DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Lnx2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_542985.4 Gene:Lnx2 / 140887 MGIID:2155959 Length:687 Species:Mus musculus


Alignment Length:633 Identity:117/633 - (18%)
Similarity:198/633 - (31%) Gaps:232/633 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 HIESRASNGAGVSVNY----SEVTHSLLSGGLKNRFLPP---IPPKPPKRGILKGSRSNMTNVHE 180
            |:::|....:...|:.    :..|.:.:.|...:..:.|   :||:....|.:.|.| |:|    
Mouse   133 HLKNRCPGASHRRVDLERRKTSQTQTQIEGETGSTVIDPPGTLPPETDCSGTVPGER-NLT---- 192

  Fly   181 EISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDG----- 240
                      ....|.........|.:..|.||  |.|:....|......|::|..||:.     
Mouse   193 ----------PASLPVWTEEPGLDNPAFEESAA--ADSVQQPLSLPEGEITTIEIHRSNPYIQLG 245

  Fly   241 -EQTGGQQRAMTLPAN------------ARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSF 292
             ...||.:..:   .|            ||.|.|..|                 |.:....|   
Mouse   246 ISIVGGNETPL---INIVIQEVYRDGVIARDGRLLAG-----------------DQILQVNN--- 287

  Fly   293 ATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQK------------S 345
                :.:|.|..:         ||...:..|...:||.        |:|.::            :
Mouse   288 ----YDISNVSHN---------HARAVLSQPCSTLQLT--------VLRERRFGSRANSHADGSA 331

  Fly   346 PRQD-FGFSLRKAICLDRTESLTSPIFRPVIFAEPGA-------GGGAT---GLLPGDRLIKVNG 399
            ||.: |...|.|.   |.||.|...:.|..  .|||.       ||.|.   .|...||::.:||
Mouse   332 PRDEVFQVLLHKR---DSTEQLGIKLVRRT--DEPGVFILDLLEGGLAAQDGRLNSNDRVLAING 391

  Fly   400 TPVGELPREIIIEMIRNSGEAVTVEV----QPVAELVELSKRCMAPSTATVEEIDHSITN----- 455
            ..:.....|:..::|:.|||.|.:.:    :|            .||..:.|...||.:|     
Mouse   392 HDLKHGTPELAAQIIQASGERVNLTIARPGKP------------QPSNGSREAGAHSSSNHAQPP 444

  Fly   456 -----GNCNTLRRSASKRFK----RQSRHEN-----GNGGGEEGGAKGV------GHDLEA---- 496
                 |:...|.|..:.:.|    ::..||:     ..|.|.:.|...:      .|...|    
Mouse   445 SHSRPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGR 509

  Fly   497 -------------DVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVD 548
                         |:.:.|..|.|.::.....:.|:.|          ..|.:::.....|.|.:
Mouse   510 IKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVIL----------KALEVQIAEEAAQATEE 564

  Fly   549 EDDVEKQN------SPALDLVEDICELKYLNEASVLH-C----LRQRYAS----NLI------HT 592
            :.....:|      ||:.        :.:|...|.|| |    ||:.|..    :::      ||
Mouse   565 QPSAFSENEYDASWSPSW--------VMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHT 621

  Fly   593 ---------------------KAGPTLLVVNPMAPLSLYSEKVVSMFR 619
                                 |.|..::.||.::.:.:....:|.|.:
Mouse   622 NQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 29/113 (26%)
MYSc 556..1317 CDD:214580 19/106 (18%)
MYSc_Myo18 575..1305 CDD:276837 15/81 (19%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
Lnx2NP_542985.4 mRING-HC-C3HC3D_LNX2 46..90 CDD:319694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..175 4/29 (14%)
NPXY motif 207..210 1/2 (50%)
PDZ 229..315 CDD:214570 22/129 (17%)
PDZ_signaling 336..418 CDD:238492 25/86 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..454 8/48 (17%)
PDZ_signaling 463..539 CDD:238492 12/75 (16%)
PDZ_signaling 596..680 CDD:238492 11/74 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.