DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and FRMPD2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001018081.4 Gene:FRMPD2 / 143162 HGNCID:28572 Length:1309 Species:Homo sapiens


Alignment Length:571 Identity:106/571 - (18%)
Similarity:187/571 - (32%) Gaps:156/571 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 VTGSMSTDELLRLDEVRRSLKIRGRRKEKEKLPSGITADYSADFFAALNADANGGSNG------- 99
            :..|....||:    :.:|..:.|...::||                 |:.||.|.:.       
Human   846 IQNSPDNIELI----ISQSKGVGGNNPDEEK-----------------NSTANSGVSSTDILSFG 889

  Fly   100 --GAVGAADPEQDRGNEEIVASVMTHIESRASNGAGVSVNYSEVTHSLLSGGLKNRFLP------ 156
              |::.:...:|||..||:             :.|||......:.|.|       .|||      
Human   890 YQGSLLSHTQDQDRNTEEL-------------DMAGVQSLVPRLRHQL-------SFLPLKGAGS 934

  Fly   157 PIPPKPPKRGILKGSRSNMTNVHEE--ISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSI 219
            ..||.||:  |..|....:..|.|:  :.|:.:.|.....|             |.|....:...
Human   935 SCPPSPPE--ISAGEIYFVELVKEDGTLGFSVTGGINTSVP-------------YGGIYVKSIVP 984

  Fly   220 GSNSSQHGTSFTSVESLRSDGEQTGG---QQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSA 281
            |..:::.|........|:.||....|   :|....|          .|..|.:.| ||....|.:
Human   985 GGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL----------TGPGQVARL-VLERRVPRS 1038

  Fly   282 DSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSP 346
            .....:.|.|......::|.|                 ..||..|...|.:....:..::.:|: 
Human  1039 TQQCPSANDSMGDERTAVSLV-----------------TALPGRPSSCVSVTDGPKFEVKLKKN- 1085

  Fly   347 RQDFGFS---LRKAICLDRTESLTSPIFR--PVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELP 406
            ....|||   :.|..|    ..|.|.:.|  .:...:|....||  :..||.::.|||.....|.
Human  1086 ANGLGFSFVQMEKESC----SHLKSDLVRIKRLFPGQPAEENGA--IAAGDIILAVNGRSTEGLI 1144

  Fly   407 REIIIEMIRNSGEAVTVEV--QPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRF 469
            .:.::.::|.:.:.||:.:  .|...|.||.:....|..:..:|...:....:|.:........:
Human  1145 FQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSW 1209

  Fly   470 KRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKL 534
            :..:..:.|.|.|           |..:.:..:..|..|                  |::.|...
Human  1210 RDSASPDAGEGLG-----------LRPESSQKAIREAQW------------------GQNRERPW 1245

  Fly   535 SLRLLHNGE------QLTVDEDDVEKQNSPALDLVED---ICELKYLNEAS 576
            :..|.|:.|      :|..:.|:.....|...|:.::   :|::..|...|
Human  1246 ASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 21/93 (23%)
MYSc 556..1317 CDD:214580 5/24 (21%)
MYSc_Myo18 575..1305 CDD:276837 1/2 (50%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
FRMPD2NP_001018081.4 KIND 15..197 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..249
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..302
B41 346..550 CDD:214604
FERM_C_PTPH13 546..647 CDD:270008
PDZ_signaling 773..857 CDD:238492 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..880 7/37 (19%)
PDZ 947..1034 CDD:214570 20/110 (18%)
PDZ 1078..1167 CDD:214570 21/95 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1204..1228 4/34 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.