Protein Alignment Mhcl and myo-1

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 1967
• Identity: 435/1967 - (22%)
• Similarity: 802/1967 - (40%)
• Gaps: 482/1967 - (24%)

  Fly   495 EADVADASQP----ERVWL--VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVE 553
            |..:||.|:|    :.||:  ...|.....|:.|...:.       ::.:...|:.:|:.:|.|:
 Worm    19 EQQLADQSRPYDSKKNVWIPDAEEGYIEGVIKGPGPKAD-------TVIVTAGGKDVTLKKDIVQ 76

  Fly   554 KQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMF 618
            :.|.|..:..||:..|.:||:||||..||.|||:.||:|.:|...:|:||...|.:|::.|..||
 Worm    77 EVNPPKFEKTEDMSNLTFLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMF 141

  Fly   619 RGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFIN 683
            .|.:..:||||:::::..|||.:::...:||::..|.||:||:.:.|..:.|.|....:....:.
 Worm   142 MGKRRTEMPPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVICYFATVGASQKAALK 206

  Fly   684 --------AEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRA 740
                    .:::.....:||||||.||..|:|::|..:.:.:.|::.|.:||..::..|.|:.|.
 Worm   207 EGEKEVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTLASCDIEHYLLEKSRV 271

  Fly   741 GRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP-----FISLSQKLEDRHRAANDFMR 800
            .|:...|..:||..::.:.....|:.||.|       :||     |::.::.|.|......:|..
 Worm   272 IRQAPGERCYHIFYQIYSDFKPQLRDELLL-------NHPISNYWFVAQAELLIDGIDDTEEFQL 329

  Fly   801 TVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTA---ARKASGLLGVN 862
            |.:||:.|..........:.:::|..|:|     .:......|.:.|.|..   |.:|..:.|::
 Worm   330 TDEAFDVLKFSPTEKMDCYRLMSAHMHMG-----NMKFKQRPREEQAEPDGQDEAERACNMYGID 389

  Fly   863 LEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVAL------- 920
            ::....|   |..|....|....||....|..| ||   :.|:..|||:.....:|..
 Worm   390 VDQFLKA---LVSPRVKVGTEWVSKGQNVDQVH-WA---IGAMAKGLYARVFHWLVKKCNLTLDQ 447

  Fly   921 --INRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRD 983
              |:|........||...:.|...|:              .|..|::.|:||..|:|...|..::
 Worm   448 KGIDRDYFIGVLDIAGFEIFDFNSFE--------------QLWINFVNEKLQQFFNHHMFVLEQE 498

  Fly   984 RYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIY 1043
            .||:|     .::..:||.: |     |.||:|.                  .|::.:||||.|.
 Worm   499 EYAREGIQWTFIDFGLDLQA-C-----IELIEKP------------------LGIISMLDEECIV 539

  Fly  1044 PNSNDDTFLERLF-SHYGDREHHSLLRKCAGPR------QFVLHHLQGTNPVLYAVDGWVRHSRE 1101
            |.:.|.|..::|. .|.|   .|....|...|:      .|.:.|..||  |.|.|..|:..:::
 Worm   540 PKATDMTLAQKLTDQHLG---KHPNFEKPKPPKGKQGEAHFAMRHYAGT--VRYNVLNWLEKNKD 599

  Fly  1102 HPGIRNAVSLLQDSSRE----EINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTT 1162
             |.....||:::.|.:.    ||.:.|.......:.|....|...|..|            ||.|
 Worm   600 -PLNDTVVSVMKASKKNDLLVEIWQDYTTQEEAAAAAKAGGGRKGGKSG------------SFMT 651

  Fly  1163 AGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEM 1227
                   :.:..:.:::.::..|.:|..||:.|.:                |:.     ..:..|
 Worm   652 -------VSMMYRESLNKLMTMLHKTHPHFIRCII----------------PNE-----KKQSGM 688

  Fly  1228 VNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKD-------VSVEQIL 1285
            ::..|:.:||..:.|||..|:.|.|||......:||:|:.:||...|.:.|       ..::.::
 Worm   689 IDAALVLNQLTCNGVLEGIRICRKGFPNRTQHPDFVQRYAILAAKEAKSSDDMKTCAGAILQALI 753

  Fly  1286 AVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAV 1350
            ...:|:...:|||.:::.|::||::.:|..||..|:..|...|:..|.|.|......||.|..:.
 Worm   754 NQKQLNDEQFRIGHTKVFFKAGVVAHIEDLRDDKLNQIITGFQSAIRWYTATADAGARRKQLNSY 818

  Fly  1351 RCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAE 1415
            ..:|||::::..:|.|.|:.|..::.|.|...:..|::....||..:|.|:.:|.|..|...:..
 Worm   819 IILQRNIRSWCVLRTWDWFLLFGKLRPQLKCGKMAEEMIKMAEEQKVLEAEAKKAESARKSQEEA 883

  Fly  1416 NQKLEAKLSEL--TVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEME 1478
            ..||.|:.|:|  .::|.:..|.|  ..|:|....:.|.::||.|.|..:::...:|....||.:
 Worm   884 YAKLSAERSKLLEALELTQGGSAA--IEEKLTRLNSARQEVEKSLNDANDRLSEHEEKNADLEKQ 946

  Fly  1479 LICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARE--LEFTKRRLHTQHE------------ 1529
            ...|:.::..:.:..:|     |.|.:.|...|:.|:|  :...:..:::|.|
 Worm   947 RRKAQQEVENLKKSIEA-----VDGNLAKSLEEKAAKENQIHSLQDEMNSQDETIGKINKEKKLL 1006

  Fly  1530 --------HDLE-------QLVALKKHLEMKLSDAYEEVVE------------QRQVVGQWKRKA 1567
                    .||:       |...|:..||..| |..||.||            :|:|.|:.| .|
 Worm  1007 EENNRQLVDDLQAEEAKQAQANRLRGKLEQTL-DEMEEAVEREKRIRAETEKSKRKVEGELK-GA 1069

  Fly  1568 QKMTNEMNDLRM------------------LLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQ 1614
            |:..:|::.:::                  .:|::.|..|.|.::.::.......::|.:..|||
 Worm  1070 QETIDELSAIKLETDASLKKKEADIHALGVRIEDEQALANRLTRQSKENAQRIIEIEDELEHERQ 1134

  Fly  1615 AKERYGREKDVLQAEKFTLEQTLADTRLDLEF-------KEEKLASLQRELEEMTFGGGTEEEFA 1672
            ::.:..|.:..||.|...|.:.|.:....||.       |:.::...:|:|:|...  ..|::.|
 Worm  1135 SRSKADRARAELQRELDELNERLDEQNKQLEIQQDNNKKKDSEIIKFRRDLDEKNM--ANEDQMA 1197

  Fly  1673 QLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEE----LEE 1733
            .:||..|          :::..:...:..|:::|.::|.....::||....:.|.|:|    :|:
 Worm  1198 MIRRKNN----------DQISALTNTLDALQKSKAKIEKEKGVLQKELDDINAQVDQETKSRVEQ 1252

  Fly  1734 VRGNGYKKIKALECQLETEHEERTL----------------LLREKHELERRLSSMEDRD----- 1777
            .|.....:|:..|.|.:.:.:.|.:                |.|:..|||..|:::....
 Worm  1253 ERLAKQYEIQVAELQQKVDEQSRQIGEYTSTKGRLSNDNSDLARQVEELEIHLATINRAKTAFSS 1317

  Fly  1778 ---RVDRDAEEALNQK---------LRRDLRKYKALLK-------DAQTQLERL-------KADT 1816
               ...:.||:.|:::         |..:|.:...||:       |.|.||.|:       ||..
 Worm  1318 QLVEAKKAAEDELHERQEFHAACKNLEHELDQCHELLEEQINGKDDIQRQLSRINSEISQWKARY 1382

  Fly  1817 PGKTLI---------RQLRNQLEDAESARSLAMK------------------ARQTAEAELTEVQ 1854
            .|:.|:         |:..|::.|.:.|.|.|..                  ||...:..||.:.
 Worm  1383 EGEGLVGSEELEELKRKQMNRVMDLQEALSAAQNKVISLEKAKGKLLAETEDARSDVDRHLTVIA 1447

  Fly  1855 AM----------FDESHRARNDAEERANAAHRDRA-------ELQAQIEENEEELGELMKK---Y 1899
            ::          .|:..|..:|.::..:|..||..       :|::.::...|::..|.::   :
 Worm  1448 SLEKKQRAFDKIVDDWKRKVDDIQKEIDATTRDSRNTSTEVFKLRSSMDNLSEQIETLRRENKIF 1512

  Fly  1900 SATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTK 1964
            |..::.:| |||......::  |:......|:::..||||.||..|...:   |..||.|.|:.:
 Worm  1513 SQEIRDIN-EQITQGGRTYQ--EVHKSVRRLEQEKDELQHALDEAEAALE---AEESKVLRLQIE 1571

  Fly  1965 ELESRLELEQATRARLEVQVN---RHKEALE---------------------KLQNEVTQ----- 2000
            ..:.|.|:|:..:.:.|...|   .|:.|||                     ||:.::.|
 Worm  1572 VQQIRSEIEKRIQEKEEEFENTRKNHQRALESIQASLETEAKSKAELARAKKKLETDINQLEIAL 1636

  Fly  2001 ------------------SKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKV 2047
                              .:::|:|.|  :...|:...::||.:.|...|...:|:..:||..::
 Worm  1637 DHANKANVDAQKNLKKLFDQVKELQGQ--VDDEQRRREEIRENYLAAEKRLAIALSESEDLAHRI 1699

  Fly  2048 E-------QMESEGAALK-----------------------------------NDLRLALQR--- 2067
            |       |:|.|.|.||                                   |:|:.:.:|
 Worm  1700 EASDKHKKQLEIEQAELKSSNTELIGNNAALSAMKRKVENEVQIARNELDEYLNELKASEERARK 1764

  Fly  2068 -IADLQQAMEEEGEEE-----------------------LSESDESLSSVG--SISDLEDRLRPV 2106
             .||..:..||..:|:                       :.:::.::...|  :::.:|||:|.:
 Worm  1765 AAADADRLAEEVRQEQEHAVHVDRQRKSLELNAKELQAKIDDAERAMIQFGAKALAKVEDRVRSL 1829

  Fly  2107 HV-----KRSSQQSLNG 2118
            ..     :|..|:|:.|
 Worm  1830 EAELHSEQRRHQESIKG 1846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	394/1738 (23%)
		MYSc_Myo18	575..1305	CDD:276837	189/777 (24%)
myo-1	NP_492053.1	Myosin_N	30..73	CDD:460670	7/49 (14%)
		MYSc_class_II	98..773	CDD:276951	189/777 (24%)
		Myosin_tail_1	854..1919	CDD:460256	201/1022 (20%)