:|.:|..
 Worm    58 NLTF-TMPDGTPKKLTRAEVQEINPAKFEKTEDMSNLTFLNEASVLHNLRQRYYSMMIYTYSGLF 121

  Fly   598 LLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKST 662
            .:.:||...|.:|::.|.||:...:..:||||:::::..|:|:::..:.:||::..|.||:||:.
 Worm   122 CVFINPYKMLPIYTDSVASMYVNKRRAEMPPHLFAVSDEAFRNMMSDKENQSMLITGESGAGKTE 186

  Fly   663 SFKHALNYLALAAGAYNNFINAE-----KVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQT 722
            :.|..:.|.|: .|:.|....:|     :|......:|||||..|..|.|::|..:.:.:.||:.
 Worm   187 NTKKVIAYFAM-IGSGNKDQKSESSLENQVVQANPAIEAFGNGATTRNYNSSRYGKFIRIHFDRK 250

  Fly   723 GQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHL-ENITSEDSHPFISLSQ 786
            |::....::..|.|:.|..::...|.|:||..:::...|  |::...| :||.   .:.|:|.::
 Worm   251 GKLVGGDIEHYLLEKSRVIKQAPGERSYHIFYQIMTQKA--LRERYGLSDNIR---DYKFVSQAE 310

  Fly   787 KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTART-QFANPT 850
            ..........::..|..||..:....:....::.:.:||.|:|.:...:......|.. ...:||
 Worm   311 ITVPGMNDTEEWQITDGAFNVMGFSEREKDDLYKLCSAIMHIGNSTFKQKPRDEQAEVDDMTSPT 375

  Fly   851 AARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWA----------WECLEAL 905
            ||.|   |.|:|.:...:|   ||:|..             ..|.||.          | .:.||
 Worm   376 AACK---LFGINTDQFLNA---LTRPRI-------------KVGMEWVNKGQNVQQVDW-AVGAL 420

  Fly   906 VIGLYSEALAAVVALINRQI-CTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYL 965
            ...:|:.....::..:|:.: ..|...:..|.::|..||:    |          :...|..|::
 Worm   421 SKAIYARMFNWLIKRVNKTLQANSDEMVYYIGVLDIAGFEIFDRN----------SFEQLWINFV 475

  Fly   966 QERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDL 1025
            .|:||..|:|...|..::.|.:|     .::..:||.| |     |.||:|.             
 Worm   476 NEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGLDLQS-C-----IELIEKP------------- 521

  Fly  1026 REHDRRGMLWLLDEEAIYPNSNDDTFLERLFS-HYGDREHHSLLRKCAGPR------QFVLHHLQ 1083
                 .|::.:||||.|.|.::|.|::::|.: |.|   .|...:|...|:      .|.:.|..
 Worm   522 -----LGIVSMLDEECIVPKASDMTYVDKLLTQHLG---KHPNFQKAKPPKGKQAEAHFSIMHYA 578

  Fly  1084 GTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQ 1148
            ||  |.|..:.|:..::: |...:||::|:.|.:|.:  ||  .|..              |...
 Worm   579 GT--VRYNAEQWLDKNKD-PLNDSAVAILKTSDKEGV--LY--QLWE--------------EYQT 622

  Fly  1149 SLRRVSSIRRSFTTAGVKRNS-----IMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKY 1208
            .:.|..|.:|....|..|..|     :....:.::..::..|..|..||:.|.:      .:.|.
 Worm   623 DVDREESEKRGKAQAKKKGKSASFLTVSTMYRESLTSLMTMLHTTHPHFIRCII------PNEKK 681

  Fly  1209 TANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDL 1273
            |:.               :::.||:.:||..:.|||..|:.|.|||..:...:|..|:.:||.|.
 Worm   682 TSG---------------LIDAPLVLNQLTCNGVLEGIRICRKGFPNRMMFADFRFRYAILAADE 731

  Fly  1274 ASNKDVS------VEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCR 1332
            ||:||.:      :.::...|:|:|.::::|.:::.||:|:|:.||..||..||..|::.|...|
 Worm   732 ASDKDAAKASKAMLRKLSKNNQLNVDTFKVGTTKVFFRAGMLARLEELRDEALSAVILKFQCSLR 796

  Fly  1333 GYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLM 1397
            .|||:.:..:|..:|.|...||.|::|::.:|.|||:||..|:.|:|...:       :|.|:..
 Worm   797 HYLAQLEYKRRLDREDAYPIIQENIRAWIKLRSWPWYRLFSRLKPMLKGMK-------SNAEIEA 854

  Fly  1398 LRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQT 1462
            |..|.:::| :..:.:.|.:|..|......:|..||...||   ||      :|:.|:|      
 Worm   855 LEKKCKELE-ENHKREEEARKKYADELRAKIDQYEETKAAH---ER------DRMLLDK------ 903

  Fly  1463 NKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQ 1527
             :.|.::|....|:                  ||:|.         .||...:..|         
 Worm   904 -RNKEIEELNRNLK------------------AESES---------NYENAKKASE--------- 931

  Fly  1528 HEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLE 1592
                ||:|    :..|.|                :|..|         :.||.:|.:|      |
 Worm   932 ----LERL----REKEKK----------------EWDEK---------ERRMQMEAEN------E 957

  Fly  1593 KKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRE 1657
            ..|.|                            .|.||.                ::::::||.:
 Worm   958 ANQHK----------------------------TQTEKL----------------KDQISTLQTD 978

  Fly  1658 LEEMTFGGGTEEEFAQLRRSKNETERRAKEQ--EEELDEMAGQIQLLEQAKLRLEMTLETMRKEA 1720
            .|:::                  .:|:|:||  .|.:||:|...|..|:|        |..:|:.
 Worm   979 FEKVS------------------AQRKAQEQMNAELVDEVASFKQKAERA--------EEQKKKL 1017

  Fly  1721 RRESQQRDEEL-EEVRGNG--YKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRD 1782
            ..:....|::| .|.|.|.  .|..|.||.||:....:.||.|:||||.        |.|...|:
 Worm  1018 VEDLDSLDDKLAAEKRANNEHVKHNKKLEGQLKATQTQLTLALKEKHEF--------DVDCKRRE 1074

  Fly  1783 AE-EALNQKLRRD---LRKYKALLKDAQTQLERLKADTPGKTLIR--------QLRNQLEDAESA 1835
            :| ..|..|.:.|   :.|.:|:|:...:::|.|:.|...:..:|        :||::.|..:..
 Worm  1075 SEIGELKLKAQGDANLISKLQAMLRKCISRIEELEEDLLEERKLRMKAERQFNELRSEYEVLQEQ 1139

  Fly  1836 RSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYS 1900
            .:.| ..:.||||.:.:|:            |||.:|.    |.:||.:...:|..:.:|.....
 Worm  1140 MAEA-SGQLTAEAHINKVR------------AEEVSNL----RRDLQKRNLNHEAYISDLCNMQY 1187

  Fly  1901 ATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHR 1940
            |||..|.    |:|:....| |.||.|        .|.||
 Worm  1188 ATVNNLR----NLSQQSATL-ESEALR--------ILDHR 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 202/805 (25%)
MYSc_Myo18 575..1305 CDD:276837 189/774 (24%)
GBP_C <1540..1750 CDD:303769 40/214 (19%)
COG1340 1565..1833 CDD:224259 62/284 (22%)
coiled coil 1723..1734 CDD:293879 2/11 (18%)
myo-6NP_001022590.1 Myosin_N 34..72 CDD:367160 11/54 (20%)
MYSc_class_II 99..769 CDD:276951 189/774 (24%)
SbcC <774..1178 CDD:223496 137/597 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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