DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Mpdz

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001292213.1 Gene:Mpdz / 17475 MGIID:1343489 Length:2069 Species:Mus musculus


Alignment Length:2369 Identity:425/2369 - (17%)
Similarity:733/2369 - (30%) Gaps:851/2369 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 ILKGSRSNMTNVHEEISFAGSAGGAGGTP-----EMLLRNTFQNE-----SLYEGAARGAG--SI 219
            :|..:..|:    |.:...|:.....|.|     :.|::|..|..     .|.:....|.|  .:
Mouse    94 LLSPNHGNL----EALPGPGAPAVMDGKPTCDELDQLIKNMAQGRHVEIFELLKPPCGGLGFSVV 154

  Fly   220 GSNSSQHGTSFTSVESLRS------DG----------------EQTGGQQRAMTLPANAR----- 257
            |..|...|.....|:.::.      ||                :||...|:|:::...|:     
Mouse   155 GLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTVQL 219

  Fly   258 ---YGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFED 319
               .|:||..:|.      ..|.||||.|    |.|:.:.|.             .|..|...|.
Mouse   220 VIARGSLPPVSSP------RISRSPSAAS----TISAHSNPM-------------HWQHVETIEL 261

  Fly   320 VELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSL--RKAICLDRTESLTSPIFRPVIFAEPGAG 382
            |                        :.....||.:  .||         |..|.:.::   ||..
Mouse   262 V------------------------NDGSGLGFGIIGGKA---------TGVIVKTIL---PGGV 290

  Fly   383 GGATG-LLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAV-------TVEVQPVAELVELSKRCM 439
            ....| |..||.::|:..|.:..:..|.:.:::|..|..|       .||..|.:..:.::   :
Mouse   291 ADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPASSSLGIT---L 352

  Fly   440 APSTATVEEIDHSITNGNCNTLRRSASKRFKRQ-SRHENGNG---GGEEGGAK------------ 488
            :.||::..|:     ..:.:|.:...|:.|..: :::..|.|   .|..|..|            
Mouse   353 SSSTSSTSEM-----RVDASTQKNDESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 412

  Fly   489 ---GVGHDLEADVAD------------------------ASQPERVWLVHRG----------GFT 516
               .|.||....:.|                        ..|..|:.|:.:|          |.|
Mouse   413 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMRKGASQEAELTSRGDT 477

  Fly   517 AA-IRLPTASSGRDEENKLSLRLLHNGEQLTVDE-------------DDVEKQNSPALDLVEDIC 567
            |. :.||..:..:|||   ||.|..|...|.::|             :||: |.:..|...:.|.
Mouse   478 AKDVDLPAENCEKDEE---SLSLKRNTSILPIEEEGFPLLSAELEEAEDVQ-QEAALLTKWQRIM 538

  Fly   568 ELKYLNEASVLHCLRQRYASNL-IHTKA------------------------GPTLLVVNPMAPL 607
            .:.|  |..|.|..:....|.| |..:|                        |..||.||.:..|
Mouse   539 GINY--EIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLL 601

  Fly   608 SLYSEKVVSMFRG--------CKTEDMPPHVYS-----------LAQTAYRSLVETRRDQSLIFM 653
            ....:.||::.:.        |....:||...|           |.:..:..|.|        |:
Mouse   602 GENHQDVVNILKELPIDVTMVCCRRTVPPIALSEMDSLDINDLELTEKPHIDLGE--------FI 658

  Fly   654 GRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLD 718
            |.|.:...          .||....:.  |||::.....:.||.|.:...  ...:|......||
Mouse   659 GSSETEDP----------MLAMSDVDQ--NAEEIQTPLAMWEAGGQSIEL--EKGSRGLGFSILD 709

  Fly   719 FDQTGQIASASLQV--LLPE--RQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSH 779
            :......|:..:.:  |:|.  .::.|             ||..|...:...:::|||.|.|:: 
Mouse   710 YQDPIDPANTVIVIRSLVPGGIAEKDG-------------RLFPGDRLMFVNDINLENSTLEEA- 760

  Fly   780 PFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTART 844
                                            .:|::|..|           |:.::|.      
Mouse   761 --------------------------------VEALKGAPS-----------GMVRIGV------ 776

  Fly   845 QFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGL 909
              |.|.......|.:... ||    || |..|:|                      |.|:   ||
Mouse   777 --AKPLPLSPEEGYVSAK-ED----AF-LCSPHA----------------------CKES---GL 808

  Fly   910 YSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFH 974
            ..:||..                |.:.|||||..::.|.  .:..:..:....:....:..:...
Mouse   809 SDKALFR----------------ADLALIDTPDAESIAE--SRFESQFSPDNDSVYSTQASIFSL 855

  Fly   975 HTTLVAPRDRYAQELVEI---EMDLASECHPGPLISLIDKAPQNHVVR----SSQRDLREHDRRG 1032
            |....:....|...|...   ::..:||...|..:||.:...||.:.|    |...|:|.....|
Mouse   856 HDGTCSDGMNYGPSLPSSPPKDVTSSSEVVLGLHLSLEELYTQNLLQRQHAGSPPTDMRPAPTSG 920

  Fly  1033 MLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGT------NPVLYA 1091
                      :|.| |.|....:...|          :||.|..:....|..:      .|.|.|
Mouse   921 ----------FPIS-DYTTTNAVEQKY----------ECANPVAWPHSQLPSSLSTSELAPALPA 964

  Fly  1092 VDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSI 1156
            |      ::::  :.:..||..|:  |.:|   :.|:::           ...|.|.::.:.|| 
Mouse   965 V------AQKY--LTDQSSLASDA--ESVN---LQSMSQ-----------EAFERTVTIAKGSS- 1004

  Fly  1157 RRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQV 1221
                        |:.:.|....||:                     |...:...:|...|..|::
Mouse  1005 ------------SLGMTVSANKDGL---------------------GVIVRSIIHGGAISRDGRI 1036

  Fly  1222 S--------SEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPE------------------SVP-- 1258
            :        :||..::       |..:|.....|.|.|..|:                  .||  
Mouse  1037 AVGDCILSINEESTIS-------LTNAQARAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAE 1094

  Fly  1259 -LLEFVRRFGLLAG-----------------DLASNKDVSVEQILAVNELDVASY-------RI- 1297
             |.||...||..||                 :|...::...|:    :||..|:|       |: 
Mouse  1095 HLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEE----SELQNAAYSSWSQPRRVE 1155

  Fly  1298 ---GPSQILFRSGV--------LSELEAKRDVLL-----------------SDRIIQLQAFCRGY 1334
               .||:.|..|.|        ||..|..|.:.:                 .||||::.    |.
Mouse  1156 LWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVD----GM 1216

  Fly  1335 LARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR 1399
            ..|....::.|:               |:|                        |..|..:.|::
Mouse  1217 DLRDASHEQAVE---------------AIR------------------------KAGNPVVFMVQ 1242

  Fly  1400 AKLEKIECDRSEVKAENQKLEAKLS-----------ELTVDLAEERSTAHIATERLEAETAERLK 1453
            :.:.:..  :|.:.:....|..|.|           :||.|.|..:|         |:||     
Mouse  1243 SIINRPR--KSPLPSLPHSLYPKYSFSSTNPFADSLQLTTDQAPSQS---------ESET----- 1291

  Fly  1454 LEKELGDQTNKVKNLQETTEKL--EMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARE 1516
             ||.      .:.|:..::..:  ||...||:.....:|||||.|:|.|......:.:|..:..:
Mouse  1292 -EKP------ALCNVPPSSPSVFSEMGSDCAQPSATAVSEDEDKEDEFGYSWKNIQERYGSLTGQ 1349

  Fly  1517 LEFTKRRLHTQHEHDLEQ--------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNE 1573
            |          |..:||:        |...|....|.:.           :||.....|......
Mouse  1350 L----------HVIELEKGQSGLGLSLAGNKDRTRMSVF-----------IVGIDPTGAAGRDGR 1393

  Fly  1574 MNDLRMLLE----------EQNARNNLLEKKQRKFDAECQSLQDAVRQERQ----AKERYGREKD 1624
            :.....|||          .||| :::::....|.........|||.|...    |.:......|
Mouse  1394 LQIADELLEINGQILYGRSHQNA-SSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAADSPSSTSD 1457

  Fly  1625 VLQAEKFTLEQTLADTRLDLEFKEEKLASL----QREL------------EEMTFGGGTEEEFAQ 1673
            ..|.::.....|.:.:..|       |:||    |.||            ||.|..|...|...:
Mouse  1458 SPQNKEVEPCSTTSASAAD-------LSSLTDVYQLELPKDQGGLGIAICEEDTINGVMIESLTE 1515

  Fly  1674 LRRSKNETERRAKEQEEELDE--MAG-----QIQLLEQAKLRLEMTLETMRKEARRESQQRDEEL 1731
            ...:..:...:..:....:|:  :||     .|.||:.||..:::|:       |.|:       
Mouse  1516 HGGAAKDGRLKPGDHILAVDDEVVAGCPVEKFISLLKTAKATVKLTV-------RAEN------- 1566

  Fly  1732 EEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLR 1796
                    ....|:.....|...||      |...:.......|.:.:...:..:.......|..
Mouse  1567 --------PACPAVPSSAVTVSGER------KDNSQTPAVPAPDLEPIPSTSRSSTPAVFASDPA 1617

  Fly  1797 KYKALLKDAQTQLERLKADTP-------------GKTLIRQLRNQLEDAESARSLAMKARQTAEA 1848
            .. .::...:|.:|..|..|.             |..:|.::   .|:..:.:.    .|..|..
Mouse  1618 TC-PIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEV---YEEGAACKD----GRLWAGD 1674

  Fly  1849 ELTEV------QAMFDESHRARNDAEERAN-AAHRDRAELQAQIEENEEELG-----ELMKKYS- 1900
            ::.||      :|..||:........:|.. ..:||.|..:      ||::.     ||.|:.. 
Mouse  1675 QILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK------EEDVCDTFTIELQKRPGK 1733

  Fly  1901 ----ATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLEL 1961
                :.|.:.|...:.||:.             :|..:|:...||..    ||  ..:|....::
Mouse  1734 GLGLSIVGKRNDTGVFVSDI-------------VKGGIADADGRLMQ----GD--QILMVNGEDV 1779

  Fly  1962 RTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF 2026
            |....|:...|.:.:...:.::|.|.|.|       ...|:.|..|:..|   |:.||.......
Mouse  1780 RHATQEAVAALLKCSLGAVTLEVGRVKAA-------PFHSERRPSQSSQV---SESSLSSFTPPL 1834

  Fly  2027 HAVSSREQ-ESLTRRKDLEKKVEQM----------ESEGAALKNDLRLALQRIADLQQAMEEEG- 2079
            ..:::.|. ||.:::..|..:::.:          :|.|.::...:...|..:......|...| 
Mouse  1835 SGINTSESLESNSKKNALASEIQGLRTVEIKKGPADSLGLSIAGGVGSPLGDVPIFIAMMHPNGV 1899

  Fly  2080 ---EEELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGS-IGGGGGSVVSS---------- 2130
               .::|...|..::..|:.:|.....:.|::.:::..|:... :.||..|||:.          
Mouse  1900 AAQTQKLRVGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCL 1964

  Fly  2131 -----TRTVVFEKDDNSPRI-TVTSPSSP 2153
                 |.:.:|..|...|:. |:|....|
Mouse  1965 AFTGLTSSSIFPDDLGPPQSKTITLDRGP 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 20/96 (21%)
MYSc 556..1317 CDD:214580 157/886 (18%)
MYSc_Myo18 575..1305 CDD:276837 148/847 (17%)
GBP_C <1540..1750 CDD:303769 43/246 (17%)
COG1340 1565..1833 CDD:224259 53/317 (17%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
MpdzNP_001292213.1 L27_2 6..63 CDD:117611
PDZ_signaling 140..222 CDD:238492 14/81 (17%)
PDZ_signaling 256..335 CDD:238492 21/114 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..372 4/31 (13%)
PDZ 375..464 CDD:214570 13/88 (15%)
PDZ_signaling 553..622 CDD:238492 12/68 (18%)
PDZ_signaling 694..777 CDD:238492 20/149 (13%)
PDZ_signaling 994..1064 CDD:238492 16/110 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1125..1144 4/22 (18%)
PDZ_signaling 1151..1242 CDD:238492 22/133 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1313 13/55 (24%)
PDZ 1349..1434 CDD:214570 17/106 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1449..1473 3/23 (13%)
PDZ_signaling 1483..1563 CDD:238492 17/86 (20%)
MPDZ_u10 1564..1625 CDD:293272 8/82 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1571..1611 6/45 (13%)
PDZ 1626..1710 CDD:214570 15/90 (17%)
PDZ_signaling 1722..1802 CDD:238492 17/98 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1809..1848 10/41 (24%)
PDZ_signaling 1859..1944 CDD:238492 11/84 (13%)
PDZ_signaling 1985..2068 CDD:238492 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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