DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and ZK849.1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_493476.1	Gene:	ZK849.1 / 173288	WormBaseID:	WBGene00014100	Length:	331	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	77/359 - (21%)
Similarity:	131/359 - (36%)	Gaps:	110/359 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1799 KALLKDAQTQ-LERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHR 1862
            |||..|.:.. :..|||.:   .:..|:.......|||:.||:|.|:....||.|::|:.:
Worm     3 KALASDEKDDWITHLKAIS---NVFTQVCTLSASEESAKKLAIKEREECLQELVELRAIAE---- 60

  Fly  1863 ARNDAEERANAAHRD-RAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAE 1926
                       ||.| ..:....:..|.:  |:      ||.:|:             .|:|:.|
Worm    61 -----------AHDDVIQQFHLLLAANHQ--GD------ATSRQI-------------FNDMKQE 93

  Fly  1927 RNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEAL 1991
            ..:..|::.|  |||                        :|::|.:|:           |..|.:
Worm    94 VGDNMERIQE--HRL------------------------VEAKLNVEK-----------RRNERM 121

  Fly  1992 EKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAA 2056
            .|..|||::..:..:.|.....:...::|.|.:.....::.|....::..|      ::|.|...
Worm   122 AKHINEVSKKSVMHLMATRFYARELAAMRQMMDLVRNAATIESAVKSKLWD------EIEKENRL 180

  Fly  2057 LKNDLRLALQRI--ADLQQAMEEEGEE------------ELSESDESLSSVGSISDLEDRLRPVH 2107
            |:.:....:.||  :||..|..|.|::            |.......|...|..    |:.|||.
Worm   181 LRLNTLWLINRINSSDLGDAAFENGDDWQSSPRLVILMREHINQGLGLEITGGC----DQFRPVV 241

  Fly  2108 V----KRS----SQQSLNGSIGGGGGSVVSSTRT 2133
            |    |||    .|..:|..|....|:.|::|.|
Worm   242 VTGKLKRSMADDDQLRVNDRILAIDGTFVTNTTT 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259	8/34 (24%)
		coiled coil	1723..1734	CDD:293879
ZK849.1	NP_493476.1	PDZ_signaling	212..296	CDD:238492	18/68 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900