DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Grip2

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1160	Identity:	227/1160 - (19%)
Similarity:	348/1160 - (30%)	Gaps:	416/1160 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 EGAARGAGSIGS------NSSQHGTSFTSVESLRSDGEQTG----------GQQRAMTLPANARY 258
            :|....||:.|:      :..:.....|.||.::.:|...|          |:.|.    :|.|.
  Rat    25 KGGKDTAGTDGALVCRRQSIPEEFRGITMVELIKREGSTLGLTISGGTDKDGKPRV----SNLRP 85

  Fly   259 GALPQGN---SQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDV 320
            |.|...:   :.|.::.     |.:...||...:....|   .|..|||          ....:|
  Rat    86 GGLAARSDLLNVGDYIR-----SVNGIRLTRLRHDEIIT---LLKNVGE----------RVVLEV 132

  Fly   321 ELPLPPVQLVKLPPPRQLVIRRQKSPR--------------QDFGFSLRKAICLDRTESLTSPIF 371
            |..|||      |.|       :.:||              ..|||.||.....|..:|
  Rat   133 EYELPP------PAP-------ENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKS------ 178

  Fly   372 RPVI--FAEPGAGGGATGLLP-GDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQ------- 426
            ||::  :..||......|.|. ||||:.::|.|:........|..::........:|:
  Rat   179 RPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALFQVEYDVATPD 243

  Fly   427 PVAE-----LVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGG 486
            .||.     :||::|   .|.:|    :..|:|.|:..........|.|..|       ..:..|
  Rat   244 TVANASGPLVVEIAK---TPGSA----LGISLTTGSHRNKPAITIDRIKPAS-------VVDRSG 294

  Fly   487 AKGVGHDLEADVADASQPERVWLVHRGGFTAAIR-------LPTASSGRDEENKLSLRLLHNGEQ 544
            |...|..:.|  .|.:..|...||......|::.       ||...|.|..:...::| :...||
  Rat   295 ALHAGDHILA--IDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRRPLKPPEAVR-IQRSEQ 356

  Fly   545 LTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYA------SNLIHTK--AGPTLLVV 601
            |...:..|...:||...                 ||....:|      |..:.:.  :.||:
  Rat   357 LHHWDPCVPSCHSPRPS-----------------HCRAPTWAPGGQDQSRSVSSTPFSSPTM--- 401

  Fly   602 NPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKH 666
            ||..|.:             ....:|....|...||.|.....:..:|.:.:..|..|......|
  Rat   402 NPAFPCA-------------NASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIVH 453

  Fly   667 ALNY-------------LALAAGAYN----------NFINAEKVNALCTILEAFGNTKTCLNSNA 708
            ....             |.|..|.:.          .||..:.....|.:|:. |:....:|..|
  Rat   454 TETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVRFIEPDSPAERCGLLQV-GDRVLAINGIA 517

  Fly   709 T------RMTQL-----------LSLDFDQTGQI--ASASLQVLLPERQ---------RAGRRLG 745
            |      ...||           |.::||....:  :|.:..|.||:|:         .|.|:.|
  Rat   518 TEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRG 582

  Fly   746 HEHSFHIMTRLLAGA----AGLLQ---KELHLENITSEDSHPF---ISLSQKLED----RHRAAN 796
            ..   .|::.:..|:    .|.|:   |.|.::||.. |..|.   :.:.::.||    :.|...
  Rat   583 EP---LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL-DHCPMEYAVQILRQCEDLVKLKIRKDE 643

  Fly   797 D---------------------------FMRTVQAFETLNIDAKAVRGIWS----------ILA- 823
            |                           ...|.:.|:.:.|.....||:..          |||
  Rat   644 DNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAI 708

  Fly   824 ------------AIYHLGIAGVT----------------KLGTGSTARTQFANPTAARKASGLLG 860
                        ||:.|.:||.|                :.|:.|.|.....:|..|.| .|||.
  Rat   709 NSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPPEALK-GGLLT 772

  Fly   861 VNLE------DLSSAAFGLTQPNAPNGGLSPSKSPT------SDTGHEWA--------------- 898
            .:..      |.:..::|   .:|..||...|.|.|      |.|..||.
  Rat   773 THFSPAVPSVDSAVESWG---SSATEGGFGGSGSYTPQVAVRSVTPQEWRSSRLKSSPPPLEPRR 834

  Fly   899 ------------------------------------W----ECLEALVIGLYSEALAAVVALINR 923
                                                |    |.||.|.....||.|..:.|.|
  Rat   835 TSYTPGPTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASI-- 897

  Fly   924 QICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE 988
                .:.|:.|:.:...|| ..|....::||.:..||:...|...|:|  |..||  .:|
  Rat   898 ----MTGTVQSVAVDGRPG-SRPWRRSREVGTSPEDLQELLLPTPLEM--HRVTL--HKD----- 948

  Fly   989 LVEIEMDLASECHPGPLISLIDKAPQNHVVR----SSQRDLREHDRRGMLWLLDEEAIYPNSNDD 1049
              .:..|.......|    |::|....|.||    :....|:..||     ||....:.....|.
  Rat   949 --PVRNDFGFSVSDG----LLEKGVYVHTVRIDGPAQHGGLQPFDR-----LLQVNHVRTRDFDC 1002

  Fly  1050 TFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPG 1104
            .....|.:..||                :|..:...||        :..||..||
  Rat  1003 CLAVPLLAEAGD----------------ILELVVSRNP--------LAQSRRTPG 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	22/103 (21%)
		MYSc	556..1317	CDD:214580	142/759 (19%)
		MYSc_Myo18	575..1305	CDD:276837	140/740 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492	20/103 (19%)
		PDZ_signaling	153..236	CDD:238492	20/88 (23%)
		PDZ_signaling	251..334	CDD:238492	20/98 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		17/111 (15%)
		PDZ_signaling	456..544	CDD:238492	14/88 (16%)
		PDZ_signaling	557..640	CDD:238492	19/86 (22%)
		PDZ_signaling	657..737	CDD:238492	14/79 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863		11/79 (14%)
		PDZ_signaling	941..1020	CDD:238492	21/112 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900