DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and nmy-2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_492186.3 Gene:nmy-2 / 172562 WormBaseID:WBGene00003777 Length:2003 Species:Caenorhabditis elegans


Alignment Length:1880 Identity:491/1880 - (26%)
Similarity:830/1880 - (44%) Gaps:398/1880 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 ADASQPERVWL-VHRGGFT--AAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPAL 560
            ||.::.:.:|: ..:.||.  |.|..|.|      :..:.:.|:..||:..|..||.:|.|.|..
 Worm    27 ADWAKKKLMWVPSEKDGFALGAVIGEPHA------DGTIDIELMETGERQRVSSDDCQKPNPPKY 85

  Fly   561 DLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTED 625
            |..||:..|..||||||||.|:|||.|||.:|.:|...:|:||...:.:|::.:...|:..|.::
 Worm    86 DKCEDMSMLTCLNEASVLHNLKQRYFSNLYYTYSGLFCVVINPYKRIPIYTDTIAEQFKCKKRKE 150

  Fly   626 MPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAG-------------- 676
            ||||::::|..||||:::.|.|||::..|.||:||:.:.|..:.|||..|.              
 Worm   151 MPPHIFAVADEAYRSMLQERDDQSILCTGESGAGKTENTKKVIQYLAYVANRSMVKNRKTSVDLD 215

  Fly   677 -AYNNFIN--AEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQ 738
             :.|..:.  .|::.....|||||||:||..|.|::|..:.:.:.||.||.|:.|:::..|.|:.
 Worm   216 TSTNRIMGQLEEQLLQANPILEAFGNSKTVKNDNSSRFGKFIRVHFDSTGCISGANIEFYLLEKS 280

  Fly   739 RAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISL-SQKLEDRHRAANDFMRTV 802
            |..::..:|.||||..:||.|.:.:.::...||:..|:  :.|:|. ..||......| :...|:
 Worm   281 RVLKQAPNERSFHIFYQLLKGLSKVQREHYLLEDSLSK--YKFVSNGDSKLAGVDDGA-EMKETL 342

  Fly   803 QAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867
            .|...:.::.:.:.||..:::|:...|....:.....:. :....|...|:|.:.|||||:.:|.
 Worm   343 NAMSIMGLNDEEIGGILRVVSAVMLFGNLEFSHENKNND-QAVLLNDAVAQKIASLLGVNVTELM 406

  Fly   868 SAAFGLTQPNAPNGGLSPSKSPTSDTGH-----EWAWECLEALVIGLYSEALAAVVALINRQI-C 926
            .|.            |.|......|..|     :.....:.|:....|......:|..:|:.: .
 Worm   407 RAF------------LKPKIKVQRDLVHRAQSVDQVNFSVGAIAKASYERLFRWLVHRLNKSLDR 459

  Fly   927 TSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQ 987
            |...:::.|.::|..||:    |          :...|..||..|:||.||::|..|..:..|..
 Worm   460 TRQQSVSFIGILDIAGFEIFETN----------SFEQLCINYTNEKLQQLFNNTMFVREQQEYLD 514

  Fly   988 ELVEIE-MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTF 1051
            |.:|.: :|......  |.|.||||.                  .|::..||:..::|..||.:|
 Worm   515 EGLEWKFLDFGLNLQ--PTIDLIDKP------------------MGIMSTLDDVCLFPQGNDQSF 559

  Fly  1052 LERLFSHYGDREHHSLLRKCAGPR-----QFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSL 1111
            ::||      ...||...|...|.     .|.:.|..|.  |.|..:|| |.....|...|.:.:
 Worm   560 VQRL------NNTHSQHPKYVVPEIRSRSDFAVVHYAGR--VDYQSEGW-RVKNMDPLNENVIDV 615

  Fly  1112 LQDSSREEINRLY-----IGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIM 1171
            |:.|....|..::     :.||:.....     |..|:.|::..::           |:.|....
 Worm   616 LKTSKESLIVDMWKDIADVCSLSAADST-----SDTGVFGSRVPKK-----------GMFRTVSQ 664

  Fly  1172 LQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQ 1236
            | .|..:..::.||..|..|||.|.:..|.. ||                    .::|..|:..|
 Worm   665 L-YKEQLARLMSTLNNTNPHFVRCIIPNHEK-KH--------------------GVLNAHLVLDQ 707

  Fly  1237 LRGSQVLEAARLHRLGFPESVPLLEFVRRF-GLLAGDL-----ASNKDVSVEQILAVNELDVASY 1295
            ||.:.|||..|:.|.|||..:|..||.:|: .|||.|:     ...|: :|.:|:...|:|...:
 Worm   708 LRCNGVLEGIRICRQGFPTRLPFQEFRQRYEKLLAPDVNPAGFMDGKN-AVYRIVQYLEVDANLF 771

  Fly  1296 RIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAF 1360
            |||.|:|.|||||::|.|..||..||..|...||.|||:|.|:.|.:||.||:|::.:|||..|:
 Worm   772 RIGQSKIFFRSGVIAEFEEMRDQKLSALIESFQAQCRGWLGRRVMVRRREQEVAIKILQRNGLAW 836

  Fly  1361 LAVRDWPWWRLLVRVTPLLNVHRTEE----------------------------QLKTANEELLM 1397
            :.:|:|.|||||.:|.|||.|...:|                            |::..:||.|:
 Worm   837 MRLREWQWWRLLTKVKPLLEVTNKDELIAEREQELKVTAEKLRRSEVFISDYKQQMEKMDEERLV 901

  Fly  1398 LRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQT 1462
            |:.:|:....:|:|:..|..::.|:..||...|.|       .::|||.|..:..|.:.|....|
 Worm   902 LKTRLDAESSERAEIFEERSRMAARRDELEGILEE-------VSKRLEIEEQKAKKADSESRKLT 959

  Fly  1463 NKVKNLQETTEKLE---MELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARE--LEFTKR 1522
            ..|::|:|..|..|   .:|:..|:.:....::.:|:..:....| .||..|:.|.|  .|....
 Worm   960 EMVRHLEENLEDEERSRQKLLLEKNSIESRLKELEAQGLELEDSG-NKLSKEKKALEERCEDLSS 1023

  Fly  1523 RLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQ-----------VVGQWK----------RK 1566
            ||..:.|.. :|||..|..||..:::..:|:.:::|           ...|.:          ||
 Worm  1024 RLIDEVERS-KQLVKAKARLEATVAEINDELEKEKQQRHNAETARRAAETQLREEQESCLEKTRK 1087

  Fly  1567 AQKMTN-------EMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK- 1623
            |:::||       |::.:.:..:|:.|....||::.|:..|:   |.||:  |...||:..|:| 
 Worm  1088 AEELTNQLMRKESELSQISIRNDEELAARQQLEREIREIRAQ---LDDAI--EETNKEKAARQKA 1147

  Fly  1624 --------DVLQAEKFTLEQTLADTRLDLEFK---EEKLASLQRELEEMTFGGGTEEEFAQLRRS 1677
                    :.|::.|..||::...|.|..:.|   :|:.|.||::|||..   .:.||..:..::
 Worm  1148 EKARRDMAEELESYKQELEESNDKTVLHSQLKAKRDEEYAHLQKQLEETV---KSSEEVVEEMKA 1209

  Fly  1678 KNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKE------ARRESQ----------- 1725
            :|  :::.:|..|.:|::..|....::||...|...|..|.|      ||.|::           
 Worm  1210 QN--QKKIEELNETIDQLKRQKISADKAKSSAESDNENFRAELSNIASARLEAEKKRKAAETSLM 1272

  Fly  1726 QRDEELEEVRGN---GYKKIKALECQLET----EHEERTL---LLREKHELERRLSSMEDRDRVD 1780
            ::|.::.|::.|   ...|:..:..:||:    :..:.||   ||::...|:.:||.:.:....|
 Worm  1273 EKDHKMREMQSNLDDLMAKLSKMNNELESIQKAKSADETLNSNLLKKNASLDMQLSELTEASEED 1337

  Fly  1781 RDAEEALNQKLR------------------------RDLRKYKALLKDAQTQLERLKADTPGKTL 1821
            |.....||.|:|                        :::::.|:||.:|     |.|.|...:.:
 Worm  1338 RRTRATLNNKIRQLEEDLAVAVEARDDALDAQEKIEKEVKEVKSLLAEA-----RKKLDEENREV 1397

  Fly  1822 IRQLRNQLED-----------AESARSLAMKARQTA-------EAELTEVQAMFDESHRARND-- 1866
            :.:||.:.|.           ||.||..|.:|::.|       :.|||:|.|...|..|....  
 Worm  1398 MEELRKKKEKELSAEKERADMAEQARDKAERAKKKAIQEAEDVQKELTDVVAATREMERKMRKFD 1462

  Fly  1867 ---AEERANA---------AH---RDRAELQAQIEENE----EELGELMKKYSATVKQLNTEQI- 1911
               ||||.|.         ||   || ||.:|.:..||    :::.:.::|...|:| |..:.: 
 Worm  1463 QQLAEERNNTLLAQQERDMAHQMLRD-AETKALVLSNELSEKKDIVDQLEKDKRTLK-LEIDNLA 1525

  Fly  1912 --------NVSEAEFKLNEMEAERNNLKEQVAELQHRL---DNVENLGDPSMAMMSKRLEL---- 1961
                    ||.|.|.....::.|.:..::|:.||:..|   |:..:..:.:|..|....|.    
 Worm  1526 STKDDAGKNVYELEKTKRRLDEELSRAEQQIIELEDALQLADDARSRVEVNMQAMRSEFERQLAS 1590

  Fly  1962 -------RTKELESRL-----ELEQATRARLEVQVNRHK------EALEKLQNEVTQSKMREMQA 2008
                   |.|.|.|::     |||...|||.....|:.|      |..||  ||.:..::.::..
 Worm  1591 REEDEDDRKKGLTSKIRNLTEELESEQRARQAAIANKKKIESQISELTEK--NEASLRQIEDLSR 1653

  Fly  2009 QDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQ 2073
            |  ::|:|...:|::.:.....:..:::|..::|.||:....|.|...|..|    :|.::..::
 Worm  1654 Q--LRKAQLGWKDLQLDVTEARAAMEDALAGQRDAEKRARASEDEIKRLTAD----IQAVSSSKR 1712

  Fly  2074 AMEEEGEEELSE----------SDESLSSVGSISDLEDR---------LRPVHVKRSSQQ 2114
            ..|.|.:|.:.|          ::|.......:.||||:         |....|::|.||
 Worm  1713 KAEAERDELIEEVSSLRASSFSNEEKRRLEAKVIDLEDQLDEEASANELAQEKVRKSQQQ 1772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 224/805 (28%)
MYSc_Myo18 575..1305 CDD:276837 208/774 (27%)
GBP_C <1540..1750 CDD:303769 59/269 (22%)
COG1340 1565..1833 CDD:224259 79/348 (23%)
coiled coil 1723..1734 CDD:293879 2/21 (10%)
nmy-2NP_492186.3 MYSc 81..793 CDD:214580 224/805 (28%)
MYSc_class_II 100..781 CDD:276951 208/774 (27%)
Myosin_tail_1 858..1934 CDD:279860 217/949 (23%)
ATP-synt_B <1104..1195 CDD:304375 26/95 (27%)
CDC37_N <1317..1396 CDD:296150 17/83 (20%)
Orbi_VP5 1599..>1865 CDD:279272 43/182 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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